Subsensitivity to rewarding and locomotor stimulant effects of a dopamine agonist following chronic mild stress
Abstract
Chronic exposure to very mild unpredictable stress has previously been found to reduce or abolish the acquisition of place preference conditioning. In the present study, chronic mild stress was found to abolish the acquisition of preferences for a distinctive environment paired with systemic administration of amphetamine (0.5 mg/kg) or quinpirole (100-400 micrograms/kg) or with quinpirole (0.75 micrograms) administered bilaterally within the nucleus accumbens. The locomotor stimulant effects of quinpirole (100-400 micrograms/kg) were also attenuated in stressed animals. The result suggest that decreased sensitivity to reward following chronic mild stress results from a decreased sensitivity of dopamine D2 receptors within the nucleus accumbens.
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Chronic and sequential exposure of rats or mice to a mild stress regimen causes decreases in responsiveness to rewards, including decreased consumption of and preference for sucrose solutions and decreased rewarding properties of pharmacological and natural rewards in the place preference paradigm.
“In particular, Willner and colleagues originally reported that chronic and sequential exposure of rats or mice to a mild stress regimen caused decreases in responsiveness to rewards [190,191], commonly reported as a decrease in the consumption of and preference for sucrose solutions, and a decrease in the rewarding properties of pharmacological and natural rewards in the place preference behavior”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [193]
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Lü, L., & Shaham, Y. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80062-8 · Cited by 5 · see citing works
Effects of Social Subordination on Macaque Neurobehavioral Outcomes: Focus on Neurodevelopment
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Andersen, N. D., Sterrett, J. D., Costanza-Chavez, G. W., Zambrano, C. A., Baratta, M. V., Frank, M. G., Maier, S. F., & Lowry, C. A. (2023) · Neuromethods · doi:10.1007/978-1-0716-3218-5_7 · Cited by 3 · see citing works
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Possíveis inter-relações entre a submissão ao Chronic Mild Stree(CMS) e o desempenho operante
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Efeitos da fluoxetina sobre a eficácia de reforçadores condicionados
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Models of Affective Illness: Chronic Mild Stress
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Self-citationMonoaminergic mechanisms in mood-associated behaviours and neurochemistry in rats
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The Effect of Early Life Stress on Methamphetamine Damage in the Striatum
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Monoaminergic and Glutamatergic Mechanisms in a Realistic Animal Model of Depression
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Self-citationChronic Unpredictable Mild Stress: An Important Model of Depression to Develop New Anti-Depressants
Yadav, S. K., Radheshyam, R., Gupta, A., Kumar, A., & Dharamveer (2020) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2020.v64i01.019
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- Authors
- Papp, M., Muscat, R., & Willner, P.
- Venue
- Psychopharmacology
- Published
- 1993-01
- Volume
- 110
- Issue
- 1-2
- Pages
- 152-158
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2072647181
- Cited by
- 79
- References
- 54
- Citations by year
- 2024: 1 · 2023: 2 · 2020: 2 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- chronic mild stress, dopamine agonists, quinpirole, amphetamine, nucleus accumbens, dopamine D2 receptor, reward sensitivity, locomotor stimulant effects
- MeSH terms
- Animals, Conditioning, Operant, Dextroamphetamine, Drinking Behavior, Ergolines, Food Deprivation, Male, Motor Activity, Reward, Stimulation, Chemical, Stress, Psychological, Sucrose, Water Deprivation, Dopamine Agonists, Quinpirole, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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