The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Thalamic Microinfusion of Antibody to a Voltage-gated Potassium Channel Restores Consciousness during Anesthesia
Open accessAbstract
POTASSIUM (K) channels play a major role in regulating tissue excitability. There are at least four different types of K channels that serve slightly different functions in the nervous system, including voltage-gated (Kv), calcium-activated (KCa), inward rectifying (Kir), and 2-pore (K2P) domain background leak channels.1Many authors have suggested that K channels are involved in producing the effects of anesthesia.1–6Much recent focus has been placed on distinguishing K2P channels as possible targets of anesthetic action,6,7yet interactions with various other K channels like the Kv channels may also be important.2,3,8,9Kv channels are further divided into 12 families (Kv1–Kv12) on the basis of sequence homology and similarity to Drosophila melanogaster (i.e. , fruit-fly) genes.10In Drosophila , the Kv channel genes produce multiple versions of a particular channel and are more commonly known by historical nomenclature such as: Shaker (Kv1.1–Kv1.8), Shab (Kv2.1–Kv2.2), Shaw (Kv3.1–Kv3.4), Shal (Kv4.1–Kv4.3), and ether-a-go-go (Kv10.1–Kv10.2). The eight members of the Shaker -related K channel family (Kv1.1–Kv1.8) are involved with generating voltage-dependent outward currents that regulate action potential threshold, as well as waveform and pacemaker activity in excitable tissue. Kv channels are generally composed of tetramers of alpha subunits. When they are expressed as homomeric channels, most have “delayed rectifier” properties, and the others will exhibit fairly rapid inactivation.11The different Kv1.x family members (where x is any one of the possible eight different subunits) can coassemble into channels with mixed heteromeric alpha subunit compositions. Furthermore, Kv-beta subunits also exist and add on another layer of complex functional diversity in vivo .11The subunit composition of the Kv1 channels not only determines their gating and kinetic properties, it also dramatically affects their expression and localization.11The idea that Kv channels might play a role in anesthesia emerged from the discovery that Drosophila Shaker mutants shake their legs vigorously during ether anesthesia.12,13The Shaker mutant lacks a normal functioning Kv1.x channel, suggesting that the suppression of neural activity under ether anesthesia depends to some extent on a properly functioning Kv1.x channel. Indeed, the amount of isoflurane needed to anesthetize a Shaker mutant with a completely nonfunctioning Kv1.x channel is more than twice the dose needed to anesthetize wild-type flies.14Importantly, the changes in isoflurane doses needed to anesthetize various other Shaker mutants parallels the expected reductions in ionic currents mediated through the respective malfunctioning K channels.14In other words, the more defective the K channel (and the less current that passes through it), the greater the dose of isoflurane needed to anesthetize a particular Shaker mutant. This seems to suggest that anesthesia might work in part by hijacking the functioning of the Kv1.x channel.Recently, the unconsciousness of sleep was also linked to a voltage-dependent K channel.15Mutagenesis analysis was used to screen more than 9,000 Drosophila lines to identify those with a limited ability to sleep. Genetic analysis of these flies revealed a point mutation in a conserved domain of the Shaker gene that involves the voltage sensing portion of Kv1.2 channel.15,16Thus, for Drosophila to sleep, it appears to need current to properly flow through its Kv1.2 channels. Taken together with the earlier anesthesia work, this suggests Kv1.2 channels might be involved with mediating the effects of volatile anesthetics on consciousness.Concurrent with the developments in sleep neurophysiology, a possible role for the central medial thalamus (CMT) in contributing to the unconsciousness of anesthesia was recently identified.17Anesthetic-induced unconsciousness can be reversed with a localized and site-specific microinfusion of nicotine into the CMT of rats.17As the loss of