Enhancing Recovery From Sepsis: A Review

Prescott, Hallie C.; Angus, Derek C.

doi:10.1001/jama.2017.17687

Cited by 1,059Sepsis Diagnosis and TreatmentIntensive Care Unit Cognitive DisordersVitamin C and Antioxidants Research

Enhancing Recovery From Sepsis: A Review

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Prescott, Hallie C., Angus, Derek C.·2018·JAMA

DOI 10.1001/jama.2017.17687PMC PMC5839473

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Abstract

Importance: Survival from sepsis has improved in recent years, resulting in an increasing number of patients who have survived sepsis treatment. Current sepsis guidelines do not provide guidance on posthospital care or recovery. Observations: Each year, more than 19 million individuals develop sepsis, defined as a life-threatening acute organ dysfunction secondary to infection. Approximately 14 million survive to hospital discharge and their prognosis varies. Half of patients recover, one-third die during the following year, and one-sixth have severe persistent impairments. Impairments include development of an average of 1 to 2 new functional limitations (eg, inability to bathe or dress independently), a 3-fold increase in prevalence of moderate to severe cognitive impairment (from 6.1% before hospitalization to 16.7% after hospitalization), and a high prevalence of mental health problems, including anxiety (32% of patients who survive), depression (29%), or posttraumatic stress disorder (44%). About 40% of patients are rehospitalized within 90 days of discharge, often for conditions that are potentially treatable in the outpatient setting, such as infection (11.9%) and exacerbation of heart failure (5.5%). Compared with patients hospitalized for other diagnoses, those who survive sepsis (11.9%) are at increased risk of recurrent infection than matched patients (8.0%) matched patients (P < .001), acute renal failure (3.3% vs 1.2%, P < .001), and new cardiovascular events (adjusted hazard ratio [HR] range, 1.1-1.4). Reasons for deterioration of health after sepsis are multifactorial and include accelerated progression of preexisting chronic conditions, residual organ damage, and impaired immune function. Characteristics associated with complications after hospital discharge for sepsis treatment are not fully understood but include both poorer presepsis health status, characteristics of the acute septic episode (eg, severity of infection, host response to infection), and quality of hospital treatment (eg, timeliness of initial sepsis care, avoidance of treatment-related harms). Although there is a paucity of clinical trial evidence to support specific postdischarge rehabilitation treatment, experts recommend referral to physical therapy to improve exercise capacity, strength, and independent completion of activities of daily living. This recommendation is supported by an observational study involving 30 000 sepsis survivors that found that referral to rehabilitation within 90 days was associated with lower risk of 10-year mortality compared with propensity-matched controls (adjusted HR, 0.94; 95% CI, 0.92-0.97, P < .001). Conclusions and Relevance: In the months after hospital discharge for sepsis, management should focus on (1) identifying new physical, mental, and cognitive problems and referring for appropriate treatment, (2) reviewing and adjusting long-term medications, and (3) evaluating for treatable conditions that commonly result in hospitalization, such as infection, heart failure, renal failure, and aspiration. For patients with poor or declining health prior to sepsis who experience further deterioration after sepsis, it may be appropriate to focus on palliation of symptoms.

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Living in neighborhoods with low socioeconomic status is associated with worse outcomes.
“Additionally, living in neighborhoods with low SES is associated with an increased risk of sepsis (575), community-acquired bacteremia (575) and death from bacteremia (576) and worse outcomes (577).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [577]
The Clinical Sequelae section describes worse outcomes after sepsis, including reduced quality of life, but does not link them to neighborhood socioeconomic status. Searches for neighborhood socioeconomic status, income, and poverty found no passage addressing that association. (LLM, conf=0.75)
Experimental — accuracy not yet measured
Almost 40% of sepsis survivors are re-hospitalised within 3 months, often for preventable conditions, contributing to increased healthcare costs.
“Almost 40% of sepsis survivors are re-hospitalised within 3 months, often for preventable conditions [580], contributing to increased healthcare costs [581].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [580]
Sepsis survivors are at increased risk for recurrent infection, AKI, and new cardiovascular events compared to patients hospitalised for other diagnoses.
