The Adult Respiratory Distress Syndrome Cognitive Outcomes Study: Long-Term Neuropsychological Function in Survivors of Acute Lung Injury

Mikkelsen, Mark E.; Christie, Jason D.; Lanken, Paul N.; Biester, Rosette C.; Thompson, B. Taylor; Bellamy, Scarlett L.; Localio, A. Russell; Demissie, Ejigayehu; Hopkins, Ramona O.; Angus, Derek C.

doi:10.1164/rccm.201111-2025oc

Cited by 615Intensive Care Unit Cognitive DisordersRespiratory Support and MechanismsInfectious Encephalopathies and Encephalitis

The Adult Respiratory Distress Syndrome Cognitive Outcomes Study: Long-Term Neuropsychological Function in Survivors of Acute Lung Injury

Open access

Mikkelsen, Mark E., Christie, Jason D., Lanken, Paul N., Biester, Rosette C., Thompson, B. Taylor, Bellamy, Scarlett L., Localio, A. Russell, Demissie, Ejigayehu +2 more·2012·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.201111-2025ocPMC PMC3381234

Open this paper in CoChat — free account

Abstract

Rationale: Cognitive and psychiatric morbidity is common and potentially modifiable after acute lung injury (ALI). However, practical measures of neuropsychological function for use in multicenter trials are lacking. Objectives: To determine whether a validated telephone-based neuropsychological test battery is feasible in a multicenter trial. To determine the frequency and risk factors for long-term neuropsychological impairment. Methods: As an adjunct study to the Acute Respiratory Distress Syndrome Clinical Trials Network Fluid and Catheter Treatment Trial, we assessed neuropsychological function at 2 and 12 months post–hospital discharge. Measurements and Main Results: Of 406 eligible survivors, we approached 261 to participate and 213 consented. We tested 122 subjects at least once, including 102 subjects at 12 months. Memory, verbal fluency, and executive function were impaired in 13% (12 of 92), 16% (15 of 96), and 49% (37 of 76) of long-term survivors. Long-term cognitive impairment was present in 41 of the 75 (55%) survivors who completed cognitive testing. Depression, post-traumatic stress disorder, or anxiety was present in 36% (37 of 102), 39% (40 of 102), and 62% (63 of 102) of long-term survivors. Enrollment in a conservative fluid-management strategy (P = 0.005) was associated with cognitive impairment and lower partial pressure of arterial oxygen during the trial was associated with cognitive (P = 0.02) and psychiatric impairment (P = 0.02). Conclusions: Neuropsychological function can be assessed by telephone in a multicenter trial. Long-term neuropsychological impairment is common in survivors of ALI. Hypoxemia is a risk factor for long-term neuropsychological impairment. Fluid management strategy is a potential risk factor for long-term cognitive impairment; however, given the select population studied and an unclear mechanism, this finding requires confirmation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1164/rccm.201111-2025oc

