Cited by 108Attention Deficit Hyperactivity DisorderTreatment of Major DepressionChild and Adolescent Psychosocial and Emotional Development

Attention deficit hyperactivity disorder in childhood among adults with major depression

Alpert, Jonathan E., Maddocks, Anne, Nierenberg, Andrew A., O'Sullivan, Richard, Pava, Joel A., Worthington, John J., Biederman, Joseph, Rosenbaum, Jerrold F. +1 more·1996·Psychiatry Research

Abstract

The prevalence of attention deficit hyperactivity disorder (ADHD) with childhood onset and its relationship to course and treatment outcome of major depressive disorder (MDD) in adults was studied in 116 patients (ages 18-65) consecutively enrolled for treatment of MDD. Sixteen percent of the patient were found to meet full or subthreshold criteria for the DSM-III-R diagnosis of childhood ADHD. Twelve percent endorsed persistence of ADHD symptoms into adulthood. Depressed adults meeting criteria for childhood ADHD did not differ significantly from other depressed adults on any measures related to the chronicity or severity of the mood disorder, Axis I comorbidity, or response to acute antidepressant treatment. Our results are clinically important as they suggest that clinicians need to be aware of the possibility that a substantial proportion of patients with MDD may suffer from comorbid ADHD and that treatments need to include the targeting of possible residual ADHD symptoms in addition to those of depression.

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Crossref · 10.1016/0165-1781(96)02912-5

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Authors
Alpert, J. E., Maddocks, A., Nierenberg, A. A., O'Sullivan, R., Pava, J. A., Worthington, J. J., Biederman, J., Rosenbaum, J. F., & Fava, M.
Affiliations
Massachusetts General Hospital (US)
Corresponding author
Alpert, Jonathan E.
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
1996-06
Volume
62
Issue
3
Pages
213-219
ISSN
0165-1781 (ISSN-L)
OpenAlex
W2097442107
Cited by
108
References
37
Citations by year
2025: 4 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 9 · 2013: 4 · 2012: 5
FWCI
1.94
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r01mh048483-01a1)
  • National Institute of Mental Health (R01-MH48483)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
attention deficit hyperactivity disorder, childhood-onset ADHD, major depressive disorder, comorbidities, antidepressant response, Axis I comorbidity
MeSH terms
Adolescent, Adult, Aged, Antidepressive Agents, Attention Deficit Disorder with Hyperactivity, Child, Depressive Disorder, Female, Humans, Male, Middle Aged, Personality Development, Psychiatric Status Rating Scales, Comorbidity

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