“In addition, sepsis survivors are at increased risk for recurrent infection, AKI and new cardiovascular events compared to patients hospitalised for other diagnoses [580].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [580]
There are a growing number of online resources and informational brochures regarding post intensive care and post-sepsis syndrome.
“There are a growing number of online resources and informational brochures regarding “post intensive care” / “post-sepsis syndrome”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [580]
Physical rehabilitation programmes have benefit in related populations such as older patients with cognitive impairment, patients following stroke or traumatic brain injury.
“Nonetheless, based on their strong rationale, and benefit in related populations [580] (e.g., older patients with cognitive impairment, patients following stroke or traumatic brain injury), we suggest referral to rehabilitation programmes in survivors of sepsis.”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [580]

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Hopkins, R. O., Suchyta, M. R., Kamdar, B. B., Darowski, E. S., Jackson, J. C., & Needham, D. M. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201701-059sr · Cited by 145 · see citing works
Psychiatric Diagnoses and Psychoactive Medication Use Among Nonsurgical Critically Ill Patients Receiving Mechanical Ventilation
Wunsch, H., Christiansen, C. F., Johansen, M. B., Olsen, M., Ali, N., Angus, D. C., & Sørensen, H. T. (2014) · JAMA · doi:10.1001/jama.2014.2137 · Cited by 143 · see citing works
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Surviving critical illness: What is next? An expert consensus statement on physical rehabilitation after hospital discharge.
Major, M. E., Kwakman, R., Kho, M. E., Connolly, B., McWilliams, D., Denehy, L., Hanekom, S., Patman, S., Gosselink, R., Jones, C., et al. (2016) · Critical Care · doi:10.1186/s13054-016-1508-x · Cited by 141 · see citing works
Physical rehabilitation interventions for adult patients during critical illness: an overview of systematic reviews
Connolly, B. A., O'Neill, B. M., Salisbury, L., & Blackwood, B. (2016) · Thorax · doi:10.1136/thoraxjnl-2015-208273 · Cited by 140 · see citing works
Inappropriate medication prescriptions in elderly adults surviving an intensive care unit hospitalization.
Morandi, A., Vasilevskis, E., Pandharipande, P. P., Girard, T. D., Solberg, L. M., Neal, E. B., Koestner, T., Torres, R. E., Thompson, J. L., Shintani, A. K., et al. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12329 · Cited by 126 · see citing works
Association of Postdischarge Rehabilitation with Mortality in Intensive Care Unit Survivors of Sepsis
Chao, P.-W., Shih, C.-J., Lee, Y.-J., Tseng, C.-M., Kuo, S., Shih, Y.-N., Chou, K., Tarng, D., Li, S., Ou, S., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201406-1170oc · Cited by 121 · see citing works
Rehabilitation for older people in long-term care
Förster, A., Lambley, R., Hardy, J., Young, J. B., Smith, J., Green, J., & Burns, E. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004294.pub2 · Cited by 117 · see citing works
Symmetrical peripheral gangrene (purpura fulminans) complicating pneumococcal sepsis
Johansen, K. H., & Hansen, S. T. (1993) · The American Journal of Surgery · doi:10.1016/s0002-9610(05)80452-0 · Cited by 116 · see citing works
A systematic review of the effect of physical exercise on cognition in stroke and traumatic brain injury patients
Vanderbeken, I., & Kerckhofs, E. (2016) · Neurorehabilitation · doi:10.3233/nre-161388 · Cited by 108 · see citing works
Peer support as a novel strategy to mitigate post-intensive care syndrome.
