The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Intrahepatic Cholestasis of Pregnancy
Abstract
In Brief Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease that typically presents in the third trimester. The clinical features are maternal pruritus in the absence of a rash and deranged liver function tests, including raised serum bile acids. Intrahepatic cholestasis of pregnancy is associated with an increased risk of adverse perinatal outcomes, including spontaneous preterm delivery, meconium staining of the amniotic fluid, and stillbirth. It is commonly treated with ursodeoxycholic acid. There is accumulating evidence to suggest that intrahepatic cholestasis of pregnancy has a lasting influence on both maternal and fetal health. We review the etiology, diagnosis, and management of this intriguing condition. Intrahepatic cholestasis of pregnancy causes pruritus, deranged liver function, and raised serum bile acids and is associated with an increased risk of adverse perinatal outcomes.
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Cites
Glantz, A., Marschall, H.-U., & Mattsson, L.-Å. (2004) · Hepatology · doi:10.1002/hep.20336 · Cited by 844
Geenes, V., Chappell, L. C., Seed, P. T., Steer, P. J., Knight, M., & Williamson, C. (2014) · Hepatology · doi:10.1002/hep.26617 · Cited by 479
Self-citationIntrahepatic cholestasis of pregnancy: A retrospective case-control study of perinatal outcome
Rioseco, A. J., Ivankovic, M. B., Manzur, A., Hamed, F., Kato, S. R., Parer, J. T., & Germain, A. M. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(94)70304-3 · Cited by 380
Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy
Jacquemin, E., Cresteil, D., Manouvrier, S., Boute, O., & Hadchouel, M. (1999) · The Lancet · doi:10.1016/s0140-6736(05)77221-4 · Cited by 367
Palma, J., Reyes, H., Ribalta, J., Hernández, I., Sandoval, L., Almuna, R., Liepins, J., Lira, F., Sedano, M., Silva, O., et al. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80146-8 · Cited by 339
Fetal outcome in obstetric cholestasis
Fisk, N. M., & Storey, G. N. B. (1988) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1988.tb06791.x · Cited by 332
Intrahepatic cholestasis of pregnancy: A French prospective study
Bacq, Y., Sapey, T., Brechot, M., Pierre, F., Fignon, A., & Dubois, F. (1997) · Hepatology · doi:10.1002/hep.510260216 · Cited by 329
MARSCHALL, H., WAGNER, M., ZOLLNER, G., FICKERT, P., DICZFALUSY, U., GUMHOLD, J., SILBERT, D., FUCHSBICHLER, A., BENTHIN, L., & GRUNDSTROM, R. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.009 · Cited by 325
Wikström Shemer, E., Marschall, H., Ludvigsson, J., & Stephansson, O. (2013) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12174 · Cited by 299
Kremer, A. E., van Dijk, R., Leckie, P., Schaap, F. G., Kuiper, E. M. M., Mettang, T., Reiners, K. S., Raap, U., van Buuren, H. R., van Erpecum, K. J., et al. (2012) · Hepatology · doi:10.1002/hep.25748 · Cited by 291
Cited by
Ovadia, C., Seed, P. T., Sklavounos, A., Geenes, V., Di Ilio, C., Chambers, J., Kohari, K., Bacq, Y., Bozkurt, N., Brun-Furrer, R., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(18)31877-4 · Cited by 574
Self-citationWestbrook, R. H., Dusheiko, G., & Williamson, C. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.030 · Cited by 264
Self-citationPlacental metabolomics for assessment of pregnancy complications: A systematic review
Mercer, G. V., & Cahill, L. S. (2026) · Molecular Omics · doi:10.1093/molecular-omics/aaiag015 · Cited by 2
Metadata
- Authors
- Williamson, C., & Geenes, V.
- Venue
- Obstetrics & Gynecology
- Published
- 2014-07
- Volume
- 124
- Issue
- 1
- Pages
- 120-133
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2043385334
- Cited by
- 469
- References
- 54
- FWCI
- 22.56
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
