Understanding and Enhancing Sepsis Survivorship. Priorities for Research and Practice
Open accessAbstract
An estimated 14.1 million patients survive sepsis each year. Many survivors experience poor long-term outcomes, including new or worsened neuropsychological impairment; physical disability; and vulnerability to further health deterioration, including recurrent infection, cardiovascular events, and acute renal failure. However, clinical trials and guidelines have focused on shorter-term survival, so there are few data on promoting longer-term recovery. To address this unmet need, the International Sepsis Forum convened a colloquium in February 2018 titled “Understanding and Enhancing Sepsis Survivorship.” The goals were to identify gaps and limitations of current research and shorter- and longer-term priorities for understanding and enhancing sepsis survivorship. Twenty-six experts from eight countries participated. The top short-term priorities identified by nominal group technique culminating in formal voting were to better leverage existing databases for research, develop and disseminate educational resources on postsepsis morbidity, and partner with sepsis survivors to define and achieve research priorities. The top longer-term priorities were to study mechanisms of long-term morbidity through large cohort studies with deep phenotyping, build a harmonized global sepsis registry to facilitate enrollment in cohorts and trials, and complete detailed longitudinal follow-up to characterize the diversity of recovery experiences. This perspective reviews colloquium discussions, the identified priorities, and current initiatives to address them.
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Post-critical illness programmes are consistently well-liked by patients and offer an environment to learn about challenges sepsis survivors face and to pilot and test interventions for enhancing recovery.
“While efficacy data are equivocal, these programmes are consistently well-liked by patients and offer an environment to learn about challenges sepsis survivors face, as well as to pilot and test interventions for enhancing recovery [637, 643].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [643]
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Cites
The third international consensus definitions for sepsis and septic shock (Sepsis-3).
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0287 · Cited by 28,250 · see citing works
Self-citationThe UK Biobank resource with deep phenotyping and genomic data
Bycroft, C., Freeman, C., Petkova, D., Band, G., Elliott, L. T., Sharp, K., Motyer, A., Vukcevic, D., Delaneau, O., O’Connell, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0579-z · Cited by 8,876 · see citing works
Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4683-6 · Cited by 6,621 · see citing works
Self-citationSeymour, C. W., Liu, V. X., Iwashyna, T. J., Brunkhorst, F. M., Rea, T. D., Scherag, A., Rubenfeld, G., Kahn, J. M., Shankar-Hari, M., Singer, M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0288 · Cited by 3,939 · see citing works
Self-citationThe Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652 · see citing works
Fleischmann, C., Scherag, A., Adhikari, N. K. J., Hartog, C. S., Tsaganos, T., Schlattmann, P., Angus, D. C., & Reinhart, K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0781oc · Cited by 3,548 · see citing works
Self-citationWilson, I. B. (1995) · JAMA · doi:10.1001/jama.1995.03520250075037 · Cited by 3,027 · see citing works
Long-term cognitive impairment after critical illness
Pandharipande, P. P., Girard, T. D., Jackson, J. C., Morandi, A., Thompson, J. L., Pun, B. T., Brummel, N. E., Hughes, C. G., Vasilevskis, E. E., Shintani, A. K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301372 · Cited by 2,842 · see citing works
Self-citationNeedham, D. M., Davidson, J., Cohen, H., Hopkins, R. O., Weinert, C., Wunsch, H., Zawistowski, C., Bemis-Dougherty, A., Berney, S. C., Bienvenu, O. J., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318232da75 · Cited by 2,639 · see citing works
Self-citationLong-term cognitive impairment and functional disability among survivors of severe sepsis.
Iwashyna, T. J., Ely, E. W., Smith, D. M., & Langa, K. M. (2010) · JAMA · doi:10.1001/jama.2010.1553 · Cited by 2,582 · see citing works
Self-citationCohort Profile: the Health and Retirement Study (HRS)
Sonnega, A., Faul, J. D., Ofstedal, M. B., Langa, K. M., Phillips, J. W., & Weir, D. R. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu067 · Cited by 2,318 · see citing works
Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014.
Rhee, C., Dantes, R., Epstein, L., Murphy, D. J., Seymour, C. W., Iwashyna, T. J., Kadri, S. S., Angus, D. C., Danner, R. L., Fiore, A. E., et al. (2017) · JAMA · doi:10.1001/jama.2017.13836 · Cited by 1,884 · see citing works
Self-citationRecognizing Sepsis as a Global Health Priority — A WHO Resolution
Reinhart, K., Daniels, R., Kissoon, N. “., Machado, F. R., Schachter, R. D., & Finfer, S. R. (2017) · New England Journal of Medicine · doi:10.1056/nejmp1707170 · Cited by 1,361 · see citing works
Self-citationPost-Hospital Syndrome — An Acquired, Transient Condition of Generalized Risk
Krumholz, H. M. (2013) · New England Journal of Medicine · doi:10.1056/nejmp1212324 · Cited by 1,218 · see citing works
The global burden of paediatric and neonatal sepsis: a systematic review
Fleischmann-Struzek, C., Goldfarb, D. A., Schlattmann, P., Schlapbach, L. J., Reinhart, K., & Kissoon, N. “. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30063-8 · Cited by 1,208 · see citing works
Self-citationA Group Process Model for Problem Identification and Program Planning
Delbecq, A. L., & de Ven, A. H. V. (1971) · The Journal of Applied Behavioral Science · doi:10.1177/002188637100700404 · Cited by 1,152 · see citing works
Cohort Profile: The HUNT Study, Norway
Krokstad, S., Langhammer, A., Hveem, K., Holmen, T., Midthjell, K., Stene, T., Bratberg, G., Heggland, J., & Holmen, J. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys095 · Cited by 1,127 · see citing works
Long-Term Cognitive Impairment After Critical Illness