Mikkelsen, M. E., Jackson, J. C., Hopkins, R. O., Thompson, C., Andrews, A., Netzer, G., Bates, D. M., Bunnell, A. E., Christie, L. M., Greenberg, S. B., et al. (2016) · AACN Advanced Critical Care · doi:10.4037/aacnacc2016667 · Cited by 101 · see citing works
Physical activity, muscle strength, and exercise capacity 3 months after severe sepsis and septic shock
Borges, R. C., Carvalho, C. R. F., Colombo, A. S., Borges, M. P. D. S., & Soriano, F. G. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-3914-y · Cited by 100 · see citing works
Stress Disorders Following Prolonged Critical Illness in Survivors of Severe Sepsis
Wintermann, G., Brunkhorst, F. M., Petrowski, K., Strauss, B. M., Oehmichen, F., Pohl, M., & Rosendahl, J. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000936 · Cited by 99 · see citing works
Effect of supervised aerobic exercise rehabilitation on physical fitness and quality-of-life in survivors of critical illness: an exploratory minimized controlled trial (PIX study)
Batterham, A. M., Bonner, S., Wright, J., Howell, S. J., Hugill, K., & Danjoux, G. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu051 · Cited by 92 · see citing works
A Clinic Model: Post–Intensive Care Syndrome and Post–Intensive Care Syndrome-Family
Huggins, E. L., Bloom, S. L., Stollings, J. L., Camp, M., Sevin, C. M., & Jackson, J. C. (2016) · AACN Advanced Critical Care · doi:10.4037/aacnacc2016611 · Cited by 87 · see citing works
Acute and long-term dysphagia in critically ill patients with severe sepsis: results of a prospective controlled observational study
Zielske, J., Bohne, S., Brunkhorst, F. M., Axer, H., & Guntinas‐Lichius, O. (2014) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-014-3148-6 · Cited by 84 · see citing works
Chronically critically ill patients: Health-related quality of life and resource use after a disease management intervention.
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Long‐term physical outcome in patients with septic shock
Poulsen, J. B., Møller, K., Kehlet, H., & Perner, A. (2009) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2009.01921.x · Cited by 81 · see citing works
A Qualitative Investigation of Patients’ and Caregivers’ Experiences of Severe Sepsis*
Gallop, K., Kerr, C., Nixon, A., Verdian, L., Barney, J. B., & Beale, R. J. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000613 · Cited by 72 · see citing works
Unintentional continuation of medications intended for acute illness after hospital discharge: A population-based cohort study.
Scales, D. C., Fischer, H. D., Li, P., Bierman, A. S., Fernandes, O., Mamdani, M., Rochon, P., Urbach, D. R., & Bell, C. M. (2016) · Journal of General Internal Medicine · doi:10.1007/s11606-015-3501-5 · Cited by 70 · see citing works
Declining Case Fatality Rates for Severe Sepsis
Iwashyna, T. J., & Angus, D. C. (2014) · JAMA · doi:10.1001/jama.2014.2639 · Cited by 66 · see citing works
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Issues of survivorship are rarely addressed during intensive care unit stays. Baseline results from a statewide quality improvement collaborative.
