The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
Open accessAbstract
OBJECTIVE: To test the hypothesis that duration of delirium in the intensive care unit is an independent predictor of long-term cognitive impairment after critical illness requiring mechanical ventilation. DESIGN: Prospective cohort study. SETTING: Medical intensive care unit in a large community hospital in the United States. PATIENTS: Mechanically ventilated medical intensive care unit patients who were assessed daily for delirium while in the intensive care unit and who underwent comprehensive cognitive assessments 3 and 12 mos after discharge. MEASUREMENTS AND MAIN RESULTS: Of 126 eligible patients, 99 survived>or=3 months after critical illness; long-term cognitive outcomes were obtained for 77 (78%) patients. Median age was 61 yrs, 51% were admitted with sepsis/acute respiratory distress syndrome, and median duration of delirium was 2 days. At 3-mo and 12-mo follow-up, 79% and 71% of survivors had cognitive impairment, respectively (with 62% and 36% being severely impaired). After adjusting for age, education, preexisting cognitive function, severity of illness, severe sepsis, and exposure to sedative medications in the intensive care unit, increasing duration of delirium was an independent predictor of worse cognitive performance-determined by averaging age-adjusted and education-adjusted T-scores from nine tests measuring seven domains of cognition-at 3-mo (p=.02) and 12-mo follow-up (p=.03). Duration of mechanical ventilation, alternatively, was not associated with long-term cognitive impairment (p=.20 and .58). CONCLUSIONS: In this study of mechanically ventilated medical intensive care unit patients, duration of delirium (which is potentially modifiable) was independently associated with long-term cognitive impairment, a common public health problem among intensive care unit survivors.
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Cites
Mild Cognitive Impairment: Clinical Characterization and Outcome
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Sessler, C. N., Gosnell, M. S., Grap, M. J., Brophy, G. M., O'Neal, P. V., Keane, K. A., Tesoro, E. P., & Elswick, R. K. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2107138 · Cited by 3,695
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Self-citationDelirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
Ely, E. W. (2004) · JAMA · doi:10.1001/jama.291.14.1753 · Cited by 3,073
Self-citationOne-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome
Herridge, M. S., Cheung, A. M., Tansey, C. M., Matte-Martyn, A., Diaz-Granados, N., Al-Saidi, F., Cooper, A. B., Guest, C. B., Mazer, C. D., Mehta, S., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022450 · Cited by 2,334 · cited 1×
“Although advances in critical care medicine have significantly reduced mortality for patients with critical illness, survivors often do not recover to their previous cognitive or functional status (1).”
BackgroundIntensive Care Delirium Screening Checklist: evaluation of a new screening tool
Bergeron, N., Dubois, M.-J., Dumont, M., Dial, S., & Skrobik, Y. (2001) · Intensive Care Medicine · doi:10.1007/s001340100909 · Cited by 1,487
Inouye, S. K., Viscoli, C. M., Horwitz, R. I., Hurst, L. D., & Tinetti, M. E. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-6-199309150-00005 · Cited by 854
The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): a review
Jorm, A. F. (2004) · International Psychogeriatrics · doi:10.1017/s1041610204000390 · Cited by 823 · cited 1×
“97), sensitive (75%– 100%), and specific (68%– 86%) as a screening test for dementia (67).”
BackgroundTwo-Year Cognitive, Emotional, and Quality-of-Life Outcomes in Acute Respiratory Distress Syndrome
Hopkins, R. O., Weaver, L. K., Collingridge, D., Parkinson, R. B., Chan, K. J., & Orme, J. F. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-763oc · Cited by 759
Cited by
Long-term cognitive impairment after critical illness
Pandharipande, P. P., Girard, T. D., Jackson, J. C., Morandi, A., Thompson, J. L., Pun, B. T., Brummel, N. E., Hughes, C. G., Vasilevskis, E. E., Shintani, A. K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301372 · Cited by 2,842
Self-citationNeedham, D. M., Davidson, J., Cohen, H., Hopkins, R. O., Weinert, C., Wunsch, H., Zawistowski, C., Bemis-Dougherty, A., Berney, S. C., Bienvenu, O. J., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318232da75 · Cited by 2,639
Long-term cognitive impairment and functional disability among survivors of severe sepsis.
Iwashyna, T. J., Ely, E. W., Smith, D. M., & Langa, K. M. (2010) · JAMA · doi:10.1001/jama.2010.1553 · Cited by 2,582
Self-citationLong COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
Yong, S. J. (2021) · Infectious Diseases · doi:10.1080/23744235.2021.1924397 · Cited by 1,339
Long-term complications of critical care
Desai, S. V., Law, T. J., & Needham, D. M. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181fd66e5 · Cited by 870
Metadata
- Authors
- Girard, T. D., Jackson, J. C., Pandharipande, P. P., Pun, B. T., Thompson, J. L., Shintani, A. K., Gordon, S. M., Canonico, A. E., Dittus, R. S., Bernard, G. R., & Wesley Ely, E.
- Venue
- Critical Care Medicine
- Published
- 2010-07
- Volume
- 38
- Issue
- 7
- Pages
- 1513-1520
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2117839048
- Cited by
- 1,213
- References
- 9
- FWCI
- 52.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Girard, T. D., Jackson, J. C., Pandharipande, P. P., Pun, B. T., Thompson, J. L., Shintani, A. K., Gordon, S. M., Canonico, A. E., Dittus, R. S., Bernard, G. R., & Wesley Ely, E. (2010). Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Critical Care Medicine. https://doi.org/10.1097/ccm.0b013e3181e47be1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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