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Cited by 255Reproductive Biology and FertilityReproductive Health and TechnologiesOvarian function and disorders

Impact of oxidative stress on female fertility

Open access
Ruder, Elizabeth H, Hartman, Terryl J, Goldman, Marlene B·2009·Current Opinion in Obstetrics & Gynecology
DOI 10.1097/gco.0b013e32832924baPMC PMC2749720
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Abstract

PURPOSE OF REVIEW: To review the role of oxidative stress in the context of female fertility. RECENT FINDINGS: Oxidative stress is associated with decreased female fertility in animal and in-vitro models, but no studies to date have directly assessed the relationship in women. Exposures associated with oxidative stress and with evidence to influence the timing and maintenance of a viable pregnancy include pregnancy complications (e.g. preeclampsia), extremes of body weight, alcohol, tobacco, and caffeine intake. Intake of antioxidant nutrients, including use of multivitamins, impacts the generation of reactive oxygen species and may play a beneficial role in female fertility. SUMMARY: Infertility is a significant public health problem and diagnosis and treatment are stressful, invasive, and costly. The role of oxidative stress in female fertility is an understudied and compelling area for investigation. Identifying modifiable factors to decrease oxidative stress in the gynecologic environment may be an inexpensive and noninvasive therapy for increasing fertility.

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  • Excess generation of ROS and oxidative stress can adversely affect normal reproductive processes, and supplementation with antioxidants may improve menstrual cycle regularity, prevent ovulatory disorders and enhance fertility.

    “Excess generation of ROS and oxidative stress can adversely affect normal reproductive processes and supplementation with antioxidants may improve menstrual cycle regularity, prevent ovulatory disorders as well as enhance fertility (Ruder et al., 2009).”

    From Iron, Oxidative Stress and Health (2012) · cites this paper as Ruder et al., 2009

