Cited by 362Intensive Care Unit Cognitive DisordersTraumatic Brain Injury ResearchAlcoholism and Thiamine Deficiency

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Delirium in critically ill patients: Impact on long-term health-related quality of life and cognitive functioning*

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van den Boogaard, Mark, Schoonhoven, Lisette, Evers, Andrea W.M., van der Hoeven, Johannes G., van Achterberg, Theo, Pickkers, Peter·2012·Critical Care Medicine

DOI 10.1097/ccm.0b013e31822e9fc9

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Abstract

OBJECTIVE: To examine the impact of delirium during intensive care unit stay on long-term health-related quality of life and cognitive function in intensive care unit survivors. DESIGN: Prospective 18-month follow-up study. SETTING: Four intensive care units of a university hospital. PATIENTS: A median of 18 months after intensive care discharge, questionnaires were sent to 1,292 intensive care survivors with (n = 272) and without (n = 1020) delirium during their intensive care stay. MEASUREMENTS AND MAIN RESULTS: The Short Form-36v1, checklist individual strength-fatigue, and cognitive failure questionnaire were used. Covariance analysis was performed to adjust for relevant covariates. Of the 915 responders, 171 patients were delirious during their intensive care stay (median age 65 [interquartile range 58-85], Acute Physiology and Chronic Health Evaluation II score 17 [interquartile range 14-20]), and 745 patients were not (median age 65 [interquartile range 57-72], Acute Physiology and Chronic Health Evaluation II score 13 [interquartile range 10-16]). After adjusting for covariates, no differences were found between delirium and nondelirium survivors on the Short Form-36 and checklist individual strength-fatigue. However, survivors who had suffered from delirium reported that they made significantly more social blunders, and their total cognitive failure questionnaire score was significantly higher, compared to survivors who had not been delirious. Survivors of a hypoactive delirium subtype performed significantly better on the domain mental health than mixed and hyperactive delirium patients. Duration of delirium was significantly correlated to problems with memory and names. CONCLUSIONS: Intensive care survivors with delirium during their intensive care unit stay had a similar adjusted health-related quality of life evaluation, but significantly more cognitive problems than those who did not suffer from delirium, even after adjusting for relevant covariates. In addition, the duration of delirium was related to long-term cognitive problems.

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Authors: van den Boogaard, M., Schoonhoven, L., Evers, A. W. M., van der Hoeven, J. G., van Achterberg, T., & Pickkers, P.
Affiliations: Radboud University Nijmegen (NL)
ORCID: Schoonhoven, Lisette
Evers, Andrea W.M.
Pickkers, Peter
Venue: Critical Care Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-01
Volume: 40
Issue: 1
Pages: 112-118
ISSN: 0090-3493 (ISSN-L)
DOI: 10.1097/ccm.0b013e31822e9fc9
OpenAlex: W2061187046
Cited by: 361
References: 206
Citations by year: 2026: 10 · 2025: 11 · 2024: 19 · 2023: 12 · 2022: 22 · 2021: 42 · 2020: 38 · 2019: 32 · 2018: 40 · 2017: 30 · 2016: 30 · 2015: 19 · 2014: 15 · 2013: 18 · 2012: 18
FWCI: 13.80
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (acceptedVersion)
Radboud Repository (Radboud University) (submittedVersion, other-oa)
Lirias (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords: delirium, intensive care unit survivors, health-related quality of life, cognitive function, long-term cognitive impairment, hypoactive delirium, hyperactive delirium, delirium duration, memory impairment, post-intensive care syndrome
MeSH terms: Aged, Aged, 80 and over, Cognition, Cognition Disorders, Delirium, Humans, Intensive Care Units, Middle Aged, Neuropsychological Tests, Prospective Studies, Quality of Life, Critical Illness

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Delirium in critically ill patients: Impact on long-term health-related quality of life and cognitive functioning*

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