Cited by 193Autism Spectrum Disorder ResearchChild and Adolescent Psychosocial and Emotional DevelopmentChild Nutrition and Feeding Issues

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Characterization of Depression in Children With Autism Spectrum Disorders

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Magnuson, Katherine M., Constantino, John N.·2011·Journal of Developmental & Behavioral Pediatrics

DOI 10.1097/dbp.0b013e318213f56cPMC PMC3154372

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Abstract

Depressive syndromes represent a disabling comorbidity for many children with autism spectrum disorders (ASD); however, the ascertainment of depression can be complicated by phenotypic overlap between the 2 conditions, by ways in which autistic symptomatology can mask cardinal features of depression and by atypical manifestations of depression in children with ASD. These issues have contributed to wide variation in the estimation of prevalence rates of depression in individuals with ASD and invoke the need for new approaches to the specific detection of depression and other neuropsychiatric comorbidities that aggregate in children affected by ASD. The authors review the scientific literature relevant to the occurrence of depression in ASD and consider important parameters of risk, including psychosocial factors such as insight into affectation status, as well as biological factors such as the aggregation of depressive syndromes in certain families affected by autism, which has suggested possible overlap in genetic influences underlying the 2 conditions. Variability in the manifestations of depression across environmental contexts provides important clues to intervention and underscores the potential importance of involving multiple informants in ascertaining depression in children and adolescents with ASD. A practical strategy for evaluating the presence of depression in youth with ASD is synthesized from the available data and discussed.

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Authors: Magnuson, K. M., & Constantino, J. N.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Magnuson, Katherine M.
ORCID: Constantino, John N.
Venue: Journal of Developmental & Behavioral Pediatrics
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-05
Volume: 32
Issue: 4
Pages: 332-340
ISSN: 0196-206X (ISSN-L)
DOI: 10.1097/dbp.0b013e318213f56c
PMC: PMC3154372
OpenAlex: W2079422843
Cited by: 193
References: 74
Citations by year: 2026: 5 · 2025: 19 · 2024: 15 · 2023: 23 · 2022: 16 · 2021: 15 · 2020: 12 · 2019: 13 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 7
FWCI: 0.79
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Developmental & Behavioral Pediatrics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD42541, R01HD042541)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords: depression, autism spectrum disorder, comorbidities, children and adolescents, diagnostic assessment, phenotypic overlap, atypical depression, familial aggregation, genetic overlap, multiple informants, depression prevalence, neuropsychiatric comorbidity
MeSH terms: Child, Child Development Disorders, Pervasive, Depressive Disorder, Humans, Comorbidity

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Characterization of Depression in Children With Autism Spectrum Disorders

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