Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in an elderly Swedish population
Abstract
OBJECTIVE: To investigate the prevalence of different symptoms of partial androgen deficiency in aging men (PADAM) and to correlate them with blood concentrations of testosterone and bioavailable testosterone. DESIGN: A total of 370 men, aged 55 to 75 years, were invited to one of three primary healthcare centers in Sweden. They were asked to complete a questionnaire regarding demographic data, medical history, mood status, medication, castration therapy and smoking, exercise and alcohol habits, as well as different symptoms of PADAM. The 10 questions from a previously used questionnaire (the ADAM questionnaire) were included. The men were offered blood tests for analyses of testosterone, follicle stimulating hormone, luteinizing hormone, steroid hormone-binding globulin, and albumin. From these test results, we calculated the bioavailable testosterone. RESULTS: Of the questionnaires sent out, 81.6% were returned and eligible for evaluation. Blood samples were obtained from 85.8% of men answering the questionnaire. Many of the symptoms, including five from the ADAM questionnaire, were more common in older age groups (P < 0.05). Three symptoms, deterioration in work performance, decreased strength and/or endurance, and bothersome hot flushes, were associated with low bioavailable testosterone and/or testosterone (P < 0.05). Testosterone and bioavailable testosterone did not differ between age groups, but bioavailable testosterone was higher in men with three or fewer symptoms on the ADAM questionnaire. CONCLUSIONS: Symptoms associated with PADAM often occur in an elderly population, but we could only find an association between three symptoms and blood testosterone concentrations, one being bothersome hot flushes. It is likely that these symptoms have a more complex background than only PADAM.
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Available hypogonadism questionnaires correlate with aging and diabetes mellitus, but their associations with total and free testosterone are variable.
“Available questionnaires demonstrate correlations with aging and DM with variable associations noted with TT and fT levels.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [118]
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- Authors
- Spetz, A.-C. E., Palmefors, L., Skobe, R. S. P., Strömstedt, M. T., Fredriksson, M. G., Theodorsson, E., & Hammar, M. L.
- Affiliations
- Linköping University (SE)
- Linköping University Hospital (SE)
- Corresponding author
- Spetz, Anna-Clara E.
- Venue
- Menopause
- Published
- 2007-11
- Volume
- 14
- Issue
- 6
- Pages
- 999-1005
- ISSN
- 1072-3714 (ISSN-L)
- OpenAlex
- W2018221577
- Cited by
- 30
- References
- 28
- Citations by year
- 2024: 1 · 2016: 1 · 2014: 3 · 2013: 2 · 2012: 7
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Menopause The Journal of The North American Menopause Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- testosterone, bioavailable testosterone, ADAM questionnaire, hot flashes, employee performance, muscle strength and endurance, older men, hormone replacement therapy
- MeSH terms
- Aged, Aging, Cross-Sectional Studies, Humans, Male, Middle Aged, Surveys and Questionnaires, Severity of Illness Index, Sweden, Testosterone, Hot Flashes, Andropause
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