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

One-year post-discharge, ARDS survivors show high rates of anxiety, depression, executive dysfunction and post-traumatic stress disorder.
“Moreover, one-year post-discharge, ARDS survivors show high rates of anxiety, depression, executive dysfunction and post-traumatic stress disorder [121, 122].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [121]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53221.x · Cited by 25,553 · see citing works
An inventory for measuring clinical anxiety: Psychometric properties.
Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.56.6.893 · Cited by 14,407 · see citing works
Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941 · see citing works
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730 · see citing works
A simulation study of the number of events per variable in logistic regression analysis
Peduzzi, P., Concato, J., Kemper, E., Holford, T. R., & Feinstein, A. R. (1996) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00236-3 · Cited by 9,655 · see citing works
The American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746 · see citing works
Association between Water Intake, Chronic Kidney Disease, and Cardiovascular Disease: A Cross-Sectional Analysis of NHANES Data
Sontrop, J. M., Dixon, S. N., Garg, A. X., Jiménez, I. B., Dohein, O., Huang, S. S., & Clark, W. F. (2013) · American Journal of Nephrology · doi:10.1159/000350377 · Cited by 5,903 · see citing works
Incidence and Outcomes of Acute Lung Injury
Rubenfeld, G. D., Caldwell, E., Peabody, E., Weaver, J., Martin, D. P., Neff, M., Stern, E. J., & Hudson, L. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050333 · Cited by 3,684 · see citing works
Comparison of Two Fluid-Management Strategies in Acute Lung Injury
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa062200 · Cited by 3,538 · see citing works
Functional Disability 5 Years after Acute Respiratory Distress Syndrome
Herridge, M. S., Tansey, C. M., Matte, A. L., TOMLINSON, G. A., Diaz-Granados, N., Cooper, A., Guest, C. B., Mazer, C. D., Mehta, S., Stewart, T. E., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011802 · Cited by 2,829 · see citing works
Long-term cognitive impairment and functional disability among survivors of severe sepsis.
Iwashyna, T. J., Ely, E. W., Smith, D. M., & Langa, K. M. (2010) · JAMA · doi:10.1001/jama.2010.1553 · Cited by 2,582 · see citing works
Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome
(2004) · New England Journal of Medicine · doi:10.1056/nejmoa032193 · Cited by 2,565 · see citing works
Simulation Study of Confounder-Selection Strategies
Maldonado, G., & Greenland, S. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116813 · Cited by 2,491 · see citing works
One-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome
Herridge, M. S., Cheung, A. M., Tansey, C. M., Matte-Martyn, A., Diaz-Granados, N., Al-Saidi, F., Cooper, A. B., Guest, C. B., Mazer, C. D., Mehta, S., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022450 · Cited by 2,334 · see citing works
Wechsler Adult Intelligence Scale--Third Edition
Wechsler, D. (2019) · PsycTESTS Dataset · doi:10.1037/t49755-000 · Cited by 2,327 · see citing works
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365 · see citing works
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
Girard, T. D., Jackson, J. C., Pandharipande, P. P., Pun, B. T., Thompson, J. L., Shintani, A., Gordon, S. M., Canonico, A. E., Dittus, R. S., Bernard, G. R., et al. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181e47be1 · Cited by 1,217 · see citing works
The Hayling and Brixton Tests
Burgess, P., & Shallice, T. (1997) · UCL Discovery (University College London) · Cited by 972 · see citing works
Multiattribute Utility Function for a Comprehensive Health Status Classification System
Torrance, G. W., Feeny, D. H., Furlong, W. J., Barr, R. D., ZHANG, Y., & Wang, Q. (1996) · Medical Care · doi:10.1097/00005650-199607000-00004 · Cited by 900 · see citing works
Long-term complications of critical care
Desai, S. V., Law, T. J., & Needham, D. M. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181fd66e5 · Cited by 870 · see citing works
Two-Year Cognitive, Emotional, and Quality-of-Life Outcomes in Acute Respiratory Distress Syndrome
Hopkins, R. O., Weaver, L. K., Collingridge, D., Parkinson, R. B., Chan, K. J., & Orme, J. F. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-763oc · Cited by 759 · see citing works
Self-citation
Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury.
Lung (2009) · New England Journal of Medicine · doi:10.1056/nejmoa061895 · Cited by 747 · see citing works
Posttraumatic stress disorder in general intensive care unit survivors: a systematic review
Davydow, D. S., Gifford, J. M., Desai, S. V., Needham, D. M., & Bienvenu, O. J. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2008.05.006 · Cited by 678 · see citing works
Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome
HOPKINS, R. O., WEAVER, L. K., POPE, D., ORME, J. F., BIGLER, E. D., & LARSON-LOHR, V. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.1.9708059 · Cited by 668 · see citing works
Self-citation
The Long-term Psychological Effects of Daily Sedative Interruption on Critically Ill Patients
Kress, J. P., Gehlbach, B. K., Lacy, M. A., Pliskin, N. H., Pohlman, A. S., & Hall, J. B. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200303-455oc · Cited by 645 · see citing works
Association Between Acute Care and Critical Illness Hospitalization and Cognitive Function in Older Adults
Ehlenbach, W. J. (2010) · JAMA · doi:10.1001/jama.2010.167 · Cited by 515 · see citing works
Depression in general intensive care unit survivors: a systematic review
Davydow, D. S., Gifford, J. M., Desai, S. V., Bienvenu, O. J., & Needham, D. M. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1396-5 · Cited by 455 · see citing works
One-Year Trajectories of Care and Resource Utilization for Recipients of Prolonged Mechanical Ventilation: A Cohort Study
Unroe, M., Kahn, J. M., Carson, S. S., Govert, J. A., Martinu, T., Sathy, S. J., Clay, A. S., Chia, J., Gray, A., Tulsky, J. A., et al. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-3-201008030-00007 · Cited by 427 · see citing works
Delirium in critically ill patients: Impact on long-term health-related quality of life and cognitive functioning*
van den Boogaard, M., Schoonhoven, L., Evers, A. W. M., van der Hoeven, J. G., van Achterberg, T., & Pickkers, P. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31822e9fc9 · Cited by 361 · see citing works
Posttraumatic Stress Disorder and Health-Related Quality of Life in Long-Term Survivors of Acute Respiratory Distress Syndrome
Kapfhammer, H. P., Rothenhäusler, H. B., Krauseneck, T., Stoll, C., & Schelling, G. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.45 · Cited by 335 · see citing works
Psychiatric Morbidity in Survivors of the Acute Respiratory Distress Syndrome: A Systematic Review
Davydow, D. S., Desai, S. V., Needham, D. M., & Bienvenu, O. J. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31816aa0dd · Cited by 330 · see citing works
Validity of the Zung Self-rating Depression Scale
Biggs, J. T., Wylie, L. T., & Ziegler, V. E. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.132.4.381 · Cited by 326 · see citing works
Impaired financial abilities in mild cognitive impairment
Griffith, H. R., Belue, K., Sicola, A., Krzywanski, S., ZAMRINI, E. Y., Harrell, L. E., & Marson, D. C. (2003) · Neurology · doi:10.1212/wnl.60.3.449 · Cited by 322 · see citing works
Cognitive and physical rehabilitation of intensive care unit survivors: Results of the RETURN randomized controlled pilot investigation*
Jackson, J. C., Ely, E. W., Morey, M. C., Anderson, V. M., Denne, L. B., Clune, J., Siebert, C. S., Archer, K. R., Torres, R., Janz, D., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182373115 · Cited by 318 · see citing works
The relationship between cognitive performance and employment and health status in long-term survivors of the acute respiratory distress syndrome: results of an exploratory study
Rothenhäusler, H., Ehrentraut, S., Stoll, C., Schelling, G., & Kapfhammer, H. (2001) · General Hospital Psychiatry · doi:10.1016/s0163-8343(01)00123-2 · Cited by 307 · see citing works
A Prospective Study of Complications of Pulmonary Artery Catheterizations in 500 Consecutive Patients
Boyd, K. D., Thomas, S. J., Gold, J., & Boyd, A. D. (1983) · CHEST Journal · doi:10.1378/chest.84.3.245 · Cited by 291 · see citing works
Education and dementia
