Dopamine receptor antagonists impair place conditioning after acute stress in rats
Abstract
An immediate and robust release of dopamine appears in the brain under an acute stressor, but the functional role of dopamine under stress remains elusive. We recently showed conditioned place preference (CPP) induced by the acute application of a stressor such as being placed on an elevated stand or immobilized in a restraint holder. This study tested whether dopamine is involved in such CPP. The selective dopamine D1 and D2 receptor antagonists, SCH23390 and raclopride, respectively, were injected before stressor manipulation. The doses of SCH23390 (0.025 and 0.05 mg/kg) and raclopride (0.05 and 0.1 mg/kg) used to test for stressor-induced CPP were verified to be ineffective on spontaneous locomotor activity. The results showed that both drugs attenuated the development of stressor-induced CPP. Such a CPP blocking effect by pretreatment of dopamine receptor antagonist was true for either kind of stressor manipulated. These findings indicate that an acute stressor can facilitate a follow-up place conditioning, and that dopamine is involved in the present type of CPP formation.
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Learning of responses to aversive stimuli in rodents during fear conditioning is inhibited by dopaminergic antagonists.
“learning of responses to aversive stimuli in rodents (ie. during fear conditioning) is inhibited by dopaminergic antagonists [66–68].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [68]
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- Authors
- Shen, Y.-L., Chen, Y.-C., & Liao, R.-M.
- Affiliations
- National Chengchi University (TW)
- Corresponding author
- Chen, Yao-Chu
- Liao, Ruey-Ming
- ORCID
- Liao, Ruey-Ming
- Venue
- Behavioural Pharmacology
- Published
- 2010-02
- Volume
- 21
- Issue
- 1
- Pages
- 77-82
- ISSN
- 0955-8810 (ISSN-L)
- OpenAlex
- W1975801973
- Cited by
- 14
- References
- 29
- Citations by year
- 2023: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dopamine, acute stress, conditioned place preference, dopamine D1 receptor, dopamine D2 receptor, SCH 23390, raclopride, dopamine antagonists, restraint stress
- MeSH terms
- Animals, Benzazepines, Choice Behavior, Conditioning, Operant, Male, Motor Activity, Stress, Psychological, Rats, Wistar, Dopamine Antagonists, Raclopride, Rats
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