Is the Androgen Deficiency of Aging Men (ADAM) questionnaire useful for the screening of partial androgenic deficiency of aging men?
Open accessAbstract
Background Androgen serum levels significantly decrease in older men, causing quality of life impairment and increasing the risk of chronic disease. This disorder is defined as PADAM (Partial Androgen Deficiency of Aging Men).Objective To evaluate a PADAM screening tool and determine the prevalence of this disorder in healthy adult men.Methods This was a cross-sectional study in which 96 men aged 40 or more of the South Metropolitan Region of Santiago de Chile were surveyed with the Androgen Deficiency of Aging Men (ADAM) questionnaire of the Saint Louis University and sampled for the serum determination of total testosterone, sexual hormone binding globulin (SHBG) and albumin. Also free and bioavailable testosterone were calculated. PADAM was considered present if items 1 or 7 or any 3 other questions of the ADAM questionnaire were positive. An available testosterone of <198.4 ng/dL was used as a gold standard for the diagnosis of PADAM.Results A total of 78 men (81.3%) were identified as possible PADAM according to the ADAM questionnaire. Total testosterone levels fell from 503.6+/-180.1 ng/dL in men aged 40 to 54 years to 382.1+/-247.3 in those >70 years; however this was not statistically significant (ANOVA, p=0.06). In the same age groups, SHBG significantly increased (31.0+/-15.0 to 47.5+/-15.0 nmol/L, p<0.001) whereas free and available testosterone significantly decreased (10.6+/-3.2 to 6.4+/-3.6 ng/dL and 266.6+/-81.2 to 152.2+/-97.6 ng/dL, respectively, p<0.0001). Overall (n=96), available testosterone confirmed PADAM diagnosis in 27 cases (28.1%). The ADAM tool rendered a 83.3% sensitivity and 19.7% specificity in the detection of PADAM. Item 1 (decreased sexual desire) was a better predictor of hypogonadism than the complete questionnaire (63.3% sensitivity and 66.7% specificity).Conclusion In this series, in accordance to available testosterone, the prevalence of PADAM was determined to be high, in which the ADAM questionnaire rendered a low diagnostic efficiency. PADAM diagnosis could be clinically suspected when symptoms of sexual dysfunction are present.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Among hypogonadism questionnaires, the AMS and ADAM scales show the highest sensitivity (81-97%) but poor specificity (19-39%).
“The sensitivity and specificity of the various scales have been reported, with overall findings demonstrating the highest sensitivities with the AMS and ADAM questionnaires (81–97%) with concomitant poor specificity (19–39%).”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [116]
Cites
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760 · see citing works
Investigation, treatment and monitoring of late-onset hypogonadism in males
Wang, C., Nieschlag, E., Swerdloff, R., Behre, H. M., Hellstrom, W. J., Gooren, L. J., Kaufman, J. M., Legros, J.-J., Lunenfeld, B., Morales, A., et al. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0601 · Cited by 867 · see citing works
Validation of a screening questionnaire for androgen deficiency in aging males
Morley, J. E., Charlton, E., Patrick, P., Kaiser, F. E., Cadeau, P., McCready, D., & Perry, H. M. (2000) · Metabolism · doi:10.1053/meta.2000.8625 · Cited by 662 · see citing works
Araujo, A. B., O’Donnell, A. B., Brambilla, D. J., Simpson, W. B., Longcope, C., Matsumoto, A. M., & McKinlay, J. B. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031719 · Cited by 591 · see citing works
Testosterone action on skeletal muscle
Herbst, K. L., & Bhasin, S. (2004) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200405000-00006 · Cited by 457 · cited 2× · see citing works
“This situation s associated to decreased libido, erectile dysfunction and also to epression, insomnia, irritability, abdominal obesity and decreased one and muscular mass [3–5].”
