The Eczema Area and Severity Index – a practical guide
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ABSTRACT: Atopic dermatitis is a chronic inflammatory skin condition that affects approximately 18 million people in the United States. Assessing the extent and severity of atopic dermatitis is critical for determining baseline disease burden and treatment effectiveness for both investigators and clinicians. Considerable efforts over the past several decades have been made in developing a highly validated instrument called the Eczema Area and Severity Index (EASI). Although several guides exist for the EASI, questions continue to arise regarding its use and interpretation. This review was developed to serve as the definitive guide for the EASI and to address commonly asked questions.
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Erythema is frequently underestimated and may appear more violaceous and grey in individuals with darker skin tone.
“For example, erythema, a common marker of inflammation, is frequently underestimated and may appear more violaceous and grey in individuals with darker skin tone.72,73”
From Assessing the performance of artificial intelligence models in evaluating inflammatory skin disease severity: a systematic review and meta-analysis (2025) · cites this paper as [72]
The “Tips for Assessing Erythema” section says that underestimating inflammation in darker skin is a common pitfall and that erythema may appear more violaceous than pink. It does not describe erythema as grey. No page number is available in our copy. (LLM, conf=0.88)
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- Authors
- Hanifin, J. M., Baghoomian, W., Grinich, E., Leshem, Y. A., Jacobson, M., & Simpson, E. L.
- Affiliations
- Oregon Health & Science University (US)
- Tel Aviv University (IL)
- Corresponding author
- Hanifin, Jon M.
- Baghoomian, Wenelia
- Grinich, Erin
- Jacobson, Michael
- Simpson, Eric Lawrence
- ORCID
- Venue
- Dermatitis
- Publisher
- SAGE Publications
- Published
- 2022-05
- Volume
- 33
- Issue
- 3
- Pages
- 187-192
- ISSN
- 1710-3568 (ISSN-L)
- 2162-5220
- PMC
- PMC9154300
- OpenAlex
- W4280586178
- Cited by
- 213
- References
- 12
- Citations by year
- 2026: 57 · 2025: 67 · 2024: 64 · 2023: 23 · 2022: 2
- FWCI
- 38.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Dermatitis (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- Eczema Area and Severity Index, atopic dermatitis, disease severity assessment, disease burden, patient-reported outcome measures
- MeSH terms
- Dermatitis, Atopic, Eczema, Humans, Severity of Illness Index, Treatment Outcome
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