consciousness associated with sleep and anesthesia may share overlapping neurobiological mechanisms,18–21and nicotine is known to also block various K channels,22,23including some Kv channels,24the hypothesis is raised that anesthetic effects on consciousness might involve interactions with Kv1.2 channels located, in part, in the CMT. Herein, we open the investigation into this area of research by microinfusing a Kv1.2 channel blocking antibody directly into the CMT of rats placed in an anesthetic chamber exposed to a dose of inhalational agent that is just sufficient to render them unconscious. As in the case of Drosophila Shaker mutants, which have a chronic malfunction of Kv1.x channels, the acute conduction blockade of the Kv1.2 channels in the CMT should act to rapidly increase the anesthetic dose required to keep the animals unconscious. As the dose of anesthesia will be held constant after the localized antibody microinfusion, a positive result (indicating the possible contr
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Localized infusion of KV1 channel inhibitors into the central thalamus of rodents reverses ongoing sevoflurane or desflurane anesthesia at steady-state [59, 60], arguing that these channels play an important role in establishing arousal thresholds across evolutionarily distant species.”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [59]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
Franks, N. P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2372 · Cited by 1,295
Alkire, M. T., Hudetz, A. G., & Tononi, G. (2008) · Science · doi:10.1126/science.1149213 · Cited by 1,245
Self-citationVan der Werf, Y. D., Witter, M. P., & Groenewegen, H. J. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00181-9 · Cited by 994
Mechanisms of Actions of Inhaled Anesthetics
Campagna, J. A., Miller, K. W., & Forman, S. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021261 · Cited by 805
Molecular and neuronal substrates for general anaesthetics
Rudolph, U., & Antkowiak, B. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1496 · Cited by 771
Gutman, G. A., Chandy, K. G., Adelman, J. P., Aiyar, J., Bayliss, D. A., Clapham, D. E., Covarriubias, M., Désir, G. V., Furuichi, K., Ganetzky, B., et al. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.9 · Cited by 582
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
Nelson, L. E., Guo, T. Z., Lu, J., Saper, C. B., Franks, N. P., & Maze, M. (2002) · Nature Neuroscience · doi:10.1038/nn913 · Cited by 568
Reduced sleep in Drosophila Shaker mutants
Cirelli, C., Bushey, D., Hill, S., Huber, R., Kreber, R. A., Ganetzky, B., & Tononi, G. (2005) · Nature · doi:10.1038/nature03486 · Cited by 474
Localization of Voltage-Gated Ion Channels IN Mammalian Brain
Trimmer, J. S., & Rhodes, K. J. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032102.113328 · Cited by 442
Cited by
Sorted by citations
Boveroux, P., Vanhaudenhuyse, A., Bruno, M.-A., Noirhomme, Q., Lauwick, S., Luxen, A., Degueldre, C., Plenevaux, A., Schnakers, C., Phillips, C., et al. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181f697f5 · Cited by 630
Taylor, N. E., Van Dort, C. J., Kenny, J. D., Pei, J., Guidera, J. A., Vlasov, K. Y., Lee, J. T., Boyden, E. S., Brown, E. N., & Solt, K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614340113 · Cited by 269
Friedman, E. B., Sun, Y., Moore, J. T., Hung, H.-T., Meng, Q. C., Perera, P., Joiner, W. J., Thomas, S. A., Eckenhoff, R. G., Sehgal, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011903 · Cited by 218
Tasserie, J., Uhrig, L., Sitt, J. D., Manasova, D., Dupont, M., Dehaene, S., & Jarraya, B. (2022) · Science Advances · doi:10.1126/sciadv.abl5547 · Cited by 171
The Neural Circuits Underlying General Anesthesia and Sleep
Moody, O. A., Zhang, E. R., Vincent, K. F., Kato, R., Melonakos, E. D., Nehs, C. J., & Solt, K. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005361 · Cited by 176
Sleep-wake control and the thalamus
Gent, T. C., Bassetti, C. L., & Adamantidis, A. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.08.002 · Cited by 175
The thalamic dynamic core theory of conscious experience