Govindan, S., Iwashyna, T. J., Watson, S. R., Hyzy, R. C., & Miller, M. A. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201401-007bc · Cited by 63 · see citing works
Predicting Cognitive Sequelae in Survivors of Critical Illness with Cognitive Screening Tests
Woon, F. L. M., Dunn, C. B., & Hopkins, R. O. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201112-2261oc · Cited by 62 · see citing works
Acute Respiratory Distress Syndrome, Sepsis, and Cognitive Decline: A Review and Case Study
Jackson, J. C., Hopkins, R. O., Miller, R. R., Gordon, S. M., Wheeler, A. P., & Ely, E. W. (2009) · Southern Medical Journal · doi:10.1097/smj.0b013e3181b6a592 · Cited by 58 · see citing works
Depressive symptoms in spouses of older patients with severe sepsis*
Davydow, D. S., Hough, C. L., Langa, K. M., & Iwashyna, T. J. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182536a81 · Cited by 57 · see citing works
Predicting Performance Status 1 Year After Critical Illness in Patients 80 Years or Older: Development of a Multivariable Clinical Prediction Model
Heyland, D. K., Stelfox, H. T., Garland, A., Cook, D., Dodek, P., Kutsogiannis, J., Jiang, X., Turgeon, A. F., & Day, A. G. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001762 · Cited by 56 · see citing works
Long-term home and community-based exercise programs improve function in community-dwelling older people with cognitive impairment: a systematic review
Lewis, M., Peiris, C. L., & Shields, N. (2016) · Journal of physiotherapy · doi:10.1016/j.jphys.2016.11.005 · Cited by 56 · see citing works
Risk of Recurrence After Surviving Severe Sepsis: A Matched Cohort Study
Shen, H.-N., Lu, C., & Yang, H.-H. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001824 · Cited by 43 · see citing works
1397: SEPSIS SURVIVORS’ SATISFACTION WITH SUPPORT SERVICES DURING AND AFTER THEIR HOSPITALIZATION
Huang, C. Y., Daniels, R., Lembo, A., Heymann, T., O’Brien, J., Hartog, C. S., Reinhart, K., & Nguyen, H. B. (2016) · Critical Care Medicine · doi:10.1097/01.ccm.0000510071.45969.89 · Cited by 5 · see citing works
1413: MENTAL, PHYSIOLOGIC, AND FUNCTIONAL DISABILITIES IN POST-SEPSIS SYNDROME: AN INTERNATIONAL SURVEY
Huang, C. Y., Daniels, R., Lembo, A., Heymann, T., O’Brien, J., Hartog, C. S., Reinhart, K., & Nguyen, H. B. (2016) · Critical Care Medicine · doi:10.1097/01.ccm.0000510087.19527.46 · Cited by 4 · see citing works

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Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review
Wiersinga, W. J., Rhodes, A., Cheng, A. C., Peacock, S. J., & Prescott, H. C. (2020) · JAMA · doi:10.1001/jama.2020.12839 · Cited by 4,609 · see citing works
Self-citation
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935 · see citing works
Self-citation
The immunology of sepsis
van der Poll, T., Shankar‐Hari, M., & Wiersinga, W. J. (2021) · Immunity · doi:10.1016/j.immuni.2021.10.012 · Cited by 1,063 · see citing works
Sixty-day outcomes among patients hospitalized with COVID-19
Chopra, V., Flanders, S. A., O’Malley, M., Malani, A. N., & Prescott, H. C. (2021) · Annals of Internal Medicine · doi:10.7326/m20-5661 · Cited by 723 · see citing works
Self-citation
The Role of Inflammation in Depression and Fatigue
Lee, C.-H., & Giuliani, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01696 · Cited by 640 · see citing works
Mitochondria in health, disease, and aging
Harrington, J. S., Ryter, S. W., Plataki, M. E., Price, D. R., & Choi, A. M. K. (2023) · Physiological Reviews · doi:10.1152/physrev.00058.2021 · Cited by 622 · see citing works
Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005357 · Cited by 513 · see citing works
Self-citation
Sepsis and Septic Shock
Meyer, N. J., & Prescott, H. C. (2024) · New England Journal of Medicine · doi:10.1056/nejmra2403213 · Cited by 435 · see citing works
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Outcomes after Critical Illness
Herridge, M. S., & Azoulay, É. (2023) · New England Journal of Medicine · doi:10.1056/nejmra2104669 · Cited by 378 · see citing works
Sepsis-Induced Immunosuppression
Torres, L. K., Pickkers, P., & van der Poll, T. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-061121-040214 · Cited by 372 · see citing works
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Cavaillon, J., Singer, M., & Skirecki, T. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201810128 · Cited by 318 · see citing works
Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome
Hawkins, R. B., Raymond, S. L., Stortz, J. A., Horiguchi, H., Brakenridge, S. C., Gardner, A. K., Efron, P. A., Bihorac, A., Segal, M. S., Moore, F. A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01511 · Cited by 293 · see citing works
The Global Burden of Sepsis and Septic Shock
Via, L. L., Sangiorgio, G., Stefani, S., Marıno, A., Nunnari, G., Cocuzza, S. G., Mantia, I. L., Cacopardo, B. S., Stracquadanio, S., Spampinato, S., et al. (2024) · Epidemiologia · doi:10.3390/epidemiologia5030032 · Cited by 289 · see citing works
Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations
Parotto, M., Gyöngyösi, M., Howe, K. L., Myatra, S. N., Ranzani, O., Shankar‐Hari, M., & Herridge, M. S. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00239-4 · Cited by 271 · see citing works
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial
Moskowitz, A., Huang, D. T., Hou, P. C., Gong, J., Doshi, P. B., Grossestreuer, A. V., Andersen, L. W., Ngo, L., Sherwin, R. L., Berg, K. M., et al. (2020) · JAMA · doi:10.1001/jama.2020.11946 · Cited by 253 · see citing works
ED door-to-antibiotic time and long-term mortality in sepsis.
