Therapeutic Effects and Mechanisms of Herbal Medicines for Treating Polycystic Ovary Syndrome: A Review

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome

(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050 · see citing works

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605 · see citing works

Autophagy: Renovation of Cells and Tissues

Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,467 · see citing works

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214 · see citing works

The Nerve Growth Factor 35 Years Later

Levi‐Montalcini, R. (1987) · Science · doi:10.1126/science.3306916 · Cited by 3,109 · see citing works

Men at risk: occupation and male infertility.

Claman, P. (2004) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01188-9 · Cited by 2,219 · see citing works

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0178 · Cited by 2,143 · see citing works

Role of oxidative stress in female reproduction

Agarwal, A., Gupta, S., & Sharma, R. K. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-28 · Cited by 1,729 · see citing works

Role of reactive oxygen species in the pathophysiology of human reproduction.

Agarwal, A., Saleh, R., & Bedaiwy, M. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04948-8 · Cited by 1,578 · see citing works

Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome

Legro, R. S., Barnhart, H. X., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., McGovern, P. G., Cataldo, N. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063971 · Cited by 1,027 · see citing works

p53 and metabolism

Vousden, K. H., & Ryan, K. M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2715 · Cited by 959 · see citing works

Follicular Growth and Atresia in Mammalian Ovaries: Regulation by Survival and Death of Granulosa Cells

Matsuda, F., Inoue, N., MANABE, N., & Ohkura, S. (2012) · Journal of Reproduction and Development · doi:10.1262/jrd.2011-012 · Cited by 864 · see citing works

The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

Feng, Z., Hu, W., de Stanchina, E., Teresky, A. K., Jin, S., Lowe, S., & Levine, A. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4149 · Cited by 633 · see citing works

Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment

DeUgarte, C. M., Bartolucci, A. A., & Azziz, R. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.11.070 · Cited by 589 · see citing works

Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis

Escobar-Morreale, H. F., Luque‐Ramírez, M., & González, F. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.11.036 · Cited by 522 · see citing works

Macrophage contributions to ovarian function

Wu, R. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh011 · Cited by 387 · see citing works

Redox Considerations in Female Reproductive Function and Assisted Reproduction: From Molecular Mechanisms to Health Implications

Agarwal, A. K., Gupta, S., Sekhon, L. H., & Shah, R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1964 · Cited by 360 · see citing works

Oxidative stress and antioxidants: exposure and impact on female fertility

Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn011 · Cited by 351 · see citing works

Is PCOS an inflammatory process?

Duleba, A. J., & Dokras, A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.11.023 · Cited by 327 · see citing works

Roles of oxidative stress in polycystic ovary syndrome and cancers

Zuo, T., Zhu, M., & Xu, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8589318 · Cited by 319 · see citing works

Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS)

Barrea, L., Arnone, A., Annunziata, G., Muscogiuri, G., Laudisio, D., Salzano, C., Pugliese, G., Colao, A., & Savastano, S. (2019) · Nutrients · doi:10.3390/nu11102278 · Cited by 306 · see citing works

Impact of oxidative stress on female fertility

Ruder, E. H., Hartman, T. J., & Goldman, M. B. (2009) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32832924ba · Cited by 255 · see citing works

Molecules and their functions in autophagy

Pyo, J.-O., Nah, J., & Jung, Y. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.2.029 · Cited by 252 · see citing works

New Approach to Polycystic Ovary Syndrome and Other Forms of Anovulatory Infertility

Laven, J. S. E., Imani, B., Eijkemans, M. J. C., & Fauser, B. C. J. M. (2002) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200211000-00022 · Cited by 235 · see citing works

Sonographic determination of a possible adverse effect of clomiphene citrate on endometrial growth

Gonen, Y., & Casper, R. F. (1990) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137165 · Cited by 193 · see citing works

The role of autophagy in follicular development and atresia in rat granulosa cells

Choi, J. Y., Jo, M., Lee, E. Y., Yoon, B.-K., & Choi, D. S. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.11.021 · Cited by 183 · see citing works

An Increased Intraovarian Synthesis of Nerve Growth Factor and Its Low Affinity Receptor Is a Principal Component of Steroid-Induced Polycystic Ovary in the Rat

Lara, H. E., Dissen, G. A., Leyton, V., Paredes, A., Fuenzalida, H., Fiedler, J. L., & Ojeda, S. R. (2000) · Endocrinology · doi:10.1210/endo.141.3.7395 · Cited by 182 · see citing works

Activation of ovarian sympathetic nerves in polycystic ovary syndrome

Lara, H. E., Ferruz, J. L., Luza, S., Bustamante, D. A., Borges, Y., & Ojeda, S. R. (1993) · Endocrinology · doi:10.1210/endo.133.6.7902268 · Cited by 182 · see citing works

Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles

Amato, G. (2003) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(03)00233-3 · Cited by 171 · see citing works

Obesity, depression, and chronic low-grade inflammation in women with polycystic ovary syndrome

Benson, S., Janssen, O. E., Hahn, S., Tan, S., Dietz, T., Mann, K., Pleger, K., Schedlowski, M., Arck, P., & Elsenbruch, S. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.07.003 · Cited by 156 · see citing works

Up-Regulated Expression of WNT5a Increases Inflammation and Oxidative Stress via PI3K/AKT/NF-κB Signaling in the Granulosa Cells of PCOS Patients

Zhao, Y., Zhang, C., Huang, Y., Yu, Y., Li, R., Li, M., Liu, N., Liu, P., & Qiao, J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2419 · Cited by 154 · see citing works

A role for trkA nerve growth factor receptors in mammalian ovulation

Dissen, G. A., Hill, D. F., da Costa, M. E. L. T., Dees, C., Lara, H. E., & Ojeda, S. R. (1996) · Endocrinology · doi:10.1210/en.137.1.198 · Cited by 152 · see citing works

AKT is involved in granulosa cell autophagy regulation via mTOR signaling during rat follicular development and atresia

Choi, J., Jo, M., Lee, E., & Choi, D. (2013) · Reproduction · doi:10.1530/rep-13-0386 · Cited by 134 · see citing works

Quercetin Decreases Insulin Resistance in a Polycystic Ovary Syndrome Rat Model by Improving Inflammatory Microenvironment

Wang, Z., Zhai, D., Zhang, D., Bai, L., Yao, R., Yu, J., Cheng, W., & Yu, C. (2016) · Reproductive Sciences · doi:10.1177/1933719116667218 · Cited by 133 · see citing works

The role of p53 in cell metabolism

Zhang, X., Qin, Z.-H., & Wang, J. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.151 · Cited by 128 · see citing works

Oestrogen receptor α and β, androgen receptor and progesterone receptor mRNA and protein localisation within the developing ovary and in small growing follicles of sheep

Juengel, J. L., Heath, D. A., Quirke, L. D., & McNatty, K. P. (2005) · Reproduction · doi:10.1530/rep.1.00704 · Cited by 125 · see citing works

Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model

Nampoothiri, L. P., Maharjan, R., & Nagar, P. (2010) · Journal of Ayurveda and Integrative Medicine · doi:10.4103/0975-9476.74090 · Cited by 119 · see citing works

The mechanisms involved in the action of metformin in regulating ovarian function in hyperandrogenized mice

Elia, E. M. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal057 · Cited by 103 · see citing works

Role of Oxidative Stress in Polycystic Ovary Syndrome

Lee, J. Y., Baw, C., Gupta, S., Aziz, N., & Agarwal, A. K. (2010) · Current Women s Health Reviews · doi:10.2174/157340410791321336 · Cited by 99 · see citing works

The effects of metformin and rosiglitazone, alone and in combination, on the ovary and endometrium in polycystic ovary syndrome

Legro, R. S., Zaino, R. J., Demers, L. M., Kunselman, A. R., Gnatuk, C. L., Williams, N. I., & Dodson, W. C. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.12.025 · Cited by 98 · see citing works

Small Molecule Inhibitors of NF-κB and JAK/STAT Signal Transduction Pathways as Promising Anti-Inflammatory Therapeutics

Ivanenkov, Y. A., Balakin, K. V., & Lavrovsky, Y. (2010) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955711793564079 · Cited by 97 · see citing works

Linkage of regulators of TGF‐β activity in the fetal ovary to polycystic ovary syndrome

Hatzirodos, N., Bayne, R. A. L., Irving‐Rodgers, H. F., Hummitzsch, K., Sabatier, L., Lee, S. S., Bonner, W. M., Gibson, M. A., Rainey, W. E., Carr, B. R., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-181099 · Cited by 90 · see citing works

Steroid-induced polycystic ovaries in rats: effect of electro-acupuncture on concentrations of endothelin-1 and nerve growth factor (NGF), and expression of NGF mRNA in the ovaries, the adrenal glands, and the central nervous system

Stener‐Victorin, E., Lundeberg, T., Cajander, S. B., Aloe, L., Manni, L., Waldenström, U., & Janson, P. O. (2003) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-1-33 · Cited by 82 · see citing works

Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway

Zhao, H., Zhou, D., Chen, Y., Liu, D., Chu, S., & Zhang, S. (2017) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/s40199-017-0188-7 · Cited by 78 · see citing works

Plasma monocyte chemoattractant protein‐1 (MCP‐1) and macrophage inflammatory protein‐1α are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment

Glintborg, D., Andersen, M., Richelsen, B., & Bruun, J. M. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03523.x · Cited by 78 · see citing works

Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model

Nampoothiri, L. P., Desai, B., & Maharjan, R. (2012) · Pharmacognosy Research · doi:10.4103/0974-8490.94736 · Cited by 67 · see citing works

Oriental Medicine Kyung-Ok-Ko Prevents and Alleviates Dehydroepiandrosterone-Induced Polycystic Ovarian Syndrome in Rats

Jang, M., Lee, M. J., Lee, J., Bae, C., Kim, S., Ryu, J. H., & Cho, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087623 · Cited by 66 · see citing works

Molecular mechanisms of a novel selenium-based complementary medicine which confers protection against hyperandrogenism-induced polycystic ovary

Rezvanfar, M. A., Rezvanfar, M. A., Ahmadi, A., Saadi, H. A. S., Baeeri, M., & Abdollahi, M. R. (2012) · Theriogenology · doi:10.1016/j.theriogenology.2012.03.008 · Cited by 62 · see citing works

Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome.

Farideh, Z. Z., Bagher, M., Amirzargar, A., Akram, A., & Kazem, M. (2010) · Europe PMC (PubMed Central) · Cited by 56 · see citing works

Serum paraoxonase 1 activity and oxidant/antioxidant status in Saudi women with polycystic ovary syndrome

Mohamadin, A. M., Habib, F., & Elahi, T. F. (2009) · Pathophysiology · doi:10.1016/j.pathophys.2009.11.004 · Cited by 54 · see citing works

Beneficial metabolic effects of the Malaysian herb Labisia pumila var. alata in a rat model of polycystic ovary syndrome

Mannerås, L., Fazliana, M., Nazaimoon, W. M. W., Lönn, M., Gu, H. F., Östenson, C., & Stener‐Victorin, E. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.10.032 · Cited by 54 · see citing works

Polycystic Ovarian Syndrome and the Metabolic Syndrome

Sartor, B. M., & Dickey, R. P. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200512000-00012 · Cited by 51 · see citing works

Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model.

Jelodar, G., Masoomi, S., & Rahmanifar, F. (2018) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2018.25778.6349 · Cited by 50 · see citing works

Effect of the aqueous extract of Foeniculum vulgare (fennel) on the kidney in experimental PCOS female rats.

Sadrefozalayi, S., & Farokhi, F. (2014) · Europe PMC (PubMed Central) · Cited by 49 · see citing works

On the Relation of Oxidative Stress in Delivery Mode in Pregnant Women; A Toxicological Concern

Vakiliyan, K., Ranjbar, A., Zarganjfard, A., Mortazavi, M., Vosough-Ghanbari, S., Mashaiee, S., & Abdollahi, M. R. (2008) · Toxicology Mechanisms and Methods · doi:10.1080/15376510802232134 · Cited by 47 · see citing works

Peripheral catecholamine alterations in adolescents with polycystic ovary syndrome

Garcia‐Rudaz, C., Armando, I., Levin, G. M., Escobar, M. E., & Barontini, M. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00511.x · Cited by 46 · see citing works

Xiao-Yao-San, a Chinese Medicine Formula, Ameliorates Chronic Unpredictable Mild Stress Induced Polycystic Ovary in Rat

Sun, H., Li, Q., Liu, Y., Wei, X., Pan, C., Fan, J., & Han, J. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00729 · Cited by 41 · see citing works

Cryptotanshinone Reverses Reproductive and Metabolic Disturbances in PCOS Model Rats via Regulating the Expression of CYP17 and AR

Yu, J., Zhai, D., Li, H., Zhang, D., Bai, L., Cai, Z., & Yu, C. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/670743 · Cited by 41 · see citing works

Comparison of the effects of Ginger extract with clomiphene citrate on sex hormones in rats with polycystic ovarian syndrome

Atashpour, S., Jahromi, H. K., Jahromi, Z. K., & Maleknasab, M. (2017) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.29252/ijrm.15.9.561 · Cited by 40 · see citing works

Deregulation of tissue homeostasis in endometria from patients with polycystic ovarian syndrome with and without endometrial hyperplasia

Villavicencio, A. N. P., Bacallao, K., Gabler, F., Fuentes, A., Albornoz, J. I. J., Casals, A., & Vega, M. (2006) · Gynecologic Oncology · doi:10.1016/j.ygyno.2006.09.003 · Cited by 37 · see citing works

Modulation of translation and induction of autophagy by bacterial exoproducts

von Hoven, G., Kloft, N., Neukirch, C., Ebinger, S., Bobkiewicz, W., Weis, S., Böller, K., Janda, K. D., & Husmann, M. (2012) · Medical Microbiology and Immunology · doi:10.1007/s00430-012-0271-0 · Cited by 36 · see citing works