Ward, L. M. (2011) · Consciousness and Cognition · doi:10.1016/j.concog.2011.01.007 · Cited by 176
The Biology of General Anesthesia from Paramecium to Primate
Kelz, M. B., & Mashour, G. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.071 · Cited by 151
Mashour, G. A., & Hudetz, A. G. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00044 · Cited by 133
Brain areas that influence general anesthesia
Leung, L. S., Luo, T., Ma, J., & Herrick, I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.08.001 · Cited by 126
Regulation of cortical activity and arousal by the matrix cells of the ventromedial thalamic nucleus
Honjoh, S., Sasai, S., Schiereck, S. S., Nagai, H., Tononi, G., & Cirelli, C. (2018) · Nature Communications · doi:10.1038/s41467-018-04497-x · Cited by 118
Anesthesia and the neurobiology of consciousness
Mashour, G. A. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.002 · Cited by 127
Palanca, B. J. A., Mitra, A., Larson-Prior, L., Snyder, A. Z., Avidan, M. S., & Raichle, M. E. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000731 · Cited by 112
The thalamus: gateway to the mind
Ward, L. M. (2013) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1256 · Cited by 124
Mashour, G. A., Orser, B. A., Avidan, M. S., & Warner, D. S. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31820fc9b6 · Cited by 111
Turning a Negative into a Positive: Ascending GABAergic Control of Cortical Activation and Arousal
Brown, R. E., & McKenna, J. T. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00135 · Cited by 95
Human neural correlates of sevoflurane-induced unconsciousness
Palanca, B. J. A., Avidan, M. S., & Mashour, G. A. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex244 · Cited by 97
Bao, W., Xu, W., Pan, G.-J., Wang, T., Han, Y., Qu, W., Li, W., & Huang, Z. (2021) · Current Biology · doi:10.1016/j.cub.2021.02.011 · Cited by 91
Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I
Quintana, A., Morgan, P. G., Kruse, S. E., Palmiter, R. D., & Sedensky, M. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042904 · Cited by 86
“Although many authors hypothesize that anesthetics act diffusely throughout the CNS, others attribute their actions to specific brain regions; for example, a portion of the rat brainstem has been dubbed the ‘‘mesopontine tegmental anesthesia area’’ since injection of GABAA receptor agonists into this region produces a…”
BackgroundJoiner, W. J., Friedman, E. B., Hung, H.-T., Koh, K., Sowcik, M., Sehgal, A., & Kelz, M. B. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003605 · Cited by 82
Pal, D., Li, D., Dean, J. G., Brito, M. A., Liu, T., Fryzel, A. M., Hudetz, A. G., & Mashour, G. A. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1910-19.2019 · Cited by 80
Prefrontal cortex as a key node in arousal circuitry
Mashour, G. A., Pal, D., & Brown, E. N. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.07.002 · Cited by 83
Consciousness, Anesthesia, and the Thalamocortical System
Mashour, G. A., & Alkire, M. T. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318277a9c6 · Cited by 79
Self-citationReimann, H. M., & Niendorf, T. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00008 · Cited by 75
Lioudyno, M. I., Birch, A. M., Tanaka, B. S., Sokolov, Y., Goldin, A. L., Chandy, K. G., Hall, J. E., & Alkire, M. T. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0344-13.2013 · Cited by 68
Self-citationInvolvement of Tuberomamillary Histaminergic Neurons in Isoflurane Anesthesia
Luo, T., & Leung, L.-W. S. (2011) · Anesthesiology · doi:10.1097/aln.0b013e3182207655 · Cited by 67
Hambrecht‐Wiedbusch, V. S., Li, D., & Mashour, G. A. (2017) · Anesthesiology · doi:10.1097/aln.0000000000001512 · Cited by 68
Paraventricular thalamus controls consciousness transitions during propofol anaesthesia in mice
Wang, Y.-L., Wang, L., Xu, W., He, M., Dong, H., Shi, H., Chen, Y., & Huang, Z. (2023) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.01.016 · Cited by 60
Cognitive Activation by Central Thalamic Stimulation: The Yerkes-Dodson Law Revisited
Mair, R. G., Onos, K. D., & Hembrook‐Short, J. R. (2010) · Dose-Response · doi:10.2203/dose-response.10-017.mair · Cited by 65
Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics
Covarrubias, M., Barber, A. F., Carnevale, V., Treptow, W. L., & Eckenhoff, R. G. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.09.032 · Cited by 56
Liu, X., Xue, Q., Zeng, Q., Li, Q., Liu, J., Feng, X., & Yu, B. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.08.011 · Cited by 54
Safavynia, S. A., Keating, G. L., Speigel, I. A., Fidler, J. A., Kreuzer, M., Rye, D. B., Jenkins, A., & García, P. S. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001134 · Cited by 54
From Genetics to Structure to Function: Exploring Sleep in Drosophila
Bushey, D., & Cirelli, C. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-387003-2.00009-4 · Cited by 55
The Role of Dendritic Signaling in the Anesthetic Suppression of Consciousness
Meyer, K. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000673 · Cited by 53
Caffeine accelerates recovery from general anesthesia
Wang, Q., Fong, R., Mason, P., Fox, A. P., & Xie, Z. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00792.2013 · Cited by 53
The Neurobiology of Anesthetic Emergence
Tarnal, V., Vlisides, P. E., & Mashour, G. A. (2015) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0000000000000212 · Cited by 49
Mapelli, J., Gandolfi, D., Giuliani, E., Casali, S., Congi, L., Barbieri, A., D'Angelo, E. U., & Bigiani, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-83714-y · Cited by 46
α2-Adrenergic Stimulation of the Ventrolateral Preoptic Nucleus Destabilizes the Anesthetic State
McCarren, H. S., Chalifoux, M. R., Han, B., Moore, J. T., Meng, Q. C., Baron-Hionis, N., Sedigh-Sarvestani, M., Contreras, D., Beck, S. G., & Kelz, M. B. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1135-14.2014 · Cited by 45
Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans
Fong, R., Wang, L., Zacny, J. P., Khokhar, S., Apfelbaum, J. L., Fox, A. P., & Xie, Z. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002367 · Cited by 43
Asymmetric neural dynamics characterize loss and recovery of consciousness
Huang, Z., Tarnal, V., Vlisides, P. E., Janke, E., McKinney, A., Picton, P., Mashour, G. A., & Hudetz, A. G. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118042 · Cited by 43
Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats
Guidera, J. A., Taylor, N. E., Lee, J. T., Vlasov, K. Y., Pei, J., Stephen, E. P., Mayo, J. P., Brown, E. N., & Solt, K. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00036 · Cited by 42
Kenny, J. D., Chemali, J. J., Cotten, J. F., Dort, C. J. V., Kim, S., Ba, D. E., Taylor, N. E., Brown, E. N., & Solt, K. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001234 · Cited by 43
Regulatory effect of general anesthetics on activity of potassium channels
Li, Y., Xu, J., Xu, Y., Zhao, X.-Y., Liu, Y., Wang, J., Wang, G.-M., Lv, Y.-T., Tang, Q.-Y., & Zhang, Z. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0239-1 · Cited by 39
Andrada, J., Livingston, P., Lee, B.-J., & Antognini, J. F. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3182405228 · Cited by 39
Halothane-induced Hypnosis Is Not Accompanied by Inactivation of Orexinergic Output in Rodents
Gompf, H. S., Chen, J., Sun, Y., Yanagisawa, M., Aston‐Jones, G., & Kelz, M. B. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b764b3 · Cited by 37
Woll, K. A., Peng, W., Liang, Q., Zhi, L., Jacobs, J. A., Maciunas, L. J., Bhanu, N. V., Garcia, B. A., Covarrubias, M., Loll, P. J., et al. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00222 · Cited by 38
Sleep and Anesthesia Interactions: A Pharmacological Appraisal
Scharf, M. T., & Kelz, M. B. (2012) · Current anesthesiology reports · doi:10.1007/s40140-012-0007-0 · Cited by 41
Memory formation during anaesthesia: plausibility of a neurophysiological basis
Veselis, R. A. (2015) · British Journal of Anaesthesia · doi:10.1093/bja/aev035 · Cited by 37
Mitochondrial Function in Astrocytes Is Essential for Normal Emergence from Anesthesia in Mice
Ramadasan-Nair, R., Hui, J., Itsara, L. S., Morgan, P. G., & Sedensky, M. M. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002528 · Cited by 37
Antibody therapeutics targeting ion channels: are we there yet?
