Pre-eclampsia part 2: prediction, prevention and management

Chaiworapongsa, Tinnakorn; Chaemsaithong, Piya; Korzeniewski, Steven J.; Yeo, Lami; Romero, Roberto

doi:10.1038/nrneph.2014.103

Cited by 132Pregnancy and preeclampsia studiesNeurological Complications and SyndromesMaternal Mental Health During Pregnancy and Postpartum

Pre-eclampsia part 2: prediction, prevention and management

Open access

Chaiworapongsa, Tinnakorn, Chaemsaithong, Piya, Korzeniewski, Steven J., Yeo, Lami, Romero, Roberto·2014·Nature Reviews Nephrology

DOI 10.1038/nrneph.2014.103PMC PMC5898797

Open this paper in CoChat — free account

Abstract

An antiangiogenic state might constitute a terminal pathway for the multiple aetiologies of pre-eclampsia, especially those resulting from placental abnormalities. The levels of angiogenic and antiangiogenic proteins in maternal blood change prior to a diagnosis of pre-eclampsia, correlate with disease severity and have prognostic value in identifying women who will develop maternal and/or perinatal complications. Potential interventions exist to ameliorate the imbalance of angiogenesis and, hence, might provide opportunities to improve maternal and/or perinatal outcomes in pre-eclampsia. Current strategies for managing pre-eclampsia consist of controlling hypertension, preventing seizures and timely delivery of the fetus. Prediction of pre-eclampsia in the first trimester is of great interest, as early administration of aspirin might reduce the risk of pre-eclampsia, albeit modestly. Combinations of biomarkers typically predict pre-eclampsia better than single biomarkers; however, the encouraging initial results of biomarker studies require external validation in other populations before they can be used to facilitate intervention in patients identified as at increased risk. Angiogenic and antiangiogenic factors might also be useful in triage of symptomatic patients with suspected pre-eclampsia, differentiating pre-eclampsia from exacerbations of pre-existing medical conditions and performing risk assessment in asymptomatic women. This Review article discusses the performance of predictive and prognostic biomarkers for pre-eclampsia, current strategies for preventing and managing the condition and its long-term consequences.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrneph.2014.103