BackgroundHouse, J. S., Lantz, P. M., & Herd, P. (2005) · The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · doi:10.1093/geronb/60.special_issue_2.s15 · Cited by 407 · see citing works
Morales, A., & Lunenfeld, B. (2002) · The Aging Male · doi:10.1080/tam.5.2.74.86 · Cited by 266 · see citing works
Urban–rural mental health differences in Great Britain: findings from the National Morbidity Survey
Paykel, E. S., Abbott, R., Jenkins, R., Brugha, T. S., & Meltzer, H. (2000) · Psychological Medicine · doi:10.1017/s003329179900183x · Cited by 253 · see citing works
Trudy Harpham, C. (1994) · Social Science & Medicine · doi:10.1016/0277-9536(94)90332-8 · Cited by 219 · see citing works
Physical Activity and Parameters of Aging: A Physiological Perspective
Westerterp, K. R., & Meijer, E. P. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.suppl_2.7 · Cited by 175 · see citing works
Comparison of screening questionnaires for the diagnosis of hypogonadism
Morley, J. E., Perry, H. M., Kevorkian, R. T., & Patrick, P. (2006) · Maturitas · doi:10.1016/j.maturitas.2005.07.004 · Cited by 168 · see citing works
The validity of a single-question self-report of erectile dysfunction
O’Donnell, A. B., de Araújo, A. B., Goldstein, I., & McKinlay, J. B. (2005) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2005.0076.x · Cited by 163 · see citing works
Impaired quality of life among middle aged women: A multicentre Latin American study
Chedraui, P. A., Blümel, J. E., Barón, G., Belzares, E., Bencosme, A., Calle, A., Danckers, L., Espinoza, M. T., Flores, D., Gómez, G., et al. (2008) · Maturitas · doi:10.1016/j.maturitas.2008.09.026 · Cited by 153 · see citing works
Self-citationThe Aging Males' Symptoms (AMS) scale: review of its methodological characteristics.
Daig, I., Heinemann, L. A. J., Kim, S., Leungwattanakij, S., Badia, X. C., Myon, E., Moore, C., Saad, F., Potthoff, P., & Thai, D. M. (2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-77 · Cited by 137 · see citing works
Tancredi, A., Reginster, J., Schleich, F., Pire, G., Maassen, P., Luyckx, F., & Legros, J. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510355 · Cited by 102 · see citing works
Social participation of older adults in Quebec
Desrosiers, J., Noreau, L., & Rochette, A. (2004) · Aging Clinical and Experimental Research · doi:10.1007/bf03324572 · Cited by 91 · see citing works
Metabolic syndrome, testosterone deficiency and erectile dysfunction never come alone
Yassin, A. A., Saad, F., & Gooren, L. J. (2008) · Andrologia · doi:10.1111/j.1439-0272.2008.00851.x · Cited by 77 · see citing works
Correlations between Hormones, Physical, and Affective Parameters in Aging Urologic Outpatients
Beutel, M. E., Wiltink, J., Hauck, E. W., Auch, D., Behre, H. M., Brähler, E., & Weidner, W. (2005) · European Urology · doi:10.1016/j.eururo.2005.02.015 · Cited by 68 · see citing works
Morales, Á., Spevack, M., Emerson, L. E., Kuzmarov, I. W., Casey, R. W., Black, A. M., & Tremblay, R. R. (2007) · The Aging Male · doi:10.1080/13685530701342686 · Cited by 62 · see citing works
Martínez-Jabaloyas, J. M., Zaragoza, A. Q., Rodríguez-Navarro, R., Queipo-Zaragozá, J. A., Gil‐Salom, M., & Chuan-Nuez, P. (2007) · European Urology · doi:10.1016/j.eururo.2007.05.021 · Cited by 46 · see citing works
Testosterone and men's quality of life
Moncada, I. (2006) · The Aging Male · doi:10.1080/13685530601003180 · Cited by 45 · see citing works
Endogenous sex steroids, weight change and rates of hip bone loss in older men: the MrOS study
