Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study
Abstract
Objective The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms.Study design This was a population-based prospective cohort study.Results An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to 2.15) for caffeine intake of less than 200 mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more mg/day, respectively. Nausea or vomiting during pregnancy did not materially affect this observed association, nor did the change in intake pattern of caffeine during pregnancy. In addition, the magnitude of the association appeared to be stronger among women without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that among women with such a history (aHR 0.81, 0.34 to 1.94).Conclusion Our results demonstrated that high doses of caffeine intake during pregnancy increase the risk of miscarriage, independent of pregnancy-related symptoms.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies on sporadic miscarriage have shown associations with smoking, alcohol and caffeine.
“Studies on sporadic miscarriage have shown associations with smoking, 25,158 alcohol 26,159 and caffeine.27,160,161”
From Recurrent MiscarriageGreen‐top Guideline No. 17 (2023) · cites this paper as [160]
Weng et al. reported a hazard ratio of 2.23 for spontaneous abortion among 164 women who consumed 200 mg/day or more of caffeine and of 1.34 for 899 women who consumed less than 200 mg/day.
“Weng et al. (125) reported a hazard ratio of 2.23 for spontaneous abortion among 164 women who consumed 200 mg/day or more of caffeine and of 1.34 for 899 women who consumed less than 200 mg/day (125).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [125]
Cites
Applied Survival Analysis: Regression Modeling of Time-to-Event Data
Hosmer, D. W., Lemeshow, S. A., & May, S. J. (2008) · Cited by 3,030 · see citing works
Applied Survival Analysis: Regression Modeling of Time to Event Data
Rao, P., Hosmer, D. W., & Lemeshow, S. A. (2000) · Journal of the American Statistical Association · doi:10.2307/2669422 · Cited by 876 · see citing works
Therneau, T. (1997) · Lecture notes in statistics · doi:10.1007/978-1-4684-6316-3_5 · Cited by 390 · see citing works
Caffeine metabolism in the newborn
Aldridge, A., Aranda, J. V., & Neims, A. H. (1979) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1979254447 · Cited by 268 · see citing works
Caffeine Intake and the Risk of First-Trimester Spontaneous Abortion
Cnattingius, S., Signorello, L. B., Annerén, G., Clausson, B., Ekbom, A., Ljunger, E., Blot, W. J., McLaughlin, J. K., Petersson, G., Rane, A., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012213432503 · Cited by 264 · see citing works
Li, D., Odouli, R., Wi, S., Janevic, T. M., Golditch, I. M., Bracken, T. D., Senior, R., Rankin, R. F., & Iriye, R. (2002) · Epidemiology · doi:10.1097/00001648-200201000-00004 · Cited by 204 · see citing works
Self-citationCoffee and fetal death: a cohort study with prospective data
Bech, B. H., Nohr, E. A., Vaeth, M., Henriksen, T. B., & Olsen, J. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi317 · Cited by 202 · see citing works
Knight, C. A., Knight, I., Mitchell, D. C., & Zepp, J. E. (2004) · Food and Chemical Toxicology · doi:10.1016/j.fct.2004.05.002 · Cited by 189 · see citing works
The disposition of caffeine during and after pregnancy.
Aldridge, A., Bailey, J. R., & Neims, A. H. (1981) · PubMed · Cited by 178 · see citing works
The effect of caffeine on placental and fetal blood flow in human pregnancy
Kirkinen, P. P., Jouppila, P. I., KOIVULA, A., Vuori, J., & Puukka, M. (1983) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(83)90250-8 · Cited by 176 · see citing works
Passage of caffeine into human gonadal and fetal tissue
Goldstein, A., & Warren, R. (1962) · Biochemical Pharmacology · doi:10.1016/0006-2952(62)90106-5 · Cited by 165 · see citing works
Caffeine: its direct and indirect influence on reproduction.
