The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
What is IgG4? A review of the biology of a unique immunoglobulin subtype
Abstract
PURPOSE OF REVIEW: Recent descriptions of the group of clinical disorders collectively defined as IgG4-related systemic disease (IgG4-RSD) have prompted this review of the unique biology of the IgG4 antibody. This article will discuss IgG4 structure and function, the unique phenomenon of half-antibody exchange, and the implications of IgG4 biology for its proposed role in immunologic diseases. RECENT FINDINGS: IgG4 antibodies have unique structural and functional properties and undergo 'half-antibody exchange' in vivo, resulting in recombined antibodies composed of two different binding specificities. The production of IgG4 antibodies appears to be driven in part by T helper 2 (Th2) cytokines that mediate allergic responses and IgE production. Although serum IgG4 levels in healthy individuals vary significantly, data from multiple sclerosis (MS) patients suggest tight regulation of individual IgG4 levels over time. IgG4-RSD represents a diverse group of clinical disorders unified by elevated IgG4 levels and specific histopathologic findings. A key unanswered question is whether IgG4, a relatively weak activator of effector cells, is pathogenic in these disorders. SUMMARY: IgG4 is a unique antibody biologically and structurally. Increased understanding of its precise role in the clinical syndromes that comprise IgG4-RSD may ultimately elucidate the underlying pathogenesis.
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Cites
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Cited by
IgG4‐Related Disease: Clinical and Laboratory Features in One Hundred Twenty‐Five Patients
Wallace, Z. S., Deshpande, V., Mattoo, H., Mahajan, V. S., Kulikova, M., Pillai, S., & Stone, J. H. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39205 · Cited by 666
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The clinical significance of allergen-specific IgG4 in allergic diseases
Qin, L., Tang, L.-F., Cheng, L., & Wang, H.-Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1032909 · Cited by 71
Metadata
- Authors
- Nirula, A., Glaser, S. M., Kalled, S. L., & Taylora, F. R.
- Venue
- Current Opinion in Rheumatology
- Published
- 2011-01
- Volume
- 23
- Issue
- 1
- Pages
- 119-124
- ISSN
- 1040-8711 (ISSN-L)
- OpenAlex
- W2090542053
- Cited by
- 309
- References
- 30
- FWCI
- 16.26
- Type
- journal article
- Language
- en
- Open access
- closed
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