GC-MS analysis of Cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female Wistar rats

Soumya, V., Muzib, Y. I., Venkatesh, P., & Hariprasath, K. (2014) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(14)60103-5 · Cited by 35 · see citing works

Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries

Pak, S. C., Lim, S., Nah, S.-Y., Lee, J., Hill, J. A., & Bae, C. S. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.042 · Cited by 31 · see citing works

Cryptotanshinone reverses reproductive and metabolic disturbances in prenatally androgenized rats via regulation of ovarian signaling mechanisms and androgen synthesis

Yang, X., Zhang, Y., Wu, X., Bae, C. S., Hou, L., Kuang, H., Wang, Y., & Stener‐Victorin, E. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00334.2010 · Cited by 29 · see citing works

[Adrenergic innervation of ovaries in Stein-Leventhal syndrome].

Семенова (1969) · PubMed · Cited by 29 · see citing works

Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome

Zuo, T., Zhu, M., Xu, W., Wang, Z., & Song, H. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484074 · Cited by 28 · see citing works

The effects of metformin on uterine tissue of hyperandrogenized BALB/c mice

Elia, E. M., Belgorosky, D., Faut, M., Vighi, S., Pustovrh, M. C., Luigi, D., & Motta, A. B. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap033 · Cited by 25 · see citing works

Insulin resistance and the polycystic ovary syndrome: recent advances

Nestler, J. E. (2000) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200012000-00009 · Cited by 24 · see citing works

Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome

Xing, Y., Liu, Y., Liu, X., Wang, S.-L., Li, P., Lin, X.-H., Sui, C., Xu, C., Qi, B., & Tong, Q. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4384 · Cited by 24 · see citing works

The Effect of Herbal Medicine on Nerve Growth Factor in Estradiol Valerate-induced Polycystic Ovaries in Rats

Lee, J. C., Pak, S. C., Lee, S. H., Lim, S., Bai, Y. H., Jin, C. S., Kim, J. S., Na, C. S., Bae, C. S., Oh, K. S., et al. (2003) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x03001636 · Cited by 23 · see citing works

Therapeutic Effect of Korean Red Ginseng Extract on Infertility Caused by Polycystic Ovaries

Jung, J.-H., Park, H., Kim, T., Jeong, M.-J., Lim, S., Nah, S.-Y., Cho, I., Park, S., Kang, S.-S., Moon, C., et al. (2011) · Journal of Ginseng Research · doi:10.5142/jgr.2011.35.2.250 · Cited by 20 · see citing works

Cryptotanshinone reverses reproductive disturbances in rats with dehydroepiandrosterone-induced polycystic ovary syndrome.

Xia, Y., Zhao, P., Huang, H., Xie, Y., Lü, R., & Dong, L. (2017) · Europe PMC (PubMed Central) · Cited by 19 · see citing works

Effects of Oriental Medicine Kyung-Ok-Ko on Uterine Abnormality in Hyperandrogenized Rats

Lee, M. J., Jang, M., Bae, C., Park, K. S., Kim, H., Lee, S., Lee, S. W., Kim, Y. O., & Cho, I. (2016) · Rejuvenation Research · doi:10.1089/rej.2015.1787 · Cited by 15 · see citing works

Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model

Pak, S. C., Kim, S.-E., Oh, D.-M., Shim, K. M., Jeong, M. J., Lim, S., Nah, S. Y., Park, S. H., Kang, S. S., Moon, C., et al. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-1306-y · Cited by 13 · see citing works

An Atractylodes macrocephala Koidz extract alleviates hyperandrogenism of polycystic ovarian syndrome

Zhou, J., Barry, J. A., Jx, P., Wang, F.-F., Fu, Z.-Z., Hardiman, P. J., Duez, P., & Qu, F. (2016) · ORBi UMONS · Cited by 9 · see citing works

CHINESE HERBAL MEDICINE ALLEVIATING HYPERANDROGENISM OF PCOS RATS THROUGH REGULATING PPARG1 AND HDAC3 EXPRESSION IN THE OVARIES

Gu, Y., Ff, W., Dx, Y., Zhou, J., Ye, Y.-H., Zhu, Y.-H., Jiang, D., & Qu, F. (2015) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.21010/ajtcam.v12i2.2 · Cited by 5 · see citing works

Effects of Bushen Tongmai Recipe (补肾通脉方) on protein kinase Bα expression in polycystic ovary rats with insulin resistance