Ps, W., & Lodge, J. R. (1977) · PubMed · Cited by 136 · see citing works
Moderate Caffeine Use and the Risk of Spontaneous Abortion and Intrauterine Growth Retardation
Mills, J. L. (1993) · JAMA · doi:10.1001/jama.1993.03500050071028 · Cited by 134 · see citing works
Caffeine consumption during pregnancy and association with late spontaneous abortion
Srisuphan, W., & Bracken, M. B. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90385-6 · Cited by 115 · see citing works
Maternal Caffeine Consumption and Spontaneous Abortion
Signorello, L. B., & McLaughlin, J. K. (2004) · Epidemiology · doi:10.1097/01.ede.0000112221.24237.0c · Cited by 95 · see citing works
The Associations of Maternal Caffeine Consumption and Nausea with Spontaneous Abortion
Wen, W., Shu, X., Jacobs, D. R., & Brown, J. E. (2001) · Epidemiology · doi:10.1097/00001648-200101000-00008 · Cited by 90 · see citing works
Maternal Caffeine Consumption and Spontaneous Abortion
Dlugosz, L., Belanger, K. D., HELLENBRAND, K. G., Holford, T. R., Leaderer, B. P., & Bracken, M. B. (1996) · Epidemiology · doi:10.1097/00001648-199605000-00006 · Cited by 87 · see citing works
Caffeine Consumption during Pregnancy and Spontaneous Abortion
Fenster, L., Eskenazi, B., Windham, G. C., & Swan, S. H. (1991) · Epidemiology · doi:10.1097/00001648-199105000-00002 · Cited by 87 · see citing works
Caffeinated Beverages, Decaffeinated Coffee, and Spontaneous Abortion
Fenster, L., Hubbard, A., Swan, S. H., Windham, G. C., Waller, K., Hiatt, R. A., & Benowitz, N. L. (1997) · Epidemiology · doi:10.1097/00001648-199709000-00008 · Cited by 72 · see citing works
Caffeine Metabolism and the Risk of Spontaneous Abortion of Normal Karyotype Fetuses
Signorello, L. B., Nordmark, A., Granath, F., Blot, W. J., McLaughlin, J. K., Annerén, G., Lundgren, S., Ekbom, A., Rane, A., & Cnattingius, S. (2001) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(01)01575-7 · Cited by 47 · see citing works
Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation
Parazzini, F., Chatenoud, L., Cintio, E. D., Mezzopane, R., Surace, M., Zanconato, G., Fedele, L., & Benzi, G. (1998) · Human Reproduction · doi:10.1093/humrep/13.8.2286 · Cited by 46 · see citing works
CAFFEINE AND SPONTANEOUS ABORTION OF KNOWN KARYOTYPE
Kline, J. K., Levin, B. L., Silverman, J., Kinney, A. M., STEIN, Z. A., Susser, M. W., & Warburton, D. (1991) · Epidemiology · doi:10.1097/00001648-199111000-00004 · Cited by 42 · see citing works
Risk Factors for Spontaneous Abortion: A Preliminary Study on Saudi Women
Al‐Ansary, L. A., & Babay, Z. A. (1994) · Journal of the Royal Society of Health · doi:10.1177/146642409411400403 · Cited by 26 · see citing works
Does caffeine consumption during pregnancy increase the risk of fetal mortality? A literature review
Matijasevich, A., Santos, I. S., & Barros, F. C. (2005) · Cadernos de Saúde Pública · doi:10.1590/s0102-311x2005000600014 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557 · see citing works
Wikoff, D. S., Welsh, B. T., Henderson, R. G., Brorby, G. P., Britt, J. K., Myers, E. F., Goldberger, J. J., Lieberman, H. R., O’Brien, C. P., Peck, J. D., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.04.002 · Cited by 451 · see citing works
Glade, M. J. (2010) · Nutrition · doi:10.1016/j.nut.2010.08.004 · Cited by 307 · see citing works
Li, D., LIU, L., & Odouli, R. (2008) · Human Reproduction · doi:10.1093/humrep/den342 · Cited by 283 · see citing works
Self-citationImpact of oxidative stress on female fertility
Ruder, E. H., Hartman, T. J., & Goldman, M. B. (2009) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32832924ba · Cited by 255 · see citing works
Keegan, J. A., Parva, M., Finnegan, M., Gerson, A., & Belden, M. (2010) · Journal of Addictive Diseases · doi:10.1080/10550881003684723 · Cited by 237 · see citing works
The second wave: Toward responsible inclusion of pregnant women in research.