Ensrud, K. E., Lewis, C. E., Lambert, L. C., Taylor, B. C., Fink, H. A., Barrett-Connor, E. L., Cauley, J. A., Stefanick, M. L., & ORWOLL, E. S. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0088-z · Cited by 45 · see citing works
Haren, M. T., Morley, J. E., Chapman, I. M., O’Loughlin, P. D., & Wittert, G. (2002) · Climacteric · doi:10.1080/cmt.5.1.15.25 · Cited by 38 · see citing works
Spetz, A.-C. E., Palmefors, L., Skobe, R. S. P., Strömstedt, M. T., Fredriksson, M. G., Theodorsson, E., & Hammar, M. L. (2007) · Menopause · doi:10.1097/gme.0b013e318057786b · Cited by 30 · see citing works
Correlations of androgen deficiency with clinical symptoms in Taiwanese males
Lin, Y., Hwang, T. I. S., Chiang, H., Yang, C.-C., Wu, H., Wu, T.-H., & Huang, S. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901417 · Cited by 23 · see citing works
Gooren, L. J. (2008) · Frontiers of hormone research · doi:10.1159/000176045 · Cited by 17 · see citing works
Lejeune, H., Déchaud, H., & Pugeat, M. (2003) · PubMed · Cited by 14 · see citing works
Jabaloyas, J. M. M., Zaragoza, A. Q., Cortés, C., Zaragozá, J. A. Q., Salom, M. G., & Nuez, P. C. (2008) · Actas Urológicas Españolas · doi:10.1016/s0210-4806(08)73895-6 · Cited by 11 · see citing works
Florenzano, R. U., Julia Acuña, R., Claudio Fullerton, U., & Castro, C. (1998) · PubMed · Cited by 11 · see citing works
AGING MALE SYMPTOMS AND SERUM TESTOSTERONE LEVELS IN HEALTHY JAPANESE MIDDLE-AGED MEN
Kawa, G., Taniguchi, H., Kinoshita, H., Matsuda, T., Urakami, M., & Sawaragi, I. (2008) · The Japanese Journal of Urology · doi:10.5980/jpnjurol1989.99.645 · Cited by 9 · see citing works
The laboratory assessment of partial androgen deficiency of the aging male.
Romanelli, F., & Latini, M. (2005) · PubMed · Cited by 6 · see citing works
Comparación de distintos métodos para evaluar la función androgénica en el adulto mayor
Claudia Campusano, M., Francisca Brusco, G., Carmen Campino, J., Luis Rodríguez, P., & Eugenio Arteaga, U. (2006) · Revista médica de Chile · doi:10.4067/s0034-98872006000900006 · Cited by 5 · see citing works
[Midlife crisis in men? Subjectively perceived physical and mental changes in men of advancing age].
Seikowski, K., Stöbe, K., & Harth, W. (2008) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
How to recognize late-onset hypogonadism in men with sexual dysfunction
Corona, G., Rastrelli, G., Vignozzi, L., Mannucci, E., & Maggi, M. (2012) · Asian Journal of Andrology · doi:10.1038/aja.2011.138 · Cited by 108 · see citing works
Trost, L. W., & Mulhall, J. P. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.04.068 · Cited by 98 · see citing works
Predicting low testosterone in aging men: a systematic review
Millar, A. C., Lau, A. N. C., TOMLINSON, G. A., Kraguljac, A. P., Simel, D. L., Detsky, A. S., & Lipscombe, L. L. (2016) · Canadian Medical Association Journal · doi:10.1503/cmaj.150262 · Cited by 57 · see citing works
EMAS position statement: Testosterone replacement therapy in the aging male
Dimopoulou, C., Ceauşu, I., Depypere, H. T., Lambrinoudaki, I. V., Mueck, A. O., Pérez-López, F. R., Rees, M., van der Schouw, Y. T., Senturk, L. M., Simonsini, T., et al. (2015) · Maturitas · doi:10.1016/j.maturitas.2015.11.003 · Cited by 55 · see citing works
Systematic Literature Review of the Epidemiology of Nongenetic Forms of Hypogonadism in Adult Males
Zarotsky, V., Huang, M., Carman, W. J., Morgentaler, A., Singhal, P. K., Coffin, D., & Jones, T. H. (2014) · Journal of Hormones · doi:10.1155/2014/190347 · Cited by 37 · see citing works
