Cited by 584Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

The involvement of nucleus accumbens dopamine in appetitive and aversive motivation

Salamone, John D.·1994·Behavioural Brain Research

Abstract

In recent years, considerable emphasis has been placed upon the putative role of nucleus accumbens dopamine systems in appetitive motivation and positive reinforcement. However, considerable evidence indicates that brain dopamine in general, and nucleus accumbens dopamine in particular, is involved in aspects of aversive motivation. Administration of dopamine antagonists or localized interference with nucleus accumbens dopamine systems has been shown to disrupt active avoidance behavior. In addition, accumbens dopamine release and metabolism is activated by a wide variety of stressful conditions. A review of the literature indicates that there are substantial similarities between the characteristics of dopaminergic involvement in appetitive and aversive motivation. There is conflicting evidence about the role of dopamine in emotion, and little evidence to suggest that the profound and consistent changes in instrumental behavior produced by interference with DA systems are due to direct dopaminergic mediation of positive affective responses such as hedonia. It is suggested that nucleus accumbens dopamine is involved in aspects of sensorimotor functions that are involved in both appetitive and aversive motivation.

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Crossref · 10.1016/0166-4328(94)90153-8

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Authors
Salamone, J. D.
Affiliations
University of Connecticut (US)
Corresponding author
Salamone, John D.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
1994-04
Volume
61
Issue
2
Pages
117-133
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2079322728
Cited by
584
References
238
Citations by year
2026: 4 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 16 · 2021: 6 · 2020: 7 · 2019: 12 · 2018: 15 · 2017: 15 · 2016: 24 · 2015: 28 · 2014: 22 · 2013: 32 · 2012: 18
FWCI
1.98
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
nucleus accumbens, dopamine, appetitive motivation, aversive motivation, avoidance behavior, positive reinforcement, stress, dopamine antagonists, hedonia, instrumental behavior, sensorimotor function
MeSH terms
Animals, Appetitive Behavior, Arousal, Avoidance Learning, Dopamine, Motivation, Nucleus Accumbens, Receptors, Dopamine, Reinforcement, Psychology

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