Lyerly, A. D., Little, M. O., & Faden, R. (2008) · PubMed · doi:10.1353/ijf.0.0047 · Cited by 193 · see citing works
Risk factors for miscarriage from a prevention perspective: a nationwide follow-up study
Feodor Nilsson, S., Andersen, P., Strandberg‐Larsen, K., & Nybo Andersen, A. (2014) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12694 · Cited by 192 · see citing works
Alkaloids in the human food chain – Natural occurrence and possible adverse effects
Koleva, I. I., van Beek, T. A., Soffers, A. E. M. F., Dusemund, B., & Rietjens, I. M. C. M. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100165 · Cited by 187 · see citing works
Monteiro, J., Alves, M. G., Oliveira, P. F., & Silva, B. M. (2016) · Molecules · doi:10.3390/molecules21080974 · Cited by 189 · see citing works
The association between psychological stress and miscarriage: A systematic review and meta-analysis
Qu, F., Wu, Y., Zhu, Y.-H., Barry, J., Ding, T., Baio, G., Muscat, R., Todd, B. K., Wang, F.-F., & Hardiman, P. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-01792-3 · Cited by 182 · see citing works
Study, N. B. D. P., Dott, M. M., Rasmussen, S. A., HOGUE, C. J. R., & Reefhuis, J. (2009) · Maternal and Child Health Journal · doi:10.1007/s10995-009-0458-1 · Cited by 169 · see citing works
Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer
van Dam, R. M. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-120 · Cited by 161 · see citing works
Lyerly, A. D., Mitchell, L. M., Armstrong, E. M., Harris, L. H., Kukla, R., Kuppermann, M., & Little, M. O. (2009) · The Hastings Center Report · doi:10.1353/hcr.0.0211 · Cited by 152 · see citing works
Recurrent MiscarriageGreen‐top Guideline No. 17
Regan, L., Rai, R., Saravelos, S., Li, T., & the Royal College of Obstetricians and Gynaecologists (2023) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17515 · Cited by 158 · see citing works
Bakker, R., Steegers, E. A., Obradov, A., Raat, H., Hofman, A., & Jaddoe, V. W. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28792 · Cited by 144 · see citing works
Evidence-based management of recurrent miscarriages
Jeve, Y. B., & Davies, W. (2014) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.142475 · Cited by 147 · see citing works
"Toward a Clearer Definition of Confounding" Revisited With Directed Acyclic Graphs
Howards, P. P., Schisterman, E. F., Poole, C., Kaufman, J. S., & Weinberg, C. R. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws127 · Cited by 143 · see citing works
Evaluation of the reproductive and developmental risks of caffeine
Brent, R. L., Christian, M. S., & Diener, R. M. (2011) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20288 · Cited by 141 · see citing works
Shawe, J., Delbaere, I., Ekstrand, M., Hegaard, H. K., Larsson, M., Mastroiacovo, P., Stern, J., Steegers, E. A. P., Stephenson, J., & Tydén, T. (2014) · The European Journal of Contraception & Reproductive Health Care · doi:10.3109/13625187.2014.990088 · Cited by 141 · see citing works
Pharmacology of caffeine and its effects on the human body
Reddy, V. S., Shiva, S. M., Manikantan, S., & Ramakrishna, S. (2024) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2024.100138 · Cited by 154 · see citing works
Hammiche, F., Laven, J. S. E., Mil, N. H. G., de Cock, M., de Vries, J. H. M., Lindemans, J. W., Steegers, E., & Steegers‐Theunissen, R. P. M. (2011) · Human Reproduction · doi:10.1093/humrep/der225 · Cited by 128 · see citing works
The Medicinal Chemistry of Caffeine
Faudone, G., Arifi, S., & Merk, D. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00261 · Cited by 122 · see citing works
Sadeu, J. C., Hughes, C. L., Agarwal, S. K., & Foster, W. G. (2010) · Critical Reviews in Toxicology · doi:10.3109/10408444.2010.493552 · Cited by 116 · see citing works
Peck, J. D., Leviton, A., & Cowan, L. D. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.06.019 · Cited by 112 · see citing works
A meta-analysis of risk of pregnancy loss and caffeine and coffee consumption during pregnancy
Li, J., Zhao, H., Song, J., Zhang, J., Tang, Y., & Xin, C. (2015) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2015.03.033 · Cited by 102 · see citing works
