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Cited by 20Reproductive Biology and FertilityOvarian function and disordersReproductive Physiology in Livestock

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Age-related changes in luteal dynamics: preliminary associations with antral follicular dynamics and hormone production during the human menstrual cycle

Baerwald, Angela, Vanden Brink, Heidi, Hunter, Caitlin, Beuker, Denae, Lim, Hyun, Lee, Chel Hee, Chizen, Donna·2018·Menopause
DOI 10.1097/gme.0000000000001021
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Abstract

Objective: The aim of the study was to test the hypothesis that the development of luteal phase dominant follicles (LPDFs) as women age is associated with abnormal luteal function. Methods: Luteal and antral follicle diameter were quantified in ovulatory women of midreproductive age (MRA; 18-35 y; n = 9) and advanced reproductive age (ARA; 45-55 y; n = 16) every 1 to 3 days during one complete interovulatory interval. Blood was drawn at each visit and assayed for progesterone, estradiol, inhibin A, follicle-stimulating hormone, and luteinizing hormone. Luteal diameter and hormone profiles were compared within MRA and ARA women with versus without LPDFs. Results: Luteal growth and regression profiles were similar in MRA women with typical versus no LPDFs (13.9, 14.8 mm; P > 0.1); however, luteal phase estradiol and progesterone were greater in MRA women with typical (91.1 ng/L, 8.81 μg/L) versus no (48.8 ng/L, 7.32 μg/L) LPDFs, respectively (LPDF effect, P < 0.1). In the ARA group, mean luteal diameter was lowest in women with atypical LPDFs (12.3 mm), greatest in those with typical LPDFs (16.0 mm), and moderate in those with no LPDFs (13.6 mm), (P < 0.1). Reduced luteal growth in ARA women with atypical versus typical and/or no LPDFs occurred simultaneously to greater luteal phase estradiol (199 vs 69.0, 78.4 ng/L) lower progesterone (7.38 vs 10.7, 13.8 ug/L), and lower inhibin A (36.3, 35.6, 51.2) (P < 0.1). Conclusions: The development of LPDFs as women age was associated with reduced luteal growth, greater estradiol, lower progesterone, and lower inhibin A. These findings provide preliminary evidence that variations in antral folliculogenesis contribute to luteal insufficiency during the menopausal transition.

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Crossref · 10.1097/gme.0000000000001021

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Research works printed but not linked: 2

  1. Brink, 2013, Age-related changes in major ovarian follicular wave dynamics during the human menstrual cycle, Menopause, 20, 1243, 10.1097/GME.0b013e31828cfb62 · DOI · Paper page
  2. Pierson, 1990, Ultrasonographic visualiztion of human ovulation, From Ovulation to Implantation Proceedings of the 7th Reinier de Graaf Symposium, 73

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Metadata

Authors
Baerwald, A., Vanden Brink, H., Hunter, C., Beuker, D., Lim, H., Lee, C. H., & Chizen, D.
Affiliations
  • University of Saskatchewan (CA)
  • Department of Obstetrics, Gynecology and Reproductive Sciences, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Corresponding author
Baerwald, Angela
ORCID
Venue
Menopause
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-04
Volume
25
Issue
4
Pages
399-407
ISSN
  • 1072-3714 (ISSN-L)
  • 1530-0374
DOI
10.1097/gme.0000000000001021
OpenAlex
W2770267480
Cited by
20
References
36
Citations by year
2026: 4 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 1
FWCI
1.03
Type
journal article
Language
en
Open access
closed
Locations
  • Menopause The Journal of The North American Menopause Society (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
Keywords
luteal insufficiency, luteal function, folliculogenesis, age-related changes, advanced reproductive age, progesterone, estradiol, inhibin A, menstrual cycle, ovulation, luteal regression, luteinizing hormone
MeSH terms
Adult, Aging, Female, Follicular Phase, Follicle Stimulating Hormone, Ovarian Follicle, Humans, Luteal Phase, Menopause, Menstrual Cycle, Middle Aged, Ovulation, Young Adult

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