Low testosterone concentrations and the symptoms of testosterone deficiency according to the Androgen Deficiency in Ageing Males (ADAM) and Ageing Males’ Symptoms rating scale (AMS) questionnaires: Testosterone levels and symptoms in ageing men
Abstract
OBJECTIVE: First, to assess the association between the concentration of serum testosterone and the symptoms of testosterone deficiency according to two screening questionnaires. Second, to investigate the effects in elderly men with a low-normal testosterone concentration of testosterone supplementation over a period of 6 months on symptoms of testosterone deficiency according to the screening questionnaires. DESIGN, SETTING AND PARTICIPANTS: A total of 587 men between 60 and 80 years of age with an eligible serum testosterone measurement and completion of the screening questionnaires were included in the study. Of these 587 men, 237 men with testosterone levels <13·7 nmol/l were included in a double-blind, randomized, placebo-controlled trial of testosterone supplementation. INTERVENTION: One hundred and sixty milligrams per day of oral testosterone undecanoate or a matching placebo for 6 months. MEASUREMENTS: The Androgen Deficiency in Ageing Males (ADAM) and the Ageing Males' Symptoms rating scale (AMS) questionnaires. RESULTS: There was no significant association between the total testosterone concentration and the scores on the two questionnaires. However, age was significantly associated with the scores on the ADAM (OR 1·14, 95% CI 1·05-1·23) and the AMS (OR 1·03, 95% CI 1·01-1·08) questionnaire. After supplementation with testosterone, there were no effects on the scores on the two questionnaires in the testosterone group compared with the placebo group. CONCLUSION: The findings do not support the use of the ADAM or AMS questionnaire in the evaluation of late-onset hypogonadism in ageing men. Moreover, 6 months of oral testosterone supplementation had no significant effect on scores of the ADAM and AMS questionnaire in this group of elderly men with low-normal testosterone levels.
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Available hypogonadism questionnaires correlate with aging and diabetes mellitus, but their associations with total and free testosterone are variable.
“Available questionnaires demonstrate correlations with aging and DM with variable associations noted with TT and fT levels.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [119]
Some randomized controlled trials show modest improvements in questionnaire scales after testosterone administration, while others fail to find consistent associations.
“Although select RCTs have demonstrated modest improvements in scales following T administration, others have failed to identify consistent associations.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [119]
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- Authors
- Emmelot-Vonk, M. H., Verhaar, H. J. J., Nakhai-Pour, H. R., Grobbee, D. E., & van der Schouw, Y. T.
- Affiliations
- University Medical Center Utrecht (NL)
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2011-03-07
- Volume
- 74
- Issue
- 4
- Pages
- 488-494
- ISSN
- 0300-0664 (ISSN-L)
- OpenAlex
- W1944521773
- Cited by
- 37
- References
- 28
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 6 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 8
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- ZonMw
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- andropause, ADAM questionnaire, testosterone supplementation, older men, age-related symptoms, screening questionnaire
- MeSH terms
- Aged, Aged, 80 and over, Androgens, Humans, Male, Middle Aged, Surveys and Questionnaires, Testosterone
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