Chen, L.-W., Wu, Y., Neelakantan, N., Chong, M. F.-F., Pan, A., & van Dam, R. M. (2016) · Public Health Nutrition · doi:10.1017/s1368980015002463 · Cited by 100 · see citing works
Pharmacological potential of methylxanthines: Retrospective analysis and future expectations
Monteiro, J., Alves, M. G., Oliveira, P. F., & Silva, B. M. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1461607 · Cited by 103 · see citing works
Impacts of Caffeine during Pregnancy
Qian, J., Chen, Q., Ward, S. M., Duan, E., & Zhang, Y. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.11.004 · Cited by 99 · see citing works
James, J. E. (2020) · BMJ Evidence-Based Medicine · doi:10.1136/bmjebm-2020-111432 · Cited by 98 · see citing works
Vitamin E as an Antioxidant in Female Reproductive Health
Mutalip, S. S. M., Rahim, S. A., & Rajikin, M. H. (2018) · Antioxidants · doi:10.3390/antiox7020022 · Cited by 91 · see citing works
Doepker, C., Lieberman, H. R., Smith, A. P., Peck, J. D., El-Sohemy, A., & Welsh, B. T. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033243 · Cited by 87 · see citing works
Rivkees, S. A., & Wendler, C. C. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e31820efbcf · Cited by 86 · see citing works
Environmental exposure to endocrine-disrupting chemicals and miscarriage
Krieg, S. A., Shahine, L. K., & Lathi, R. B. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.06.043 · Cited by 84 · see citing works
Louis, G. M. B., Sapra, K. J., Schisterman, E. F., Lynch, C. D.-J., Maisog, J. M., Grantz, K. L., & Sundaram, R. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.03.009 · Cited by 83 · see citing works
Maternal caffeine consumption and risk of neural tube defects
Schmidt, R. J., Romitti, P. A., Burns, T. L., Browne, M. L., Druschel, C. M., & Olney, R. S. (2009) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20624 · Cited by 81 · see citing works
Effects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcomes
Jahanfar, S., & Jaafar, S. H. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006965.pub4 · Cited by 81 · see citing works
Modest maternal caffeine exposure affects developing embryonic cardiovascular function and growth
Momoi, N., Tinney, J. P., Liu, L., Elshershari, H., Hoffmann, P. J., Ralphe, J. C., Keller, B. B., & Tobita, K. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.91469.2007 · Cited by 78 · see citing works
Caffeine intake during pregnancy, late miscarriage and stillbirth
Greenwood, D. C., Alwan, N., Boylan, S., Cade, J. E., Charvill, J., Chipps, K. C., Cooke, M. S., Dolby, V. A., Hay, A. W. M., Kassam, S., et al. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9443-7 · Cited by 74 · see citing works
Caffeine and Clinical Outcomes in Premature Neonates
Kumar, V., & Lipshultz, S. E. (2019) · Children · doi:10.3390/children6110118 · Cited by 72 · see citing works
Fetal exposure to nonsteroidal anti-inflammatory drugs and spontaneous abortions
Daniel, S., Koren, G., Lunenfeld, E., Bilenko, N., Ratzon, R., & Levy, A. (2014) · Canadian Medical Association Journal · doi:10.1503/cmaj.130605 · Cited by 70 · see citing works
Update and New Insights on Future Cancer Drug Candidates From Plant-Based Alkaloids
Tilaoui, M., Mouse, H. A., & Zyad, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.719694 · Cited by 67 · see citing works
Pregnancy‐induced changes in the pharmacokinetics of caffeine and its metabolites
Tian, Y., Campbell, S., Stockmann, C. R., Tak, C. R., Schoen, K., Clark, E., Varner, M. W., Spigarelli, M. G., & Sherwin, C. M. T. (2015) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.632 · Cited by 67 · see citing works
Li, D., Ferber, J. R., & Odouli, R. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.196 · Cited by 62 · see citing works
Self-citationLyngsø, J., Ramlau‐Hansen, C. H., Bay, B., Ingerslev, H. J., Hulmán, Á., & Kesmodel, U. S. (2017) · Clinical Epidemiology · doi:10.2147/clep.s146496 · Cited by 60 · see citing works
Volume and type of alcohol during early pregnancy and the risk of miscarriage
