Cited by 72Pelvic floor disorders treatmentsSexual function and dysfunction studiesUterine Myomas and Treatments

Quality of life and sexual function 2 years after vaginal surgery for prolapse.

Open access
Lukacz, Emily S., Warren, Lauren Klein, Richter, Holly E., Brubaker, Linda, Barber, Matthew D., Norton, Peggy, Weidner, Alison C., Nguyen, John N. +1 more·2016·Obstetrics & Gynecology

Abstract

OBJECTIVE: To longitudinally assess the effect of native tissue vaginal apical prolapse repair with anti-incontinence surgery on quality of life, sexual function, and body image between uterosacral and sacrospinous suspensions. METHODS: A planned secondary analysis was performed on 374 women enrolled in a randomized trial of the two types of native tissue repair for apical prolapse. Condition-specific and generic quality of life, sexual function, overall and de novo dyspareunia, and body image were assessed using validated instruments at baseline; 6, 12, and 24 months postoperatively; and changes from baseline were assessed and compared between surgical groups. General linear mixed models were used for comparisons and clinically significant differences were assessed using minimum important differences. RESULTS: Of the women randomized, 82% had outcomes available at 2 years. Overall, clinically and statistically significant improvements in generic and condition-specific quality of life and sexual function were observed after surgery. Dyspareunia rates decreased from 25% to 16% by 24 months with only 3% of all women undergoing treatment. De novo dyspareunia occurred in 5% and 10% by 12 and 24 months, respectively. Body image scores also significantly improved from baseline. There were no clinically meaningful or statistically significant differences between groups for any of these outcomes (all P>.05). CONCLUSION: Native tissue vaginal prolapse surgery results in statistically and clinically significant improvements in quality of life, sexual function, and body image at 24 months with no significant differences between uterosacral and sacrospinous suspensions. One in 10 women experience de novo dyspareunia but few requested treatment. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00597935.

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  • A conservative estimate of the minimal clinically important difference for the POPDI has been previously reported to be 34.3 points.

    “A conservative estimate of the minimal clinically important difference for the POPDI has been previously reported to be 34.3 points.18,19”

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Authors
Lukacz, E. S., Warren, L. K., Richter, H. E., Brubaker, L., Barber, M. D., Norton, P., Weidner, A. C., Nguyen, J. N., & Gantz, M. G.
Affiliations
Cleveland Clinic (US)
Venue
Obstetrics & Gynecology
Published
2016-06
Volume
127
Issue
6
Pages
1071-1079
ISSN
0029-7844 (ISSN-L)
OpenAlex
W2372075305
Cited by
72
References
29
Citations by year
2026: 6 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 1
FWCI
9.93
Type
journal article
Language
en
Open access
Locations
  • Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U10HD041261, U10HD054136, UG1HD041261, U10HD054214, U01HD041249, U10HD054215, UG1HD054215, U01HD069031, U10HD041267, U10HD054241, U10HD041250, UG1HD054214)
Topics
  • Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
Keywords
quality of life, sexual function, dyspareunia, body image, anti-incontinence surgery, long-term outcomes
MeSH terms
Body Image, Female, Humans, Middle Aged, Postoperative Period, Quality of Life, Surveys and Questionnaires, Sexual Behavior, Urinary Incontinence, Uterine Prolapse, Suburethral Slings

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