The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Triterpenoids as new promising anticancer drugs
Abstract
Triterpenoids are structurally diverse organic compounds, characterized by a basic backbone modified in multiple ways, allowing the formation of more than 20 000 naturally occurring triterpenoid varieties. Several triterpenoids, including ursolic and oleanolic acid, betulinic acid, celastrol, pristimerin, lupeol, and avicins possess antitumor and anti-inflammatory properties. To improve antitumor activity, some synthetic triterpenoid derivatives have been synthesized, including cyano-3,12-dioxooleana-1,9 (11)-dien-28-oic (CDDO), its methyl ester (CDDO-Me), and imidazolide (CDDO-Im) derivatives. Of these, CDDO, CDDO-Me, and betulinic acid have shown promising antitumor activities and are presently under evaluation in phase I studies. Triterpenoids are highly multifunctional and the antitumor activity of these compounds is measured by their ability to block nuclear factor-kappaB activation, induce apoptosis, inhibit signal transducer, and activate transcription and angiogenesis.
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1 retracted
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Cited by
Pollier, J., & Goossens, A. (2012) · Phytochemistry · doi:10.1016/j.phytochem.2011.12.022 · Cited by 499
Shanmugam, M. K., Dai, X., Kumar, A. P., Tan, B. K. H., Sethi, G., & Bishayee, A. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.01.016 · Cited by 271
Kulkarni, A. A., Thatcher, T. H., Olsen, K. C., Maggirwar, S. B., Phipps, R. P., & Sime, P. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015909 · Cited by 189
Quinoa Secondary Metabolites and Their Biological Activities or Functions
Lin, M., Han, P., Li, Y., Wang, W., Lai, D., & Zhou, L. (2019) · Molecules · doi:10.3390/molecules24132512 · Cited by 152
Novel Derivative of Bardoxolone Methyl Improves Safety for the Treatment of Diabetic Nephropathy
Huang, Z., Mou, Y., Xu, X., Zhao, D., Lai, Y., Xu, Y., Chen, C., Li, P., Peng, S., Tian, J., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00971 · Cited by 40
Metadata
- Authors
- Petronelli, A., Pannitteri, G., & Testa, U.
- Venue
- Anti-Cancer Drugs
- Published
- 2009-11
- Volume
- 20
- Issue
- 10
- Pages
- 880-892
- ISSN
- 0959-4973 (ISSN-L)
- OpenAlex
- W1977773503
- Cited by
- 381
- References
- 108
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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