Avalos, L. A., Roberts, S. C., Kaskutas, L. A., Block, G., & Li, D.-K. (2014) · Substance Use & Misuse · doi:10.3109/10826084.2014.912228 · Cited by 59 · see citing works
Self-citationJin, J.-Q., Yao, M.-Z., Ma, C.-L., Ma, J., & Chen, L. (2016) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2015.12.020 · Cited by 58 · see citing works
Buscariollo, D., Fang, X.-F., Greenwood, V., Xue, H.-L., Rivkees, S., & Wendler, C. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087547 · Cited by 57 · see citing works
Hu, S., Xia, L., Luo, H., Xu, Y., Yu, H., Xu, D., & Wang, H. (2019) · Toxicology · doi:10.1016/j.tox.2019.02.008 · Cited by 55 · see citing works
Kuczkowski, K. M. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-0991-6 · Cited by 54 · see citing works
Hongyacha, a Naturally Caffeine-Free Tea Plant from Fujian, China
Jin, J.-Q., Chai, Y., Liu, Y., Zhang, J., Yao, M.-Z., & Chen, L. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03433 · Cited by 54 · see citing works
Épidémiologie des pertes de grossesse
Delabaere, A., Huchon, C., Deffieux, X., Beucher, G., Gallot, V., Nedellec, S., Vialard, F., Carcopino, X., Quibel, T., Subtil, D., et al. (2014) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2014.09.011 · Cited by 54 · see citing works
Maternal caffeine consumption and sine causa recurrent miscarriage
Stefanidou, E., Caramellino, L., Patriarca, A., & Menato, G. (2011) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2011.04.024 · Cited by 52 · see citing works
Intrauterine exposure to caffeine and inattention/overactivity in children
Bekkhus, M., Skjøthaug, T., Nordhagen, R., & BORGE, A. I. H. (2010) · Acta Paediatrica · doi:10.1111/j.1651-2227.2010.01744.x · Cited by 47 · see citing works
Maternal caffeine intake and its effect on pregnancy outcomes
Jarosz, M. J., Wierzejska, R. E., & Siuba, M. (2011) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2011.11.021 · Cited by 47 · see citing works
Signs and Symptoms of Early Pregnancy Loss: A Systematic Review
Sapra, K. J., Joseph, K. S., Galea, S., Bates, L. M., Louis, G. M. B., & Ananth, C. V. (2016) · Reproductive Sciences · doi:10.1177/1933719116654994 · Cited by 46 · see citing works
Risk factors for early miscarriage among Chinese: a hospital-based case-control study
Xu, G., Wu, Y., Yang, L., Lü, Y., Guo, H., Zhang, F., Guan, Y., & Wu, Y. Y. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.02.013 · Cited by 45 · see citing works
Office management of early pregnancy loss.
Prine, L. W., & MacNaughton, H. (2011) · PubMed · Cited by 45 · see citing works
Porciúncula, L. O., Sallaberry, C., Mioranzza, S., Botton, P. H. S., & Rosemberg, D. B. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.09.009 · Cited by 42 · see citing works
Sasaki, S., Limpar, M., Sata, F., Kobayashi, S., & Kishi, R. (2017) · Pediatric Research · doi:10.1038/pr.2017.70 · Cited by 43 · see citing works
van der Hoeven, T., Browne, J. L., Uiterwaal, C. S. P. M., van der Ent, C. K., Grobbee, D. E., & Dalmeijer, G. W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177619 · Cited by 43 · see citing works
Association of prenatal exposure to acetaminophen and coffee with childhood asthma
Liu, X., Liew, Z., Olsen, J., Pedersen, L. H., Bech, B. H., Agerbo, E., Yuan, W., & Li, J. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3940 · Cited by 41 · see citing works
Caffeine and caffeinated beverage consumption and risk of spontaneous abortion
Hahn, K. A., Wise, L. A., Rothman, K. J., Mikkelsen, E. M., Brogly, S. B., Sørensen, H. T., Riis, A. H., & Hatch, E. E. (2015) · Human Reproduction · doi:10.1093/humrep/dev063 · Cited by 41 · see citing works
Bidel, S., & Tuomilehto, J. O. (2010) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2013.09.02.99 · Cited by 41 · see citing works
Embryonic caffeine exposure induces adverse effects in adulthood
Wendler, C. C., Busovsky-McNeal, M., Ghatpande, S. K., Kalinowski, A., Russell, K. S., & Rivkees, S. A. (2008) · The FASEB Journal · doi:10.1096/fj.08-124941 · Cited by 39 · see citing works
[Caffeine--common ingredient in a diet and its influence on human health].