Chen, W., Liu, Z., Wang, L., Zeng, Q., Wang, H., & Sun, Y. (2013) · The Aging Male · doi:10.3109/13685538.2013.805319 · Cited by 35 · see citing works
Hypogonadism: Easy to define, hard to diagnose, and controversial to treat
Sterling, J., Bernie, A., & Ramasamy, R. (2015) · Canadian Urological Association Journal · doi:10.5489/cuaj.2416 · Cited by 31 · see citing works
Andropause and the development of cardiovascular disease presentation-more than an epi-phenomenon
Ernst, R. S., Phan, A., & Robert, D. W. J. (2011) · 老年心脏病学杂志：英文版 · doi:10.3724/sp.j.1263.2011.00035 · Cited by 24 · see citing works
Herbal approaches to system dysfunctions
(2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06992-5.00009-8 · Cited by 20 · see citing works
Liu, Z., Liu, J., Shi, X., Wang, L., Yang, Y., Tao, M., & Fu, Q. (2016) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22073 · Cited by 19 · see citing works
Cabral, R. D., Busin, L., Rosito, T. E., & Koff, W. J. (2014) · The Aging Male · doi:10.3109/13685538.2014.908460 · Cited by 18 · see citing works
Validation of an Arabic ADAM questionnaire for androgen deficiency screening in the Arab community
Rabah, D. M., & Arafa, M. A. (2009) · The Aging Male · doi:10.3109/13685530903265065 · Cited by 18 · see citing works
The “Aging Males’ Symptoms” Scale (AMS): predictive value for lowered circulating androgens
Zengerling, F., Schrader, A. J., Cronauer, M. V., Stemann, H., Schrader, M. G., & Rinnab, L. J. (2012) · The Aging Male · doi:10.3109/13685538.2012.729232 · Cited by 16 · see citing works
EMAS position statement: Late parenthood
Mintziori, G., Lambrinoudaki, I. V., Kolibianakis, E. M., Ceauşu, I., Depypere, H., Erel, C. T., Pérez-López, F. R., Schenck-Gustafsson, K. G., van der Schouw, Y. T., Simoncini, T., et al. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.07.008 · Cited by 12 · see citing works
Ugwu, T. E., & Ikem, R. T. (2017) · Journal of Endocrinology Metabolism and Diabetes of South Africa · doi:10.1080/16089677.2017.1318534 · Cited by 12 · see citing works
Clinical relevance of low androgen to gastroesophageal reflux symptoms
Harada, K., Hanayama, Y., Yasuda, M., Hasegawa, K., Obika, M., Kataoka, H. U., Itoshima, K., Okada, K., & Otsuka, F. (2018) · Endocrine Journal · doi:10.1507/endocrj.ej18-0187 · Cited by 12 · see citing works
Testosterone for ‘late-onset hypogonadism’ in men?
(2010) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2010.01.0004 · Cited by 10 · see citing works
Awareness of andropause in males: A North Indian study
Sarpal, S. S., Ashat, M., Puri, S., Goel, N. K., Koushal, V., & Singh, A. (2011) · Indian Journal of Medical Sciences · doi:10.4103/0019-5359.108952 · Cited by 9 · see citing works
Late-onset hypogonadism or ADAM: diagnosis
Martits, A., Costa, E., Nardi, A., Nardozza, A., Faria, G., Facio, F., & Bernardo, W. (2014) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.60.04.003 · Cited by 8 · see citing works
Akehi, Y., Tanabe, M., Yano, H., Takashi, Y., Kawanami, D., Nomiyama, T., & Yanase, T. (2022) · Endocrine Journal · doi:10.1507/endocrj.ej22-0073 · Cited by 8 · see citing works
Hamanoue, N., Tanabe, M., Tanaka, T., Akehi, Y., Murakami, J., Nomiyama, T., & Yanase, T. (2017) · Endocrine Journal · doi:10.1507/endocrj.ej16-0619 · Cited by 8 · see citing works
Androgen deficiency syndrome in older people
Lee, Y. (2014) · Journal of the American Association of Nurse Practitioners · doi:10.1002/2327-6924.12114 · Cited by 6 · see citing works
Vieira, M. D. C. S., Leitão, A. E., Vieira, G. R., Moratelli, J., Boing, L., Seemann, T., & Guimarães, A. C. D. A. (2018) · The Aging Male · doi:10.1080/13685538.2018.1454421 · Cited by 6 · see citing works
Symptoms of testosterone deficiency in early middle aged men
Holm, A. S., Fredrikson, M. G., & Hammar, M. L. (2012) · The Aging Male · doi:10.3109/13685538.2012.669435 · Cited by 5 · see citing works
Effects and significance of estradiol in men
Tõke, J., Czirják, G., Bezzegh, A., Vásárhelyi, B., Rácz, K., & Patócs, A. (2014) · Orvosi Hetilap · doi:10.1556/oh.2014.29914 · Cited by 4 · see citing works
Profile of sexuality and symptoms of lower urinary tract in non-institutionalized elderly
Taha, K. A., Rocha, F. T., & Castilho, L. N. (2020) · International braz j urol · doi:10.1590/s1677-5538.ibju.2019.0162 · Cited by 3 · see citing works
ADAM AND AMS SCALE FOR ASSESSING ANDROPAUSE AMONG AGING INDIAN MEN
Puri, S., & Singh, A. (2015) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 3 · see citing works
Tadayon, M., Abedi, P., Emam, S. J., Malihi, R., & Hosseini, M. (2013) · Cited by 2 · see citing works
Waddankeri, S., Waddankeri, M. S., Arora, K. S., & Mangshetty, B. G. (2024) · Journal of the Association of Physicians of India · doi:10.59556/japi.72.0514 · Cited by 2 · see citing works
Vieira, M. D. C. S., Boing, L., Machado, Z., & Guimarães, A. C. D. A. (2017) · Revista Brasileira de Ciência e Movimento · doi:10.31501/rbcm.v25i1.6371 · Cited by 2 · see citing works
Irnandi, D. F., Hanggara, D. S., Khotimah, H., Rifqi, M. S., Evangelista, B. A., Gonius, A., & Kusdijanto, A. Y. (2023) · Indonesian Andrology and Biomedical Journal · doi:10.20473/iabj.v4i2.51414 · Cited by 1 · see citing works
Lee, C., Chen, Y., Jiang, K.-H., Chu, C., Hsu, S., Chen, C.-L., & Chen, C.-Y. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75701 · Cited by 1 · see citing works
The Institute of Medicine White Paper on Testosterone: Current Perspective
Donatucci, C. F. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-179-0_1
Ansary, E. A. F., Islam, M. N., Hossain, M. B., Mamun, M. A. A., Talukder, M. F. A., Bhuiyan, F. K., & Chowdhury, M. N. (2017) · Journal of Dhaka Medical College · doi:10.3329/jdmc.v26i1.34004
The Use of Patient Reported Outcome Questionnaires in the Diagnosis of Androgen Deficiency
Lowe, G. J., Bailey, G. C., & Krupski, T. L. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-179-0_4
- Authors
- Blümel, J. E., Chedraui, P., Gili, S. A., Navarro, A., Valenzuela, K., & Vallejo, S.
- Affiliations
- University of Chile (CL)
- Universidad Católica de Santiago de Guayaquil (EC)
- Universidad Andrés Bello (CL)
- Corresponding author
- Chedraui, Peter
- Venue
- Maturitas
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 63
- Issue
- 4
- Pages
- 365-368
- ISSN
- 0378-5122 (ISSN-L)
- OpenAlex
- W2030552757
- Cited by
- 37
- References
- 34
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Maturitas (publishedVersion)
- PubMed (publishedVersion)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- ADAM questionnaire, testosterone, free testosterone, bioavailable testosterone, older men, prevalence, questionnaire sensitivity and specificity, decreased sexual desire, quality of life, chronic disease risk, healthy men, age-related testosterone decline
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Androgens, Cross-Sectional Studies, Humans, Male, Middle Aged, Surveys and Questionnaires, Serum Albumin, Sex Hormone-Binding Globulin, Testosterone, Statistics, Nonparametric, Andropause
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