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  1. [1]Sharma RK Agarwal A Role of reactive oxygen species in male infertility Urology 1996 48 835 850 8973665
  2. [2]Jordao AA Jr Chiarello PG Arantes MR Effect of an acute dose of ethanol on lipid peroxidation in rats: action of vitamin E Food Chem Toxicol 2004 42 459 464 14871588
  3. [3]Sodergren E Cederberg J Basu S Vessby B Vitamin E supplementation decreases basal levels of F(2)-isoprostanes and prostaglandin f(2alpha) in rats J Nutr 2000 130 10 14 10613758
  4. [4]Djuric Z Depper JB Uhley V Oxidative DNA damage levels in blood from women at high risk for breast cancer are associated with dietary intakes of meats, vegetables, and fruits J Am Diet Assoc 1998 98 524 528 9597024
  5. [6]Sugino N The role of oxygen radical-mediated signaling pathways in endometrial function Placenta 2007 28 Suppl A S133 S136 17291583
  6. [7]Sugino N Kashida S Takiguchi S Induction of superoxide dismutase by decidualization in human endometrial stromal cells Mol Hum Reprod 2000 6 178 184 10655460
  7. [8]Das S Chattopadhyay R Ghosh S Reactive oxygen species level in follicular fluid – embryo quality marker in IVF? Hum Reprod (Oxf) 2006 21 2403 2407 16861701
  8. [9]Wiener-Megnazi Z Vardi L Lissak A Oxidative stress indices in follicular fluid as measured by the thermochemiluminescence assay correlate with outcome parameters in in vitro fertilization Fertil Steril 2004 82 Suppl 3 1171 1176 15474091
  9. [10]Yie SM Brown GM Liu GY Melatonin and steroids in human pre-ovulatory follicular fluid: seasonal variations and granulosa cell steroid production Hum Reprod (Oxf) 1995 10 50 55 7745070
  10. [11]Manda K Ueno M Anzai K AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice J Pineal Res 2007 42 386 393 17439555
  11. [12]Tan DX Manchester LC Terron MP One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007 42 28 42 17198536
  12. [13]Zavodnik IB Domanski AV Lapshina EA Melatonin directly scavenges free radicals generated in red blood cells and a cell-free system: chemiluminescence measurements and theoretical calculations Life Sci 2006 79 391 400 16698043
  13. [14]Tomas-Zapico C Coto-Montes A A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes J Pineal Res 2005 39 99 104 16098085
  14. Tamura H Takasaki A Miwa I Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate J Pineal Res 2008 44 280 287 Describes an inverse relationship between follicular fluid oxidative stress and oocyte quality and demonstrates that oral supplementation of melatonin and vitamin E are associated with a reduction in markers of follicular fluid oxidative stress 18339123
  15. [16]Czeizel AE Metneki J Dudas I The effect of preconceptional multivitamin supplementation on fertility Int J Vitam Nutr Res 1996 66 55 58 8698547
  16. Chavarro JE Rich-Edwards JW Rosner BA Willett WC Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility Fertil Steril 2008 89 668 676 Describes an association of multivitamin use with incident ovulatory disorders 17624345 PMC2366795
  17. [18]Barrington JW Lindsay P James D Selenium deficiency and miscarriage: a possible link? Br J Obstet Gynaecol 1996 103 130 132 8616128
  18. [19]Vural P Akgul C Yildirim A Canbaz M Antioxidant defence in recurrent abortion Clin Chim Acta 2000 295 169 177 10767402
  19. [20]Plessinger MA Woods JR Jr Miller RK Pretreatment of human amnion-chorion with vitamins C and E prevents hypochlorous acid-induced damage Am J Obstet Gynecol 2000 183 979 985 11035350
  20. [21]Woods JR Jr Plessinger MA Miller RK Vitamins C and E: missing links in preventing preterm premature rupture of membranes? Am J Obstet Gynecol 2001 185 5 10 11483896
  21. [22]Bilodeau JF Hubel CA Current concepts in the use of antioxidants for the treatment of preeclampsia J Obstet Gynaecol Can 2003 25 742 750 12970809
  22. [23]Chappell LC Seed PT Briley A A longitudinal study of biochemical variables in women at risk of preeclampsia Am J Obstet Gynecol 2002 187 127 136 12114900
  23. Stein PT Scholl TO Schluter MD Oxidative stress early in pregnancy and pregnancy outcome Free Radic Res 2008 42 841 848 Describes the association of markers of oxidative stress in early pregnancy with pregnancy outcomes. Isoprostanes were associated with an increased risk of preeclampsia and 8-OHdG was associated with lower infant birth weight 18985484
  24. Bernardi F Guolo F Bortolin T Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia J Obstet Gynecol Res 2008 34 948 951 The first study to directly correlate markers of inflammation and oxidative stress with preeclampsia 19012691
  25. [26]Poston L Briley AL Seed PT Vitamin C and vitamin E in pregnant women at risk for preeclampsia (VIP trial): randomised placebo-controlled trial Lancet 2006 367 1145 1154 16616557
  26. [27]Banerjee S Chambers AE Campbell S Is vitamin E a safe prophylaxis for preeclampsia? Am J Obstet Gynecol 2006 194 1228 1233 16579948
  27. [28]Roberts VH Smith J McLea SA Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta Placenta 2008 30 169 175 19100619 PMC2657925
  28. [29]Ehrmann DA Polycystic ovary syndrome N Engl J Med 2005 352 1223 1236 15788499
  29. [30]Stamets K Taylor DS Kunselman A A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome Fertil Steril 2004 81 630 637 15037413
  30. [31]Norman RJ Noakes M Wu R Improving reproductive performance in overweight/obese women with effective weight management Hum Reprod Update 2004 10 267 280 15140873
  31. [33]Augood C Duckitt K Templeton AA Smoking and female infertility: a systematic review and meta-analysis Hum Reprod (Oxf) 1998 13 1532 1539 9688387
  32. [34]Neal MS Hughes EG Holloway AC Foster WG Sidestream smoking is equally as damaging as mainstream smoking on IVF outcomes Hum Reprod (Oxf) 2005 20 2531 2535 15919779
  33. [35]Tiboni GM Bucciarelli T Giampietro F Influence of cigarette smoking on vitamin E, vitamin A, beta-carotene and lycopene concentrations in human preovulatory follicular fluid Int J Immunopathol Pharmacol 2004 17 389 393 15461873
  34. [36]Alberg A The influence of cigarette smoking on circulating concentrations of antioxidant micronutrients Toxicology 2002 180 121 137 12324189
  35. [37]Dietrich M Block G Norkus EP Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase gamma-tocopherol in vivo after adjustment for dietary antioxidant intakes Am J Clin Nutr 2003 77 160 166 12499336
  36. [38]Hartman TJ Baer DJ Graham LB Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women Eur J Clin Nutr 2005 59 161 168 15367922
  37. [39]Eggert J Theobald H Engfeldt P Effects of alcohol consumption on female fertility during an 18-year period Fertil Steril 2004 81 379 383 14967377
  38. [40]Tolstrup JS Kjaer SK Holst C Alcohol use as predictor for infertility in a representative population of Danish women Acta Obstet Gynecol Scand 2003 82 744 749 12848646
  39. [41]Bolumar F Olsen J Rebagliato M Bisanti L Caffeine intake and delayed conception: a European multicenter study on infertility and subfecundity. European Study Group on Infertility Subfecundity Am J Epidemiol 1997 145 324 334 9054236
  40. [43]Lynch CD Klebanoff MA Louis GM Is caffeine use during pregnancy really unsafe? Am J Obstet Gynecol 2008 199 e16 Epub 18691688 PMC4138531
  41. [44]Savitz DA Chan RL Herring AH Caffeine and miscarriage risk Epidemiology (Camb) 2008 19 55 62 18091004

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Authors
Ruder, E. H., Hartman, T. J., & Goldman, M. B.
Affiliations
  • National Institutes of Health (US)
  • Pennsylvania State University (US)
  • Dartmouth–Hitchcock Medical Center (US)
Corresponding author
Ruder, Elizabeth H
ORCID
Venue
Current Opinion in Obstetrics & Gynecology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-06
Volume
21
Issue
3
Pages
219-222
ISSN
1040-872X (ISSN-L)
DOI
10.1097/gco.0b013e32832924ba
PMC
PMC2749720
OpenAlex
W2036615909
Cited by
255
References
3
Citations by year
2026: 11 · 2025: 19 · 2024: 20 · 2023: 23 · 2022: 21 · 2021: 16 · 2020: 22 · 2019: 13 · 2018: 16 · 2017: 15 · 2016: 20 · 2015: 15 · 2014: 11 · 2013: 10 · 2012: 8
FWCI
1.04
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Obstetrics & Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD049762)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
oxidative stress, female fertility, infertility, reactive oxygen species, antioxidants, multivitamins, preeclampsia, pregnancy complications, body weight, alcohol consumption, tobacco use, caffeine consumption, modifiable risk factors
MeSH terms
Abortion, Habitual, Antioxidants, Female, Humans, Infertility, Female, Pre-Eclampsia, Pregnancy, Oxidative Stress

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