Sun, H., & Li, M. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.202 · Cited by 34
Propofol disrupts the functional core-matrix architecture of the thalamus in humans
Huang, Z., Mashour, G. A., & Hudetz, A. G. (2024) · Nature Communications · doi:10.1038/s41467-024-51837-1 · Cited by 35
Timic Stamenic, T., Feseha, S., Valdez, R., Zhao, W., Klawitter, J., & Todorovic, S. M. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz002 · Cited by 28
Neurobiological basis of emergence from anesthesia
Song, X., & Hu, J.-J. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.02.006 · Cited by 32
Caffeine accelerates recovery from general anesthesia via multiple pathways
Fong, R., Khokhar, S., Chowdhury, A. N., Xie, K. G., Wong, J. H.-Y., Fox, A. P., & Xie, Z. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00393.2017 · Cited by 29
Liang, Q., Anderson, W. D., Jones, S. T., Souza, C. S., Hosoume, J. M., Treptow, W. L., & Covarrubias, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143363 · Cited by 26
Kantonen, O., Laaksonen, L., Alkire, M. T., Scheinin, A., Långsjö, J., Kallionpää, R., Kaisti, K. K., Radek, L., Johansson, J. J., Laitio, T. T., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2339-22.2023 · Cited by 26
Self-citationCascella, M., Bimonte, S., & Muzio, M. R. (2018) · World Journal of Methodology · doi:10.5662/wjm.v8.i2.9 · Cited by 27
Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness
Cacciatore, M., Magnani, F. G., Barbadoro, F., Ippoliti, C., Stanziano, M., Clementi, L., Nigri, A., Nanetti, L., Marino, S., Porta, F. L., et al. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1509668 · Cited by 26
Progress in modelling of brain dynamics during anaesthesia and the role of sleep-wake circuitry
Nguyen, G., & Postnova, S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114388 · Cited by 21
Zheng, Z. S., & Monti, M. M. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.960439 · Cited by 24
Kaskinoro, K., Maksimow, A. T., Georgiadis, S., Långsjö, J., Scheinin, H., Karjalainen, P. A., & Jääskeläinen, S. K. (2014) · Anaesthesia · doi:10.1111/anae.12868 · Cited by 21
Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels
Bu, W., Liang, Q., Zhi, L., Maciunas, L. J., Loll, P. J., Eckenhoff, R. G., & Covarrubias, M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0437-2 · Cited by 16
Bao, W., Ding, J., Jiang, S., Yao, Z., Qu, W., Li, W., Huang, Z., & Han, Y. (2023) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006436 · Cited by 18
Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei
Hu, Y., Wang, Y., Zhang, L., Luo, M., & Wang, Y. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01286-z · Cited by 17
Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics
Stamenić, T. T., & Todorovic, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042349 · Cited by 16
Xia, J.-M., Fan, B., Yi, X., Ni, W., Zhou, Y., Chen, D., Yi, W.-J., Feng, L., Xia, Y., Li, S., et al. (2023) · Anesthesiology · doi:10.1097/aln.0000000000004798 · Cited by 15
Fox, A. P., Wagner, K. R., Towle, V. L., Xie, K. G., & Xie, Z. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241818 · Cited by 15
Gupta, S., Dura, J. A., Freites, J. A., Tobias, D. J., & Blasie, J. K. (2012) · Langmuir · doi:10.1021/la301219z · Cited by 14
Modelling Sleep and General Anaesthesia
SLEIGH, J. W., Voss, L. J., Steyn‐Ross, M. L., Steyn‐Ross, D. A., & Wilson, M. T. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0173-5_2 · Cited by 15
Gent, T. C., & Adamantidis, A. (2017) · Clinical and Translational Neuroscience · doi:10.1177/2514183x17726281 · Cited by 13
Stamenić, T. T., & Todorovic, S. M. (2018) · eNeuro · doi:10.1523/eneuro.0016-18.2018 · Cited by 12
Mansouri, M. T., & García, P. S. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005379 · Cited by 13
Pillay, S., Liu, X., Baracskay, P., & Hudetz, A. G. (2014) · Brain Connectivity · doi:10.1089/brain.2014.0254 · Cited by 12
Mashour, G. A. (2022) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005983 · Cited by 11
The memory stages of a spatial Y-maze task are not affected by a low dose of ketamine/midazolam
Valentim, A. M., Ribeiro, P. O., Olsson, I. A. S., & Antunes, L. M. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.027 · Cited by 11
Luppi, A. I., Uhrig, L., Tasserie, J., Signorelli, C. M., Stamatakis, E. A., Alain Destexhe, A., Jarraya, B., & Cofré, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.30.547281 · Cited by 10
Brain areas modulation in consciousness during sevoflurane anesthesia
Jie, L., Cai, H., Chen, Y., & Chen, G. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.1031613 · Cited by 8
Yuan, C., Zhang, Y., Zhang, Y., Cao, S., Wang, Y., Fu, B., & Yu, T. (2016) · PubMed · Cited by 9
