The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Characterization of Depression in Children With Autism Spectrum Disorders
Open accessAbstract
Depressive syndromes represent a disabling comorbidity for many children with autism spectrum disorders (ASD); however, the ascertainment of depression can be complicated by phenotypic overlap between the 2 conditions, by ways in which autistic symptomatology can mask cardinal features of depression and by atypical manifestations of depression in children with ASD. These issues have contributed to wide variation in the estimation of prevalence rates of depression in individuals with ASD and invoke the need for new approaches to the specific detection of depression and other neuropsychiatric comorbidities that aggregate in children affected by ASD. The authors review the scientific literature relevant to the occurrence of depression in ASD and consider important parameters of risk, including psychosocial factors such as insight into affectation status, as well as biological factors such as the aggregation of depressive syndromes in certain families affected by autism, which has suggested possible overlap in genetic influences underlying the 2 conditions. Variability in the manifestations of depression across environmental contexts provides important clues to intervention and underscores the potential importance of involving multiple informants in ascertaining depression in children and adolescents with ASD. A practical strategy for evaluating the presence of depression in youth with ASD is synthesized from the available data and discussed.
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“A co-occurring diagnosis may be further complicated by the ways in which the symptoms and features overlap (e.g., social withdrawal) and by the atypical manifestation of depression symptoms in ASD [115].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [115]
In the citing paper
“Further, ER problems may manifest differently in ASD.15,38,59”
From Emotion Regulation (2014) · cites this paper as [59]
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Genetic Epidemiology of Major Depression: Review and Meta-Analysis
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Autism as a strongly genetic disorder: evidence from a British twin study
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Comorbid psychiatric disorders in children with autism: interview development and rates of disorders
Leyfer, O. T., Folstein, S. E., Bacalman, S., Davis, N. O., Dinh, E., Morgan, J., Tager-Flusberg, H., & Lainhart, J. E. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0123-0 · Cited by 1,637
Autistic Traits in the General Population: A Twin Study
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Self-citationBullying, Depression, and Suicidality in Adolescents
Klomek, A. B., Marrocco, F. A., KLEINMAN, M., Schonfeld, I. S., & Gould, M. S. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000242237.84925.18 · Cited by 990
The Prevalence of Anxiety and Mood Problems among Children with Autism and Asperger Syndrome
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Prevalence of Parent-Reported Diagnosis of Autism Spectrum Disorder Among Children in the US, 2007
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Cited by
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An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options
Masi, A., DeMayo, M. M., Glozier, N., & Guastella, A. J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0100-y · Cited by 987
The Role of Emotion Regulation in Autism Spectrum Disorder
Mazefsky, C. A., Herrington, J., Siegel, M., Scarpa, A., Maddox, B. B., Scahill, L., & White, S. W. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.006 · Cited by 881
Prevalence of Depressive Disorders in Individuals with Autism Spectrum Disorder: A Meta-Analysis
Hudson, C. C., Hall, L., & Harkness, K. L. (2019) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-018-0402-1 · Cited by 411
Co-occurring psychiatric conditions in autism spectrum disorder
Rosen, T. E., Mazefsky, C. A., Vasa, R. A., & Lerner, M. D. (2018) · International Review of Psychiatry · doi:10.1080/09540261.2018.1450229 · Cited by 325
Mazefsky, C. A., & White, S. W. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2013.07.002 · Cited by 323
Metadata
- Authors
- Magnuson, K. M., & Constantino, J. N.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Magnuson, Katherine M.
- ORCID
- Constantino, John N.
- Venue
- Journal of Developmental & Behavioral Pediatrics
- Published
- 2011-05
- Volume
- 32
- Issue
- 4
- Pages
- 332-340
- ISSN
- 0196-206X (ISSN-L)
- PMC
- PMC3154372
- OpenAlex
- W2079422843
- Cited by
- 193
- References
- 74
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 15 · 2023: 23 · 2022: 16 · 2021: 15 · 2020: 12 · 2019: 13 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 7
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Developmental & Behavioral Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD42541, R01HD042541)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- depression, autism spectrum disorder, comorbidities, children and adolescents, diagnostic assessment, phenotypic overlap, atypical depression, familial aggregation, genetic overlap, multiple informants, depression prevalence, neuropsychiatric comorbidity
- MeSH terms
- Child, Child Development Disorders, Pervasive, Depressive Disorder, Humans, Comorbidity
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