Wierzejska, R. E. (2012) · PubMed · Cited by 39 · see citing works
Association mapping of caffeine content with TCS1 in tea plant and its related species
Jin, J.-Q., Yao, M.-Z., Ma, C.-L., Ma, J., & Chen, L. (2016) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2016.04.032 · Cited by 38 · see citing works
Hu, S., Liu, K., Luo, H., Xu, D., Chen, L., Zhang, L., & Wang, H. (2019) · Toxicology · doi:10.1016/j.tox.2019.02.015 · Cited by 38 · see citing works
Lorenzo, A., León, D., Castillo, C. A., Ruiz, M. A., Albasanz, J. L., & Martı́n, M. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22287 · Cited by 35 · see citing works
Caffeine consumption and miscarriage: a prospective cohort study
Pollack, A. Z., Louis, G. M. B., Sundaram, R., & Lum, K. J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.07.992 · Cited by 35 · see citing works
Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Caffeine Disposition in Pregnancy
Darakjian, L. I., & Kaddoumi, A. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01276 · Cited by 34 · see citing works
He, Z., Zhu, C., Huang, H., Liu, L., Wang, L., Chen, L., Magdalou, J., & Wang, H. (2016) · Toxicology Research · doi:10.1039/c5tx00265f · Cited by 33 · see citing works
Pereira‐Figueiredo, D., Nascimento, A., Cunha-Rodrigues, M. C., Brito, R., & Calaza, K. D. C. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01077-4 · Cited by 33 · see citing works
Lv, F., Fan, G., Wan, Y., Chen, Y., Ni, Y., Huang, J., Xu, D., Zhang, W., & Wang, H. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147691 · Cited by 32 · see citing works
Long-term consequences of disrupting adenosine signaling during embryonic development
Rivkees, S. A., & Wendler, C. C. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.02.001 · Cited by 31 · see citing works
Caffeine in Food and Dietary Supplements: Examining Safety
Institute of Medicine (2014) · National Academies Press eBooks · doi:10.17226/18607 · Cited by 32 · see citing works
Bakker, R., Steegers, E. A. P., Raat, H., Albert Hofman, D., & Jaddoe, V. W. V. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.242 · Cited by 30 · see citing works
Kouk, L., Neo, G. H., Malhotra, R., Allen, J. C., Beh, S. M., Tan, T., & Østbye, T. (2013) · Singapore Medical Journal · doi:10.11622/smedj.2013148 · Cited by 29 · see citing works
The allegheny general modification of the Harvard Breast Cosmesis Scale for the retreated breast.
Trombetta, M. G., Julian, T. B., Kim, Y., Werts, E. D., & Parda, D. S. (2009) · PubMed · Cited by 29 · see citing works
He, Z., Zhang, J., Huang, H., Yuan, C., Zhu, C., Magdalou, J., & Wang, H. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.12.001 · Cited by 28 · see citing works
Caffeine exposure alters cardiac gene expression in embryonic cardiomyocytes
Fang, X., Mei, W., Barbazuk, W. B., Rivkees, S. A., & Wendler, C. C. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00307.2014 · Cited by 27 · see citing works
Shangguan, Y., Wen, Y., Tan, Y., Qin, J., Jiang, H., Magdalou, J., Chen, L., & Wang, H. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.08.008 · Cited by 27 · see citing works
Caffeinated Beverages—Unveiling Their Impact on Human Health
Čižmárová, B., Kraus, V., & Birková, A. (2025) · Beverages · doi:10.3390/beverages11010018 · Cited by 32 · see citing works
Howards, P. P., Hertz‐Picciotto, I., Bech, B. H., Nohr, E. A., Andersen, A. N., Poole, C., & Olsen, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050372 · Cited by 26 · see citing works
Lipid-Lowering Nutraceuticals for an Integrative Approach to Dyslipidemia
Cheung, B., Sikand, G., Dineen, E. H., Malik, S., & El-Farra, A. B. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12103414 · Cited by 25 · see citing works
Foetal response to maternal coffee intake: role of habitual versus non-habitual caffeine consumption