Cites

147 of 147 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Maternal plasma concentrations of sVEGFR-1 and soluble endoglin increase before preeclampsia is diagnosed, making them potential biomarkers for the disease.
“that causes maternal plasma concentrations of sVEGFR-1 and soluble endoglin to increase before preeclampsia is diagnosed, making them potential biomarkers for the disease(111, 120, 128, 129, 132, 133, 137, 138, 154–179).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [111]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101 · see citing works
Untitled work
(2013) · doi:10.1097/01.aog.0000437382.03963.88 · Cited by 3,961 · see citing works
Circulating angiogenic factors and the risk of preeclampsia
Levine, R. J., Maynard, S. E., Qian, C., Lim, K.-H., England, L. J., Yu, K. F., Schisterman, E. F., Thadhani, R., Sachs, B. P., Epstein, F. H., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031884 · Cited by 3,720 · see citing works
Circulating angiogenic factors and the risk of preeclampsia*
(2004) · Obstetrics and Gynecology · doi:10.1097/00006250-200405000-00028 · Cited by 2,623 · see citing works
Evaluation of High-Sensitivity C-Reactive Protein and Serum Lipid Profile in Southeastern Nigerian Women with Pre-Eclampsia
Onuegbu, A. J., Olisekodiaka, J. M., Udo, J., Umeononihu, O. S., Amah, U. K., Okwara, J. E., & Atuegbu, C. (2015) · Medical Principles and Practice · doi:10.1159/000381778 · Cited by 2,057 · see citing works
Soluble endoglin contributes to the pathogenesis of preeclampsia
Venkatesha, S., Toporsian, M., Lam, C., Hanai, J.-I., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K.-H., Yuan, H.-T., Libermann, T. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1429 · Cited by 1,855 · see citing works
Self-citation
Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial
Altman, D. G., Carroli, G., Duley, L., Farrell, B., Moodley, J., Neilson, J., & Smith, D. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08778-0 · Cited by 1,488 · see citing works
Prevention of Preeclampsia and Intrauterine Growth Restriction With Aspirin Started in Early Pregnancy
Bujold, E., Roberge, S., Lacasse, Y., Bureau, M., Audibert, F., Marcoux, S., Forest, J., & Giguère, Y. (2010) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181e9322a · Cited by 1,096 · see citing works
Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Hofmeyr, G. J., Lawrie, T. A., Atallah, Á. N., & Duley, L. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001059.pub3 · Cited by 1,059 · see citing works
CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women
(1994) · The Lancet · doi:10.1016/s0140-6736(94)92633-6 · Cited by 1,017 · see citing works
Antiplatelet agents for preventing pre-eclampsia and its complications
Duley, L., Henderson-Smart, D. J., Meher, S., & King, J. F. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004659.pub2 · Cited by 1,016 · see citing works
Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data
Askie, L. M., Duley, L., Henderson-Smart, D. J., & Stewart, L. A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60712-0 · Cited by 1,014 · see citing works
Pre-eclampsia part 1: current understanding of its pathophysiology
Chaiworapongsa, T., Chaemsaithong, P., Yeo, L., & Romero, R. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.102 · Cited by 956 · see citing works
Self-citation
Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial
The Eclampsia Trial Collaborative Group (1995) · The Lancet · doi:10.1016/s0140-6736(95)91034-4 · Cited by 836 · see citing works
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial
Koopmans, C. M., Bijlenga, D., Groen, H., Vijgen, S. M. C., Aarnoudse, J. G., Bekedam, D. J., van den Berg, P. P., de Boer, K., Burggraaff, J. M., Bloemenkamp, K. W. M., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60736-4 · Cited by 791 · see citing works
Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis
Brown, M. C., Best, K. E., Pearce, M. S., Waugh, J., Robson, S. C., & Bell, R. (2013) · European Journal of Epidemiology · doi:10.1007/s10654-013-9762-6 · Cited by 745 · see citing works
"Which Anticonvulsant for Women with Eclampsia? Evidence from the Collaborative Eclampsia Trial."
(1995) · Studies in Family Planning · doi:10.2307/2138105 · Cited by 735 · see citing works
Preeclampsia and the Risk of End-Stage Renal Disease
Vikse, B. E., Irgens, L. M., Leivestad, T., Skjærven, R., & Iversen, B. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706790 · Cited by 673 · see citing works
Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia
Rana, S., Powe, C. E., Salahuddin, S., Verlohren, S., Perschel, F. H., Levine, R. J., Lim, K.-H., Wenger, J. B., Thadhani, R., & Karumanchi, S. A. (2012) · Circulation · doi:10.1161/circulationaha.111.054361 · Cited by 668 · see citing works
Trial of Calcium to Prevent Preeclampsia
Levine, R. J., Hauth, J. C., Curet, L. B., Sibai, B. M., Catalano, P. M., Morris, C. D., DerSimonian, R., Esterlitz, J. R., Raymond, E. G., Bild, D. E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370201 · Cited by 634 · see citing works
Preeclampsia: An imbalance in placental prostacyclin and thromboxane Production
Walsh, S. W. (1985) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(85)80223-4 · Cited by 601 · see citing works
Competing Risks Model in Early Screening for Preeclampsia by Biophysical and Biochemical Markers
Akolekar, R., Syngelaki, A., Poon, L. C., Wright, D. E., & Nicolaides, K. H. (2012) · Fetal Diagnosis and Therapy · doi:10.1159/000341264 · Cited by 601 · see citing works
Magnesium sulphate and other anticonvulsants for women with pre-eclampsia
Duley, L., Gülmezoglu, A. M., Henderson-Smart, D. J., & Chou, D. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000025.pub2 · Cited by 588 · see citing works
Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model
von Dadelszen, P., Payne, B. A., Li, J., Ansermino, J. M., Pipkin, F. B., Côté, A., Douglas, M. J., Gruslin, A., Hutcheon, J. A., Joseph, K. S., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61351-7 · Cited by 585 · see citing works
RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy
Magee, L. A., Helewa, M. E., Rey, É., Cardew, S., Côté, A., Douglas, M. J., Firoz, T., Gibson, P., Gruslin, A., Lange, I. R., et al. (2008) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)32776-1 · Cited by 580 · see citing works
Diagnosis, Prevention, and Management of Eclampsia
