Attention deficit hyperactivity disorder in childhood among adults with major depression
Abstract
The prevalence of attention deficit hyperactivity disorder (ADHD) with childhood onset and its relationship to course and treatment outcome of major depressive disorder (MDD) in adults was studied in 116 patients (ages 18-65) consecutively enrolled for treatment of MDD. Sixteen percent of the patient were found to meet full or subthreshold criteria for the DSM-III-R diagnosis of childhood ADHD. Twelve percent endorsed persistence of ADHD symptoms into adulthood. Depressed adults meeting criteria for childhood ADHD did not differ significantly from other depressed adults on any measures related to the chronicity or severity of the mood disorder, Axis I comorbidity, or response to acute antidepressant treatment. Our results are clinically important as they suggest that clinicians need to be aware of the possibility that a substantial proportion of patients with MDD may suffer from comorbid ADHD and that treatments need to include the targeting of possible residual ADHD symptoms in addition to those of depression.
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ADHD occurs in around 10-20% of people with common mental health problems.
“ADHD occurs in around 10-20% of people with common mental health problems according to epidemiological and clinical research [22-27].”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [25]
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- Authors
- Alpert, J. E., Maddocks, A., Nierenberg, A. A., O'Sullivan, R., Pava, J. A., Worthington, J. J., Biederman, J., Rosenbaum, J. F., & Fava, M.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- Alpert, Jonathan E.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 62
- Issue
- 3
- Pages
- 213-219
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2097442107
- Cited by
- 108
- References
- 37
- Citations by year
- 2025: 4 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 9 · 2013: 4 · 2012: 5
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01mh048483-01a1)
- National Institute of Mental Health (R01-MH48483)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- attention deficit hyperactivity disorder, childhood-onset ADHD, major depressive disorder, comorbidities, antidepressant response, Axis I comorbidity
- MeSH terms
- Adolescent, Adult, Aged, Antidepressive Agents, Attention Deficit Disorder with Hyperactivity, Child, Depressive Disorder, Female, Humans, Male, Middle Aged, Personality Development, Psychiatric Status Rating Scales, Comorbidity
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