Ngandu, T., Strauss, E. I. V., Helkala, E.-L., Winblad, B. G., Nissinen, A. M., Tuomilehto, J. O., Soininen, H. S., & Kivipelto, M. (2007) · Neurology · doi:10.1212/01.wnl.0000277456.29440.16 · Cited by 290 · see citing works
Survivorship Will Be the Defining Challenge of Critical Care in the 21st Century
Iwashyna, T. J. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-3-201008030-00013 · Cited by 259 · see citing works
Long-term Cognitive and Psychological Outcomes in the Awakening and Breathing Controlled Trial
Jackson, J. C., Girard, T. D., Gordon, S. M., Thompson, J. L., Shintani, A., Thomason, J. W. W., Pun, B. T., Canonico, A. E., Dunn, J., Bernard, G. R., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0442oc · Cited by 255 · see citing works
Depressive Symptoms and Impaired Physical Function after Acute Lung Injury: A 2-Year Longitudinal Study
Bienvenu, O. J., Colantuoni, E., Méndez-Téllez, P. A., Dinglas, V. D., Shanholtz, C. B., Husain, N., Himmelfarb, C. D., Herridge, M. S., Pronovost, P. J., & Needham, D. M. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201103-0503oc · Cited by 236 · see citing works
An empirical approach to determining criteria for abnormality in test batteries with multiple measures.
Ingraham, L. J., & Aiken, C. B. (1996) · Neuropsychology · doi:10.1037/0894-4105.10.1.120 · Cited by 231 · see citing works
Systematic review identifies number of strategies important for retaining study participants
Robinson, K. A., Dennison, C. R., Wayman, D. M., Pronovost, P. J., & Needham, D. M. (2007) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.11.023 · Cited by 222 · see citing works
The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health-related quality of life in survivors
Schelling, G., Stoll, C., Kapfhammer, H., Rothenhäusler, H., Krauseneck, T., Durst, K., Haller, M., & Briegel, J. (1999) · Critical Care Medicine · doi:10.1097/00003246-199912000-00012 · Cited by 202 · see citing works
Intensive care unit drug use and subsequent quality of life in acute lung injury patients
Nelson, B. J., Weinert, C., BURY, C. L., Marinelli, W. A., & Gross, C. R. (2000) · Critical Care Medicine · doi:10.1097/00003246-200011000-00013 · Cited by 181 · see citing works
Quality of life, emotional, and cognitive function following acute respiratory distress syndrome
Hopkins, R. O., Weaver, L. K., Chan, K. J., & Orme, J. F. (2004) · Journal of the International Neuropsychological Society · doi:10.1017/s135561770410711x · Cited by 178 · see citing works
Self-citation
Prolonged cognitive dysfunction in survivors of critical illness
Sukantarat, K., Burgess, P., Williamson, R. C., & Brett, S. (2005) · Anaesthesia · doi:10.1111/j.1365-2044.2005.04148.x · Cited by 156 · see citing works
Significant cognitive dysfunction in non-delirious patients identified during and persisting following critical illness
Jones, C., Griffiths, R. D., Slater, T., Benjamin, K. S., & Wilson, S. L. (2006) · Intensive Care Medicine · doi:10.1007/s00134-006-0112-y · Cited by 140 · see citing works
Torture of a Norwegian ship's crew
Weisæth, L. (1989) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1989.tb05255.x · Cited by 124 · see citing works
Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome
Hopkins, R. O., Key, C. W., Suchyta, M. R., Weaver, L. K., & Orme, J. F. (2009) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2009.11.003 · Cited by 121 · see citing works
Self-citation
Motivational effects on neuropsychological functioning: Comparison of depressed versus nondepressed individuals.
Richards, P. M., & Ruff, R. M. (1989) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.57.3.396 · Cited by 115 · see citing works
Cognitive, mood and quality of life impairments in a select population of ARDS survivors
Mikkelsen, M. E., Shull, W. H., Biester, R. C., Taichman, D. B., Lynch, S., Demissie, E., Hansen-Flaschen, J. H., & Christie, J. D. (2008) · Respirology · doi:10.1111/j.1440-1843.2008.01419.x · Cited by 96 · see citing works
Self-citation
Self-reported Depressive Symptoms and Memory Complaints in Survivors Five Years After ARDS
Adhikari, N. K. J., Tansey, C. M., McAndrews, M. P., Matte, A. L., Pinto, R. L., Cheung, A. M., Diaz-Granados, N., & Herridge, M. S. (2011) · CHEST Journal · doi:10.1378/chest.11-1667 · Cited by 96 · see citing works
Long-term psychological effects of a no-sedation protocol in critically ill patients
Strøm, T., Stylsvig, M., & Toft, P. (2011) · Critical Care · doi:10.1186/cc10586 · Cited by 89 · see citing works
Cytokine and Other Immunologic Markers in Chronic Fatigue Syndrome and Their Relation to Neuropsychological Factors
Patarca-Montero, R., Antoni, M. H., FLETCHER, M. A., & Klimas, N. G. (2001) · Applied Neuropsychology · doi:10.1207/s15324826an0801_7 · Cited by 84 · see citing works
Screening for Preexisting Cognitive Impairment in Older Intensive Care Unit Patients: Use of Proxy Assessment
Pisani, M. A., Inouye, S. K., McNicoll, L., & Redlich, C. A. (2003) · Journal of the American Geriatrics Society · doi:10.1034/j.1600-0579.2003.00215.x · Cited by 80 · see citing works
Self-Reported Symptoms of Depression and Memory Dysfunction in Survivors of ARDS
Adhikari, N. K. J., McAndrews, M. P., Tansey, C. M., Matte, A. L., Pinto, R. L., Cheung, A. M., Diaz-Granados, N., Barr, A., & Herridge, M. S. (2009) · CHEST Journal · doi:10.1378/chest.08-0974 · Cited by 77 · see citing works
Motivational effects on neuropsychological functioning: Comparison of depressed versus nondepressed individuals.
Richards, P. M., & Ruff, R. M. (1989) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.57.3.396 · Cited by 76 · see citing works
Intensive care unit hypoglycemia predicts depression during early recovery from acute lung injury*
Dowdy, D. W., Dinglas, V. D., Méndez-Téllez, P. A., Bienvenu, O. J., Sevransky, J., Himmelfarb, C. D., Shanholtz, C. B., & Needham, D. M. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31818781f5 · Cited by 72 · see citing works
Costs of Mini Mental State Examination-Related Cognitive Impairment
Jönsson, L., Lindgren, P., Wimo, A. B., Jönsson, B., & Winblad, B. G. (1999) · PharmacoEconomics · doi:10.2165/00019053-199916040-00008 · Cited by 70 · see citing works
Are intensive care factors associated with depressive symptoms 6 months after acute lung injury?*
Dowdy, D. W., Bienvenu, O. J., Dinglas, V. D., Méndez-Téllez, P. A., Sevransky, J., Shanholtz, C. B., & Needham, D. M. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819fea55 · Cited by 57 · see citing works
Formation and validation of a telephone battery to assess cognitive function in acute respiratory distress syndrome survivors
Christie, J. D., Biester, R. C., Taichman, D. B., Shull, W. H., Hansen-Flaschen, J. H., Shea, J. A., & Hopkins, R. O. (2006) · Journal of Critical Care · doi:10.1016/j.jcrc.2005.11.004 · Cited by 55 · see citing works
Self-citation
Relationships among Anxiety, Defensiveness, Sex, Task Difficulty, and Performance on Various Neuropsychological Tasks
Buckelew, S. P., & Hannay, H. J. (1986) · Perceptual and Motor Skills · doi:10.2466/pms.1986.63.2.711 · Cited by 47 · see citing works
The Effect of Pulmonary Artery Catheter Use on Costs and Long-Term Outcomes of Acute Lung Injury
Clermont, G., Kong, L., Weissfeld, L. A., Lave, J. R., Rubenfeld, G. D., Roberts, M. S., Connors, A. F., Bernard, G. R., Thompson, B., Wheeler, A. P., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022512 · Cited by 47 · see citing works
Self-citation
Validation of a brief telephone battery for neurocognitive assessment of patients with pulmonary arterial hypertension
Taichman, D. B., Christie, J. D., Biester, R. C., Mortensen, J., White, J., Kaplan, S. S., Hansen-Flaschen, J. H., Palevsky, H. I., Elliott, C. G., & Hopkins, R. O. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-39 · Cited by 24 · see citing works
Self-citation
Repeated attempts using different strategies are important for timely contact with study participants
Chen, K., Colantuoni, E., Siddiqi, F., Dinglas, V. D., Sepúlveda, K. A., Fan, E., Pronovost, P. J., & Needham, D. M. (2010) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.08.007 · Cited by 19 · see citing works
Air Embolism Associated with Pulmonary Artery Catheter Introducer Kit
POBLAR, D. D., HINKLE, J. C., Fay, M., & Condon, B. F. (1982) · Anesthesiology · doi:10.1097/00000542-198204000-00014 · Cited by 14 · see citing works
Impaired financial abilities in mild cognitive impairment: A direct assessment approach
Rozzini, L., Chilovi, B. V., Trabucchi, M., & Padovani, A. (2003) · Neurology · doi:10.1212/wnl.60.12.2021 · Cited by 14 · see citing works
Improving clinical trials of long-term outcomes
Rubenfeld, G. D. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181922bb7 · Cited by 12 · see citing works