Sibai, B. M. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000152351.13671.99 · Cited by 543 · see citing works
Stroke and Severe Preeclampsia and Eclampsia: A Paradigm Shift Focusing on Systolic Blood Pressure
Martin, J. N., Jr., Thigpen, B. D., Moore, R., Rose, C. H., Cushman, J., & May, W. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000151116.84113.56 · Cited by 504 · see citing works
Diagnostic Accuracy of Placental Growth Factor in Women With Suspected Preeclampsia
Chappell, L. C., Duckworth, S., Seed, P. T., Griffin, M., Myers, J., Mackillop, L. H., Simpson, N., Waugh, J. J. S., Anumba, D. O. C., Kenny, L. C., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.003215 · Cited by 501 · see citing works
Prediction of early, intermediate and late pre‐eclampsia from maternal factors, biophysical and biochemical markers at 11–13 weeks
Akolekar, R., Syngelaki, A., Sarquis, R., Zvanca, M. E., & Nicolaides, K. H. (2011) · Prenatal Diagnosis · doi:10.1002/pd.2660 · Cited by 444 · see citing works
Drugs for treatment of very high blood pressure during pregnancy
Duley, L., Meher, S., & Jones, L. V. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001449.pub3 · Cited by 423 · see citing works
Diagnosis, Prevention and Management of Eclampsia
&NA; (2005) · Obstetric Anesthesia Digest · doi:10.1097/00132582-200509000-00010 · Cited by 377 · see citing works
Hypertension in Pregnancy
Fisher, K. A., Luger, A., Spargo, B. H., & Lindheimer, M. D. (1981) · Medicine · doi:10.1097/00005792-198107000-00002 · Cited by 374 · see citing works
Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia
Chaiworapongsa, T., Romero, R., Espinoza, J., Bujold, E., Mee Kim, Y., Gonçalves, L. F., Gomez, R., & Edwin, S. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.03.043 · Cited by 368 · see citing works
Self-citation
Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model
Kumasawa, K., Ikawa, M., Kidoya, H., Hasuwa, H., Saito‐Fujita, T., Morioka, Y., Takakura, N., Kimura, T., & Okabe, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011293108 · Cited by 366 · see citing works
Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia
Chaiworapongsa, T., Romero, R., Kim, Y. M., Kim, G. J., Kim, M. R., Espinoza, J., Bujold, E., Gonçalves, L., Gomez, R., Edwin, S., et al. (2005) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050400028816 · Cited by 359 · see citing works
Self-citation
First trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications
Ong, C. Y. T., Liao, A. W., Spencer, K., Munim, S., & Nicolaides, K. H. (2000) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2000.tb11618.x · Cited by 347 · see citing works
Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia
Thadhani, R., Kisner, T., Hagmann, H., Boßung, V., Noack, S., Schaarschmidt, W., Jank, A., Kribs, A., Cornely, O. A., Kreyssig, C., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.034793 · Cited by 347 · see citing works
Chronic kidney disease in pregnancy
Williams, D. J., & Davison, J. M. (2008) · BMJ · doi:10.1136/bmj.39406.652986.be · Cited by 319 · see citing works
Pharmacokinetic Changes During Pregnancy and Their Clinical Relevance
Loebstein, R., Lalkin, A., & Koren, G. (1997) · Clinical Pharmacokinetics · doi:10.2165/00003088-199733050-00002 · Cited by 312 · see citing works
Guidelines for the management of hypertensive disorders of pregnancy 2008
Lowe, S. A., Brown, M. A., Dekker, G., Gatt, S. P., McLintock, C., McMahon, L. P., Mangos, G., Moore, M. P., Müller, P., Paech, M. J., et al. (2009) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2009.01003.x · Cited by 296 · see citing works
Evaluation and management of severe preeclampsia before 34 weeks' gestation
Sibai, B. M. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.07.017 · Cited by 280 · see citing works
A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia
Kusanovic, J. P., Romero, R. J., Chaiworapongsa, T., Erez, O., Mittal, P., Vaisbuch, E., Mazaki‐Tovi, S., Gotsch, F., Edwin, S. S., Gómez, R., et al. (2009) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767050902994754 · Cited by 277 · see citing works
Self-citation
Calcium Supplementation to Prevent Hypertensive Disorders of Pregnancy
Belizán, J. M., Villar, J., González, L. M., Campodonico, L., & Bergel, E. F. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111143252002 · Cited by 273 · see citing works
A novel approach to first‐trimester screening for early pre‐eclampsia combining serum PP‐13 and Doppler ultrasound
Nicolaides, K. H., Bindra, R. R., Turan, O. M., Chefetz, I., Sammar, M., Meiri, H., Tal, J., & Cuckle, H. (2005) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.2686 · Cited by 268 · see citing works
Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers
Kenny, L. C., Broadhurst, D., Dunn, W. B., Brown, M., North, R. A., McCowan, L. M. E., Roberts, C. T., Cooper, G. J. S., Kell, D. B., & Baker, P. N. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.157297 · Cited by 266 · see citing works
Recombinant Vascular Endothelial Growth Factor 121 Attenuates Hypertension and Improves Kidney Damage in a Rat Model of Preeclampsia
Li, Z., Zhang, Y., Jing, Y., Kapoun, A. M., Shao, Q., Kerr, I., Lam, A., O’Young, G., Sannajust, F. J., Stathis, P., et al. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.092098 · Cited by 258 · see citing works
The relationship between calcium intake and edema-, proteinuria-, and hypertension-gestosis: an hypothesis
Belizán, J. M., & Villar, J. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.10.2202 · Cited by 252 · see citing works
Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms‐like tyrosine kinase 1 and soluble endoglin in the prediction of pre‐eclampsia: a systematic review and meta‐analysis
Kleinrouweler, C. E., Wiegerinck, M. M. J., Ris‐Stalpers, C., Bossuyt, P. M., van der Post, J., von Dadelszen, P., Mol, B. W., & Pajkrt, E. (2012) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2012.03311.x · Cited by 251 · see citing works
Maternal Plasma Cell-Free Fetal and Maternal DNA at 11-13 Weeks' Gestation: Relation to Fetal and Maternal Characteristics and Pregnancy Outcomes
Poon, L. C., Musci, T. J., Song, K., Syngelaki, A., & Nicolaides, K. H. (2013) · Fetal Diagnosis and Therapy · doi:10.1159/000346806 · Cited by 246 · see citing works
Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia
Levine, R. J., Qian, C., LeShane, E. S., Yu, K., England, L. J., Schisterman, E. F., Wataganara, T., Romero, R. J., & Bianchi, D. W. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2003.12.019 · Cited by 243 · see citing works
