The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Serologic issues in IgG4-related systemic disease and autoimmune pancreatitis
Abstract
PURPOSE OF REVIEW: IgG4-related systemic disease (ISD) is a recently recognized syndrome affecting multiple organs. Autoimmune pancreatitis (AIP) is the pancreatic manifestation of ISD and mimics pancreatic cancer. Current data show frequent association with serum IgG4 elevation and other serologic abnormalities. Here we explore the diagnostic and possible prognostic utility and pathogenetic implications of serologic abnormalities in ISD. RECENT FINDINGS: Serum IgG4 elevations (>140 mg/dl) are seen in 70-80% of AIP patients and also in 5% of normal population and 10% of pancreatic cancer making it an unsuitable single marker for diagnosis. However, when combined with other features of AIP, it can be of great diagnostic value though its utility in monitoring of therapy or as a marker or predictor of relapse is limited. Several other antibodies have been identified in AIP against pancreas-specific antigens like trypsinogens I and II, pancreatic secretory trypsin inhibitor (PSTI) and plasminogen binding protein (PBP) and other nonpancreas-specific antigens. Anti-PBP antibodies appear to have potential diagnostic utility but require further validation. SUMMARY: No single serologic marker is diagnostic of ISD. Serum IgG4 elevation has convincing diagnostic utility when combined with other disease features although its value in disease monitoring may be limited.
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High Serum IgG4 Concentrations in Patients with Sclerosing Pancreatitis
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Diagnosis of Autoimmune Pancreatitis: The Mayo Clinic Experience
Chari, S. T., Smyrk, T. C., Levy, M. J., Topazian, M. D., Takahashi, N., Zhang, L., Clain, J. E., Pearson, R. K., Petersen, B. T., Vege, S. S., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.05.017 · Cited by 972
Self-citationImmunoglobulin G4-associated cholangitis: clinical profile and response to therapy
Ghazale, A., Chari, S. T., Zhang, L., Smyrk, T. C., Takahashi, N., Levy, M. J., Topazian, M. D., Clain, J. E., Pearson, R. K., Petersen, B. T., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.12.009 · Cited by 890
Self-citationStandard steroid treatment for autoimmune pancreatitis
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Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease
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Differences in Clinical Profile and Relapse Rate of Type 1 Versus Type 2 Autoimmune Pancreatitis
Sah, R. P., Chari, S. T., Pannala, R., Sugumar, A., Clain, J. E., Levy, M. J., Pearson, R. K., Smyrk, T. C., Petersen, B. T., Topazian, M. D., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.054 · Cited by 460
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Vidarsson, G., Dekkers, G., & Rispens, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00520 · Cited by 2,667
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Consensus statement on the pathology of IgG4-related disease
Deshpande, V., Zen, Y., Chan, J. K., Yi, E. E., Sato, Y., Yoshino, T., Klöppel, G., Heathcote, J. G., Khosroshahi, A., Ferry, J. A., et al. (2012) · Modern Pathology · doi:10.1038/modpathol.2012.72 · Cited by 2,596
Self-citationIgG4-Related Disease: Dataset of 235 Consecutive Patients
Inoue, D., Yoshida, K., Yoneda, N., Ozaki, K., Matsubara, T., Nagai, K., Okumura, K., Toshima, F., Toyama, J., Minami, T., et al. (2015) · Medicine · doi:10.1097/md.0000000000000680 · Cited by 451
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Metadata
- Authors
- Sah, R. P., & Chari, S. T.
- Venue
- Current Opinion in Rheumatology
- Published
- 2011-01
- Volume
- 23
- Issue
- 1
- Pages
- 108-113
- ISSN
- 1040-8711 (ISSN-L)
- OpenAlex
- W2327278694
- Cited by
- 340
- References
- 51
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- closed
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