Age-related changes in major ovarian follicular wave dynamics during the human menstrual cycle
Abstract
OBJECTIVE: Changes in antral follicle count, hormone production, and menstrual cyclicity as women age are well documented. However, age-related changes in ovarian follicular wave dynamics in women are not understood. The objective of this study was to test the hypothesis that major follicular wave dynamics (ie, those in which a dominant follicle develops) differ in women with age. METHODS: A prospective, cross-sectional, observational study was conducted in 58 women of mid-reproductive age (MRA; 18-35 y; n = 27), late reproductive age (LRA; 36-44 y; n = 10), and advanced reproductive age (ARA; 45-55 y; n = 21). The number and diameters of all follicles ≥ 2 mm were quantified ultrasonographically every 2 to 3 days for one complete interovulatory interval (IOI). Only ovulatory cycles were evaluated. Antral follicle count and major follicular wave dynamics during the IOI were compared among age groups using SPSS version 19.0 (α = 0.05). RESULTS: One (36/58, 62%) or two (22/58, 38%) major follicular waves were observed during the IOI in all women evaluated. The prevalence of follicular-phase dominant follicles (FPDFs) and luteal-phase dominant follicles (LPDFs) was not different among the MRA, LRA, and ARA groups (FPDFs: 27/27 [100%], 10/10 [100%], and 20/21 [95%], respectively; LPDFs: 10/17 [37%], 3/10 [30%], and 10/21 [48%], respectively; P > 0.050). All FPDFs were ovulatory. One LPDF ovulated during menses in the ARA group; all other LPDFs in the MRA, LRA, and ARA groups were anovulatory. On average, LPDFs emerged earlier relative to ovulation (days -6, -2, and -2; P = 0.049), grew longer (11, 3, and 6 d; P = 0.005), and developed to a larger diameter (24, 11, and 11 mm; P = 0.032) in the ARA group versus the MRA and LRA groups. In follicular-phase major waves, there was a tendency for a greater prevalence of polyovulation as women aged (ARA 3/21 [14%] vs MRA 0/27 [0%]; P = 0.070). CONCLUSIONS: One or two major follicular waves develop during the IOI, irrespective of age. The prevalence of LPDFs (range, 30%-50%) and FPDFs (range, 95%-100%) during the IOI does not differ with age. However, the growth dynamics of major waves change as women age. On average, LPDFs emerge earlier, grow for a longer period, and grow to a larger diameter in ovulatory women of advanced versus mid or late reproductive age. There is a greater tendency for polyovulation in the follicular-phase major wave as women age.
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Hormonal patterns during the luteal phase show changes with age, with greater absences of ovulatory cycles, while reductions in luteal phase progesterone become more common.
“Hormonal patterns during the luteal phase of the menstrual cycle also show changes with age, with greater absences of ovulatory cycles, while reductions in luteal phase progesterone become more common [107–109].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [107]
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Estimation of Gestational Age From Fetal Foot Length Measurement
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COMPARATIVE SERUM PHTHALATE CONCENTRATIONS IN FERTILE VERSUS INFERTILE MEN AND WOMEN IN SASKATCHEWAN
Roy, S. (2014) · University Library - University of Saskatchewan (University of Saskatchewan)
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Repeatability of ovarian antral follicular wave dynamics in women
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Self-citation
- Authors
- Brink, H. V., Chizen, D., Hale, G., & Baerwald, A.
- Affiliations
- The University of Sydney (AU)
- University of Saskatchewan (CA)
- Corresponding author
- Baerwald, Angela
- Venue
- Menopause
- Published
- 2013-12
- Volume
- 20
- Issue
- 12
- Pages
- 1243-1254
- ISSN
- 1072-3714 (ISSN-L)
- OpenAlex
- W1983860818
- Cited by
- 44
- References
- 64
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 2
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Menopause The Journal of The North American Menopause Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Keywords
- menstrual cycle, dominant follicle, antral follicle count, folliculogenesis, ovulation, late reproductive age, advanced reproductive age, ovarian aging, anovulation, follicle size, follicle count
- MeSH terms
- Adult, Age Factors, Corpus Luteum, Female, Follicle Stimulating Hormone, Ovarian Follicle, Humans, Menstrual Cycle, Middle Aged, Ovulation, Young Adult
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