Cited by 80Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuroscience and Neuropharmacology Research

Subsensitivity to rewarding and locomotor stimulant effects of a dopamine agonist following chronic mild stress

Papp, Mariusz, Muscat, Richard, Willner, Paul·1993·Psychopharmacology

Abstract

Chronic exposure to very mild unpredictable stress has previously been found to reduce or abolish the acquisition of place preference conditioning. In the present study, chronic mild stress was found to abolish the acquisition of preferences for a distinctive environment paired with systemic administration of amphetamine (0.5 mg/kg) or quinpirole (100-400 micrograms/kg) or with quinpirole (0.75 micrograms) administered bilaterally within the nucleus accumbens. The locomotor stimulant effects of quinpirole (100-400 micrograms/kg) were also attenuated in stressed animals. The result suggest that decreased sensitivity to reward following chronic mild stress results from a decreased sensitivity of dopamine D2 receptors within the nucleus accumbens.

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Crossref · 10.1007/bf02246965

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53 of 53 references verified0 citation errors · 0 not checkable

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  • Chronic and sequential exposure of rats or mice to a mild stress regimen causes decreases in responsiveness to rewards, including decreased consumption of and preference for sucrose solutions and decreased rewarding properties of pharmacological and natural rewards in the place preference paradigm.

    “In particular, Willner and colleagues originally reported that chronic and sequential exposure of rats or mice to a mild stress regimen caused decreases in responsiveness to rewards [190,191], commonly reported as a decrease in the consumption of and preference for sucrose solutions, and a decrease in the rewarding properties of pharmacological and natural rewards in the place preference behavior”

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Authors
Papp, M., Muscat, R., & Willner, P.
Venue
Psychopharmacology
Published
1993-01
Volume
110
Issue
1-2
Pages
152-158
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2072647181
Cited by
79
References
54
Citations by year
2024: 1 · 2023: 2 · 2020: 2 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
1.19
Type
journal article
Language
en
Open access
closed
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
chronic mild stress, dopamine agonists, quinpirole, amphetamine, nucleus accumbens, dopamine D2 receptor, reward sensitivity, locomotor stimulant effects
MeSH terms
Animals, Conditioning, Operant, Dextroamphetamine, Drinking Behavior, Ergolines, Food Deprivation, Male, Motor Activity, Reward, Stimulation, Chemical, Stress, Psychological, Sucrose, Water Deprivation, Dopamine Agonists, Quinpirole, Rats

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