Flagged first, then by citations

Research works printed but not linked: 5

[32]Mikkelsen ME, Lanken PN, Biester R, Gallop R, Bellamy S, Localio AR, Hopkins RO, Angus DC. Christie JD, for the ARDSNet. Conservative fluid strategy is associated with neurocognitive deficits in survivors of acute lung injury [abstract]. Am J Respir Crit Care Med 2008;177:A819 [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Am%20J%20Respir%20Crit%20Care%20Med&title=Christie%20JD,%20for%20the%20ARDSNet.%20Conservative%20fluid%20strategy%20is%20associated%20with%20neurocognitive%20deficits%20in%20survivors%20of%20acute%20lung%20injury%20[abstract]&author=ME%20Mikkelsen&author=PN%20Lanken&author=R%20Biester&author=R%20Gallop&author=S%20Bellamy&volume=177&publication_year=2008&pages=A819&)]
[41]Wechsler D. Wechsler Memory Scale. San Antonio: The Psychology Corporation; 1997 [[Google Scholar](https://scholar.google.com/scholar_lookup?Wechsler%20D.%20Wechsler%20Memory%20Scale.%20San%20Antonio:%20The%20Psychology%20Corporation;%201997)]
[42]Lezak MD. Neuropsychological assessment. New York: Oxford University Press; 1995 [[Google Scholar](https://scholar.google.com/scholar_lookup?Lezak%20MD.%20Neuropsychological%20assessment.%20New%20York:%20Oxford%20University%20Press;%201995)]
[44]Heaton RK, Grant I, Matthews CG. Comprehensive norms for an expanded Halstead-Reitan battery: demographic corrections, research findings and clinical applications. Odessa: Psychological Assessment Resources, Inc; 1991 [[Google Scholar](https://scholar.google.com/scholar_lookup?Heaton%20RK,%20Grant%20I,%20Matthews%20CG.%20Comprehensive%20norms%20for%20an%20expanded%20Halstead-Reitan%20battery:%20demographic%20corrections,%20research%20findings%20and%20clinical%20applications.%20Odessa:%20Psychological%20Assessment%20Resources,%20Inc;%201991)]
[45]Heaton RK. Comprehensive norms for an expanded Halstead-Reitan battery: a supplement for the WAIS-R. Odessa: Psychological Assessment Resources, Inc; 1994 [[Google Scholar](https://scholar.google.com/scholar_lookup?Heaton%20RK.%20Comprehensive%20norms%20for%20an%20expanded%20Halstead-Reitan%20battery:%20a%20supplement%20for%20the%20WAIS-R.%20Odessa:%20Psychological%20Assessment%20Resources,%20Inc;%201994)]

