The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Intestinal microbiota composition in patients with amyotrophic lateral sclerosis: establishment of bacterial and archaeal communities analyses
Open accessAbstract
BACKGROUND: Emerging evidences have indicated that the composition of gut microbiota was significantly influenced by central nervous system diseases. The digestion and metabolism disturbances of patients with amyotrophic lateral sclerosis (ALS) might be strongly associated with ALS; however, this has rarely been evaluated in these populations. This study was to evaluate bacterial and archaeal composition of gut flora and the corresponding metabolism performance of these micro-organisms in fecal samples of patients with ALS. METHODS: A comparative study was performed on the intestinal microbiota from eight patients with ALS and eight healthy individuals at Huadong Hospital during November 2017 to April 2018; meanwhile, the metabolite concentrations of human endotoxin, short-chain fatty acids (SCFA), NO2-N/NO3-N, and γ-aminobutyric acid were also evaluated by spectrophotometry methods. The correlations between intestinal microbiota and metabolite concentration were compared between the two groups using one-way analysis of variance; the relative abundance of beneficial and harmful micro-organisms in fecal samples was also analyzed. RESULTS: In general, the richness and evenness of bacterial and archaeal communities of healthy individuals were healthier than that of patients with ALS. The phylum Firmicutes/Bacteroidetes ratio, genus Methanobrevibacter showed an enhancive tendency in patients with ALS, whereas the relative abundance of beneficial micro-organisms (genera Faecalibacterium and Bacteroides) presented a significant decrease tendency in patients with ALS. In addition, the average concentrations of human endotoxin, SCFA, NO2-N/NO3-N, and γ-aminobutyric acid in patients with ALS and healthy individuals were 64.2 vs. 65.3 EU/mL, 57.5 vs. 55.3 μg/mL, 5.7 vs. 5.3 ng/mL, and 6.1 vs. 5.4 μmol/L, respectively, indicating that the digestion and metabolism functions of gastrointestinal tract of patients might decline with this disease. CONCLUSIONS: The relative abundance of beneficial and harmful micro-organisms respectively showed decrease and increase tendency in patients with ALS.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gut microbiome composition and metabolome are altered in many brain disorders.
“Interestingly, several studies have found that the gut microbiome composition and, consequently, metabolome are altered in many brain disorders (138–142).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [142]
The Discussion reports altered gut microbial composition in patients with ALS. The Results report only nonsignificant increases in the measured fecal metabolites, so they do not establish a changed metabolome as a consequence of the microbial changes. This study focuses on ALS; it does not establish the claim across many brain disorders. (LLM, conf=0.88)
Experimental — accuracy not yet measuredA comparative study in human ALS patients showed an elevated relative abundance of pathobionts compared to bacterial strains related to beneficial metabolism function.
“A comparative study conducted in human patients showed an elevated relative abundance of pathobionts compared to bacterial strains related to beneficial metabolism function (142).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [142]
The Discussion reports that beneficial Faecalibacterium and Bacteroides decreased in patients with ALS compared with healthy individuals. The Introduction describes an increase in harmful Dorea, but attributes that finding to an earlier study; this paper’s own reported findings do not establish an increase in bacterial pathobionts. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis
Brooks, B. R., Miller, R. G., Swash, M., & Munsat, T. L. (2000) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/146608200300079536 · Cited by 5,433
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888 · cited 1×
“It was generally accepted that the biodiversity and composition of these micro-organisms were significantly related to human metabolism, immunity and gut-brain axis diseases.([9-11]) In literature, the variation of microbial biodiversity and communities showed apparent interactions with the disease progression of cent…”
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275
Self-citationPopulation-based metagenomics analysis reveals markers for gut microbiome composition and diversity
Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Mujagic, Z., Vila, A. V., Falony, G., Vieira-Silva, S., et al. (2016) · Science · doi:10.1126/science.aad3369 · Cited by 1,914
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755
Interactions between commensal intestinal bacteria and the immune system
Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,683
The central nervous system and the gut microbiome