Li, Q., Huang, D., Lu, F., Xie, Y., Xu, L., Zou, X., Gong, D., & Wang, Z.-S. (2010) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-010-0515-z · Cited by 4 · see citing works

HemoHIM Improves Ovarian Morphology and Decreases Expression of Nerve Growth Factor in Rats with Steroid-Induced Polycystic Ovaries

Kim, S. H., Lee, H. J., Kim, J., Moon, C., Kim, J. C., Bae, C. S., Park, H. R., Jung, U., & Jo, S. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.1323 · Cited by 3 · see citing works

Potential Health Benefits of Curcumin on Female Reproductive Disorders: A Review

Kamal, D. A. M., Salamt, N., Yusuf, A. N. M., Kashim, M. I. A. M., & Mokhtar, M. H. (2021) · Nutrients · doi:10.3390/nu13093126 · Cited by 88 · see citing works

β-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota

Yu, Y., Cao, Y., Huang, W., Liu, Y., Lü, Y., & Zhao, J. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.667130 · Cited by 71 · see citing works

Herbs as a Source for the Treatment of Polycystic Ovarian Syndrome: A Systematic Review

Lakshmi, J. T., Babu, A. N., Kiran, S. S. M., Nori, L. P., Hassan, N. A. G. M., Ashames, A., Bhandare, R. R., & SHAIK, A. B. (2023) · BioTech · doi:10.3390/biotech12010004 · Cited by 65 · see citing works

Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome (PCOS) and Other Oxidative Stress-Related Disorders

Novakovic, S., Jakovljevic, V. L., Jović, N., Andrić, K., Milinković, M., Anicic, T., Pindović, B., Kareva, E. N., Фисенко, В. П., Dimitrijević, A., et al. (2024) · Antioxidants · doi:10.3390/antiox13040392 · Cited by 34 · see citing works

Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia

Rani, R., Chitme, H. R., Kukreti, N., Pant, P., Abdel‐Wahab, B. A., Khateeb, M. M., Habeeb, M. S., & Bakir, M. B. (2023) · Nutrients · doi:10.3390/nu15102238 · Cited by 27 · see citing works

Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management

Muhammed Saeed, A. A., Noreen, S., Awlqadr, F. H., Farooq, M. I., Qadeer, M., Rai, N., Farag, H. A., & Saeed, M. N. (2025) · Journal of Health, Population and Nutrition · doi:10.1186/s41043-025-00899-y · Cited by 29 · see citing works

Effect of berberine combined with metformin on autophagy in polycystic ovary syndrome by regulating AMPK/AKT/mTOR pathway

Jin, R., Chen, A., Ye, Y., Ren, Y., Lu, J., Xuan, F., & Zhou, W. (2024) · Molecular Reproduction and Development · doi:10.1002/mrd.23768 · Cited by 22 · see citing works

Incredible Combination of Lifestyle Modification and Herbal Remedies for Polycystic Ovarian Syndrome Management

Balkrishna, A., Rana, M., Mishra, S., Srivastava, D., Bhardwaj, R., Singh, S., Rajput, S. K., & Arya, V. (2023) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2023/3705508 · Cited by 21 · see citing works

Curcumin and its formulations for the treatment of polycystic ovary syndrome: current insights and future prospects

Mallya, P., & Lewis, S. A. (2025) · Journal of Ovarian Research · doi:10.1186/s13048-025-01660-z · Cited by 19 · see citing works

Therapeutic potential of natural compounds in targeting cancer stem cells: a promising approach for cancer treatment

Debnath, I., & Kundu, M. (2025) · Discover Oncology · doi:10.1007/s12672-025-03190-y · Cited by 19 · see citing works

Irpex lacteus polysaccharide exhibits therapeutic potential for ovarian fibrosis in PCOS rats via the TGF-β1/smad pathway

Zhou, Y., Wu, Y., Chong, C., Zhong, S.-M., Wang, Z., Qin, X., Liu, Z., Liu, J.-Y., & Song, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18741 · Cited by 19 · see citing works

An Exploration of Herbal Extracts Loaded Phyto-phospholipid Complexes (Phytosomes) Against Polycystic Ovarian Syndrome: Formulation Considerations

Tiwari, G., Tıwarı, R., Sharma, S. K., & Ramachandran, V. (2022) · Pharmaceutical Nanotechnology · doi:10.2174/2211738510666220919125434 · Cited by 14 · see citing works

Efficacy of a Proprietary Fenugreek Seed Extract ( Trigonella foenum-graecum , Furocyst®) in Women with Polycystic Ovary Syndrome (PCOS): a Randomized, Double-Blind, Placebo-Controlled Study