Sorted by citations

Acute respiratory distress syndrome
Matthay, M. A., Zemans, R. L., Zimmerman, G. A., Arabi, Y. M., Beitler, J. R., Mercat, A., Herridge, M. S., Randolph, A. G., & Calfee, C. S. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0069-0 · Cited by 2,420 · see citing works
Acute respiratory distress syndrome
Meyer, N. J., Gattinoni, L., & Calfee, C. S. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00439-6 · Cited by 1,186 · see citing works
Enhancing Recovery From Sepsis: A Review
Prescott, H. C., & Angus, D. C. (2018) · JAMA · doi:10.1001/jama.2017.17687 · Cited by 1,059 · see citing works
Self-citation
Mechanisms and treatment of organ failure in sepsis
Lelubre, C., & Vincent, J. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0005-7 · Cited by 860 · see citing works
Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis
Premraj, L., Kannapadi, N. V., Briggs, J., Seal, S. M., Battaglini, D., Fanning, J. P., Suen, J. Y., Robba, C., Fraser, J. F., & Cho, S. (2022) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120162 · Cited by 778 · see citing works
Post-intensive care syndrome: An overview
Rawal, G., Yadav, S., & Kumar, R. (2017) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2016-0016 · Cited by 612 · see citing works
An Official American Thoracic Society Clinical Practice Guideline: The Diagnosis of Intensive Care Unit–acquired Weakness in Adults
Fan, E., Cheek, F. M., Chlan, L. L., Gosselink, R., Hart, N., Herridge, M. S., Hopkins, R. O., Hough, C. L., Kress, J. P., Latronico, N., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201411-2011st · Cited by 563 · see citing works
Self-citation
Guidelines on the management of acute respiratory distress syndrome
Griffiths, M., McAuley, D. F., Perkins, G. D., Barrett, N. A., Blackwood, B., Boyle, A. J., Chee, N., Connolly, B. A., Dark, P. M., Finney, S. J., et al. (2019) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2019-000420 · Cited by 506 · see citing works
Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysis
Silversides, J. A., Major, E., Ferguson, A. J., Mann, E. E., McAuley, D. F., Marshall, J. C., Blackwood, B., & Fan, E. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4573-3 · Cited by 448 · see citing works
Exploring the Scope of Post–Intensive Care Syndrome Therapy and Care: Engagement of Non–Critical Care Providers and Survivors in a Second Stakeholders Meeting
Elliott, D., Davidson, J. E., Harvey, M. A., Bemis-Dougherty, A., Hopkins, R. O., Iwashyna, T. J., Wagner, J., Weinert, C., Wunsch, H., Bienvenu, O. J., et al. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000525 · Cited by 425 · see citing works
Self-citation
Long-term complications of COVID-19
Desai, A. D., Lavelle, M. P., Boursiquot, B. C., & Wan, E. Y. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00375.2021 · Cited by 427 · see citing works
Acute respiratory distress syndrome
Sweeney, R. M., & McAuley, D. F. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00578-x · Cited by 402 · see citing works
Association Between Fluid Balance and Outcomes in Critically Ill Children
Alobaidi, R., Morgan, C., Basu, R. K., Stenson, E. K., Featherstone, R. M., Majumdar, S. R., & Bagshaw, S. M. (2018) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2017.4540 · Cited by 387 · see citing works
Understanding brain dysfunction in sepsis
Sonneville, R., Verdonk, F., Rauturier, C., Klein, I. F., Wolff, M., Annane, D., Chrétien, F. C., & Sharshar, T. (2013) · Annals of Intensive Care · doi:10.1186/2110-5820-3-15 · Cited by 353 · see citing works
A Randomized Trial of an Intensive Physical Therapy Program for Patients with Acute Respiratory Failure
Moss, M., Nordon‐Craft, A., Malone, D., Pelt, D. V., Frankel, S. K., Warner, M. L., Kriekels, W., McNulty, M. C., Fairclough, D. L., & Schenkman, M. L. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201505-1039oc · Cited by 349 · see citing works
Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA)
Malbrain, M. L. N. G., Länger, T., Annane, D., Gattinoni, L., Elbers, P., Hahn, R. G., laet, I. D., Minini, A., Wong, A. V.-K., İnce, C., et al. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-00679-3 · Cited by 337 · see citing works
Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms
Sasannejad, C., Ely, E. W., & Lahiri, S. (2019) · Critical Care · doi:10.1186/s13054-019-2626-z · Cited by 326 · see citing works
Risk factors for post–intensive care syndrome: A systematic review and meta-analysis
Lee, M., Kang, J., & Jeong, Y. J. (2019) · Australian Critical Care · doi:10.1016/j.aucc.2019.10.004 · Cited by 312 · see citing works
Cognitive decline after sepsis.
Annane, D., & Sharshar, T. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70246-2 · Cited by 290 · see citing works
Conservative versus Liberal Oxygenation Targets for Mechanically Ventilated Patients. A Pilot Multicenter Randomized Controlled Trial
Panwar, R., Hardie, M., Bellomo, R., Barrot, L., Eastwood, G. M., Young, P. J., Capellier, G., Harrigan, P. W. J., & Bailey, M. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201505-1019oc · Cited by 287 · see citing works
Physical and Cognitive Performance of Patients with Acute Lung Injury 1 Year after Initial Trophic versus Full Enteral Feeding. EDEN Trial Follow-up
Needham, D. M., Dinglas, V. D., Morris, P. E., Jackson, J. C., Hough, C. L., Méndez-Téllez, P. A., Wozniak, A. W., Colantuoni, E., Ely, E. W., Rice, T. W., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201304-0651oc · Cited by 282 · see citing works
Self-citation
One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial
Needham, D. M., Dinglas, V. D., Bienvenu, O. J., Colantuoni, E., Wozniak, A. W., Rice, T. W., Hopkins, R. O., & for the NIH NHLBI ARDS Network (2013) · BMJ · doi:10.1136/bmj.f1532 · Cited by 278 · see citing works
Self-citation
COVID-19 cognitive deficits after respiratory assistance in the subacute phase: A COVID-rehabilitation unit experience
Alemanno, F., Houdayer, E., Parma, A., Spina, A., Forno, A. D., Scatolini, A., Angelone, S. M., Brugliera, L., Tettamanti, A., Beretta, L., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246590 · Cited by 285 · see citing works
Post-acute COVID-19 syndrome
Montani, D., Savale, L., Noël, N., Meyrignac, O., Colle, R., Gasnier, M., Corruble, E., Beurnier, A., Jutant, E., Pham, T. O., et al. (2022) · European Respiratory Review · doi:10.1183/16000617.0185-2021 · Cited by 266 · see citing works
Prevention and Management of Delirium in the Intensive Care Unit
Mart, M. F., Roberson, S. W., Salas, B., Pandharipande, P. P., & Ely, E. W. (2020) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0040-1710572 · Cited by 262 · see citing works
Short‐term neuropsychiatric outcomes and quality of life in COVID‐19 survivors
Méndez, R., Balanzá‐Martínez, V., Luperdi, S. C., Estrada, I., Latorre, A., González‐Jiménez, P., Feced, L., Bouzas, L., Yépez, K., Ferrando, A. D. G., et al. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13262 · Cited by 247 · see citing works
The cognitive consequences of the COVID-19 epidemic: collateral damage?
Ritchie, K., Chan, D., & Watermeyer, T. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa069 · Cited by 226 · see citing works
Approaches to Addressing Post–Intensive Care Syndrome among Intensive Care Unit Survivors. A Narrative Review
Brown, S. M., Bose, S., Banner‐Goodspeed, V., Beesley, S. J., Dinglas, V. D., Hopkins, R. O., Jackson, J. C., Mir-Kasimov, M., Needham, D. M., & Sevin, C. M. (2019) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201812-913fr · Cited by 225 · see citing works
Self-citation
The standard of care of patients with ARDS: ventilatory settings and rescue therapies for refractory hypoxemia
Bein, T., Grasso, S., Moerer, O., Quintel, M., Guérin, C., Deja, M., Brondani, A., & Mehta, S. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4325-4 · Cited by 219 · see citing works
Mortality and quality of life in the five years after severe sepsis
Cuthbertson, B. H., Elders, A., Hall, S., Taylor, J., MacLennan, G., MacKirdy, F. N., MacKenzie, S. J., & the Scottish Critical Care Trials Group and the Scottish Intensive Care Society Audit Group (2013) · Critical Care · doi:10.1186/cc12616 · Cited by 215 · see citing works
Bidirectional Relationship between Cognitive Function and Pneumonia
Shah, F. A., Pike, F., Alvarez, K., Angus, D. C., Newman, A. B., López, O. L., Tate, J. A., Kapur, V. K., Wilsdon, A., Krishnan, J. A., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201212-2154oc · Cited by 215 · see citing works
Self-citation
The Epidemiology of Acute Respiratory Distress Syndrome in Patients Presenting to the Emergency Department With Severe Sepsis
Mikkelsen, M. E., Shah, C. V., Meyer, N. J., Gaieski, D. F., Lyon, S. M., Miltiades, A., Goyal, M. K., Fuchs, B. D., Bellamy, S. L., & Christie, J. D. (2013) · Shock · doi:10.1097/shk.0b013e3182a64682 · Cited by 215 · see citing works
Self-citation
Advancing precision medicine for acute respiratory distress syndrome
Beitler, J. R., Thompson, B., Baron, R. M., Bastarache, J. A., Denlinger, L. C., Esserman, L. J., Gong, M. N., LaVange, L. M., Lewis, R. J., Marshall, J. C., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00157-0 · Cited by 213 · see citing works
Self-citation
Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial
Patel, B. K., Wolfe, K. S., Patel, S. B., Dugan, K. C., Esbrook, C. L., Pawlik, A. J., Stulberg, M., Kemple, C., Teele, M., Zeleny, E., et al. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(22)00489-1 · Cited by 228 · see citing works
Current incidence and outcome of the acute respiratory distress syndrome
Villar, J., Blanco, J., & Kacmarek, R. M. (2015) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000266 · Cited by 207 · see citing works
Extracorporeal life support for adults with acute respiratory distress syndrome
Combes, A., Schmidt, M., Hodgson, C. L., Fan, E., Ferguson, N. D., Fraser, J. F., Jaber, S., Pesenti, A. M., Ranieri, V. M., Rowan, K., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06290-1 · Cited by 205 · see citing works
Long-Lasting Cognitive Abnormalities after COVID-19
Ferrucci, R., Dini, M., Groppo, E., Rosci, C. E., Reitano, M. R., Bai, F., Poletti, B., Brugnera, A., Silani, V., Monforte, A. D., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11020235 · Cited by 203 · see citing works
Comprehensive care of ICU survivors: Development and implementation of an ICU recovery center
Sevin, C. M., Bloom, S. L., Jackson, J. C., Wang, L., Ely, E. W., & Stollings, J. L. (2018) · Journal of Critical Care · doi:10.1016/j.jcrc.2018.02.011 · Cited by 204 · see citing works
A systematic review of neuropsychological and psychiatric sequalae of COVID-19: implications for treatment
Vanderlind, W. M., Rabinovitz, B. B., Miao, I. Y., Oberlin, L. E., Castellano, C. B., Fridman, C. B., Jaywant, A., & Kanellopoulos, D. (2021) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000713 · Cited by 197 · see citing works
Cognitive impairment after intensive care unit admission: a systematic review
Wolters, A. E., Slooter, A. J. C., van der Kooi, A. W., & van Dijk, D. (2013) · Intensive Care Medicine · doi:10.1007/s00134-012-2784-9 · Cited by 195 · see citing works
Post-traumatic stress disorder: A differential diagnostic consideration for COVID-19 survivors
Kaseda, E. T., & Levine, A. J. (2020) · The Clinical Neuropsychologist · doi:10.1080/13854046.2020.1811894 · Cited by 175 · see citing works
Resilience in Survivors of Critical Illness in the Context of the Survivors’ Experience and Recovery
Maley, J. H., Brewster, I., Mayoral, I., Siruckova, R., Adams, S., McGraw, K. A., Piech, A., Detsky, M. E., & Mikkelsen, M. E. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201511-782oc · Cited by 166 · see citing works
Self-citation
Postintensive Care Syndrome in Survivors of Critical Illness Related to Coronavirus Disease 2019: Cohort Study From a New York City Critical Care Recovery Clinic*
Martillo, M. A., Dangayach, N. S., TABACOF, L. R., Spielman, L. A., Dams-O’Connor, K., Chan, C. C., Kohli-Seth, R. D., Cortes, M., & Escalon, M. X. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005014 · Cited by 163 · see citing works
Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia
Hodgson, C. L., Hayes, K., Everard, T., Nichol, A., Davies, A. R., Bailey, M., Tuxen, D. V., Cooper, D. J., & Pellegrino, V. (2012) · Critical Care · doi:10.1186/cc11811 · Cited by 160 · see citing works
Psychiatric Symptoms in Acute Respiratory Distress Syndrome Survivors: A 1-Year National Multicenter Study
Huang, M., Parker, A. M., Bienvenu, O. J., Dinglas, V. D., Colantuoni, E., Hopkins, R. O., & Needham, D. M. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001621 · Cited by 157 · see citing works
Self-citation
Both Positive and Negative Fluid Balance May Be Associated With Reduced Long-Term Survival in the Critically Ill
Balakumar, V., Murugan, R., Sileanu, F. E., Palevsky, P. M., Clermont, G., & Kellum, J. A. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002372 · Cited by 154 · see citing works
Mechanical Ventilation for Acute Respiratory Distress Syndrome during Extracorporeal Life Support. Research and Practice
Abrams, D. C., Schmidt, M., Pham, T. O., Beitler, J. R., Fan, E., Goligher, E. C., McNamee, J. J., Patroniti, N. A., Wilcox, M. E., Combes, A., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201907-1283ci · Cited by 151 · see citing works
F ifty Y ears of R esearch in ARDS. Gas Exchange in Acute Respiratory Distress Syndrome
Radermacher, P., Maggiore, S. M., & Mercat, A. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201610-2156so · Cited by 151 · see citing works
Natural History of Cognitive Impairment in Critical Illness Survivors. A Systematic Review
Honarmand, K., Lalli, R. S., Priestap, F. A., Chen, J., McIntyre, C. W., Owen, A. M., & Slessarev, M. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201904-0816ci · Cited by 150 · see citing works
Mechanical Ventilation in ARDS
Jia, S., & Hyzy, R. C. (2022) · Springer eBooks · doi:10.1007/978-3-031-14138-6_20 · Cited by 148 · see citing works
Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms
Wang, X., Cui, L., & Ji, X. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00796-3 · Cited by 145 · see citing works
Psychiatric Diagnoses and Psychoactive Medication Use Among Nonsurgical Critically Ill Patients Receiving Mechanical Ventilation
Wunsch, H., Christiansen, C. F., Johansen, M. B., Olsen, M., Ali, N., Angus, D. C., & Sørensen, H. T. (2014) · JAMA · doi:10.1001/jama.2014.2137 · Cited by 143 · see citing works
Self-citation
Patient-important outcomes in randomized controlled trials in critically ill patients: a systematic review
Gaudry, S., Messika, J., Ricard, J.-D., Guillo, S., Pasquet, B., Dubief, E., Boukertouta, T., Dreyfuss, D., & Tubach, F. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0243-z · Cited by 140 · see citing works
Fluid Overload
O’Connor, M. E., & Prowle, J. R. (2015) · Critical Care Clinics · doi:10.1016/j.ccc.2015.06.013 · Cited by 140 · see citing works
COVID-19 and Alzheimer’s disease: how one crisis worsens the other
Xia, X., Wang, Y., & Zheng, J. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00237-2 · Cited by 136 · see citing works
Impact of Acute Lung Injury and Acute Respiratory Distress Syndrome After Traumatic Brain Injury in the United States
Rincón, F., Ghosh, S., Dey, S., Maltenfort, M., Vibbert, M. D., Urtecho, J. S., McBride, W. C., Moussouttas, M., BELL, R. D., Ratliff, J. K., et al. (2012) · Neurosurgery · doi:10.1227/neu.0b013e3182672ae5 · Cited by 136 · see citing works
Long-term consequences of COVID-19 on cognitive functioning up to 6 months after discharge: role of depression and impact on quality of life
Poletti, S., Palladini, M., Mazza, M. G., LORENZO, R. D., Bollettini, I., Sara, B., Bravi, B., Ceciclio, B., Stefania, C., Valentina, C., et al. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01346-9 · Cited by 136 · see citing works
Volume Overload: Prevalence, Risk Factors, and Functional Outcome in Survivors of Septic Shock
Mitchell, K. H., Carlbom, D., Caldwell, E., Leary, P. J., Himmelfarb, J., & Hough, C. L. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201504-187oc · Cited by 133 · see citing works
COVID-19 pandemic. What should Physical and Rehabilitation Medicine specialists do? A clinician's perspective
Carda, S., Invernizzi, M., Bavikatte, G., Bensmaïl, D., Bianchi, F., Deltombe, T., Draulans, N., Esquenazi, A., Francisco, G. E., Gross, R., et al. (2020) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.20.06317-0 · Cited by 130 · see citing works
Cooccurrence of and Remission From General Anxiety, Depression, and Posttraumatic Stress Disorder Symptoms After Acute Lung Injury: A 2-Year Longitudinal Study
Bienvenu, O. J., Colantuoni, E., Mendez-Tellez, P. A., Shanholtz, C., Dennison-Himmelfarb, C. R., Pronovost, P. J., & Needham, D. M. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000752 · Cited by 128 · see citing works
One‐year cognitive follow‐up of COVID‐19 hospitalized patients
Ferrucci, R., Dini, M., Rosci, C. E., Capozza, A., Groppo, E., Reitano, M. R., Allocco, E., Poletti, B., Brugnera, A., Bai, F., et al. (2022) · European Journal of Neurology · doi:10.1111/ene.15324 · Cited by 129 · see citing works
Long-term survival benefit from treatment at a specialty center after cardiac arrest
Elmer, J., Rittenberger, J. C., Coppler, P. J., Guyette, F. X., Doshi, A. A., & Callaway, C. W. (2016) · Resuscitation · doi:10.1016/j.resuscitation.2016.09.008 · Cited by 124 · see citing works
Fluid management in acute kidney injury
Perner, A., Prowle, J. R., Joannidis, M., Young, P. J., Hjortrup, P. B., & Pettilä, V. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4817-x · Cited by 117 · see citing works
Potentially Modifiable Risk Factors for Long-Term Cognitive Impairment After Critical Illness: A Systematic Review
Sakusic, A., O’Horo, J. C., Dziadzko, M. A., Dziadzko, V., Ali, R., Singh, T. D., Kashyap, R., Farrell, A. M., Fryer, J. D., Petersen, R. C., et al. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.11.005 · Cited by 111 · see citing works
Management of severe acute respiratory distress syndrome: a primer
Grotberg, J. C., Reynolds, D., & Kraft, B. D. (2023) · Critical Care · doi:10.1186/s13054-023-04572-w · Cited by 112 · see citing works
Cumulative fluid balance predicts mortality and increases time on mechanical ventilation in ARDS patients: An observational cohort study
van Mourik, N., Metske, H. A., Hofstra, J. J., Binnekade, J. M., Geerts, B. F., Schultz, M. J., & Vlaar, A. P. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224563 · Cited by 108 · see citing works