Mulder, E. J. H., Tegaldo, L., Bruschettini, P., & Visser, G. H. A. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109106310 · Cited by 25 · see citing works
Qian, J., Zhang, Y., Qu, Y., Zhang, L., Shi, J., Zhang, X., Liu, S., Kim, B. H., Hwang, S. J., Zhou, T., et al. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy155 · Cited by 25 · see citing works
Jafari, A., Naghshi, S., Shahinfar, H., Salehi, S. O., Kiany, F., Askari, M., Surkan, P. J., & Azadbakht, L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.886224 · Cited by 24 · see citing works
Boer, K., Steegers‐Theunissen, R. P. M., & Steegers, E. A. P. (2008) · Reproductive medicine and assisted reproductive techniques series · doi:10.3109/9780203092200.003 · Cited by 23 · see citing works
Anderson, B. L., Juliano, L. M., & Schulkin, J. A. (2009) · Journal of Women s Health · doi:10.1089/jwh.2008.1186 · Cited by 23 · see citing works
Association between periodontitis and spontaneous abortion: A case‐control study
Chanomethaporn, A., Chayasadom, A., Wara‐aswapati, N., Kongwattanakul, K., Suwannarong, W., Tangwanichgapong, K., Sumanonta, G., Matangkasombut, O., Dasanayake, A. P., & Pitiphat, W. (2018) · Journal of Periodontology · doi:10.1002/jper.18-0174 · Cited by 24 · see citing works
Monji, F., Siddiquee, A. A.-M., & Hashemian, F. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173561 · Cited by 21 · see citing works
Caffeine Acts via A1 Adenosine Receptors to Disrupt Embryonic Cardiac Function
Buscariollo, D. L., Breuer, G. A., Wendler, C. C., & Rivkees, S. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028296 · Cited by 22 · see citing works
Regulation of Cardiovascular Development by Adenosine and Adenosine-Mediated Embryo Protection
Rivkees, S. A., & Wendler, C. C. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.226811 · Cited by 21 · see citing works
Zhu, Y., Chen, H., Zhao, X., Li, B., He, H., Cheng, H., Wang, H., & Ao, Y. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.07.011 · Cited by 20 · see citing works
Bender-Atik, R., Hepworth‐Jones, B. E., & Doyle, P. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777851.003 · Cited by 19 · see citing works
Guideline No. 464: Recurrent Pregnancy Loss
Motan, T., Cockwell, H., Elliott, J., Antaki, R., & White, J. S. (2025) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2025.103167 · Cited by 17 · see citing works
Surma, S., & Witek, A. (2022) · Ginekologia Polska · doi:10.5603/gp.a2022.0061 · Cited by 17 · see citing works
Fausses couches précoces « à répétition » : bilan et prise en charge
Gallot, V., Nedellec, S., Capmas, P., Legendre, G., Lejeune, V., Subtil, D., Nizard, J., Lévêque, J., Deffieux, X., Herve, B., et al. (2014) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2014.09.014 · Cited by 16 · see citing works
Chang, Y.-F., Liu, T., & Liu, S.-T. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.079 · Cited by 17 · see citing works
- Authors
- Weng, X., Odouli, R., & Li, D.-K.
- Affiliations
- Kaiser Permanente (US)
- Corresponding author
- Li, De-Kun
- ORCID
- Li, De-Kun
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 198
- Issue
- 3
- Pages
- 279.e1-279.e8
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1973666876
- Cited by
- 279
- References
- 24
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 14 · 2023: 10 · 2022: 5 · 2021: 11 · 2020: 11 · 2019: 35 · 2018: 13 · 2017: 17 · 2016: 16 · 2015: 20 · 2014: 19 · 2013: 10 · 2012: 15
- FWCI
- 16.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kaiser Permanente
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- caffeine consumption, pregnancy, miscarriage, nausea and vomiting of pregnancy, history of miscarriage, maternal diet
- MeSH terms
- Abortion, Spontaneous, Adult, Beverages, Caffeine, Female, Humans, Pregnancy, Prospective Studies, Risk Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review