The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
New Insights Into the Comorbidity Between ADHD and Major Depression in Adolescent and Young Adult Females
Abstract
Objective The main aim of this study was to evaluate the association between attention-deficit/hyperactivity disorder (ADHD) and major depression (MD) in adolescent and young adult females.Method Subjects were females with (n = 140) and without (n = 122) ADHD ascertained from pediatric and psychiatric settings. Subjects were followed prospectively for 5 years into adolescence and young adulthood and reassessed in multiple nonoverlapping domains including psychiatric, cognitive, interpersonal, family, and educational functioning.Results Females with ADHD had a 2.5 times higher risk for MD at adolescent follow-up compared with control females, adjusting for psychiatric comorbidity. MD in females with ADHD was associated with an earlier age at onset, greater than twice the duration, more severe depression-associated impairment, a higher rate of suicidality, and a greater likelihood of requiring psychiatric hospitalization than MD in control girls. Parental MD and proband mania were significant predictors of MD among females with ADHD, independently of other predictors.Conclusions MD emerging in the context of ADHD in females is an impairing and severe comorbidity worthy of further clinical and scientific considerations.
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“which was no longer found in adulthood-the authors noted low medication adherence into adulthood (Biederman et al. 2008).”
From The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders (2022) · cites this paper as Biederman et al. 2008
In the citing paper
“Biederman et al. (2008) found that treatment for ADHD had a significant protective effect (odds ratio [OR]: 0.15 [0.04-0.6]) for developing SUD in adolescence”
From The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders (2022) · cites this paper as Biederman et al. 2008
In the citing paper
“Wealso noted that studies in samples followed over time showed enhanced protection against the development of SUD lost over time, presumably linked to adherence (Biederman et al. 2008; Quinn et al. 2017).”
From The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders (2022) · cites this paper as Biederman et al. 2008
In the citing paper
“A variety of other behavioral, developmental, and physical conditions can be comorbid in children and adolescents who are evaluated for ADHD, including emotional or behavioral conditions or a history of these problems.”
From Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents (2019) · cites this paper as [55]
In the citing paper
“Other studies have documented the comorbidity between ADHD and depression [76, 77].”
From The brain anatomy of attention-deficit/hyperactivity disorder in young adults—a magnetic resonance imaging study (2017) · cites this paper as [76]
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Subcommittee on Attention-Deficit/Hyperactivity Disorder, S. C. O. Q. I. A. M. (2011) · Pediatrics · doi:10.1542/peds.2011-2654 · Cited by 2,185
Wolraich, M. L., Hagan, J. F., Allan, C., Chan, E., Davison, D., Earls, M., Evans, S. W., Flinn, S. K., Froehlich, T., Frost, J., et al. (2019) · Pediatrics · doi:10.1542/peds.2019-2528 · Cited by 1,562
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“The treatment of depression in the setting of comorbid ADHD is generally more difficult and treatment resistance is more common (Biederman et al., 2008; Nierenberg et al., 2005).”
BackgroundLive fast, die young? A review on the developmental trajectories of ADHD across the lifespan
Franke, B., Michelini, G., Asherson, P., Banaschewski, T., Bilbow, A., Buitelaar, J. K., Cormand, B., Faraone, S. V., Ginsberg, Y., Haavik, J., et al. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.08.001 · Cited by 643
Self-citationGender Differences in Attention-Deficit/Hyperactivity Disorder
Rucklidge, J. J. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2010.01.006 · Cited by 571
Metadata
- Authors
- BIEDERMAN, J., BALL, S. W., MONUTEAUX, M. C., MICK, E., SPENCER, T. J., McCREARY, M., COTE, M., & FARAONE, S. V.
- Affiliations
- Harvard University (US)
- Corresponding author
- BIEDERMAN, JOSEPH
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 47
- Issue
- 4
- Pages
- 426-434
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2062790466
- Cited by
- 331
- References
- 43
- Citations by year
- 2026: 9 · 2025: 24 · 2024: 17 · 2023: 14 · 2022: 19 · 2021: 25 · 2020: 27 · 2019: 22 · 2018: 19 · 2017: 19 · 2016: 15 · 2015: 12 · 2014: 23 · 2013: 25 · 2012: 16
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R03MH079954)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD036317, 5 R01 HD36317-07)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- attention deficit hyperactivity disorder, major depressive disorder, comorbidities, adolescent girls, young adult women, age of onset, depression duration, suicidality, psychiatric hospitalization, parental depression, mania, functional disability
- MeSH terms
- Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Bipolar Disorder, Major Depressive Disorder, Female, Follow-Up Studies, Hospitalization, Humans, Phenotype, Pregnancy, Pregnancy in Adolescence, Risk Factors, Social Environment, Suicide, Attempted, Comorbidity, Case-Control Studies, Age of Onset, Genetic Predisposition to Disease
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