Zheng, Z. S., & Monti, M. M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/688283 · Cited by 11
Jang, H., Fotiadis, P., Mashour, G. A., Hudetz, A. G., & Huang, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-66832-3 · Cited by 8
Lu, P.-L., Tsai, M., Jaw, F., & Yen, C. (2019) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-00656-3 · Cited by 6
Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics
Yang, E., Zhi, L., Liang, Q., & Covarrubias, M. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.01.013 · Cited by 5
Mashour, G. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800948-2.00009-1 · Cited by 6
Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice
Labbaf, A., Dellin, M., Komadowski, M. A., Chetkovich, D. M., Decher, N., Pape, H.-C., Seebohm, G., Budde, T., & Zobeiri, M. (2023) · Biological Chemistry · doi:10.1515/hsz-2023-0116 · Cited by 4
Berger, M., & García, P. S. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001207 · Cited by 4
Steffey, E. P., Brosnan, R. J., & Mama, K. R. (2024) · doi:10.1002/9781119830306.ch28 · Cited by 4
Comparison of anaesthetic- and seizure-induced states of unconsciousness: a narrative review
Gruenbaum, B. F. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.07.056 · Cited by 3
rKv1.2 overexpression in the central medial thalamic area decreases caffeine-induced arousal
Cazzin, C., Piccoli, L., Massagrande, M., Garbati, N., Michielin, F., Knaus, H. G., Ring, C., Morrison, A. D., Merlo‐Pich, E., Rovó, Z., et al. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00719.x · Cited by 3
South Africa's foreign policy and international relations during 2012
Kotzé, D. (2012) · South African Yearbook of International Law · Cited by 3
Kelz, M. B., & SLEIGH, J. W. (2012) · Anesthesiology · doi:10.1097/aln.0b013e3182518cc4 · Cited by 3
Propofol Disrupts the Functional Core-Matrix Architecture of the Thalamus in HumansPreprint
Huang, Z., Mashour, G. A., & Hudetz, A. G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.23.576934 · Cited by 3
Anesthesia and the Thalamocortical System
Alkire, M. T. (2009) · Contemporary clinical neuroscience · doi:10.1007/978-1-60761-462-3_6 · Cited by 2
Self-citationXylazine-ketamine anesthesia following premedication of New Zealand white rabbits with vitamin C.
Yanmaz, L. E., Doğan, E., Okumuş, Z., Şenocak, M. G., Prastiwi, A., & Yıldırım, F. (2016) · Kafkas Universitesi Veteriner Fakultesi Dergisi · Cited by 2
McKinstry-Wu, A. R., & Kelz, M. B. (2023) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.11.002 · Cited by 1
Stamenić, T. T., Feseha, S., Fine-Raquet, B., Tadic, V. P., & Todorovic, S. M. (2025) · Experimental Biology and Medicine · doi:10.3389/ebm.2025.10553 · Cited by 1
The worm sheds light on anesthetic mechanisms
Singaram, V. K., Morgan, P. G., & Sedensky, M. M. (2012) · Worm · doi:10.4161/worm.20002
Behavioural effects of anaesthetics in mice - risk of cognitive alterations
Valentim, A. M. (2012)
Optogenetic Dissection of Sleep–Wake Control: Evidence for a Thalamic Control of Sleep Architecture
Latchoumane, C.-F. V., & Shin, H. (2017) · Cambridge University Press eBooks · doi:10.1017/9781107281875.030
Thalamic Mechanisms Mediating the Sedating Effects of General Anesthesia
Mesbah-Oskui, B. L. (2016) · TSpace (University of Toronto)
MacIver, M. B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734986474.793555990
Metadata
- Authors
- Alkire, M. T., Asher, C. D., Franciscus, A. M., & Hahn, E. L.
- Affiliations
- Associate Professor in Residence, Department of Anesthesiology and Perioperative Care and Fellow, the Center for the Neurobiology of Learning and Memory.
- Medical Student.
- University of California, Irvine (US)
- Staff Research Associate, Department of Anesthesiology.
- Venue
- Anesthesiology
- Published
- 2009-04-01
- Volume
- 110
- Issue
- 4
- Pages
- 766-773
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2090397682
- Cited by
- 105
- References
- 63
- Citations by year
- 2025: 4 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 9 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 8
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- voltage-gated potassium channels, anesthesia, consciousness, microinfusion, thalamus, Shakers, Shaw, Kv1.1, Kv1.2, Kv1.3 potassium channel, Kv1.4, Kv1.5, Kv1.6
- MeSH terms
- Sevoflurane, Desflurane, Anesthesia, Inhalation, Animals, Antibodies, Arousal, Consciousness, Cytoskeletal Proteins, Drosophila, Isoflurane, Male, Methyl Ethers, Microinjections, Nerve Tissue Proteins, Thalamic Nuclei, Potassium Channels, Rats, Sprague-Dawley, Anesthetics, Inhalation, Rats, Kv1.2 Potassium Channel
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