Singh, A., Gainder, S., Banerjee, P., Goel, A., Kumar, P., Mondal, B., Banik, S. P., & Bagchi, D. (2022) · Journal of the American Nutrition Association · doi:10.1080/27697061.2022.2126410 · Cited by 14 · see citing works

Inhibition of 8-oxoguanine DNA glycosylase (OGG1) expression suppresses polycystic ovarian syndrome via the NF-κB signaling pathway

Xia, J., Wu, S., Wu, G., & Yang, J. (2022) · Reproductive Biology · doi:10.1016/j.repbio.2022.100679 · Cited by 13 · see citing works

Nuciferine protects hyperandrogen‐injured ovarian granulosa cells by inhibiting ferroptosis via SOX2‐mediated activation of the SLC7A11/GPX4 axis

Yang, H., Chen, S., Yin, S., & Ding, Q. (2024) · Journal of Applied Toxicology · doi:10.1002/jat.4697 · Cited by 11 · see citing works

Erchen Decoction ameliorates the rat model of polycystic ovary syndrome by regulating the steroid biosynthesis pathway

Zhang, J., Huang, H., Xiao, M., Jiang, X., Yang, Y., Huang, M., Wang, S., Zhu, B., & Zhao, M. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156852 · Cited by 11 · see citing works

Gut microbiota dysbiosis in polycystic ovary syndrome: focus on diet, probiotics, and traditional Chinese medicine

Zhu, S., Chen, H., He, B., Zhang, Y., Li, P., & Kuang, J. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1659783 · Cited by 10 · see citing works

Comparative advantage and efficacy of natural products for polycystic ovary syndrome

Lee, J.-S., An, S., Kim, Y. W., Choi, L. Y., Kim, D. Y., & Kim, M. H. (2025) · Journal of Ovarian Research · doi:10.1186/s13048-025-01756-6 · Cited by 10 · see citing works

Pharmacological Appraisal of Phyllanthus emblica in Letrozole‐Induced Polycystic Ovarian Syndrome Female Rats Model

Jiang-yu, H., Manzoor, M., Siddique, R., Manzoor, H., Moazzam, S., Bazmi, R. R., & Hussain, L. (2025) · Journal of Food Biochemistry · doi:10.1155/jfbc/8015756 · Cited by 6 · see citing works

Phytotherapy in Polycystic Ovary Syndrome (PCOS) Management: A Systematic Review

Mohamed, S. S., Allam, A. T., Elalfy, A., El‐Shiekh, R. A., Reda, A. M., & Hafeez, M. S. A. E. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500982 · Cited by 6 · see citing works

The effects of flaxseed or its oil supplementations on polycystic ovary syndrome: A systematic review of clinical trials

Emamat, H., Boushehri, S. N., Eslami, M. A., Totmaj, A. S., & Ghalandari, H. (2022) · Phytotherapy Research · doi:10.1002/ptr.7698 · Cited by 5 · see citing works

The Therapeutic Impact of Garlic (Allium Sativum) on Oxidative Stress Markers among Polycystic Ovary Syndrome Patients: A Randomized, Double-Blinded Clinical Trial

Zadhoush, R., Naeini, A. A., Feizi, A., Naghshineh, E., & Ghazvini, M. A. (2023) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_229_21 · Cited by 5 · see citing works

Protective Effect of Marjoram Against Letrozole-Induced Ovarian Damage in Rats with Polycystic Ovarian Syndrome Entails Activation of Nrf2 and Suppression of NF-κB

Al‐Harbi, L. N., AlSedairy, S. A., Alshammari, G. M., Binobead, M. A., & Arzoo, S. (2025) · Pharmaceuticals · doi:10.3390/ph18091291 · Cited by 4 · see citing works

Nanoparticles for Polycystic Ovary Syndrome (PCOS) Therapy: Exosomes and Synthetic Nanoparticles, Challenges and Opportunities

Momen-Mesgin, R., Nejati, V., Talatapeh, S. P., Imani, Z., & Rezaie, J. (2025) · Cell Biochemistry and Function · doi:10.1002/cbf.70114 · Cited by 3 · see citing works

Flavonoids and polycystic ovary syndrome

Shen, H., & Liu, Y. (2026) · Food & Function · doi:10.1039/d5fo04823k · Cited by 3 · see citing works

Integrating evidence-based lifestyle and adjunct therapies for long-term management of polycystic ovary syndrome: mechanistic insights and clinical implications

Nandagopal, P. B., Jayakrishnan, G., Kaithamattathil, A. V., & Manickam, V. (2026) · Frontiers in Reproductive Health · doi:10.3389/frph.2026.1821411 · Cited by 3 · see citing works

The Effect of Garlic (Allium Sativum) on Polycystic Ovary Syndrome Related Hormones and Glycemic Parameters: A Randomized, Double-Blinded Clinical Trial