Long-Term Outcome after Prolonged Mechanical Ventilation: A Long-Term Acute-Care Hospital Study
Jubran, A., Grant, B. J. B., Duffner, L. A., Collins, E. G., Lanuza, D. M., Hoffman, L. A., & Tobin, M. J. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201806-1131oc · Cited by 108 · see citing works
Lower vs Higher Fluid Volumes During Initial Management of Sepsis
Meyhoff, T. S., Møller, M. H., Hjortrup, P. B., Cronhjort, M., Perner, A., & Wetterslev, J. (2020) · CHEST Journal · doi:10.1016/j.chest.2019.11.050 · Cited by 107 · see citing works
Respiratory support in patients with acute respiratory distress syndrome: an expert opinion
Chiumello, D., Brochard, L. J., Marini, J. J., Slutsky, A. S., Mancebo, J., Ranieri, V. M., Thompson, B., Papazian, L., Schultz, M. J., Amato, M. B. P., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1820-0 · Cited by 103 · see citing works
Self-citation
Favorable Neurocognitive Outcome with Low Tidal Volume Ventilation after Cardiac Arrest
Beitler, J. R., Ghafouri, T. B., Jinadasa, S. P., Mueller, A., Hsu, L., Anderson, R. J., Joshua, J., Tyagi, S. K., Malhotra, A., Sell, R., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201609-1771oc · Cited by 102 · see citing works
Review: Post-Intensive Care Syndrome: Unique Challenges in the Neurointensive Care Unit
LaBuzetta, J. N., Rosand, J. M., & Vranceanu, A. (2019) · Neurocritical Care · doi:10.1007/s12028-019-00826-0 · Cited by 103 · see citing works
Peer support as a novel strategy to mitigate post-intensive care syndrome.
Mikkelsen, M. E., Jackson, J. C., Hopkins, R. O., Thompson, C., Andrews, A., Netzer, G., Bates, D. M., Bunnell, A. E., Christie, L. M., Greenberg, S. B., et al. (2016) · AACN Advanced Critical Care · doi:10.4037/aacnacc2016667 · Cited by 101 · see citing works
Self-citation
Sepsis-Associated Brain Dysfunction: A Review of Current Literature
Czempik, P. F., Pluta, M. P., & Krzych, Ł. J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17165852 · Cited by 99 · see citing works
The clinical practice guideline for the management of ARDS in Japan
Hashimoto, S., Sanui, M., Egi, M., Ohshimo, S., Shiotsuka, J., Seo, R., Tanaka, R., Tanaka, Y., Norisue, Y., Hayashi, Y., et al. (2017) · Journal of Intensive Care · doi:10.1186/s40560-017-0222-3 · Cited by 100 · see citing works
Cognitive impairment in people with previous COVID-19 infection: A scoping review
Bertuccelli, M., Ciringione, L., Rubega, M., Bisiacchi, P. S., Masiero, S., & Felice, A. D. (2022) · Cortex · doi:10.1016/j.cortex.2022.06.002 · Cited by 99 · see citing works
Cognitive decline following acute viral infections: literature review and projections for post-COVID-19
Damiano, R. F., Guedes, B. F., de Rocca, C. C., de Pádua Serafim, A., Castro, L. H. M., Munhoz, C. D., Nitrini, R., Filho, G. B., Miguel, E. C., Lucchetti, G., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01286-4 · Cited by 98 · see citing works
Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome
Toner, P. G., McAuley, D. F., & Shyamsundar, M. (2015) · Critical Care · doi:10.1186/s13054-015-1091-6 · Cited by 97 · see citing works
The Association between Acute Respiratory Distress Syndrome, Delirium, and In-Hospital Mortality in Intensive Care Unit Patients
Hsieh, S.-J. J., Soto, G. J., Hope, A. A., Ponea, A. M., & Gong, M. N. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201409-1690oc · Cited by 96 · see citing works
Oxygen Thresholds and Mortality During Extracorporeal Life Support in Adult Patients*
Munshi, L., Kiss, A., Cypel, M., Keshavjee, S. H., Ferguson, N. D., & Fan, E. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002643 · Cited by 92 · see citing works
Potential Strategies to Prevent Ventilator-associated Events
Klompas, M. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201506-1161ci · Cited by 97 · see citing works
Post Intensive Care Syndrome (PICS): an overview of the definition, etiology, risk factors, and possible counseling and treatment strategies
Ramnarain, D., Aupers, E., Oudsten, B. L. D., Oldenbeuving, A. W., Vries, J. D., & Pouwels, S. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1981289 · Cited by 96 · see citing works
Improving Post–Intensive Care Unit Neuropsychiatric Outcomes: Understanding Cognitive Effects of Physical Activity
Hopkins, R. O., Suchyta, M. R., Farrer, T. J., & Needham, D. M. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201206-1022cp · Cited by 94 · see citing works
Self-citation
A Systematic Review of Risk Factors Associated With Cognitive Impairment After Pediatric Critical Illness*
Kachmar, A. G., Irving, S. Y., Connolly, C., & Curley, M. A. Q. (2018) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000001430 · Cited by 92 · see citing works
Survival ≠ Recovery
Schwitzer, E., Schwab, K. E., Brinkman, L., DeFrancia, L., VanVleet, J., Baqi, E., Aysola, R., & Qadir, N. (2023) · CHEST Critical Care · doi:10.1016/j.chstcc.2023.100003 · Cited by 98 · see citing works
ARDS Clinical Practice Guideline 2021
Tasaka, S., Ohshimo, S., Takeuchi, M., Yasuda, H., Ichikado, K., Tsushima, K., Egi, M., Hashimoto, S., Shime, N., Saitô, O., et al. (2022) · Journal of Intensive Care · doi:10.1186/s40560-022-00615-6 · Cited by 89 · see citing works
Post-Intensive Care Syndrome and Its New Challenges in Coronavirus Disease 2019 (COVID-19) Pandemic: A Review of Recent Advances and Perspectives
Nakanishi, N., Liu, K., Kawakami, D., Kawai, Y., Morisawa, T., Nishida, T., Sumita, H., Unoki, T., Hifumi, T., Iida, Y., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173870 · Cited by 92 · see citing works
The spectrum of psychocognitive morbidity in the critically ill: A review of the literature and call for improvement
Karnatovskaia, L. V., Johnson, M. M., Benzo, R. P., & Gajic, O. (2014) · Journal of Critical Care · doi:10.1016/j.jcrc.2014.09.024 · Cited by 90 · see citing works
Randomized Clinical Trial of an ICU Recovery Pilot Program for Survivors of Critical Illness*
Bloom, S. L., Stollings, J. L., Kirkpatrick, O., Wang, L., Byrne, D. W., Sevin, C. M., & Semler, M. W. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003909 · Cited by 88 · see citing works
Post-Intensive Care Syndrome in Survivors from Critical Illness including COVID-19 Patients: A Narrative Review
Vrettou, C. S., Mantziou, V., Vassiliou, A. G., Orfanos, S. E., Kotanidou, Α., & Dimopoulou, I. (2022) · Life · doi:10.3390/life12010107 · Cited by 89 · see citing works
Impact of mechanical ventilation on the pathophysiology of progressive acute lung injury
Nieman, G. F., Gatto, L. A., & Habashi, N. M. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00659.2015 · Cited by 88 · see citing works
Dementia and COVID-19, a Bidirectional Liaison: Risk Factors, Biomarkers, and Optimal Health Care
Toniolo, S., the Management Group of the EAN Dementia and Cognitive Disorders Scientific Panel, Scarioni, M., Lorenzo, F. D., Hort, J., Georges, J., Tomić, S., Nobili, F. M., & Frederiksen, K. S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210335 · Cited by 85 · see citing works
The long-lasting effects of the acute respiratory distress syndrome
Mart, M. F., & Ware, L. B. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1743182 · Cited by 83 · see citing works
Delirium and long term cognition in critically ill patients
Wilcox, M. E., Girard, T. D., & Hough, C. L. (2021) · BMJ · doi:10.1136/bmj.n1007 · Cited by 86 · see citing works
In-Hospital Acute Stress Symptoms Are Associated with Impairment in Cognition 1 Year after Intensive Care Unit Admission
Davydow, D. S., Zatzick, D., Hough, C. L., & Katon, W. J. (2013) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201303-060oc · Cited by 82 · see citing works
Oxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomes in Acute Respiratory Distress Syndrome*
Aggarwal, N. R., Brower, R. G., Hager, D. N., Thompson, B., Netzer, G., Shanholtz, C. B., Lagakos, A., & Checkley, W. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002886 · Cited by 82 · see citing works
Self-citation
Hypercapnia induces IL-1β overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats
Ding, H., Deng, Y., Yang, R., Wang, Q.-S., Jiang, W., Han, Y., Huang, L., Wen, M., Zhong, W., Li, X., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1051-y · Cited by 81 · see citing works
Oxygen Toxicity in Critically Ill Adults
Hochberg, C. H., Semler, M. W., & Brower, R. G. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202102-0417ci · Cited by 82 · see citing works
Quality of life in ICU survivors and their relatives with post‐intensive care syndrome: A systematic review
Gravante, F., Trotta, F., Latina, S., Simeone, S., Alvaro, R., Vellone, E., & Pucciarelli, G. (2024) · Nursing in Critical Care · doi:10.1111/nicc.13077 · Cited by 79 · see citing works
Personalized medicine for ARDS: the 2035 research agenda
Beitler, J. R., Goligher, E. C., Schmidt, M., Spieth, P. M., Zanella, A., Martín‐Loeches, I., Calfee, C. S., Cavalcanti, A. B., & The ARDSne(x)t Investigators (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4331-6 · Cited by 77 · see citing works
Cognitive Function, Mental Health, and Health-related Quality of Life after Lung Transplantation
Cohen, D. G., Christie, J. D., Anderson, B. J., Diamond, J. M., Judy, R. P., Shah, R., Cantu, E., Bellamy, S. L., Blumenthal, N. P., Demissie, E., et al. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201311-388oc · Cited by 75 · see citing works
Self-citation

psychological function in survivors of acute lung
Carlson, C. G., Huang, D. T., Me, M., Jd, C., Pn, L., & Rc, B. (2013)
Long-term neuropsychological impairment is common in acute lung injury survivors
(2012) · British Journal of Hospital Medicine · doi:10.12968/hmed.2012.73.5.249a
Long-term outcome after acute lung injury
Hough, C. L., & Herridge, M. S. (2011) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e32834f186d · Cited by 49 · see citing works
Embracing Physical and Neuropsychological Dysfunction in Acute Lung Injury Survivors: The Time Has Come
Azoulay, É., & Moss, M. M. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201201-0013ed · Cited by 1 · see citing works
Neuromuscular and Neuropsychological Assessments in Survivors of Acute Respiratory Distress Syndrome: Exploratory Comparisons with an At-Risk Cohort
Ofoma, U. R., Reriani, M., Biehl, M., Kashyap, R., Ahmed, A., Rabinstein, A. A., & Gajic, O. (2014) · Neurocritical Care · doi:10.1007/s12028-014-0087-4

Authors: Mikkelsen, M. E., Christie, J. D., Lanken, P. N., Biester, R. C., Thompson, B. T., Bellamy, S. L., Localio, A. R., Demissie, E., Hopkins, R. O., & Angus, D. C.
Affiliations: University of Pennsylvania (US)
Pulmonary, Allergy, and Critical Care Division, Department of Medicine
Philadelphia VA Medical Center (US)
Massachusetts General Hospital (US)
Center for Clinical Epidemiology and Biostatistics, and
Intermountain Medical Center (US)
Brigham Young University (US)
Corresponding author: Mikkelsen, Mark E.
ORCID: Mikkelsen, Mark E.
Christie, Jason D.
Lanken, Paul N.
Thompson, B. Taylor
Bellamy, Scarlett L.
Localio, A. Russell
Angus, Derek C.
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2012-06
Volume: 185
Issue: 12
Pages: 1307-1315
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.201111-2025oc
PMC: PMC3381234
OpenAlex: W2101436344
Cited by: 615
References: 68
Citations by year: 2026: 21 · 2025: 42 · 2024: 41 · 2023: 43 · 2022: 55 · 2021: 81 · 2020: 59 · 2019: 43 · 2018: 40 · 2017: 40 · 2016: 44 · 2015: 32 · 2014: 35 · 2013: 28 · 2012: 11
FWCI: 28.32
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Thoracic Society
University of Pittsburgh
National Institutes of Health (n01hr016146-000, n01hr046058-006)
National Heart, Lung, and Blood Institute (T32HL07891, N01-HR46046-64, N01-HR-16146-54, N01 HR016146, N01 HR046058, N01 HR46058, T32HL007891)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Keywords: acute lung injury, neuropsychological deficits, cognitive impairment, executive function, memory, verbal fluency, depression, post-traumatic stress disorder, anxiety, fluid management, conservative fluid management, hypoxemia, risk factors, ARDS survivors
MeSH terms: Adult, Anxiety Disorders, Cognition Disorders, Depression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Respiratory Distress Syndrome, Stress Disorders, Post-Traumatic, Time Factors, Incidence, Multivariate Analysis, Logistic Models, Critical Illness, Survivors, Risk Assessment, Acute Lung Injury

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Adult Respiratory Distress Syndrome Cognitive Outcomes Study: Long-Term Neuropsychological Function in Survivors of Acute Lung Injury

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks