Cited by 434Intensive Care Unit Cognitive DisordersFamily and Patient Care in Intensive Care UnitsMental Health Treatment and Access

The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.

Depressive Symptoms After Critical Illness: A Systematic Review and Meta-Analysis

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Abstract

Objectives: To synthesize data on prevalence, natural history, risk factors, and post-ICU interventions for depressive symptoms in ICU survivors. Data Sources: PubMed, EMBASE, Cumulative Index of Nursing and Allied Health Literature, PsycINFO, and Cochrane Controlled Trials Registry (1970–2015). Study Selection: Studies measuring depression after hospital discharge using a validated instrument in more than 20 adults from non-specialty ICUs. Data Extraction: Duplicate independent review and data abstraction. Data Synthesis: The search identified 27,334 titles, with 42 eligible articles on 38 unique studies (n = 4,113). The Hospital Anxiety and Depression Scale-Depression subscale was used most commonly (58%). The pooled Hospital Anxiety and Depression Scale-Depression subscale prevalence (95% CI) of depressive symptoms at a threshold score greater than or equal to 8 was 29% (22–36%) at 2–3 months (12 studies; n = 1,078), 34% (24–43%) at 6 months (seven studies; n = 760), and 29% (23–34%) at 12–14 months (six studies; n = 1,041). The prevalence of suprathreshold depressive symptoms (compatible with Hospital Anxiety and Depression Scale-Depression subscale, ≥ 8) across all studies, using all instruments, was between 29% and 30% at all three time points. The pooled change in prevalence (95% CI) from 2–3 to 6 months (four studies; n = 387) was 5% (–1% to +12%), and from 6 to 12 months (three studies; n = 412) was 1% (–6% to +7%). Risk factors included pre-ICU psychologic morbidity and presence of in-ICU psychologic distress symptoms. We did not identify any post-ICU intervention with strong evidence of improvement in depressive symptoms. Conclusions: Clinically important depressive symptoms occurred in approximately one-third of ICU survivors and were persistent through 12-month follow-up. Greater research into treatment is needed for this common and persistent post-ICU morbidity.

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Metadata

Authors
Rabiee, A., Nikayin, S., Hashem, M. D., Huang, M., Dinglas, V. D., Bienvenu, O. J., Turnbull, A. E., & Needham, D. M.
Affiliations
Johns Hopkins University (US)
Venue
Critical Care Medicine
Published
2016-09
Volume
44
Issue
9
Pages
1744-1753
ISSN
0090-3493 (ISSN-L)
OpenAlex
W2364261361
Cited by
434
References
77
Citations by year
2026: 41 · 2025: 36 · 2024: 46 · 2023: 49 · 2022: 56 · 2021: 76 · 2020: 45 · 2019: 31 · 2018: 25 · 2017: 26 · 2016: 3
FWCI
4.46
Type
journal article
Language
en
Open access
Locations
  • Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R24HL111895)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Family and Patient Care in Intensive Care Units
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords
depressive symptoms, critical illness, intensive care unit survivors, prevalence, natural history (disease), risk factors, Hospital Anxiety and Depression Scale
MeSH terms
Adult, Critical Care, Depression, Humans, Risk Factors, Prevalence, Critical Illness

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