Pandharipande, P. P., Girard, T. D., Jackson, J. C., Morandi, A., Thompson, J. L., Pun, B. T., Brummel, N. E., Hughes, C. G., Vasilevskis, E. E., Shintani, A., et al. (2014) · Survey of Anesthesiology · doi:10.1097/sa.0000000000000071 · Cited by 1,114 · see citing works
Self-citationEnhancing Recovery From Sepsis: A Review
Prescott, H. C., & Angus, D. C. (2018) · JAMA · doi:10.1001/jama.2017.17687 · Cited by 1,059 · see citing works
Self-citationMillion Veteran Program: A mega-biobank to study genetic influences on health and disease
Gaziano, J. M., Concato, J., Brophy, M., Fiore, L., Pyarajan, S., Breeling, J., Whitbourne, S., Deen, J., Shannon, C., Humphries, D., et al. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2015.09.016 · Cited by 1,055 · see citing works
Gentile, L. F., Cuenca, A. G., Efron, P. A., Ang, D., Bihorac, A., McKinley, B. A., Moldawer, L. L., & Moore, F. A. (2012) · Journal of Trauma and Acute Care Surgery · doi:10.1097/ta.0b013e318256e000 · Cited by 801 · see citing works
Posttraumatic Stress Disorder in Critical Illness Survivors: A Metaanalysis*
Parker, A. M., Sricharoenchai, T., Raparla, S., Schneck, K. W., Bienvenu, O. J., & Needham, D. M. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000882 · Cited by 779 · see citing works
Self-citationCohort Profile: The 45 and Up Study
Collaborators, 4. A. U. S. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym184 · Cited by 707 · see citing works
Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis
The PRISM Investigators (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701380 · Cited by 600 · see citing works
Anxiety symptoms in survivors of critical illness: a systematic review and meta-analysis
Nikayin, S., Rabiee, A., Hashem, M. D., Huang, M., Bienvenu, O. J., Turnbull, A. E., & Needham, D. M. (2016) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2016.08.005 · Cited by 467 · see citing works
Self-citationNeedham, D. M., Sepúlveda, K. A., Dinglas, V. D., Chessare, C. M., Friedman, L. A., Bingham, C. O., & Turnbull, A. E. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201702-0372oc · Cited by 464 · see citing works
Self-citationGirard, T. D., Thompson, J. L., Pandharipande, P. P., Brummel, N. E., Jackson, J. C., Patel, M. B., Hughes, C. G., Chandrasekhar, R., Pun, B. T., Boehm, L. M., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30062-6 · Cited by 439 · see citing works
Self-citationDepressive Symptoms After Critical Illness: A Systematic Review and Meta-Analysis
Rabiee, A., Nikayin, S., Hashem, M. D., Huang, M., Dinglas, V. D., Bienvenu, O. J., Turnbull, A. E., & Needham, D. M. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001811 · Cited by 434 · see citing works
Self-citationLate mortality after sepsis: propensity matched cohort study
Prescott, H., Osterholzer, J., Langa, K., Angus, D., & Iwashyna, T. (2016) · British medical journal · doi:10.1136/bmj.i2375 · Cited by 320 · see citing works
Self-citationReadmission diagnoses after hospitalization for severe sepsis and other acute medical conditions
Prescott, H. C., Langa, K. M., & Iwashyna, T. J. (2015) · JAMA · doi:10.1001/jama.2015.1410 · Cited by 286 · see citing works
Self-citationLong-Term Quality of Life Among Survivors of Severe Sepsis: Analyses of Two International Trials*
Yende, S. P., Austin, S., Rhodes, A., Finfer, S. R., Opal, S. M., Thompson, B., Bozza, F. A., LaRosa, S. P., Ranieri, V. M., & Angus, D. C. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001658 · Cited by 279 · see citing works
Self-citationOsuchowski, M. F., Ayala, A., Bahrami, S., Bauer, M. W., Boros, M., Cavaillon, J., Chaudry, I. H., Coopersmith, C. M., Deutschman, C. S., Drechsler, S., et al. (2018) · Shock · doi:10.1097/shk.0000000000001212 · Cited by 260 · see citing works
Self-citationHarrison, D. A., Brady, T., & Rowan, K. (2004) · Critical Care · doi:10.1186/cc2834 · Cited by 230 · see citing works
Self-citationWatson, R. S., Choong, K. L. M., Colville, G. A., Crow, S. S., Dervan, L. A., Hopkins, R. O., Knoester, H., Pollack, M. M., Rennick, J. E., & Curley, M. A. Q. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.12.084 · Cited by 217 · see citing works
Self-citationBidirectional Relationship between Cognitive Function and Pneumonia
Shah, F. A., Pike, F., Alvarez, K., Angus, D. C., Newman, A. B., López, O. L., Tate, J. A., Kapur, V. K., Wilsdon, A., Krishnan, J. A., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201212-2154oc · Cited by 215 · see citing works
Self-citationOu, S., Chu, H., Chao, P.-W., Lee, Y.-J., Kuo, S., Chen, T., Tseng, C.-M., Shih, C.-J., & Chen, Y. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201510-2023oc · Cited by 204 · see citing works
Outcomes and Statistical Power in Adult Critical Care Randomized Trials
Harhay, M. O., Wagner, J., Ratcliffe, S. J., Bronheim, R. S., Gopal, A. D., Green, S., Cooney, E. L., Mikkelsen, M. E., Kerlin, M. P., Small, D. S., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201401-0056cp · Cited by 202 · see citing works
Ritchie, C. W., Molinuevo, J. L., Truyen, L., Satlin, A., der Geyten, S. V., & Lovestone, S. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00454-x · Cited by 202 · see citing works
Risk of Cardiovascular Events in Survivors of Severe Sepsis
Yende, S. P., Linde‐Zwirble, W. T., Mayr, F., Weissfeld, L. A., Reís, S. E., & Angus, D. C. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201307-1321oc · Cited by 182 · see citing works
Self-citationThe Association of Frailty With Post-ICU Disability, Nursing Home Admission, and Mortality
Ferrante, L. E., Pisani, M. A., Murphy, T. E., Gahbauer, E. A., Leo-Summers, L. S., & Gill, T. M. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.03.007 · Cited by 158 · see citing works
van de Klundert, N., Holman, R., Dongelmans, D. A., & de Keizer, N. F. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv291 · Cited by 151 · see citing works
Needham, D. M., Colantuoni, E., Dinglas, V. D., Hough, C. L., Wozniak, A. W., Jackson, J. C., Morris, P. E., Méndez-Téllez, P. A., Ely, E. W., & Hopkins, R. O. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)00005-9 · Cited by 147 · see citing works
Self-citationIwashyna, T. J. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201206-1138ed · Cited by 143 · see citing works
Self-citationGaudry, S., Messika, J., Ricard, J.-D., Guillo, S., Pasquet, B., Dubief, E., Boukertouta, T., Dreyfuss, D., & Tubach, F. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0243-z · Cited by 140 · see citing works
Zampieri, F. G., Soares, M., Borges, L. P., Salluh, J. I., & Ranzani, O. (2017) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20170062 · Cited by 137 · see citing works
Levy, M. M., Gesten, F. C., Phillips, G. S., Terry, K. M., Seymour, C. W., Prescott, H. C., Friedrich, M., Iwashyna, T. J., Osborn, T., & Lemeshow, S. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201712-2545oc · Cited by 137 · see citing works
Self-citationNoritomi, D. T., Ranzani, O., Monteiro, M. B., Ferreira, E. M., Santos, S. R., Leibel, F., & Machado, F. R. (2013) · Intensive Care Medicine · doi:10.1007/s00134-013-3131-5 · Cited by 133 · see citing works
Self-citationFunctional Recovery in Critically Ill Children, the “WeeCover” Multicenter Study
Choong, K. L. M., Fraser, D. D., Al-Harbi, S., Borham, A., Cameron, J. I., Cameron, S., Cheng, J., Clark, H. R., Doherty, T. J., Fayed, N., et al. (2018) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000001421 · Cited by 132 · see citing works
Self-citationMcPeake, J., Hirshberg, E. L., Christie, L. M., Drumright, K., Haines, K., Hough, C. L., Meyer, J., Wade, D., Andrews, A., Bakhru, R., et al. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003497 · Cited by 128 · see citing works
Self-citationLife after sepsis: An international survey of survivors to understand the post-sepsis syndrome.
Huang, C. Y., Daniels, R., Lembo, A., Hartog, C., O’Brien, J., Heymann, T., Reinhart, K., Nguyen, H. B., & Sepsis Survivors Engagement Project (SSEP) (2019) · International Journal for Quality in Health Care · doi:10.1093/intqhc/mzy137 · Cited by 103 · see citing works
Self-citationTurnbull, A. E., Sepúlveda, K. A., Dinglas, V. D., Chessare, C. M., Bingham, C. O., & Needham, D. M. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002435 · Cited by 100 · see citing works
Self-citationLong‐term physical outcome in patients with septic shock
Poulsen, J. B., Møller, K., Kehlet, H., & Perner, A. (2009) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2009.01921.x · Cited by 81 · see citing works
Govindan, S., Iwashyna, T. J., Watson, S. R., Hyzy, R. C., & Miller, M. A. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201401-007bc · Cited by 63 · see citing works
Self-citationBlackwood, B., Ringrow, S., Clarke, M. J., Marshall, J., Rose, L., Williamson, P. R., & McAuley, D. F. (2015) · Trials · doi:10.1186/s13063-015-0905-9 · Cited by 60 · see citing works
Self-citationHealth-related outcomes of critically ill patients with and without sepsis
Thompson, K., Taylor, C. B., Jan, S., Li, Q., Hammond, N. E., Myburgh, J., Saxena, M. K., Venkatesh, B., & Finfer, S. R. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5274-x · Cited by 60 · see citing works
Self-citationProgress on core outcome sets for critical care research
Blackwood, B., Marshall, J. C., & Rose, L. (2015) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000232 · Cited by 50 · see citing works
Self-citationPrescott, H. C., & Angus, D. C. (2018) · JAMA · doi:10.1001/jama.2017.19809 · Cited by 47 · see citing works
Self-citationRisk of Recurrence After Surviving Severe Sepsis: A Matched Cohort Study
Shen, H.-N., Lu, C., & Yang, H.-H. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001824 · Cited by 43 · see citing works
Peer support to improve recovery following critical care discharge: a case-based discussion
McPeake, J. M., Iwashyna, T. J., Devine, H., MacTavish, P., & Quasim, T. (2017) · Thorax · doi:10.1136/thoraxjnl-2016-209661 · Cited by 43 · see citing works
Self-citationThe burden of sepsis—a call to action in support of World Sepsis Day 2013
Reinhart, K., Daniels, R., Kissoon, N. “., O’Brien, J. M., Machado, F. R., & Jimenez, E. J. (2013) · Journal of Critical Care · doi:10.1016/j.jcrc.2013.04.012 · Cited by 40 · see citing works
Self-citationHashmi, M., Beane, A., Taqi, A., Memon, M., Athapattu, P. L., Khan, Z., Dondorp, A. M., & Haniffa, R. (2018) · Journal of the Intensive Care Society · doi:10.1177/1751143718814126 · Cited by 40 · see citing works
Haines, K. J., Holdsworth, C., Cranwell, K., Skinner, E. H., Holton, S., MacLeod-Smith, B., Bates, S., Iwashyna, T. J., French, C., Booth, S., et al. (2019) · Critical Care Explorations · doi:10.1097/cce.0000000000000006 · Cited by 40 · see citing works
Self-citationPublic awareness of sepsis is still poor: we need to do more
Kerrigan, S. W., & Martín‐Loeches, I. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5307-5 · Cited by 30 · see citing works
Data Enclaves for Sharing Information Derived From Clinical and Administrative Data
Platt, R., & Lieu, T. A. (2018) · JAMA · doi:10.1001/jama.2018.9342 · Cited by 28 · see citing works
Scherag, A., Hartog, C. S., Fleischmann-Struzek, C., Ouart, D., Hoffmann, F. S., König, C. M., Kesselmeier, M., Fiedler, S., Philipp, M., Braune, A., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-016827 · Cited by 23 · see citing works
Self-citationRanzani, O., Shankar‐Hari, M., Harrison, D. A., Rabello, L. S. C. F., Salluh, J. I., Rowan, K., & Soares, M. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003438 · Cited by 22 · see citing works
Self-citationPaths into Sepsis: Trajectories of Presepsis Healthcare Use
Prescott, H. C., Carmichael, A. G., Langa, K. M., Gonzalez, R., & Iwashyna, T. J. (2018) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201806-391oc · Cited by 19 · see citing works
Self-citationGlobal impact of World Sepsis Day on digital awareness of sepsis: an evaluation using Google Trends
Savelkoel, J., Claushuis, T. A. M., van Engelen, T. S. R., Scheres, L. J. J., & Wiersinga, W. J. (2018) · Critical Care · doi:10.1186/s13054-018-1981-5 · Cited by 15 · see citing works
The Urgency of Now: Attacking the Sepsis Crisis*
Staunton, O., & Staunton, C. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003047 · Cited by 11 · see citing works
The long road home: are outcomes different for patients with sepsis?
Hodgson, C. L., Walsh, T. S., & Lone, N. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5301-y · Cited by 3 · see citing works
Self-citationEnhancing Recovery After Sepsis
Jette, A. M. (2018) · Physical Therapy · doi:10.1093/ptj/pzy043 · Cited by 2 · see citing works
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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082 · see citing works
Self-citationSurviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935 · see citing works
Self-citationThe pathophysiology of sepsis and precision-medicine-based immunotherapy
Giamarellos‐Bourboulis, E. J., Aschenbrenner, A. C., Bauer, M. W., Bock, C., Calandra, T., Gat‐Viks, I., Kyriazopoulou, E., Lupșe, M. S., Monneret, G., Pickkers, P., et al. (2024) · Nature Immunology · doi:10.1038/s41590-023-01660-5 · Cited by 382 · see citing works
Self-citationStaphylococcus aureus bacteraemia mortality: a systematic review and meta-analysis
Bai, A. D., Lo, C. K. L., Komorowski, A. S., Suresh, M., Guo, K., Garg, A., Tandon, P., Senécal, J., Corpo, O. D., Stefanova, I. Z., et al. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2022.03.015 · Cited by 321 · see citing works
Natural History of Cognitive Impairment in Critical Illness Survivors. A Systematic Review
Honarmand, K., Lalli, R. S., Priestap, F. A., Chen, J., McIntyre, C. W., Owen, A. M., & Slessarev, M. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201904-0816ci · Cited by 150 · see citing works
Beyond the Brain: Peripheral Interactions after Traumatic Brain Injury
Sharkey, J., McDonald, S., Sun, M.-J., Kaukas, L., Shultz, S., Turner, R., Leonard, A., Brady, R., & Corrigan, F. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6885 · Cited by 121 · see citing works
Spies, C., Krampe, H., Paul, N., Denke, C., Kiselev, J., Piper, S. K., Kruppa, J., Grunow, J. J., Steinecke, K., Gülmez, T., et al. (2020) · Journal of the Intensive Care Society · doi:10.1177/1751143720923597 · Cited by 139 · see citing works
The burden and contemporary epidemiology of sepsis in children
Watson, R. S., Carrol, E. D., Carter, M. J., Kissoon, N. “., Ranjit, S., & Schlapbach, L. J. (2024) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(24)00140-8 · Cited by 124 · see citing works
Sepsis-Associated Mortality, Resource Use, and Healthcare Costs: A Propensity-Matched Cohort Study*
Farrah, K., McIntyre, L., Doig, C. J., Talarico, R., Taljaard, M., Krahn, M. D., Fergusson, D. A., Forster, A. J., Coyle, D., & Thavorn, K. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004777 · Cited by 110 · see citing works
Fleischmann-Struzek, C., Rose, N., Freytag, A., Spoden, M., Prescott, H. C., Schettler, A., Wedekind, L., Ditscheid, B., Storch, J., Born, S., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.34290 · Cited by 106 · see citing works
Self-citationHaines, R. W., Fowler, A. J., Liang, K., Pearse, R. M., Larsson, A. O., Puthucheary, Z., & Prowle, J. R. (2023) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000000000000203 · Cited by 102 · see citing works
Yende, S. P., & Parikh, C. R. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00487-3 · Cited by 94 · see citing works
Self-citationTaylor, S. P., Murphy, S., Rios, A., McWilliams, A. D., McCurdy, L., Chou, S., Hetherington, T. C., Rossman, W., Russo, M. J., Gibbs, M. A., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005300 · Cited by 93 · see citing works
The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness
Coopersmith, C. M., Antonelli, M. M., Bauer, S. R., Deutschman, C. S., Evans, L., Ferrer, R., Hellman, J., Jog, S., Kesecioğlu, J., Kissoon, N. “., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000004895 · Cited by 93 · see citing works
Self-citationSepsis and septic shock in France: incidences, outcomes and costs of care
Dupuis, C., Bouadma, L., Ruckly, S., Perozziello, A., Gysel, D. V., Mageau, A., Mourvillier, B., de Montmollin, É., Bailly, S., Papin, G., et al. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-00760-x · Cited by 79 · see citing works
Functional outcomes in the inpatient rehabilitation setting following severe COVID-19 infection
Olezene, C. S., Hansen, E., Steere, H. K., Giacino, J. T., Polich, G. R., Borg‐Stein, J., ZAFONTE, R. D., & Schneider, J. C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248824 · Cited by 74 · see citing works
Self-citationAssociation between Adherence to Recommended Care and Outcomes for Adult Survivors of Sepsis
Taylor, S. P., Chou, S.-H., Sierra, M. F., Shuman, T. P., McWilliams, A. D., Taylor, B. T., Russo, M., Evans, S. L., Rossman, W., Murphy, S., et al. (2020) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201907-514oc · Cited by 69 · see citing works
World Sepsis Day: a global agenda to target a leading cause of morbidity and mortality
Schlapbach, L. J., Kissoon, N. “., Alhawsawi, A. M., Aljuaid, M. H., Daniels, R., Gorordo-Delsol, L. A., Machado, F. R., Malik, I., Nsutebu, E. F., Finfer, S. R., et al. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00369.2020 · Cited by 69 · see citing works
Self-citationCritical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes
Latronico, N., Rasulo, F. A., Eikermann, M., & Piva, S. (2023) · Critical Care · doi:10.1186/s13054-023-04676-3 · Cited by 67 · see citing works
Sepsis Among Medicare Beneficiaries: 2. The Trajectories of Sepsis, 2012–2018*
Buchman, T. G., Simpson, S. Q., Sciarretta, K. L., Finne, K. P., Sowers, N., Collier, M. W., Chavan, S., Oke, I., Pennini, M. E., Santhosh, A., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004226 · Cited by 55 · see citing works
Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study
Stortz, J. A., Cox, M. C., Hawkins, R. B., Ghita, G. L., Brumback, B., Mohr, A. M., Moldawer, L. L., Efron, P. A., Brakenridge, S. C., & Moore, F. A. (2020) · Critical Care · doi:10.1186/s13054-020-02917-3 · Cited by 55 · see citing works
Keijzers, G., Macdonald, S. P. J., Udy, A. A., Arendts, G., Bailey, M., Bellomo, R., Blecher, G., Burcham, J., Coggins, A., Delaney, A. P., et al. (2020) · Emergency Medicine Australasia · doi:10.1111/1742-6723.13469 · Cited by 46 · see citing works
Soussi, S., Sharma, D., Jüni, P., Lebovic, G., Brochard, L. J., Marshall, J. C., Lawler, P. R., Herridge, M. S., Ferguson, N. D., Sorbo, L. D., et al. (2022) · Critical Care · doi:10.1186/s13054-022-03972-8 · Cited by 45 · see citing works
Self-citationSkei, N. V., Nilsen, T. I. L., Mohus, R. M., Prescott, H. C., Lydersen, S., Solligård, E., Damås, J. K., & Gustad, L. T. (2023) · Infection · doi:10.1007/s15010-023-02082-z · Cited by 41 · see citing works
Self-citationXu, T., Song, S., Zhu, K., Yang, Y., Wu, C., Wang, N., & Lu, S. (2025) · Scientific Reports · doi:10.1038/s41598-024-81860-7 · Cited by 42 · see citing works
Oxidative stress in multiple organs after sepsis in elderly rats
Margotti, W., Goldim, M. P. D. S., Machado, R. S., Bagio, É., Perin, C. H. D., Bernades, G. C., Lanzzarin, E., Stork, S. D. S., Cidreira, T., Denicol, T. L., et al. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111705 · Cited by 32 · see citing works
Return to work after hospitalization for sepsis: a nationwide, registry-based cohort study
Skei, N. V., Moe, K., Nilsen, T. I. L., Aasdahl, L., Prescott, H. C., Damås, J. K., & Gustad, L. T. (2023) · Critical Care · doi:10.1186/s13054-023-04737-7 · Cited by 32 · see citing works
Self-citationFleischmann-Struzek, C., Born, S., Kesselmeier, M., Ely, E. W., Töpfer, K., Romeike, H., Bauer, M. W., Bercker, S., Bodechtel, U., Fiedler, S., et al. (2024) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2024.101066 · Cited by 30 · see citing works
Self-citationWhat is new and different in the 2021 Surviving Sepsis Campaign guidelines
Prescott, H. C., & Ostermann, M. (2023) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-023-01028-5 · Cited by 32 · see citing works
Self-citationQuality improvement programmes in paediatric sepsis from a global perspective
de Souza, D. C., Paul, R. M., Mozún, R., Sankar, J., Jabornisky, R., Lim, E. J., Harley, A., Amri, S. A., Aljuaid, M. H., Qian, S., et al. (2024) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(24)00142-1 · Cited by 31 · see citing works
Pallanch, O., Ortalda, A., Pelosi, P. P., Latronico, N., Sartini, C., Lombardi, G., Marchetti, C., Maimeri, N., Zangrillo, A., & Cabrini, L. (2022) · Critical Care · doi:10.1186/s13054-022-03993-3 · Cited by 30 · see citing works
S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge – Update 2025
Brunkhorst, F. M., Adamzik, M., Axer, H., Bauer, M. W., Bode, C., Bone, H.-G., Brenner, T., Bucher, M., David, S., Dietrich, M., et al. (2025) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-025-01317-1 · Cited by 32 · see citing works
Kowalkowski, M. A., Rios, A., McSweeney, J., Murphy, S., McWilliams, A. D., Chou, S., Hetherington, T. C., Rossman, W., & Taylor, S. P. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202203-0590le · Cited by 28 · see citing works
The Aftermath of COVID-19: Exploring the Long-Term Effects on Organ Systems
Golzardi, M., Hromić‐Jahjefendić, A., Šutković, J., Aydın, O., Ünal‐Aydın, P., Bećirević, T., Redwan, E. M. M. M., Rubio‐Casillas, A., & Uversky, V. N. (2024) · Biomedicines · doi:10.3390/biomedicines12040913 · Cited by 27 · see citing works
Paediatric intensive care follow‐up provision in the United Kingdom and Republic of Ireland
Manning, J. C., Scholefield, B. R., Popejoy, E. M., Dodds, E., & Latour, J. M. (2020) · Nursing in Critical Care · doi:10.1111/nicc.12510 · Cited by 26 · see citing works
Reducing the global burden of sepsis: a positive legacy for the COVID-19 pandemic?
The European Society of Intensive Care Medicine (ESICM), The Global Sepsis Alliance (GSA), Reinhart, K., The Society of Critical Care Medicine (SCCM), Levy, M. M., Finfer, S. R., Machado, F. R., Kaplan, L., Kesecioğlu, J., Rhodes, A., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06409-y · Cited by 25 · see citing works
Self-citationEducational Outcomes of Childhood Survivors of Critical Illness—A Population-Based Linkage Study*
Tomaszewski, W., Ablaza, C., Straney, L. D., Taylor, C. L., Millar, J., & Schlapbach, L. J. (2022) · Critical Care Medicine · doi:10.1097/ccm.0000000000005461 · Cited by 26 · see citing works
Pandolfi, F., Brun‐Buisson, C., Guillemot, D., & Watier, L. (2023) · Critical Care · doi:10.1186/s13054-023-04726-w · Cited by 26 · see citing works
Mendelson, A. A., Erickson, D., & Villar, R. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1170429 · Cited by 24 · see citing works
Clinical Subtypes of Sepsis Survivors Predict Readmission and Mortality after Hospital Discharge
Taylor, S. P., Bray, B. C., Chou, S., Burns, R., & Kowalkowski, M. A. (2022) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202109-1088oc · Cited by 23 · see citing works
Blood count derangements after sepsis and association with post-hospital outcomes
Denstaedt, S. J., Cano, J., Wang, X. Q., Donnelly, J. P., Seelye, S. M., & Prescott, H. C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133351 · Cited by 23 · see citing works
Self-citationEducational Outcomes of Childhood Survivors of Critical Illness-A Population-Based Linkage Study
Tomaszewski, W., Ablaza, C., Straney, L. D., Taylor, C., Millar, J., & Schlapbach, L. J. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-227133 · Cited by 21 · see citing works
Born, S., Matthäus‐Krämer, C., Bichmann, A., Boltz, H.-S., Esch, M., Heydt, L., Sell, S., Streich, K., Scherag, A., Reinhart, K., et al. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1137027 · Cited by 22 · see citing works
Self-citationSkei, N. V., Nilsen, T. I. L., Knoop, S. T., Prescott, H. C., Lydersen, S., Mohus, R. M., Brkic, A., Liyanarachi, K. V., Solligård, E., Damås, J. K., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-071846 · Cited by 19 · see citing works
Self-citationSepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction
Spencer-Segal, J. L., Singer, B. H., Laborc, K. F., Somayaji, K., Watson, S. J., Standiford, T. J., & Akil, H. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104679 · Cited by 19 · see citing works
Current standard of care for septic shock
Delaney, A. P., Borges-Sa, M., Chew, M. S., Waele, J. J. D., Dye, J., Khanna, A. K., Hamzaoui, O., Hammond, N. E., Glenn Hernández, P., Herridge, M. S., et al. (2025) · Intensive Care Medicine · doi:10.1007/s00134-025-08211-6 · Cited by 19 · see citing works
Self-citationRavikumar, N., Sankar, J., & Das, R. R. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.762179 · Cited by 18 · see citing works
Raising awareness of the needs of older COVID patients after hospital discharge
Michel, J., Maggi, S., & Ecarnot, F. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01620-1 · Cited by 17 · see citing works
Wendlandt, B., Ceppe, A., Cox, C. E., Hanson, L. C., Nelson, J. E., & Carson, S. S. (2021) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202010-1300oc · Cited by 17 · see citing works
Outcomes for Patients Following Hospitalization for COVID-19
Prescott, H. C. (2021) · JAMA · doi:10.1001/jama.2021.3430 · Cited by 18 · see citing works
Self-citationTaylor, S. P., Eaton, T. A., Rios, A., Boyd, D., Tapp, H., McWilliams, A. D., Chou, S., Halpern, S. D., Angus, D. C., McCurdy, L., et al. (2025) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2025.3699 · Cited by 16 · see citing works
Self-citationWinkler, D., Rose, N., Freytag, A., Sauter, W., Spoden, M., Schettler, A., Wedekind, L., Storch, J., Ditscheid, B., Schlattmann, P., et al. (2022) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202203-195oc · Cited by 15 · see citing works
Self-citationInghammar, M., Linder, A., Lengquist, M., Frigyesi, A., Wetterberg, H., Sundén‐Cullberg, J., & Nilsson, A. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae331 · Cited by 16 · see citing works
Mid-German Sepsis Cohort (MSC): a prospective observational study of sepsis survivorship
Fleischmann-Struzek, C., Kesselmeier, M., Ouart, D., Hartog, C. S., Bauer, M. W., Bercker, S., Bucher, M., Meier‐Hellmann, A., Petros, S., Schreiber, T., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-043352 · Cited by 16 · see citing works
Self-citationDeficits in Identification of Goals and Goal‐Concordant Care After Sepsis Hospitalization
Taylor, S. P., Kowalkowski, M. A., Courtright, K. R., Burke, H. L., Patel, S., Hicks, S., Hurley, C., Mitchell, S., & Halpern, S. D. (2021) · Journal of Hospital Medicine · doi:10.12788/jhm.3714 · Cited by 15 · see citing works
Kowalkowski, M. A., Eaton, T. A., McWilliams, A. D., Tapp, H., Rios, A., Murphy, S., Burns, R., Gutnik, B., O’Hare, K., McCurdy, L., et al. (2021) · BMC Health Services Research · doi:10.1186/s12913-021-06521-1 · Cited by 14 · see citing works
Self-citationDenstaedt, S. J., Bustamante, A. C., Newstead, M. W., Moore, B. B., Standiford, T. J., Zemans, R. L., & Singer, B. H. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00123.2021 · Cited by 15 · see citing works
Postcritical illness vulnerability
Prescott, H. C., Sussman, J. B., & Wiersinga, W. J. (2020) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000761 · Cited by 14 · see citing works
Self-citationResearch Progress of Biomarkers for Sepsis and Precision Medicine
Wang, N., Huang, H.-S., Tan, Y., & Zhang, N. (2025) · Emergency Medicine International · doi:10.1155/emmi/4585495 · Cited by 12 · see citing works
Are Patients with Covid-19 at Risk of Long-Term Chronic Kidney Disease?
Kemeç, Z., & Akgül, F. (2023) · Nigerian Journal of Clinical Practice · doi:10.4103/njcp.njcp_382_22 · Cited by 12 · see citing works
50 Years of Sepsis Investigation/Enlightenment Among Adults—The Long and Winding Road
Dellinger, R. P., Levy, M. M., Schorr, C., & Townsend, S. R. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005203 · Cited by 12 · see citing works
Spoden, M., Hartog, C. S., Schlattmann, P., Freytag, A., Ostermann, M., Wedekind, L., Storch, J., Reinhart, K., Günster, C., & Fleischmann-Struzek, C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.878337 · Cited by 12 · see citing works
Self-citationda Silva, A. A., Granger, C. L., Abo, S., Sheehan, J., Barson, E., Beach, L. J., Pound, G. M., Abdelhamid, Y. A., Fetterplace, K., Fini, N. A., et al. (2024) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202307-599oc · Cited by 11 · see citing works
Bircak-Kuchtova, B., Rose, N., Geis, C., Finke, K., Pletz, M. W., Chung, H., & Fleischmann-Struzek, C. (2025) · Critical Care · doi:10.1186/s13054-025-05585-3 · Cited by 12 · see citing works
Lin, I.-H., Liao, P.-Y., Wong, L.-T., Chan, M.-C., Wu, C., & Chao, W. (2023) · BMC Emergency Medicine · doi:10.1186/s12873-023-00806-w · Cited by 11 · see citing works
Posttraumatic Stress Disorder Symptom Trajectories in ICU Family Caregivers
Wendlandt, B., Chen, Y.-T., Lin, F.-C., Toles, M., Gaynes, B., Hanson, L., & Carson, S. (2021) · Critical Care Explorations · doi:10.1097/cce.0000000000000409 · Cited by 10 · see citing works
Raman, S., English, A., O’Keefe, M., Harley, A., Steele, M., Minogue, J., Weller, K., Long, D. A., Irwin, A., & Lister, P. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.759234 · Cited by 10 · see citing works
Surviving severe COVID ‐19: Interviews with patients, informal carers and health professionals
Gonçalves, A., Williams, A., Koulouglioti, C., Leckie, T., Hunter, A., Fitzpatrick, D., Richardson, A., Hardy, B., Venn, R. M., & Hodgson, L. E. (2022) · Nursing in Critical Care · doi:10.1111/nicc.12779 · Cited by 10 · see citing works
Clinical Research: From Case Reports to International Multicenter Clinical Trials
Finfer, S. R., Cook, D., Machado, F. R., & Perner, A. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005247 · Cited by 10 · see citing works
Self-citationWu, Y., Wong, L.-T., Wu, C., & Chao, W. (2021) · Journal of Intensive Care · doi:10.1186/s40560-021-00576-2 · Cited by 10 · see citing works
Schlapbach, L. J., Zimmermann, E., Meylan, S., Stocker, M., Suter, P. M., Jakob, S. M., & on behalf of the Swiss Sepsis National Action Plan Working Group (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1114546 · Cited by 9 · see citing works
Li, Y., Wang, Y., Chen, B., Guo, J., & Zhang, D. (2023) · International Journal of Clinical Practice · doi:10.1155/2023/1688385 · Cited by 9 · see citing works
Cannabidiol effect on long-term brain alterations in septic rats: Involvement of PPARγ activation
Gava, F. F., Carli, R. J. D., Stork, S. D. S., Danielski, L. G., Bonfante, S., Joaquim, L. D. S., Metzker, K. L. L., Mathias, K., dos Santos, D., Daros, G. C., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148771 · Cited by 9 · see citing works
Changes in Self-Rated Health After Sepsis in Older Adults
Carey, M. R., Prescott, H. C., Iwashyna, T. J., Wilson, M. E., Fagerlin, A., & Valley, T. S. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.05.606 · Cited by 9 · see citing works
Self-citationSimpson, A., Long, D. A., Fleischmann-Struzek, C., Minogue, J., Venkatesh, B., Hammond, N. E., Tian, D. H., & Schlapbach, L. J. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.734205 · Cited by 9 · see citing works
Fleischmann-Struzek, C., Rose, N., Born, S., Freytag, A., Ditscheid, B., Storch, J., Schettler, A., Schlattmann, P., Wedekind, L., Pletz, M. W., et al. (2022) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-1741-3013 · Cited by 10 · see citing works
Self-citationSloan, E., Parry, S. M., da Silva, A. A., Granger, C. L., Fehlberg, Z., Gustafson, O. D., Voutier, C. R., Short, C. E., & Klaic, M. (2025) · CHEST Critical Care · doi:10.1016/j.chstcc.2025.100142 · Cited by 8 · see citing works
Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches
Murali, R., Wanjari, U. R., Mukherjee, A. G., Gopalakrishnan, A. V., Kannampuzha, S., Namachivayam, A., Madhyastha, H., Renu, K., & Ganesan, R. (2023) · Vaccines · doi:10.3390/vaccines11020489 · Cited by 8 · see citing works
Translating Postsepsis Care to Post–COVID-19 Care. The Case for a Virtual Recovery Program
Taylor, S. P., Rios, A., & Kowalkowski, M. A. (2021) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202006-649ip · Cited by 8 · see citing works
Marshall, J. C. (2020) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-020-00660-9 · Cited by 8 · see citing works
Self-citationLei, S., Ruan, H., Zhao, H., Feng, Z., Wang, J., Zhao, G., Liu, J., & Li, J. (2026) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2026.103211 · Cited by 7 · see citing works
Kattlun, F., Hertel, E., Geis, C., Scherag, A., Wickel, J., & Finke, K. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1321145 · Cited by 8 · see citing works
Eaton, T. A., Kowalkowski, M. A., Burns, R., Tapp, H., O’Hare, K., & Taylor, S. P. (2024) · BMC Health Services Research · doi:10.1186/s12913-024-11344-x · Cited by 8 · see citing works
Oud, L., & Garza, J. (2022) · Journal of Critical Care · doi:10.1016/j.jcrc.2022.153985 · Cited by 7 · see citing works
Approaches to prioritising research for clinical trial networks: a scoping review
Morton, R. L., Tuffaha, H., Blaya‐Nováková, V., Spencer, J. D., Hawley, C. M., Peyton, P., Higgins, A. M., Marsh, J. A., Taylor, W. J., Huckson, S., et al. (2022) · Trials · doi:10.1186/s13063-022-06928-z · Cited by 7 · see citing works
Long-term Renal Outcomes in Adults With Sepsis-Induced Acute Kidney Injury
Harris, P. L., & Umberger, R. A. (2020) · Dimensions of Critical Care Nursing · doi:10.1097/dcc.0000000000000432 · Cited by 7 · see citing works
Nakano, F. K., Aerde, N. V., Coppens, G., Vanhorebeek, I., Vens, C., den Berghe, G. V., & Güiza, F. (2025) · Intensive Care Medicine Experimental · doi:10.1186/s40635-025-00810-3 · Cited by 6 · see citing works
Barker, N., Scott, I. A., Seaton, R., Mehta, N., Kalke, V. R., & Redpath, L. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s400839 · Cited by 7 · see citing works
Lai, X., Kang, M., Chen, Y., Xu, F., Wang, K., & Cao, J. (2022) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2022.08.001 · Cited by 6 · see citing works
What's the Cost? Measuring the Economic Impact of Pediatric Sepsis
Carlton, E. F., Weiss, S. L., Prescott, H. C., & Prosser, L. A. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.761994 · Cited by 5 · see citing works
Self-citationLong‐term outcomes after paediatric sepsis (LOTUS)–A protocol for an Australian cohort study
Minogue, J., Schlapbach, L. J., Keogh, S. J., GIBBONS, K. S., & Long, D. A. (2023) · Nursing in Critical Care · doi:10.1111/nicc.12938 · Cited by 5 · see citing works
Recovery from Sepsis: Management beyond Acute Care
Andersen, S. K., Herridge, M., & Fiest, K. M. (2024) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0044-1787993 · Cited by 5 · see citing works
Psychometric properties of the Reintegration to Normal Living Index for sepsis survivors
Streich, K., Hartog, C. S., Fleischmann-Struzek, C., Rose, N., Bichmann, A., Kesselmeier, M., Schiefenhövel, F., Schmieding, M. L., & Born, S. (2023) · Quality of Life Research · doi:10.1007/s11136-023-03403-3 · Cited by 5 · see citing works
Call for a Singapore National Action Plan for Sepsis (SNAPS): Stop sepsis, save lives
Goh, E. L., See, K. C., & Chua, W. L. (2024) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.2023286 · Cited by 5 · see citing works
Hsiao, Y.-C., Shen, P.-Y., Wong, L.-T., Chan, M.-C., & Chao, W. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s424724 · Cited by 5 · see citing works
Skei, N. V., Nilsen, T. I. L., Mohus, R. M., Prescott, H. C., Lydersen, S., Solligård, E., Damås, J. K., & Gustad, L. T. (2023) · Research Square · doi:10.21203/rs.3.rs-2718744/v1 · Cited by 5 · see citing works
Self-citationHo, D. T., Pham, T. T., Wong, L.-T., Wu, C., Chan, M.-C., & Chao, W. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304627 · Cited by 4 · see citing works
Umberger, R. A., Cao, X., Reynolds, R. B., Kilgannon, A. R., Mayr, F., & Yende, S. P. (2024) · Dimensions of Critical Care Nursing · doi:10.1097/dcc.0000000000000672 · Cited by 4 · see citing works
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McPeake, J. M., Ahmad, N., Bradley, K., Morris, A. C., Dark, P. M., Graham, C. A., Hall, W., Moug, S. J., Oakes, M., Perry, E., et al. (2025) · Anaesthesia · doi:10.1111/anae.16634 · Cited by 4 · see citing works
Self-citationRoy, A., Krishnasamy, V., Mitra, S., Banerjee, S., Dutta, T. K., Kumar, N. S., & Roy, S. (2026) · BMC Infectious Diseases · doi:10.1186/s12879-026-12704-0 · Cited by 4 · see citing works
- Authors
- Prescott, H. C., Iwashyna, T. J., Blackwood, B., Calandra, T., Chlan, L. L., Choong, K., Connolly, B., Dark, P., Ferrucci, L., Finfer, S., Girard, T. D., Hodgson, C., Hopkins, R. O., Hough, C. L., Jackson, J. C., Machado, F. R., Marshall, J. C., Misak, C., Needham, D. M., Panigrahi, P., Reinhart, K., Yende, S., Zafonte, R., Rowan, K. M., & Angus, D. C.
- Affiliations
- University of Michigan (US)
- Queen's University Belfast (GB)
- Centre Hospitalier Universitaire Vaudois (CH)
- Mayo Clinic (US)
- McMaster University (CA)
- National Health Service (GB)
- King's College London (GB)
- National Institutes of Health (US)
- UNSW Sydney (AU)
- University of Pittsburgh (US)
- Monash University (AU)
- Brigham Young University (US)
- University of Washington (US)
- Vanderbilt University (US)
- Anesthesiology, Pain, and Intensive Care Department, Federal University of São Paulo, São Paulo, Brazil
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- Johns Hopkins University (US)
- Georgetown University Medical Center (US)
- Jena University Hospital (DE)
- Brigham and Women's Hospital (US)
- Intensive Care National Audit and Research Centre, London, United Kingdom
- Corresponding author
- Prescott, Hallie C.
- ORCID
- Prescott, Hallie C.
- Iwashyna, Theodore J.
- Blackwood, Bronagh
- Calandra, Thierry
- Chlan, Linda L.
- Choong, Karen
- Connolly, Bronwen
- Dark, Paul
- Ferrucci, Luigi
- Finfer, Simon
- Girard, Timothy D.
- Hodgson, Carol
- Hough, Catherine L.
- Jackson, James C.
- Marshall, John C.
- Needham, Dale M.
- Panigrahi, Pinaki
- Reinhart, Konrad
- Yende, Sachin
- Zafonte, Ross
- Angus, Derek C.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-10
- Volume
- 200
- Issue
- 8
- Pages
- 972-981
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC6794113
- OpenAlex
- W2948089944
- Cited by
- 166
- References
- 72
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 23 · 2023: 29 · 2022: 23 · 2021: 30 · 2020: 17 · 2019: 2
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- IRIS (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion, other-oa)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute for Health and Care Research (PDF-2015-08-015)
- Queen's University Belfast
- Queen's University
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council (1117230)
- National Institute on Aging
- National Heart, Lung, and Blood Institute (R01HL135144)
- National Institute of General Medical Sciences (R01GM097471, K08GM115859)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Keywords
- long-term recovery, neuropsychological deficits, physical disability, recurrent infections, acute kidney injury, cardiovascular events, cohort studies, phenotyping
- MeSH terms
- Survivorship, Adult, Aged, Aged, 80 and over, Critical Care, Female, Persons with Disabilities, Humans, Male, Middle Aged, Research Design, Cohort Studies, Practice Guidelines as Topic, Sepsis, Biomedical Research
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