Zadhoush, R., Naeini, A. A., Feizi, A., Naghshineh, E., & Ghazvini, M. A. (2023) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_308_21 · Cited by 3 · see citing works

Effect of Oligopin Administration on Ovarian Morphology in Women with Polycystic Ovarian Syndrome (PCOS)

Sajjadi‐Jazi, S. M., Sanginabadi, M., Moradi, B., Taheri, A. P. H., Amouei, M., Qorbani, M., Hosseini, S., Gity, M., Mohajeri‐Tehrani, M. R., Taheri, S. V., et al. (2024) · International Journal of Clinical Practice · doi:10.1155/2024/6479885 · Cited by 3 · see citing works

Seed cycling: Approach for polycystic ovarian syndrome

Zafar, M., Rabail, R., Bibi, S., Jebreen, A. M. Y., Khan, M. A., & Aadil, R. M. (2024) · Food and Humanity · doi:10.1016/j.foohum.2024.100274 · Cited by 3 · see citing works

Protective Potential of Methanol Extract of Drymaria cordata Willd. ex Schult (MEDC) on Letrozole-Induced Polycystic Ovary Syndrome Via Modulation of Apoptotic Markers, Sex Hormones and Antioxidant Status in Rat Model

Olowofolahan, A. O., Olanlokun, J. O., & Olorunsogo, O. O. (2024) · Reproductive Sciences · doi:10.1007/s43032-024-01597-6 · Cited by 3 · see citing works

ESR1 gene variants affect FSHR-depended risk of fibrocystic mastopathy in infertile women

Корнацька, А. Г., Rossokha, Z. I., Fishchuk, L., Dubenko, O. D., Medvedieva, N., Флаксемберг, М. А., Чубей, Г. В., Popova, O., & Горовенко, Н. Г. (2021) · Experimental Oncology · doi:10.32471/exp-oncology.2312-8852.vol-43-no-3.16468 · Cited by 3 · see citing works

Medicinal Plants including Spices for the Treatment of Polycystic Ovary Syndrome (PCOS) with a Preclinical-Clinical Perspective and Phytotherapeutic Approaches

Önder, A., Yılmaz, Ö. D., Çınar, A. S., & Kızılay, H. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815196801124030003 · Cited by 2 · see citing works

She ethnomedicine ameliorates ovarian dysfunction through enhanced cellular proliferation and anti-inflammation

Zhang, H., Wei, Y., Chen, L., Fan, X., Zhang, J., Zhuang, X.-D., Lin, X.-C., Lin, A.-Z., Zhong, Y.-X., Sun, Y., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120294 · Cited by 2 · see citing works

Deciphering the Molecular Mechanisms of Polycystic Ovary Syndrome and Flaxseed Therapy Through Transcriptomics and Machine Learning

Tian, S. I. P., Tang, Q., Liu, S., Yu, Y., Kang, J., & Shen, M. (2025) · IET Systems Biology · doi:10.1049/syb2.70034 · Cited by 2 · see citing works

The Role of Different Medicinal Herbs in Treatment of Polycystic Ovary Syndrome: A Review

Sharma, A., Bansal, K., & Bajpai, M. (2023) · The Natural Products Journal · doi:10.2174/2210315513666230502104141 · Cited by 2 · see citing works

Research hotspots of polycystic ovary syndrome and hyperandrogenism from 2008 to 2022: bibliometric analysis

Liu, H., Fang, X., Ma, Q., Wang, M., Hao, X., & Wang, G. (2024) · Gynecological Endocrinology · doi:10.1080/09513590.2024.2326102 · Cited by 1 · see citing works

EFFECT OF ETHANOLIC SOLVENT POLARITY ON THE PHYSIOCHEMICAL PROPERTIES OF Graptophyllum Pictum. L

Ismail, F. A., & Maddiah, N. I. (2023) · International Journal of Innovation and Industrial Revolution · doi:10.35631/ijirev.513012 · Cited by 1 · see citing works

Fennel affects porcine ovarian cell functions: The interrelationships with the environmental contaminant benzene

Sirotkin, A. V., Alexa, R., Alshamrani, A., & Harrath, A. H. (2023) · Research in Veterinary Science · doi:10.1016/j.rvsc.2023.104991 · Cited by 1 · see citing works

Recent Approaches in the Treatment of Polycystic Ovary Syndrome: An Update

(2022) · doi:10.31038/awhc.2022514 · Cited by 1 · see citing works

Successful pregnancy in a patient via holistic approach of Uni5 based treatment with recurrent implantation failure: A case report of unexplained infertility

Chhalliyil, P., Nandini, U., & Thota, N. (2022) · Panacea Journal of Medical Sciences · doi:10.18231/j.pjms.2022.131