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513
van Es, M. A., Hardiman, O. M., Chiò, A., Al‐Chalabi, A., Pasterkamp, R. J., Veldink, J. H., & van den Berg, L. H. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31287-4 · Cited by 1,361
Ott, S. J., Musfeldt, M., Wenderoth, D. F., Hampe, J., Brant, O., Fölsch, U. R., Timmis, K. N., & Schreiber, S. (2004) · Gut · doi:10.1136/gut.2003.025403 · Cited by 1,311
Faecalibacterium prausnitzii and human intestinal health
Miquel, S., Martín, R., Rossi, O., Bermúdez‐Humarán, L. G., Chatel, J., Sokol, H., Thomas, M., Wells, J. M., & Langella, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.003 · Cited by 1,278
Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076
Brain-gut-microbe communication in health and disease
Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952
Human intestinal bacteria as reservoirs for antibiotic resistance genes
Salyers, A. A., GUPTA, A., & WANG, Y. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.07.004 · Cited by 847
Incidence of amyotrophic lateral sclerosis in Europe
Logroscino, G., Traynor, B. J., Hardiman, O., Chio, A., Mitchell, D., Swingler, R. J., Millul, A., Benn, E., Beghi, E., & EURALS, F. (2010) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.183525 · Cited by 772
Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S., & Fischbach, M. A. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.09.001 · Cited by 732
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612
Fate, activity, and impact of ingested bacteria within the human gut microbiota
Derrien, M., & van Hylckama Vlieg, J. E. T. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.03.002 · Cited by 605
Julien, J. (2001) · Cell · doi:10.1016/s0092-8674(01)00244-6 · Cited by 435
How gut microbes talk to organs: The role of endocrine and nervous routes
Cani, P. D., & Knauf, C. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.05.011 · Cited by 339
Target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis
Zhang, Y.-G., Wu, S., Yi, J., Xia, Y., Jin, D., Zhou, J., & Sun, J. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.12.014 · Cited by 287 · cited 3×
“In addition, the host-bacterial interactions were apparently reduced in ALS mice treated with butyrate.([4]) The SCFA could be used as the metabolic substrates by Methanobrevibacter genus to produce methane (CH4), which resulted in the weight loss of patients with intestinal diseases.”
InfluentialAttaluri, A., Jackson, M., Valestin, J., & Rao, S. S. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.655 · Cited by 261
Fang, X., Wang, X., Yang, S., Meng, F., Wang, X., Wei, H., & Chen, T. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01479 · Cited by 211
Löfmark, S., Jernberg, C., Jansson, J. K., & Edlund, C. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl420 · Cited by 175
Motor neuron disease: the bare essentials.
Talbot, K. (2009) · PubMed · doi:10.1136/jnnp.2009.188151 · Cited by 161
Joyce, P. I., Fratta, P., Fisher, E., & Acevedo‐Arozena, A. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9339-1 · Cited by 139
The Gastrointestinal Tract Microbiome and Potential Link to Alzheimer’s Disease
Hill, J. M., Bhattacharjee, S., Pogue, A. I., & Lukiw, W. J. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00043 · Cited by 98
The enteric microbiota in the pathogenesis and management of constipation
Quigley, E. M. M. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.01.003 · Cited by 87
Metabolic Alterations to the Mucosal Microbiota in Inflammatory Bowel Disease
Davenport, M., Poles, J., Leung, J. M., Wolff, M. J., Abidi, W. M., Ullman, T. A., Mayer, L., Cho, I., & Loke, P. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000011 · Cited by 85
Potential Role of the Gut Microbiome in ALS: A Systematic Review
Wright, M. L., Fournier, C. N., Houser, M. C., Tansey, M. G., Glass, J. D., & Hertzberg, V. (2018) · Biological Research For Nursing · doi:10.1177/1099800418784202 · Cited by 67
Comparison of 16S rRNA gene sequences of genus Methanobrevibacter
Dighe, A. S., Jangid, K., González, J. M., Pidiyar, V., Patole, M. S., Ranade, D. R., & Shouche, Y. S. (2004) · BMC Microbiology · doi:10.1186/1471-2180-4-20 · Cited by 53
Yang, B., Xu, H., Wang, J., Song, X., Wang, Y., Li, F., Tian, Q., Ma, C., Wang, D., Bai, J., et al. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.08.040 · Cited by 39
Strijbos, D., van der Hofstede, J. W., Keszthelyi, D., Masclee, A., & Gilissen, L. P. L. (2017) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000959 · Cited by 22
Sun, Q., Li, Y.-R., Lan, W.-J., Yang, F., Cui, F., & Huang, X. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000200 · Cited by 4
Flagged first, then by citations
Cited by
Sorted by citations
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043
“A comparative study conducted in human patients showed an elevated relative abundance of pathobionts compared to bacterial strains related to beneficial metabolism function (142).”