Self-citation
Prenatal Screening for Aneuploidy
Driscoll, D. A., & Gross, S. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmcp0900134 · Cited by 240 · see citing works
A Competing Risks Model in Early Screening for Preeclampsia
Wright, D. E., Akolekar, R., Syngelaki, A., Poon, L. C., & Nicolaides, K. H. (2012) · Fetal Diagnosis and Therapy · doi:10.1159/000338470 · Cited by 235 · see citing works
Chesley's Hypertensive Disorders in Pregnancy
Lindheimer, M. D. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374213-1.x0001-8 · Cited by 234 · see citing works
Pitfalls With the New American College of Obstetricians and Gynecologists Task Force on Hypertension in Pregnancy
Pauli, J. M., & Repke, J. T. (2016) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000247 · Cited by 233 · see citing works
Increased Maternal Plasma Fetal DNA Concentrations in Women Who Eventually Develop Preeclampsia.
Leung, T. N., Zhang, J., Lau, T. K., et al. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.1.137 · Cited by 225 · see citing works
First‐trimester maternal serum PP‐13, PAPP‐A and second‐trimester uterine artery Doppler pulsatility index as markers of pre‐eclampsia
Spencer, K., Cowans, N. J., Chefetz, I., Tal, J., & Meiri, H. (2006) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.3876 · Cited by 216 · see citing works
Prediction of pregnancy complications by first‐trimester maternal serum PAPP‐A and free β‐hCG and with second‐trimester uterine artery Doppler
Spencer, K., Yu, C.-S., Cowans, N. J., Otigbah, C., & Nicolaides, K. H. (2005) · Prenatal Diagnosis · doi:10.1002/pd.1251 · Cited by 213 · see citing works
Magnesium sulphate and other anticonvulsants for women with pre-eclampsia
Duley, L., Gülmezoglu, A. M., & Henderson-Smart, D. J. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000025 · Cited by 211 · see citing works
Early Administration of Low-Dose Aspirin for the Prevention of Severe and Mild Preeclampsia: A Systematic Review and Meta-Analysis
Roberge, S., Giguère, Y., Villa, P., Nicolaides, K. H., Vainio, M., Forest, J., von Dadelszen, P., Vaiman, D., Tapp, S., & Bujold, E. (2012) · American Journal of Perinatology · doi:10.1055/s-0032-1310527 · Cited by 207 · see citing works
Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins
Edison, R. J., & Muenke, M. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30386 · Cited by 206 · see citing works
Review: Biochemical markers to predict preeclampsia
Anderson, U. D., Olsson, M. G., Kristensen, K. H., Åkerström, B., & Hansson, S. R. (2011) · Placenta · doi:10.1016/j.placenta.2011.11.021 · Cited by 204 · see citing works
Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial
Vadillo‐Ortega, F., Perichart‐Perera, O., Espino, S., Ávila-Vergara, M. A., Ibarra‐González, I., Ahued, R. A., Godines-Enriquez, M. S., Parry, S. I., Macones, G., & Strauss, J. F. (2011) · BMJ · doi:10.1136/bmj.d2901 · Cited by 202 · see citing works
Calcium supplementation to prevent hypertensive disorders of pregnancy
Belizán, J. M., Villar, J., Gonzalez, L., Campodónico, L., & Bergel, E. F. (1992) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(92)91075-y · Cited by 200 · see citing works
Abnormal Placentation, Angiogenic Factors, and the Pathogenesis of Preeclampsia
Silasi, M., Cohen, B., Karumanchi, S. A., & Rana, S. (2010) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2010.02.013 · Cited by 195 · see citing works
The Soluble VEGF Receptor sFlt1 Contributes to Endothelial Dysfunction in CKD
Marco, G. S. D., Reuter, S., Hillebrand, U., Amler, S., König, M., Larger, É., Oberleithner, H., Brand, E., Pavenstädt, H., & Brand, M. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009010061 · Cited by 194 · see citing works
If we know so much about preeclampsia, why haven’t we cured the disease?
Roberts, J. M., & Bell, M. J. (2013) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2013.05.003 · Cited by 189 · see citing works
Evaluation of 7 Serum Biomarkers and Uterine Artery Doppler Ultrasound for First-Trimester Prediction of Preeclampsia: A Systematic Review
Kuć, S., Wortelboer, E. J., van Rijn, B. B., Franx, A., Visser, G. H. A., & Schielen, P. C. J. I. (2011) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e3182227027 · Cited by 189 · see citing works
Uterine artery Doppler at 11 + 0 to 13 + 6 weeks and 21 + 0 to 24 + 6 weeks in the prediction of pre‐eclampsia
Plasencia, W., Maíz, N., Poon, L. C., Yu, C.-S., & Nicolaides, K. H. (2008) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.5402 · Cited by 189 · see citing works
Angiogenic factors for the prediction of preeclampsia in high-risk women
Simas, T. A. M., Crawford, S. L., Solitro, M. J., Frost, S., Meyer, B. A., & Maynard, S. E. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.06.030 · Cited by 185 · see citing works
Drugs for treatment of very high blood pressure during pregnancy
Duley, L., Henderson-Smart, D. J., & Meher, S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001449.pub2 · Cited by 185 · see citing works
Aspirin in the prevention of pre‐eclampsia in high‐risk women: a randomised placebo‐controlled PREDO Trial and a meta‐analysis of randomised trials
Villa, P., Kajantie, E., Räikkönen, K., Pesonen, A., Hämäläinen, E. K., Vainio, M., Taipale, P., Laivuori, H. M., & on behalf of the PREDO Study group (2012) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2012.03493.x · Cited by 179 · see citing works
Mapping the Theories of Preeclampsia and the Role of Angiogenic Factors
Widmer, M., Villar, J., Benigni, A., Conde-Agudelo, A., Karumanchi, S. A., & Lindheimer, M. D. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000249609.04831.7c · Cited by 176 · see citing works
Preeclampsia and future maternal health
Carty, D., Delles, C., & Dominiczak, A. F. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833a39d0 · Cited by 170 · see citing works
Recombinant Vascular Endothelial Growth Factor 121 Infusion Lowers Blood Pressure and Improves Renal Function in Rats With PlacentalIschemia-Induced Hypertension
Gilbert, J. S., Verzwyvelt, J. D., Colson, D., Arany, M., Karumanchi, S. A., & Granger, J. P. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.141937 · Cited by 167 · see citing works
Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies
Powers, R. W., Jeyabalan, A., Clifton, R. G., Van Dorsten, P., Hauth, J. C., Klebanoff, M. A., Lindheimer, M. D., Sibai, B., Landon, M., Miodovnik, M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013263 · Cited by 162 · see citing works
Pravastatin for the Prevention of Preeclampsia in High-Risk Pregnant Women
Costantine, M. M., & Cleary, K. L. (2013) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31827d8ad5 · Cited by 161 · see citing works
Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis
Conde‐Agudelo, A., Romero, R. J., Kusanovic, J. P., & Hassan, S. S. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.02.020 · Cited by 159 · see citing works
Self-citation
Clinical characterization and outcomes of preeclampsia with normal angiogenic profile
Rana, S., Schnettler, W. T., Powe, C. E., Wenger, J., Salahuddin, S., Cerdeira, A. S., Verlohren, S., Perschel, F. H., Arany, Z. P., Lim, K.-H., et al. (2013) · Hypertension in Pregnancy · doi:10.3109/10641955.2013.784788 · Cited by 155 · see citing works
Calcium supplementation during pregnancy may reduce preterm delivery in high-risk populations
Villar, J., & Repke, J. T. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90669-x · Cited by 153 · see citing works
CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group.
(1994) · PubMed · Cited by 151 · see citing works
Long-Term Complications of Preeclampsia
Williams, D. J. (2011) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2010.10.010 · Cited by 150 · see citing works
First-trimester maternal serum PP13 in the risk assessment for preeclampsia
Romero, R. J., Kusanovic, J. P., Than, N. G., Erez, O., Gotsch, F., Espinoza, J., Edwin, S. S., Chefetz, I., Gómez, R., Nien, J. K., et al. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.01.013 · Cited by 149 · see citing works
Self-citation
Longitudinal evaluation of predictive value for preeclampsia of circulating angiogenic factors through pregnancy
McElrath, T. F., Lim, K.-H., Paré, E., Rich-Edwards, J. W., Pucci, D., Troisi, R. J., & Parry, S. I. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.08.010 · Cited by 149 · see citing works
Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia
Chaiworapongsa, T., Romero, R. J., Korzeniewski, S. J., Kusanovic, J. P., Soto, E., Lam, J., Dong, Z., Than, N. G., Yeo, L., Hernandez‐Andrade, E. A., et al. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.01.016 · Cited by 144 · see citing works
Self-citation
Urinary Proteomics for Prediction of Preeclampsia
Carty, D., Siwy, J., Brennand, J. E., Zürbig, P., Mullen, W., Franke, J., McCulloch, J. W., North, R. A., Chappell, L. C., Mischak, H., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.164285 · Cited by 141 · see citing works
Maternal plasma concentrations of angiogenic/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia
Chaiworapongsa, T., Romero, R. J., Savasan, Z. A., Kusanovic, J. P., Oggè, G., Soto, E., Dong, Z., Tarca, A. L., Bhatti, G., & Hassan, S. S. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2011.589932 · Cited by 139 · see citing works
Self-citation
Chronic kidney disease may be differentially diagnosed from preeclampsia by serum biomarkers
Rolfo, A., Attini, R., Nuzzo, A. M., Piazzese, A., Parisi, S., Ferraresi, M., Todros, T., & Piccoli, G. B. (2012) · Kidney International · doi:10.1038/ki.2012.348 · Cited by 136 · see citing works
The Promise of Angiogenic Markers for the Early Diagnosis and Prediction of Preeclampsia
Hagmann, H., Thadhani, R., Benzing, T. R., Karumanchi, S. A., & Stepan, H. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2011.169094 · Cited by 136 · see citing works
Hypertension in pregnancy: the NICE guidelines: Table 1
Redman, C. W. G. (2011) · Heart · doi:10.1136/heartjnl-2011-300949 · Cited by 134 · see citing works
Angiogenic factors combined with clinical risk factors to predict preterm pre‐eclampsia in nulliparous women: a predictive test accuracy study
Myers, J., Kenny, L. C., McCowan, L. M. E., Chan, E., Dekker, G., Poston, L., Simpson, N., & North, R. (2013) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12195 · Cited by 133 · see citing works
Angiogenic Factors in Diagnosis, Management, and Research in Preeclampsia
Rana, S., Karumanchi, S. A., & Lindheimer, M. D. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02293 · Cited by 131 · see citing works
Microalbuminuria after pregnancy complicated by pre-eclampsia
Bar, J. (1999) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/14.5.1129 · Cited by 125 · see citing works
Metabolomics and first-trimester prediction of early-onset preeclampsia
Bahado-Singh, R. O., Akolekar, R., Mandal, R., Dong, E., Xia, J., Kruger, M. L., Wishart, D. S., & Nicolaides, K. H. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.680254 · Cited by 119 · see citing works
An integrative review of the side effects related to the use of magnesium sulfate for pre-eclampsia and eclampsia management
Smith, J. M., Lowe, R. F., Fullerton, J. T., Currie, S., Harris, L. F., & Felker-Kantor, E. (2013) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-13-34 · Cited by 110 · see citing works
Dietary calcium supplementation and prevention of pregnancy hypertension
López‐Jaramillo, P. (1990) · The Lancet · doi:10.1016/0140-6736(90)90112-i · Cited by 107 · see citing works
Maternal serum placental protein 13 at 11–13 weeks of gestation in preeclampsia
Akolekar, R., Syngelaki, A., Beta, J., Kocyłowski, R., & Nicolaides, K. H. (2009) · Prenatal Diagnosis · doi:10.1002/pd.2375 · Cited by 107 · see citing works
Placental volume and vascular flow assessed by 3D power Doppler and adverse pregnancy outcomes
Odibo, A. O., Goetzinger, K. R., Huster, K., Christiansen, J. K., Odibo, L., & Tuuli, M. G. (2011) · Placenta · doi:10.1016/j.placenta.2011.01.010 · Cited by 104 · see citing works
A higher maternal choline intake among third‐trimester pregnant women lowers placental and circulating concentrations of the antiangiogenic factor fms‐like tyrosine kinase‐1 (sFLT1)
Jiang, X., Bar, H., Yan, J., Jones, S., Brannon, P. M., West, A. A., Perry, C. A., Ganti, A., Pressman, E. K., Devapatla, S., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-221648 · Cited by 98 · see citing works
Can changes in angiogenic biomarkers between the first and second trimesters of pregnancy predict development of pre‐eclampsia in a low‐risk nulliparous patient population?
Myatt, L., Clifton, R., Roberts, J., Spong, C. Y., Wapner, R. J., Thorp, J. M., Mercer, B., Peaceman, A. M., Ramin, S. M., Carpenter, M., et al. (2013) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12128 · Cited by 95 · see citing works
Toxemia: new concepts in an old disease.
Romero, R. J., Lockwood, C. J., Enrique Oyarzún, E., et al. (1988) · PubMed · Cited by 94 · see citing works
Self-citation
Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis
Masuyama, H., Suwaki, N., Nakatsukasa, H., Masumoto, A., Tateishi, Y., & Hiramatrsu, Y. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.08.034 · Cited by 93 · see citing works
Low Placental Growth Factor Across Pregnancy Identifies a Subset of Women With Preterm Preeclampsia
Powers, R. W., Roberts, J. M., Plymire, D. A., Pucci, D., Datwyler, S. A., Laird, D. M., Sogin, D. C., Jeyabalan, A., Hubel, C. A., & Gandley, R. E. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.191213 · Cited by 91 · see citing works
Plasma concentrations of angiogenic/anti-angiogenic factors have prognostic value in women presenting with suspected preeclampsia to the obstetrical triage area: a prospective study
Chaiworapongsa, T., Romero, R. J., Korzeniewski, S. J., Cortez, J. M., Pappas, A., Tarca, A. L., Chaemsaithong, P., Dong, Z., Yeo, L., & Hassan, S. S. (2013) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2013.806905 · Cited by 88 · see citing works
Self-citation
First-trimester metabolomic detection of late-onset preeclampsia
Bahado-Singh, R. O., Akolekar, R., Mandal, R., Dong, E., Xia, J., Kruger, M. L., Wishart, D. S., & Nicolaides, K. H. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.11.003 · Cited by 88 · see citing works
Calcium supplementation and prevention of preeclampsia: a meta-analysis
Patrelli, T. S., Dall’Asta, A., Gizzo, S., Pedrazzi, G., Piantelli, G., Jasonni, V. M., & Modena, A. B. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.715220 · Cited by 85 · see citing works
Adenoviral Delivery of VEGF 121 Early in Pregnancy Prevents Spontaneous Development of Preeclampsia in BPH/5 Mice
Woods, A. K., Hoffmann, D. S., Weydert, C. J. D., Butler, S. D., Zhou, Y. F., Sharma, R. V., & Davisson, R. L. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.160242 · Cited by 80 · see citing works
Placental Growth Factor for the Prediction of Adverse Outcomes in Patients with Suspected Preeclampsia or Intrauterine Growth Restriction
Sibiude, J., Guibourdenche, J., Dionne, M.-D., Ray, C. L., Anselem, O., Serreau, R., Goffinet, F., & Tsatsaris, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050208 · Cited by 79 · see citing works
Transplacental transfer and distribution of pravastatin
Nanovskaya, T. N., Patrikeeva, S., Paúl, J., Costantine, M. M., Hankins, G. D. V., & Ahmed, M. S. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.05.038 · Cited by 77 · see citing works
Serum inhibin A and angiogenic factor levels in pregnancies with previous preeclampsia and/or chronic hypertension: are they useful markers for prediction of subsequent preeclampsia?
Sibai, B. M., Koch, M. A., Freire, S., Silva, J. L. P. E., Rudge, M. V. C., Costa, S. H. D. A. M., Bartz, J., Santos, C. D. B., Cecatti, J. G., Costa, R., et al. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.06.071 · Cited by 77 · see citing works
Nifedipine in pregnancy
Smith, P., Anthony, J., & Johanson, R. (2000) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2000.tb13222.x · Cited by 77 · see citing works
Angiogenic biomarkers for prediction of maternal and neonatal complications in suspected preeclampsia
Moore, A. G., Young, H. A., Keller, J. M., Ojo, L., Yan, J., Simas, T. A. M., & Maynard, S. E. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.713055 · Cited by 73 · see citing works
Cell‐free mRNA concentrations of CRH, PLAC1, and selectin‐P are increased in the plasma of pregnant women with preeclampsia
Purwosunu, Y., Sekizawa, A., Farina, A., et al. (2007) · Prenatal Diagnosis · doi:10.1002/pd.1780 · Cited by 70 · see citing works
Comprehensive Maternal Serum Proteomic Profiles of Preclinical and Clinical Preeclampsia
Rasanen, J. P., Girsen, A. I., Lu, X., Lapidus, J., Standley, M. S., Reddy, A. P., Dasari, S., Thomas, A., Jacob, T., Pouta, A. M., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr100198m · Cited by 63 · see citing works
Plasma Concentrations of Soluble Endoglin versus Standard Evaluation in Patients with Suspected Preeclampsia
Rana, S., Cerdeira, A. S., Wenger, J., Salahuddin, S., Lim, K.-H., Ralston, S. J., Thadhani, R., & Karumanchi, S. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048259 · Cited by 63 · see citing works
Preeclampsia and anaesthesia
Gogarten, W. (2009) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32832a1d05 · Cited by 62 · see citing works
Performance of messenger RNAs circulating in maternal blood in the prediction of preeclampsia at 10-14 weeks
Farina, A., Zucchini, C., Sekizawa, A., Purwosunu, Y., Sanctis, P. D., Santarsiero, G., Rizzo, N., Morano, D., & Okai, T. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.07.043 · Cited by 61 · see citing works
Prediction of preeclampsia by analysis of cell-free messenger RNA in maternal plasma
Purwosunu, Y., Sekizawa, A., Okazaki, S., Farina, A., Wibowo, N., Nakamura, M., Rizzo, N., Saito, H., & Okai, T. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.11.035 · Cited by 61 · see citing works
Committee Opinion No. 514
(2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31823ed1ef · Cited by 59 · see citing works
Soluble Fms-like tyrosine kinase associated with preeclampsia in pregnancy in systemic lupus erythematosus.
Qazi, U., Lam, C., Karumanchi, S. A., et al. (2008) · PubMed · Cited by 57 · see citing works
Young investigator award
Lagercrantz, H. (2010) · Acta Paediatrica · doi:10.1111/j.1651-2227.2010.01719.x · Cited by 52 · see citing works
Free fetal DNA is not increased before 20 weeks in intrauterine growth restriction or pre‐eclampsia
Crowley, A., Martin, C. M., Fitzpatrick, P., et al. (2006) · Prenatal Diagnosis · doi:10.1002/pd.1645 · Cited by 52 · see citing works
Cost and resource implications with serum angiogenic factor estimation in the triage of pre‐eclampsia
Schnettler, W. T., Dukhovny, D., Wenger, J., Salahuddin, S., Ralston, S. J., & Rana, S. (2013) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12259 · Cited by 51 · see citing works
Prospective evaluation of ultrasound and biochemical‐based multivariable models for the prediction of late pre‐eclampsia
Farina, A., Rapacchia, G., Sterrantino, A. F., Pula, G., Morano, D., & Rizzo, N. (2011) · Prenatal Diagnosis · doi:10.1002/pd.2849 · Cited by 50 · see citing works