Peltan, I. D., Brown, S. M., Bledsoe, J. R., Sorensen, J., Samore, M. H., Allen, T. L., & Hough, C. L. (2019) · Chest · doi:10.1016/j.chest.2019.02.008 · Cited by 243 · see citing works
Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine
Cajander, S., Kox, M., Scicluna, B. P., Weigand, M. A., Mora, R. A., Flohé, S. B., Martín‐Loeches, I., Lachmann, G., Girardis, M., García‐Salido, A., et al. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00330-2 · Cited by 238 · see citing works
Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19
Ramakrishnan, R. K., Kashour, T., Hamid, Q. A., Halwani, R., & Tleyjeh, I. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686029 · Cited by 240 · see citing works
Post-sepsis syndrome – an evolving entity that afflicts survivors of sepsis
Mostel, Z., Perl, A. C., Marck, M., Mehdi, S. F., Lowell, B., Bathija, S., Santosh, R., Pavlov, V. A., Chavan, S. S., & Roth, J. (2019) · Molecular Medicine · doi:10.1186/s10020-019-0132-z · Cited by 218 · see citing works
Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis
Yende, S. P., Kellum, J. A., Talisa, V. B., Palmer, O. M. P., Chang, C. H., Filbin, M. R., Shapiro, N. I., Hou, P. C., Venkat, A., LoVecchio, F., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.8686 · Cited by 193 · see citing works
Self-citation
Cerebral dysfunctions caused by sepsis during ageing
Manabe, T., & Heneka, M. T. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00643-7 · Cited by 191 · see citing works
Sepsis and septic shock: current approaches to management
Thompson, K., Venkatesh, B., & Finfer, S. R. (2019) · Internal Medicine Journal · doi:10.1111/imj.14199 · Cited by 191 · see citing works
Effects of post-ICU follow-up on subject outcomes: A systematic review and meta-analysis
Rosa, R. G., Ferreira, G. E., Viola, T. W., Robinson, C. C., Kochhann, R., Berto, P. P., Biason, L., Cardoso, P. R., Falavigna, M., & Teixeira, C. (2019) · Journal of Critical Care · doi:10.1016/j.jcrc.2019.04.014 · Cited by 170 · see citing works
Understanding and Enhancing Sepsis Survivorship. Priorities for Research and Practice
Prescott, H. C., Iwashyna, T. J., Blackwood, B., Calandra, T., Chlan, L. L., Choong, K., Connolly, B., Dark, P., Ferrucci, L., Finfer, S., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201812-2383cp · Cited by 166 · see citing works
Self-citation
NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis
Ye, M., Zhao, Y., Wang, Y., Xie, R., Tong, Y., Sauer, J., & Gong, S. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01137-w · Cited by 168 · see citing works
Global burden of melioidosis in 2015: a systematic review and data synthesis
Birnie, E., Virk, H. S., Savelkoel, J., Spijker, R., Bertherat, E., Dance, D. A. B., Limmathurotsakul, D., Devleesschauwer, B., Haagsma, J. A., & Wiersinga, W. J. (2019) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(19)30157-4 · Cited by 166 · see citing works
The critically ill older patient with sepsis: a narrative review
Ibarz, M., Haas, L. E. M., Ceccato, A., & Artigas, A. (2024) · Annals of Intensive Care · doi:10.1186/s13613-023-01233-7 · Cited by 177 · see citing works
Exosomal miR-21 secreted by IL-1β-primed-mesenchymal stem cells induces macrophage M2 polarization and ameliorates sepsis
Yao, M., Cui, B., Zhang, W., Ma, W., Zhao, G.-F., & Xing, L. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118658 · Cited by 162 · see citing works
The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases
Shi, X., Zhou, H., Wei, J., Mo, W., Li, Q., & Lv, X. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102553 · Cited by 160 · see citing works
Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial
Florescu, S. A., Stanciu, D., Zaharia, M. F., Kosa, A. G., Codreanu, D. R., Kidwai, A., Masood, S., Kaye, C. T., Coutts, A., MacKay, L., et al. (2022) · JAMA · doi:10.1001/jama.2022.23257 · Cited by 136 · see citing works
Sestrin2 protects dendrite cells against ferroptosis induced by sepsis
Li, J., Ren, C., Wang, L., Yao, R.-Q., Dong, N., Wu, Y., Tian, Y., & Yao, Y.-M. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04122-8 · Cited by 134 · see citing works
Rate and risk factors for rehospitalisation in sepsis survivors: systematic review and meta-analysis
Shankar‐Hari, M., Saha, R., Wilson, J., Prescott, H. C., Harrison, D. A., Rowan, K., Rubenfeld, G. D., & Adhikari, N. K. J. (2020) · Intensive Care Medicine · doi:10.1007/s00134-019-05908-3 · Cited by 131 · see citing works
Self-citation
Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity
Nascimento, D. C., Viacava, P. R., Ferreira, R. G., Damaceno, M. A., Piñeros, A. R., Melo, P. H., Donate, P. B., Toller-Kawahisa, J. E., Zoppi, D., Veras, F. P., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.005 · Cited by 129 · see citing works
Hydrogen peroxide and disease: towards a unified system of pathogenesis and therapeutics
Pravda, J. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00165-3 · Cited by 127 · see citing works
Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model
Owen, A. M., Patel, S. P., Smith, J. D., Balasuriya, B. K., Mori, S. F., Hawk, G. S., Stromberg, A. J., Kuriyama, N., Kaneki, M., Rabchevsky, A. G., et al. (2019) · eLife · doi:10.7554/elife.49920 · Cited by 126 · see citing works
Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid
Marik, P. E. (2018) · Nutrients · doi:10.3390/nu10111762 · Cited by 125 · see citing works
The burden and contemporary epidemiology of sepsis in children
Watson, R. S., Carrol, E. D., Carter, M. J., Kissoon, N. “., Ranjit, S., & Schlapbach, L. J. (2024) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(24)00140-8 · Cited by 124 · see citing works
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082 · see citing works
Self-citation
S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge
Deutsche Sepsis Gesellschaft e., V., Brunkhorst, F. M., Weigand, M. A., Pletz, M. W., Gastmeier, P., Lemmen, S., Meier‐Hellmann, A., Ragaller, M., Weyland, A., Marx, G., et al. (2020) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-020-00685-0 · Cited by 119 · see citing works
The Relationship between Stress, Inflammation, and Depression
Kim, I. B., Lee, J.-H., & Park, S. (2022) · Biomedicines · doi:10.3390/biomedicines10081929 · Cited by 126 · see citing works
Characteristics, Outcomes, and Trends of Patients With COVID-19–Related Critical Illness at a Learning Health System in the United States
Anesi, G. L., Jablonski, J., Harhay, M. O., Atkins, J. H., Bajaj, J., Baston, C., Brennan, P. J., Candeloro, C. L., Catalano, L. M., Cereda, M. F., et al. (2021) · Annals of Internal Medicine · doi:10.7326/m20-5327 · Cited by 115 · see citing works
Sepsis and Cancer: An Interplay of Friends and Foes
Mirouse, A., Vigneron, C., Llitjos, J., Chiche, J., Mira, J. P., Mokart, D., Azoulay, É., & Pène, F. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202004-1116tr · Cited by 115 · see citing works
Exploring the pathophysiology of post-sepsis syndrome to identify therapeutic opportunities
van der Slikke, E. C., An, A. Y., Hancock, R. E. W., & Bouma, H. R. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103044 · Cited by 115 · see citing works