BackgroundKanmani, S., & Koo, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207551 · Cited by 389
The Microbiome as a Modifier of Neurodegenerative Disease Risk
Fang, P., Kazmi, S. A., Jameson, K. G., & Hsiao, E. Y. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.06.008 · Cited by 226
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204
Microglia regulation of central nervous system myelin health and regeneration
Kent, S. A., & Miron, V. E. (2024) · Nature Reviews Immunology · doi:10.1038/s41577-023-00907-4 · Cited by 183
The Impact of Gut Microbiota Disorders on the Blood–Brain Barrier
Wei, T., Zhu, H., Feng, Y., Guo, R., & Wan, D. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s254403 · Cited by 171
The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)
Boddy, S. L., Giovannelli, I., Sassani, M., Cooper-Knock, J., Snyder, M. P., Segal, E., Elinav, E., Barker, L. A., Shaw, P. J., & McDermott, C. J. (2021) · BMC Medicine · doi:10.1186/s12916-020-01885-3 · Cited by 127
Spichak, S., Bastiaanssen, T. F. S., Berding, K., Vlckova, K., Clarke, G., Dinan, T. G., & Cryan, J. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.044 · Cited by 127
Masrori, P., Beckers, J., Gossye, H., & Damme, P. V. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00525-z · Cited by 80
The Gut Microbiota-Immunity Axis in ALS: A Role in Deciphering Disease Heterogeneity?
Niccolai, E., Pilato, V. D., Nannini, G., Baldi, S., Russo, E., Zucchi, E., Martinelli, I., Menicatti, M., Bartolucci, G., Mandrioli, J., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9070753 · Cited by 66
What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review
Bonnechère, B., Amin, N., & van Duijn, C. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213665 · Cited by 68
Exploring the microbiota-gut-brain axis: impact on brain structure and function
Yassin, L. K., Nakhal, M. M., Alderei, A., Almehairbi, A., Mydeen, A. B., Akour, A. A., & Hamad, M. I. K. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2025.1504065 · Cited by 64
Amyotrophic lateral sclerosis and intestinal microbiota—toward establishing cause and effect
Gotkine, M., Kviatcovsky, D., & Elinav, E. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1767464 · Cited by 55
A Gut Feeling in Amyotrophic Lateral Sclerosis: Microbiome of Mice and Men
Martin, S., Battistini, C., & Sun, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.839526 · Cited by 54
Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact
Marchi, F. D., Munitić, I., Amedei, A., Berry, J. D., Feldman, E. L., Aronica, E., Nardo, G., Weehaeghe, D. V., Niccolai, E., Prtenjača, N., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.027 · Cited by 52
Henry, N., Frank, J. A., McLouth, C. J., Trout, A. L., Morris, A. J., Chen, J., Stowe, A. M., Fraser, J. F., & Pennypacker, K. R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.797302 · Cited by 49
Gut microbiome and amyotrophic lateral sclerosis: a systematic review of current evidence
Sun, J., Huang, T., Debelius, J. W., & Fang, F. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13336 · Cited by 43
Yan, J., Chen, H., Zhang, Y., Peng, L., Wang, Z.-K., Lan, X., Yu, S., & Yang, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2353396 · Cited by 40
Choe, U. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106870 · Cited by 45
Chen, S., Cai, X., Lao, L., Wang, Y., Su, H., & Sun, H. (2024) · Aging and Disease · doi:10.14336/ad.2023.0524 · Cited by 40
Chen, S., Zhang, P., Duan, H., Wang, J., Qiu, Y., Cui, Z., Yin, Y., Wan, D., & Xie, L. (2023) · The Innovation · doi:10.1016/j.xinn.2023.100479 · Cited by 40
Bicknell, B. T., Liebert, A. D., McLachlan, C. S., & Kiat, H. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12010049 · Cited by 37
Gut microbiota immune cross-talk in amyotrophic lateral sclerosis
Kaul, M., Mukherjee, D., Weiner, H. L., & Cox, L. M. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00469 · Cited by 36
Casani-Cubel, J., Benlloch, M., Sanchis-Sanchis, C. E., Marín, R., Lajara-Romance, J. M., & Ortí, J. E. D. L. R. (2021) · Metabolites · doi:10.3390/metabo11020120 · Cited by 30
Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives
Eddin, A. N., Alfuwais, M., Eddin, R. N., AlKattan, K. M., & Yaqinuddin, A. (2024) · Nutrients · doi:10.3390/nu16050590 · Cited by 32
Gut microbiota links with cognitive impairment in amyotrophic lateral sclerosis: A multi-omics study
Gong, Z., Ba, L., Tang, J., Yang, Y., Li, Z., Liu, M., Yang, C., Ding, F., & Zhang, M. (2022) · Journal of Biomedical Research · doi:10.7555/jbr.36.20220198 · Cited by 25
Cuffaro, F., Lamminpää, I., Niccolai, E., & Amedei, A. (2024) · Nutrients · doi:10.3390/nu17010102 · Cited by 25
Gut-Brain Axis Deregulation and Its Possible Contribution to Neurodegenerative Disorders
Villavicencio-Tejo, F., Olesen, M. A., Navarro, L., Calisto, N., Iribarren, C., GARCÍA, K. P., Corsini, G., & Quintanilla, R. A. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00681-0 · Cited by 24
Gut Symptoms, Gut Dysbiosis and Gut-Derived Toxins in ALS
Lee, A., Henderson, R. D., Aylward, J., & McCombe, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031871 · Cited by 25
Gautam, P., Yadav, R., Vishwakarma, R. K., Shekhar, S., Pathak, A., & Singh, C. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00254 · Cited by 18
Metabolic Alteration and Amyotrophic Lateral Sclerosis Outcome: A Systematic Review
Brito, M. D., da Silva, G. F. G., Tilieri, E. M., de Araujo, B. P. R., Calió, M. L., & Rosenstock, T. R. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01205 · Cited by 18
Microbiome and micronutrient in ALS: From novel mechanisms to new treatments
Sun, J., & Zhang, Y. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00441 · Cited by 20
Ayala, V., Fontdevila, L., Rico-Rios, S., Povedano, M., Andrés‐Benito, P., Torres, P., Serrano, J. C. E., Pamplona, R., & Portero‐Otín, M. (2025) · Sclerosis · doi:10.3390/sclerosis3010008 · Cited by 15
Lessons to Learn from the Gut Microbiota: A Focus on Amyotrophic Lateral Sclerosis
Calvo, A. C., Valledor-Martín, I., Moreno‐Martínez, L., Toivonen, J. M., & Osta, R. (2022) · Genes · doi:10.3390/genes13050865 · Cited by 15
Non-Motor Symptoms of Amyotrophic Lateral Sclerosis: A Multi-Faceted Disorder
Nash, Y., & Sitty, M. (2021) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-210632 · Cited by 13
Overview of the Gut Microbiome
Blackmer‐Raynolds, L., & Sampson, T. R. (2023) · Seminars in Neurology · doi:10.1055/s-0043-1771463 · Cited by 11
Is gut microbiota of patients with ALS different from that of healthy individuals?
Aksun, Z. Ö., Erdoğan, Ş., Kalkancı, A., Şahin, E. A., Çuhadar, T., & Şener, H. Ö. (2024) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.55730/1300-0144.5825 · Cited by 10
Sharma, P., & Agrawal, A. (2021) · Neurosurgical Review · doi:10.1007/s10143-021-01516-2 · Cited by 10
Mazzini, L., Marchi, F. D., Niccolai, E., Mandrioli, J., & Amedei, A. (2021) · Exon Publications eBooks · doi:10.36255/exonpublications.amyotrophiclateralsclerosis.microbiota.2021 · Cited by 10
Analysis methods for the gut microbiome in neuropsychiatric and neurodegenerative disorders
Song, J. G., Yu, M., Lee, B., Lee, J., Hwang, S.-H., Na, D., & Kim, H. W. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.02.024 · Cited by 10
Microbiota Dysbiosis in Amyotrophic Lateral Sclerosis: A Systematic Review of Human Studies
Gautam, P., Vishwakarma, R. K., Nath, M., Nath, G., & Pathak, A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05481-5 · Cited by 8
Research progress on intestinal microbiota regulating cognitive function through the gut-brain axis
Lin, K., Peng, F., He, K., Qian, Z., Mei, X., Su, Z., Wujimaiti, Y., Xia, X., & Zhang, T. (2024) · Neurological Sciences · doi:10.1007/s10072-024-07525-5 · Cited by 8
Deciphering the microbial map and its implications in the therapeutics of neurodegenerative disorder
Vashishth, S., Ambasta, R. K., & Kumar, P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102466 · Cited by 7
Gut Microbes: The Gut Brain Connection
Lynch, C. M. K., O’Riordan, K. J., Clarke, G. A., & Cryan, J. F. (2023) · Springer eBooks · doi:10.1007/978-3-031-46712-7_4 · Cited by 5
Kiecka, A., & Szczepanik, M. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00800-y · Cited by 5
Yang, E. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178419 · Cited by 4
Das, S., Patel, M., Khandelwal, S., Rawat, R., Shukla, S., Kumari, A., Singh, K., & Kumar, A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70278 · Cited by 3
Gut microbiota and ALS: cause, consequence or correlation? - a systematic review
Chakraborty, D. K., Roy, T., Ngo, S. T., Al‐Chalabi, A., & Khleifat, A. A. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1774417 · Cited by 3
The Role of the Gut Microbiome Dysbiosis in Metabolic Dysfunction: A Mini Review
Shafik, A. N., Fahim, V. F., Iskander, F. A., Elsayegh, H. A., Serag, H., & Sallam, H. S. (2025) · Healthcare · doi:10.3390/healthcare13233029 · Cited by 5
A new paradigm of bidirectional regulation of the gut–spinal cord axis
Ni, S., Chen, K., Wang, H., Chen, S., Qiu, Y., Wang, T., Mo, F., Wang, S., Li, B., Bai, Y., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-01016 · Cited by 2
Gao, Y., Lu, Y., Zhao, S., Chen, R., Liu, J., Zhang, S., Bai, X., & Zhang, J. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153503 · Cited by 2
Contribution of neuroinflammation, resolution, and neuroprotection in neuropsychiatric diseases
Farooqui, A. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-88460-0.00002-3 · Cited by 2
Roy, J. R., Janaki, C. S., Rajagopal, P., & Jayaraman, S. (2024) · Springer eBooks · doi:10.1007/978-981-99-8803-7_5 · Cited by 3
Pribac, M., Moțățăianu, A., Andone, S. R., Mardale, E., & Nemeth, S. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46050271 · Cited by 3
The Role of Gut Microbiota-derived Short Chain Fatty Acids in Amyotrophic Lateral Sclerosis
Saadh, M. J., Dhiaa, S. M., Bansal, P., Dabis, H. K., Katyal, A., Saraswat, V., Ibrahim, A. A., Kadem, R. U., & Ubaid, M. (2025) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-024-00292-9 · Cited by 2
Farooqui, A. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821039-0.00004-6 · Cited by 2
Contribution of neuroinflammation, resolution, and neuroprotection in neurodegenerative diseases
Farooqui, A. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-88460-0.00010-2 · Cited by 2
Neurodegenerative Diseases and the Gut Microbiota
Cabré, S., O’Riordan, K. J., & Cryan, J. F. (2022) · Progress in inflammation research · doi:10.1007/978-3-030-91051-8_11 · Cited by 2
Microbiota as a regulator of brain vulnerability across lifespan and disease contexts
Santerre, M., Shcherbik, N., & Sawaya, B. E. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03824-0 · Cited by 1
Gut Microbiota and Neuropsychiatric Disorders
Bidaki, R., Moghaddam, S. H. H., & Sadeh, M. (2021) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.2021.3220.1 · Cited by 2
Metabolites and micronutrition in modulating amyotrophic lateral sclerosis
Claud, K., & Sun, J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385861 · Cited by 1
Update Review of the Relationship Between Gut Microbiota and Neurodegenerative Diseases
Wang, Y., Jing, G., Fu, Y., Li, Y., & Wu, C. (2024) · Diseases & Research · doi:10.54457/dr.202401007 · Cited by 1
Molecular mechanisms of neurodegeneration in neurodegenerative diseases
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821711-5.00004-8
Molecular mechanisms of neurodegeneration in neuropsychiatric diseases
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821711-5.00005-x
Xin, Z., Xin, C., Huo, J., Liu, Q., Dong, H., Li, R., & Liu, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-2061629/v1
Claypool, D. J., Zhang, Y., Xia, Y., & Sun, J. (2024) · Metabolites · doi:10.3390/metabo14010032 · Cited by 1
Role of microbiome gut-brain axis in brain disorders
Parashar, S., Kapoor, D. U., Gautam, R. K., & Thakur, A. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21680-0.00013-4
The role of gut dysbiosis in the pathogenesis of neurodegenerative diseases
Roudenský, P. (2025) · Neurologie pro praxi · doi:10.36290/neu.2025.036
Jacob, S. M., Son, B., Bagheri, S., Lee, S., Leckie, J., Chohan, B., Belway, C. R., Mascarenhas, J., Mobach, T., Korngut, L. W., et al. (2026) · Journal of Clinical Neurology · doi:10.3988/jcn.2025.0219 · Cited by 1
Ortí, J. E. D. L. R., Bargues‐Navarro, G., Sancho-Castillo, S., Privado, J., García, M. B., Sanchis-Sanchis, C. E., Martínez, L. G., Cuerda‐Ballester, M., Bolós, P. M., & Roig, F. J. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1842792
Simón‐Vicente, L., Lafont, M. O., Franch, M. A., Menéndez-Trillo, P., Rivadeneyra-Posadas, J. J., Miguel‐Pérez, I., Aguado, L., Muñoz‐Siscart, I., Díaz-Piñeiro, D., Mariscal, N., et al. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124617
Microbiome and Diseases: Gut–Brain Axis and Neurological Disorders
de Castilhos, J., & Stein‐Thoeringer, C. K. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_18
Metadata
- Authors
- Zhai, C.-D., Zheng, J.-J., An, B.-C., Huang, H.-F., & Tan, Z.-C.
- Affiliations
- Fudan University (CN)
- Corresponding author
- An, Bing-Chen
- Venue
- Chinese Medical Journal
- Published
- 2019-08-05
- Volume
- 132
- Issue
- 15
- Pages
- 1815-1822
- ISSN
- 0366-6999 (ISSN-L)
- PMC
- PMC6759115
- OpenAlex
- W2957892621
- Cited by
- 72
- References
- 35
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 14 · 2023: 6 · 2022: 10 · 2021: 14 · 2020: 7 · 2019: 1
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Chinese Medical Journal (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- amyotrophic lateral sclerosis, gut microbiota, archaea, Methanobrevibacter, Faecalibacterium, Bacteroides, Firmicutes/Bacteroidetes ratio, short-chain fatty acids, GABA, intestinal metabolism, fecal microbiota composition
- MeSH terms
- Gastrointestinal Microbiome, Adult, Aged, Amyotrophic Lateral Sclerosis, Archaea, Bacteria, Feces, Female, Humans, Male, Middle Aged, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