Potensi Daun Lidah Buaya (Aloe Vera L.) sebagai Suplemen untuk Mengurangi Risiko Sindrom Ovarium Polikistik

Suhendi, J. R. (2023) · Prosiding Workshop dan Seminar Nasional Farmasi · doi:10.24843/wsnf.2022.v02.p02 · Cited by 1 · see citing works

A review on polyherbal and supplemental approach to treat Polycystic Ovarian Syndrome

Priya, & Rana, S. (2023) · Research in Pharmacy · doi:10.25081/rip.2023.v13.8683

Nature's Remedy: Exploring Herbal Treatments for Polycystic Ovarian Syndrome

Attri, M., Raghav, A., & Chaudhary, H. (2024) · Current Nutraceuticals · doi:10.2174/0126659786282036240503112128

Beyond Conventional: Nanotechnology-driven Herbal Interventions in the Treatment of Polycystic Ovary Syndrome

Roy, M., Mazumder, R., Singh, N., Bhardwaj, S., Mishra, R., Mishra, R., & Kumar, B. (2024) · Current Drug Therapy · doi:10.2174/0115748855313334240827071434

Review on herbal drugs used in PCOS (Polycystic ovarian syndrome)

Agrahari, K. A., Barewar, S. S., Bakal, R. L., & Hatwar, P. R. (2025) · International Journal of Herbal Medicine · doi:10.22271/flora.2025.v13.i2a.974

Research Progress of Qigong Pills in the Treatment of Polycystic Ovary Syndrome

尹, 云. (2025) · Journal of Clinical Personalized Medicine · doi:10.12677/jcpm.2025.43320

Design and Characterization of a Mushroom-Enriched Chewable Supplement for PCOS Management

Rane, M. V. (2025) · International Journal for Research in Applied Science and Engineering Technology · doi:10.22214/ijraset.2025.72498

Exploring herbal alternatives to pharmaceutical treatments for Polycystic Ovary Syndrome

Madamsetty, T. (2025) · Journal of High School Science · doi:10.64336/001c.142437

Therapeutic Potential of Phyllanthus niruri (Bhumi Amla) in Ameliorating Polycystic Ovarian Syndrome Induced with Letrozole

Devi, N. S., Kumar, S. S., Bindu, N. H., Gnanavel, A., & Selvaraj, K. (2025) · Journal of Natural Remedies · doi:10.18311/jnr/2025/50955

Exploring the role of medicinal plants and nanotechnology in the management of polycystic ovarian syndrome (PCOS): a scoping review

Ichipi, O. B., Olojede, S. O., Lawal, S. K., Azu, O. O., & Naidu, E. C. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05425-3 · Cited by 1 · see citing works

Polycystic Ovary Syndrome: Classical Unani Perspectives, Contemporary Understanding, and Therapeutic Approaches: A Narrative Review

Zehra, F., Ali, S., Rather, F., & Mir, R. A. (2026) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v16i7.7874

The organelle oxidative-inflammatory network in polycystic ovary syndrome: from subcellular intercellular cascades to systemic comorbidities

Ou, K., Zhang, D., Liao, Y., Yu, T., 刘文兴, Sun, T., & Huang, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1922372

Herbal therapeutics for polycystic ovary syndrome: Mechanistic insights and therapeutic potential

Kumar, T., & Tirkey, N. N. (2022) · The Pharma Innovation · doi:10.22271/tpi.2022.v11.i11af.26451

A review on role of medicinal plants in polycystic ovarian syndrome: Pathophysiology, neuroendocrine signaling, therapeutic status and future prospects

Abasian, Z., Rostamzadeh, A., Mohammadi, M., Hosseini, M., & Rafieian‐Kopaei, M. (2018) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2018.04.005 · Cited by 72 · see citing works

Herbal compounds in the treatment of polycystic ovary syndrome: an updated systematic review

Dashti, S., Ashouri, A., & Bahri, N. (2026) · Journal of Ovarian Research · doi:10.1186/s13048-026-02030-z · Cited by 2 · see citing works

Herbal drugs used in treatment of Polycystic Ovary Syndrome (PCOS)

Thakur, S. S., Sneha, K., Anjali, K., Rajdeep, K., Shreyash, L., & Siddharth, J. (2026) · International Journal of Pharmacognosy and Life Science · doi:10.33545/27072827.2026.v7.i2a.200

Efficacy of Herbal Medicines in Management of Polycystic Ovarian Syndrome: A Scoping Review

Deupa, H., & Shankar, P. (2024) · International Journal of Ayurvedic Medicine · doi:10.47552/ijam.v14i4.4212 · Cited by 1 · see citing works