Risk Factors at Index Hospitalization Associated With Longer-term Mortality in Adult Sepsis Survivors
Shankar‐Hari, M., Harrison, D. A., Ferrando-Vivas, P., Rubenfeld, G. D., & Rowan, K. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.4900 · Cited by 109 · see citing works
Epidemiology and Costs of Postsepsis Morbidity, Nursing Care Dependency, and Mortality in Germany, 2013 to 2017
Fleischmann-Struzek, C., Rose, N., Freytag, A., Spoden, M., Prescott, H. C., Schettler, A., Wedekind, L., Ditscheid, B., Storch, J., Born, S., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.34290 · Cited by 106 · see citing works
Self-citation
Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery
Efron, P. A., Mohr, A. M., Bihorac, A., Horiguchi, H., Hollen, M. K., Segal, M. S., Baker, H. V., Leeuwenburgh, C., Moldawer, L. L., Moore, F. A., et al. (2018) · Surgery · doi:10.1016/j.surg.2018.04.011 · Cited by 105 · see citing works
Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026
Prescott, H. C., Antonelli, M. M., Alhazzani, W. A., Møller, M. H., Alshamsi, F. E., Azevedo, L. C. P., Belley‐Côté, E. P., Waele, J. D., Derde, L. P. G., Dionne, J. C., et al. (2026) · Intensive Care Medicine · doi:10.1007/s00134-026-08361-1 · Cited by 134 · see citing works
Self-citation
An approach to antibiotic treatment in patients with sepsis
Martínez, M. L., Plata-Menchaca, E. P., Ruiz‐Rodríguez, J. C., & Ferrer, R. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd.2020.01.47 · Cited by 105 · see citing works
The blood-brain barrier dysfunction in sepsis
Barichello, T., Generoso, J. S., Collodel, A., Petronilho, F. C., & Dal‐Pizzol, F. (2020) · Tissue Barriers · doi:10.1080/21688370.2020.1840912 · Cited by 99 · see citing works
Challenges of assessing the burden of sepsis
Fleischmann-Struzek, C., & Rudd, K. E. (2023) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-023-01088-7 · Cited by 99 · see citing works
Nanotherapies for sepsis by regulating inflammatory signals and reactive oxygen and nitrogen species: New insight for treating COVID-19
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Long-term mortality and outcome in hospital survivors of septic shock, sepsis, and severe infections: The importance of aftercare
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Authors: Prescott, H. C., & Angus, D. C.
Affiliations: University of Michigan (US)
University of Pittsburgh (US)
ORCID: Prescott, Hallie C.
Angus, Derek C.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2018-01-02
Volume: 319
Issue: 1
Pages: 62
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2017.17687
PMC: PMC5839473
OpenAlex: W2782135811
Semantic Scholar: 98cad261fafa6b5df5332a165d01f11de1afd48e
Cited by: 1,059
References: 93
Citations by year: 2026: 143 · 2025: 149 · 2024: 161 · 2023: 142 · 2022: 124 · 2021: 135 · 2020: 103 · 2019: 67 · 2018: 32
FWCI: 65.73
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM097471, K08GM115859)
Topics: Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Keywords: sepsis survivors, post-hospital care, post-discharge rehabilitation, physiotherapy referral, functional recovery, cognitive impairment, post-traumatic stress disorder, depression, anxiety, hospital readmission, recurrent infections, acute kidney injury, cardiovascular events, activities of daily living, sepsis severity, immune dysfunction, hospital quality of care, sepsis management guidelines
MeSH terms: Activities of Daily Living, Adult, Mental Disorders, Cognition Disorders, Hospitalization, Humans, Sepsis

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