Screening for pre-eclampsia: a systematic review of tests combining uterine artery Doppler with other markers
Pedrosa, A. C., & Matias, A. (2011) · Journal of Perinatal Medicine · doi:10.1515/jpm.2011.077 · Cited by 50 · see citing works
Hypertension in Pregnancy: The Incidence of Underlying Renal Disease and Essential Hypertension
Reiter, L., Brown, M. A., & Whitworth, J. A. (1994) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)81055-9 · Cited by 50 · see citing works
Labor induction for the preterm severe pre-eclamptic patient: is it worth the effort?
Blackwell, S. C., Redman, M. E., Tomlinson, M., et al. (2001) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/jmf.10.5.305.311 · Cited by 50 · see citing works
Application of a first‐trimester prediction model for pre‐eclampsia based on uterine arteries and maternal history in high‐risk pregnancies
Herraı̀z, I., Arbués, J., Camaño, I., Gómez‐Montes, E., Grañeras, A., & Galindo, A. (2009) · Prenatal Diagnosis · doi:10.1002/pd.2383 · Cited by 48 · see citing works
Superimposed Preeclampsia in Women with Chronic Kidney Disease
Masuyama, H., Nobumoto, E., Okimoto, N., et al. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000339935 · Cited by 47 · see citing works
Performance of the fullPIERS model in predicting adverse maternal outcomes in pre‐eclampsia using patient data from the PIERS (Pre‐eclampsia Integrated Estimate of RiSk) cohort, collected on admission
Payne, B. A., Hodgson, S., Hutcheon, J. A., Joseph, K. S., Li, J., Lee, T., Magee, L. A., Qu, Z., von Dadelszen, P., & for the PIERS Study Group (2012) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2012.03496.x · Cited by 45 · see citing works
Researching New Methods of Screening for Adverse Pregnancy Outcome: Lessons from Pre-eclampsia
Smith, G. C. S. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001274 · Cited by 43 · see citing works
The perinatal implications of angiogenic factors
Smith, G. C. S., & Wear, H. J. (2009) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e328328cf7d · Cited by 42 · see citing works
Labor induction for the preterm severe pre-eclamptic patient: is it worth the effort?
Blackwell, S., Redman, M. E., Tomlinson, M., et al. (2001) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/714904348 · Cited by 42 · see citing works
Angiogenic biomarkers for prediction of early preeclampsia onset in high-risk women
Simas, T. A. M., Crawford, S. L., Bathgate, S. L., Yan, J., Robidoux, L., Moore, M. J., & Maynard, S. E. (2013) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2013.847415 · Cited by 39 · see citing works
Prediction of pre‐eclampsia by an analysis of placenta‐derived cellular mRNA in the blood of pregnant women at 15–20 weeks of gestation
Sekizawa, A., Purwosunu, Y., Farina, A., Shimizu, H., Nakamura, M., Wibowo, N., Rizzo, N., & Okai, T. (2010) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2010.02491.x · Cited by 38 · see citing works
Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre‐eclampsia at term? An exploratory analysis of the HYPITAT trial
Tajik, P., van der Tuuk, K., Koopmans, C. M., Groen, H., van Pampus, M. G., van den Berg, P., van der Post, J., van Loon, A., de Groot, C. J. M., Kwee, A., et al. (2012) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2012.03405.x · Cited by 38 · see citing works
Angiogenic factors in preeclampsia
Goel, A., & Rana, S. (2013) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328365ad98 · Cited by 36 · see citing works
Candidate biochemical markers for screening of pre-eclampsia in early pregnancy
Forest, J., Charland, M., Massé, J., Bujold, E., Rousseau, F., Lafond, J., & Giguère, Y. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.820 · Cited by 33 · see citing works
Use of Circulating Antiangiogenic Factors to Differentiate Other Hypertensive Disorders From Preeclampsia in a Pregnant Woman on Dialysis
Shan, H. Y., Rana, S., Epstein, F. H., Stillman, I. E., Karumanchi, S. A., & Williams, M. E. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.03.011 · Cited by 29 · see citing works
Placental Protein-13 and Pregnancy-Associated Plasma Protein-A as First Trimester Screening Markers for Hypertensive Disorders and Small for Gestational Age Outcomes
Stamatopoulou, A., Cowans, N. J., Matwejew, E., von Kaisenberg, C., & Spencer, K. (2010) · Hypertension in Pregnancy · doi:10.3109/10641955.2010.484081 · Cited by 28 · see citing works
Gene expression in chorionic villous samples at 11 weeks of gestation in women who develop pre‐eclampsia later in pregnancy: implications for screening
Farina, A., Zucchini, C., Sanctis, P. D., et al. (2011) · Prenatal Diagnosis · doi:10.1002/pd.2675 · Cited by 28 · see citing works
Cell‐free fetal DNA (SRY locus) concentration in maternal plasma is directly correlated to the time elapsed from the onset of preeclampsia to the collection of blood
Farina, A., Sekizawa, A., Rizzo, N., et al. (2004) · Prenatal Diagnosis · doi:10.1002/pd.863 · Cited by 27 · see citing works
Case 38-2005
Williams, W. W., Ecker, J. L., Thadhani, R., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmcpc059031 · Cited by 24 · see citing works
Maternal Serum Soluble Endoglin at 30-33 Weeks in the Prediction of Preeclampsia
Lai, J., Syngelaki, A., Poon, L. C., Nucci, M., & Nicolaides, K. H. (2012) · Fetal Diagnosis and Therapy · doi:10.1159/000343220 · Cited by 22 · see citing works
Correction to "Magee LA, Helewa M, Moutquin J-M, von Dadelszen P. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. J Obstet Gynaecol Can 2008;30(Suppl 1):S17."
(2008) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)32870-5 · Cited by 19 · see citing works
Maternal serum PP13 and PAPP-A in first trimester, and doppler in second trimester, as markers of early pre-eclampsia
SPENCER, K. M., Cowans, N. J., Chefetz, I., et al. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.10.283 · Cited by 15 · see citing works
Management of gestational hypertension – the impact of HYPITATa
Pauli, J. M., Lauring, J. R., Stetter, C., et al. (2013) · Journal of Perinatal Medicine · doi:10.1515/jpm-2012-0179 · Cited by 10 · see citing works
Antihypertensive Treatment
Umans, J. G., Abalos, E. J., & Lindheimer, M. D. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374213-1.00020-3 · Cited by 3 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[106]Sibai BM Cunningham FG Chesley’s Hypertensive Disorders in Pregnancy Lindheimer MD Roberts JM Cunningham GC 214 225 Elsevier 2009

Sorted by citations

Untitled work
Rana (2019) · doi:10.1161/circresaha.118.313276 · Cited by 2,095 · see citing works
Pre-eclampsia part 1: current understanding of its pathophysiology
Chaiworapongsa, T., Chaemsaithong, P., Yeo, L., & Romero, R. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.102 · Cited by 956 · see citing works
Self-citation
Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity
Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253 · see citing works
Self-citation
Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction
Brownfoot, F. C., Hastie, R., Hannan, N. J., Cannon, P., Tuohey, L., Parry, L. J., Senadheera, S., Illanes, S. E., Kaitu’u-Lino, T. J., & Tong, S. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.12.019 · Cited by 222 · see citing works
Angiogenic and antiangiogenic markers for prediction and risk classification of preeclampsia
MALSHE, A. K., & SIBAI, B. M. (2017) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000267 · Cited by 18 · see citing works
Placental Drug Delivery to Treat Pre‐Eclampsia and Fetal Growth Restriction
Deepak, V., El‐Balawi, L., & Harris, L. K. (2024) · Small · doi:10.1002/smll.202311165 · Cited by 16 · see citing works

The utilization status of aspirin for the secondary prevention of ischemic stroke
Ke, X.-J., Yu, Y.-F., Guo, Z., et al. (2009) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.2009.02.010 · Cited by 5 · see citing works
Factors affecting over-the-counter use of aspirin in the secondary prophylaxis of cardiovascular disease.
Bedson, J., Whitehurst, T., Lewis, M., et al. (2001) · PubMed · Cited by 30 · see citing works
Crushed Aspirin Tablets
Blake, M. I. (1974) · JAMA · doi:10.1001/jama.1974.03240100015005 · Cited by 1 · see citing works
Evaluation of the Effectiveness of the AggreGuide A-100 in Measuring Platelet Aggregation in Individuals Taking a High or Low Dose of Aspirin
Fisher, R. G., Teitel, E. R., Yee, A. T., et al. (2013) · Laboratory Medicine · doi:10.1309/lmjf9wk85yaaaeyv · Cited by 2 · see citing works
Incidence of Aspirin Resistance in the Patient Group of a University Hospital in Korea
Lee, Y. K., Kim, H.-S., Park, J. Y., et al. (2008) · Annals of Laboratory Medicine · doi:10.3343/kjlm.2008.28.4.251 · Cited by 6 · see citing works

Authors: Chaiworapongsa, T., Chaemsaithong, P., Korzeniewski, S. J., Yeo, L., & Romero, R.
Affiliations: National Institutes of Health (US)
Corresponding author: Chaiworapongsa, Tinnakorn
ORCID: Chaiworapongsa, Tinnakorn
Chaemsaithong, Piya
Korzeniewski, Steven J.
Yeo, Lami
Romero, Roberto
Venue: Nature Reviews Nephrology
Publisher: Springer Science and Business Media LLC
Published: 2014-07-08
Volume: 10
Issue: 9
Pages: 531-540
ISSN: 1745-8323 (ISSN-L)
1759-5061
1759-507X
DOI: 10.1038/nrneph.2014.103
PMC: PMC5898797
OpenAlex: W2059849577
Cited by: 132
References: 147
Citations by year: 2026: 5 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 14 · 2021: 9 · 2020: 11 · 2019: 14 · 2018: 17 · 2017: 18 · 2016: 11 · 2015: 12 · 2014: 3
FWCI: 2.36
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Nephrology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HHSN275201300006C, ZIAHD002400)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords: preeclampsia, predictive biomarkers, prognostic factors, anti-angiogenic factors, angiogenic factors, first-trimester prediction, aspirin prophylaxis, maternal hypertension, seizure prevention, term birth, placental abnormalities, perinatal outcomes, risk stratification
MeSH terms: Female, Humans, Pre-Eclampsia, Pregnancy, Prognosis, Risk Factors, Biomarkers, Risk Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pre-eclampsia part 2: prediction, prevention and management

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks