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Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States.
Open accessAbstract
OBJECTIVES: The contribution of bacterial coinfection to critical illness associated with 2009 influenza A virus infection remains uncertain. The objective of this study was to determine whether bacterial coinfection increased the morbidity and mortality of 2009 influenza A. DESIGN: Retrospective and prospective cohort study. SETTING: Thirty-five adult U.S. intensive care units over the course of 1 yr. PATIENTS: Six hundred eighty-three critically ill adults with confirmed or probable 2009 influenza A. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A confirmed or probable case was defined as a positive 2009 influenza A test result or positive test for influenza A that was otherwise not subtyped. Bacterial coinfection was defined as documented bacteremia or any presumed bacterial pneumonia with or without positive respiratory tract culture within 72 hrs of intensive care unit admission. The mean age was 45±16 yrs, mean body mass index was 32.5±11.1 kg/m, and mean Acute Physiology and Chronic Health Examination II score was 21±9, with 76% having at least one comorbidity. Of 207 (30.3%) patients with bacterial coinfection on intensive care unit admission, 154 had positive cultures with Staphylococcus aureus (n=57) and Streptococcus pneumoniae (n=19), the most commonly identified pathogens. Bacterial coinfected patients were more likely to present with shock (21% vs. 10%; p=.0001), require mechanical ventilation at the time of intensive care unit admission (63% vs. 52%; p=.005), and have longer duration of intensive care unit care (median, 7 vs. 6 days; p=.05). Hospital mortality was 23%; 31% in bacterial coinfected patients and 21% in patients without coinfection (p=.002). Immunosuppression (relative risk 1.57; 95% confidence interval 1.20 -2.06; p=.0009) and Staphylococcus aureus at admission (relative risk 2.82; 95% confidence interval 1.76-4.51; p<.0001) were independently associated with increased mortality. CONCLUSIONS: Among intensive care unit patients with 2009 influenza A, bacterial coinfection diagnosed within 72 hrs of admission, especially with Staphylococcus aureus, was associated with significantly higher morbidity and mortality.
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“Immunosuppression is associated with more severe morbidity and a much higher risk of mortality from co/secondary bacterial infection (Rice et al., 2012).”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Rice et al., 2012
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Harris, P. A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., & Conde, J. G. (2009) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2008.08.010 · Cited by 51,384
A Modified Poisson Regression Approach to Prospective Studies with Binary Data
Zou, G. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh090 · Cited by 9,920
Liu, C., Bayer, A. S., Cosgrove, S. E., Daum, R. S., Fridkin, S. K., Gorwitz, R. J., Kaplan, S. L., Karchmer, A. W., Levine, D. P., Murray, B. E., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq146 · Cited by 4,260
Incidence and Outcomes of Acute Lung Injury
Rubenfeld, G. D., Caldwell, E., Peabody, E., Weaver, J., Martin, D. P., Neff, M., Stern, E. J., & Hudson, L. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050333 · Cited by 3,684
Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009
Jain, S., Kamimoto, L., Bramley, A. M., Schmitz, A. M., Benoit, S. R., Louie, J., Sugerman, D. E., Druckenmiller, J. K., Ritger, K. A., Chugh, R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0906695 · Cited by 1,700
Self-citationLiu, C., Bayer, A., Cosgrove, S. E., Daum, R. S., Fridkin, S. K., Gorwitz, R. J., Kaplan, S. L., Karchmer, A. W., Levine, D. P., Murray, B. E., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir034 · Cited by 1,599
Briel, M., Meade, M., Mercat, A., Brower, R. G., Talmor, D., Walter, S. D., Slutsky, A. S., Pullenayegum, E., Zhou, Q., Cook, D., et al. (2010) · JAMA · doi:10.1001/jama.2010.218 · Cited by 1,467
Critically Ill Patients With 2009 Influenza A(H1N1) Infection in Canada
Kumar, A. (2009) · JAMA · doi:10.1001/jama.2009.1496 · Cited by 1,425
Meade, M. O., Cook, D. J., Guyatt, G. H., Slutsky, A. S., Arabi, Y. M., Cooper, D. J., Davies, A. R., Hand, L. E., Zhou, Q., Thabane, L., et al. (2008) · JAMA · doi:10.1001/jama.299.6.637 · Cited by 1,370
Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico
Perez-Padilla, R., de la Rosa-Zamboni, D., Ponce de Leon, S., Hernandez, M., Quiñones-Falconi, F., Bautista, E., Ramirez-Venegas, A., Rojas-Serrano, J., Ormsby, C. E., Corrales, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904252 · Cited by 1,325
Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection
Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza (2010) · New England Journal of Medicine · doi:10.1056/nejmra1000449 · Cited by 1,056
Louie, J. K. (2009) · JAMA · doi:10.1001/jama.2009.1583 · Cited by 1,020
Critical Care Services and 2009 H1N1 Influenza in Australia and New Zealand
The ANZIC Influenza Investigators (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0908481 · Cited by 1,002
Critically Ill patients with 2009 influenza A(H1N1) in Mexico
Domínguez-Cherit, G. (2009) · JAMA · doi:10.1001/jama.2009.1536 · Cited by 840
Lung Pathology in Fatal Novel Human Influenza A (H1N1) Infection
Mauad, T., Hajjar, L. A., Callegari, G. D., da Silva, L. F. F., Schout, D., Galas, F. R. B. G., Alves, V. A. F., Malheiros, D. M. A. C., Auler, J. O. C., Ferreira, A. F., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200909-1420oc · Cited by 547
Causes and Timing of Death in Patients With ARDS
Stapleton, R. D., Wang, B. M., Hudson, L. D., Rubenfeld, G. D., Caldwell, E., & Steinberg, K. P. (2005) · CHEST Journal · doi:10.1378/chest.128.2.525 · Cited by 475
Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain
Rello, J., Rodríguez, A. H., Ibañez, P., Socías, L., Cebrián, J., Marques, A., Guerrero, J. E., Ruiz‐Santana, S., Márquez, E., Nogal-Saez, F. D., et al. (2009) · Critical Care · doi:10.1186/cc8044 · Cited by 441
2009 Pandemic Influenza A (H1N1)
Shieh, W.-J., Blau, D. M., Denison, A. M., DeLeon-Carnes, M., Adem, P., Bhatnagar, J., Sumner, J., Liu, L., Patel, M., Batten, B., et al. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100115 · Cited by 429
Self-citationDeaths from Bacterial Pneumonia during 1918–19 Influenza Pandemic
Brundage, J. F., & Shanks, G. D. (2008) · Emerging Infectious Diseases · doi:10.3201/eid1408.071313 · Cited by 384
Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans
Faix, D. J., Sherman, S. S., & Waterman, S. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmc0904264 · Cited by 300
Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
Zarychanski, R., Stuart, T. L., Kumar, A., Doucette, S. P., Elliott, L. J., Kettner, J., & Plummer, F. A. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.091884 · Cited by 270
Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
Monsalvo, A. C., Batalle, J. P., López, M. G., Krause, J. C., Klemenc, J. M., Hernandez, J. Z., Maskin, B. C., Bugna, J., Rubinstein, C. J., Aguilar, L., et al. (2010) · Nature Medicine · doi:10.1038/nm.2262 · Cited by 265
Pandemic 2009 Influenza A in Argentina: A Study of 337 Patients on Mechanical Ventilation
Estenssoro, E., Ríos, F. G., Apezteguía, C., Reina, R., Neira, J., Ceraso, D. H., Orlandi, C., Valentini, R., Tiribelli, N., Brizuela, M., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/201001-0037oc · Cited by 230
Martín-Loeches, I., Sanchez-Corral, A., Diaz, E., Granada, R. M., Zaragoza, R., Villavicencio, C., Albaya, A., Cerdá, E., Catalán, R. M., Luque, P., et al. (2011) · Chest · doi:10.1378/chest.10-1396 · Cited by 203
Risk Factors for Severe Illness with 2009 Pandemic Influenza A (H1N1) Virus Infection in China
Yu, H., Feng, Z., Uyeki, T. M., Liao, Q., Zhou, L., Feng, S., Ye, M., Xiang, N., Huai, Y., Yuan, Y., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq144 · Cited by 175
Self-citationMiller, R. R., Markewitz, B. A., Rolfs, R. T., Brown, S. M., Dascomb, K. K., Grissom, C. K., Friedrichs, M. D., Mayer, J., Hirshberg, E. L., Conklin, J., et al. (2009) · CHEST Journal · doi:10.1378/chest.09-2517 · Cited by 157
Self-citationFatalities Associated with the 2009 H1N1 Influenza A Virus in New York City
Lee, E. H., Wu, C., Lee, E. U., Stoute, A., Hanson, H., Cook, H. A., Nivin, B., Fine, A. D., Kerker, B. D., Harper, S. A., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/652446 · Cited by 126
Epidemiology of Sudden Death in Young, Competitive Athletes Due to Blunt Trauma
Thomas, M., Haas, T. S., Doerer, J. J., Hodges, J. S., Aicher, B. O., Garberich, R. F., Mueller, F. O., Cantu, R. C., & Maron, B. J. (2011) · Pediatrics · doi:10.1542/peds.2010-2743 · Cited by 84
Epidemiology of Sudden Death in Young, Competitive Athletes Due to Blunt Trauma
(2011) · PEDIATRICS · doi:10.1542/peds.2010-2743d · Cited by 72
Hanslik, T., Boëlle, P., & Flahault, A. (2010) · PLoS Currents · doi:10.1371/currents.rrn1150 · Cited by 68
Influenza A pandemics: Clinical and organizational aspects: The experience in Chile
Ugarte, S., Arancibia, F., & Soto, R. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181c87716 · Cited by 67
Update: influenza activity - United States, 2009-10 season.
(2010) · PubMed · Cited by 63
Adult intensive-care patients with 2009 pandemic influenza A(H1N1) infection
Fuhrman, C., Bonmarin, I., Bitar, D., Cardoso, T., Duport, N., Herida, M., Isnard, H., Guidet, B., Mimoz, O., Richard, J.-C., et al. (2010) · Epidemiology and Infection · doi:10.1017/s0950268810002414 · Cited by 55
Early observational research and registries during the 2009–2010 influenza A pandemic
Fowler, R., Webb, S. A. R., Rowan, K., Sprung, C. L., Thompson, B., Randolph, A. G., Jouvet, P. A., Lapinsky, S. E., Rubinson, L., Rello, J., et al. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181d20c77 · Cited by 41
Self-citationIwasenko, J. M., Cretikos, M. A., Paterson, D. L., Gibb, R., Webb, S. A. R., Smith, D. W., Blyth, C. C., Dwyer, D. E., Shi, J. Q., Robertson, P., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/653610 · Cited by 31
Novel findings from the second wave of adult pH1N1 in the United States*
Satterwhite, L. G., Mehta, A., & Martin, G. S. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181eb96dc · Cited by 15
Research works printed but not linked: 1
- Hanslik, 2010, PLoS Curr Influenza, 9, RRN1150
Cited by
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Langford, B. J., So, M., Raybardhan, S., Leung, V., Westwood, D. J., MacFadden, D. R., Soucy, J.-P. R., & Daneman, N. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.07.016 · Cited by 1,589
Alhazzani, W. A., Møller, M. H., Arabi, Y. M., Loeb, M. B., Gong, M. N., Fan, E., Oczkowski, S. J. W., Levy, M. M., Derde, L. P. G., Dzierba, A. L., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004363 · Cited by 1,578
Uyeki, T. M., Bernstein, H. H., Bradley, J. S., Englund, J. A., File, T. M., Fry, A. M., Gravenstein, S., Hayden, F. G., Harper, S. A., Hirshon, J. M., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy866 · Cited by 844
Self-citationThe co-pathogenesis of influenza viruses with bacteria in the lung.
McCullers, J. A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3231 · Cited by 722
Metadata
- Authors
- Rice, T. W., Rubinson, L., Uyeki, T. M., Vaughn, F. L., John, B. B., Miller, R. R., Higgs, E., Randolph, A. G., Smoot, B. E., & Thompson, B. T.
- Affiliations
- Vanderbilt University (US)
- Centers for Disease Control and Prevention (US)
- University of Utah (US)
- National Institutes of Health (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Venue
- Critical Care Medicine
- Published
- 2012-05
- Volume
- 40
- Issue
- 5
- Pages
- 1487-1498
- ISSN
- 0090-3493 (ISSN-L)
- PMC
- PMC3653183
- OpenAlex
- W1995615618
- Cited by
- 391
- References
- 37
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 30 · 2023: 30 · 2022: 51 · 2021: 60 · 2020: 48 · 2019: 20 · 2018: 21 · 2017: 20 · 2016: 17 · 2015: 13 · 2014: 15 · 2013: 24 · 2012: 7
- FWCI
- 14.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hr56174-20-0-1, n01hr56179-17-0-1)
- National Heart, Lung, and Blood Institute (N01 HR 56179, K23HL081431, N01 HR056179, N01 HR056174)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- bacterial co-infection, critical illness, ICU mortality, Staphylococcus aureus, Streptococcus pneumoniae, bacteremia, bacterial pneumonia, shock, mechanical ventilation, comorbidities, ICU length of stay, mortality risk factors, hospitalized adults
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Bacterial Infections, Female, Humans, Influenza, Human, Intensive Care Units, Male, Middle Aged, Prospective Studies, Retrospective Studies, United States, Chi-Square Distribution, Critical Illness, Statistics, Nonparametric, Influenza A Virus, H1N1 Subtype, Young Adult, Pandemics, Coinfection
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