Cited by 14Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolMemory and Neural Mechanisms

Dopamine receptor antagonists impair place conditioning after acute stress in rats

Shen, Ying-Ling, Chen, Yao-Chu, Liao, Ruey-Ming·2010·Behavioural Pharmacology

Abstract

An immediate and robust release of dopamine appears in the brain under an acute stressor, but the functional role of dopamine under stress remains elusive. We recently showed conditioned place preference (CPP) induced by the acute application of a stressor such as being placed on an elevated stand or immobilized in a restraint holder. This study tested whether dopamine is involved in such CPP. The selective dopamine D1 and D2 receptor antagonists, SCH23390 and raclopride, respectively, were injected before stressor manipulation. The doses of SCH23390 (0.025 and 0.05 mg/kg) and raclopride (0.05 and 0.1 mg/kg) used to test for stressor-induced CPP were verified to be ineffective on spontaneous locomotor activity. The results showed that both drugs attenuated the development of stressor-induced CPP. Such a CPP blocking effect by pretreatment of dopamine receptor antagonist was true for either kind of stressor manipulated. These findings indicate that an acute stressor can facilitate a follow-up place conditioning, and that dopamine is involved in the present type of CPP formation.

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Crossref · 10.1097/fbp.0b013e3283359f20

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Authors
Shen, Y.-L., Chen, Y.-C., & Liao, R.-M.
Affiliations
National Chengchi University (TW)
Corresponding author
  • Chen, Yao-Chu
  • Liao, Ruey-Ming
Venue
Behavioural Pharmacology
Published
2010-02
Volume
21
Issue
1
Pages
77-82
ISSN
0955-8810 (ISSN-L)
OpenAlex
W1975801973
Cited by
14
References
29
Citations by year
2023: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
dopamine, acute stress, conditioned place preference, dopamine D1 receptor, dopamine D2 receptor, SCH 23390, raclopride, dopamine antagonists, restraint stress
MeSH terms
Animals, Benzazepines, Choice Behavior, Conditioning, Operant, Male, Motor Activity, Stress, Psychological, Rats, Wistar, Dopamine Antagonists, Raclopride, Rats

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