The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Prolonged sitting: is it a distinct coronary heart disease risk factor?
Abstract
PURPOSE OF REVIEW: Prolonged sitting (sedentary behavior) has deleterious cardiovascular and metabolic correlates; however, little is known about the associations of too much sitting with all-cause and cardiovascular mortality risk. In addition to the adverse effects of total sitting time, the manner in which it is accumulated has also been postulated to be important for cardiovascular health. RECENT FINDINGS: We describe recent evidence from several research papers published in the last 12-18 months, showing deleterious relationships of sedentary behavior with mortality outcomes. We also explore emerging findings on breaking up sedentary time and its potential beneficial impact on cardiovascular health. SUMMARY: Consistent independent associations have been observed between sitting time/sedentary behaviors and elevated all-cause and cardiovascular disease mortality risk. Generally, these associations have persisted following adjustment for physical activity. Furthermore, total sedentary time (measured objectively via accelerometer) is detrimentally associated with several cardiovascular risk factors, whereas breaking up sedentary time (independent of total sedentary time and moderate-to-vigorous intensity activity) is beneficially associated. This evidence provides further support to the importance of avoiding prolonged, uninterrupted periods of sitting time for cardiovascular health. However, further evidence from intervention trials is required to establish the causal pathways.
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“The importance of long sleepers reporting significantly more television viewing time lies in the fact that sedentary behavior is an independent risk factor for cardiovascular disease [71, 72].”
From Smoking, screen-based sedentary behavior, and diet associated with habitual sleep duration and chronotype: data from the UK Biobank (2016) · cites this paper as [71]
Citations
Cites
Compendium of physical activities: an update of activity codes and MET intensities
AINSWORTH, B. E., HASKELL, W. L., WHITT, M. C., IRWIN, M. L., SWARTZ, A. M., STRATH, S. J., O???BRIEN, W. L., BASSETT, D. R., SCHMITZ, K. H., EMPLAINCOURT, P. O., et al. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009001-00009 · Cited by 8,497
Too Much Sitting: The Population Health Science of Sedentary Behavior
Owen, N., Healy, G. N., Matthews, C. E., & Dunstan, D. W. (2010) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3181e373a2 · Cited by 2,202
Self-citationHu, F. B., Li, T. Y., Colditz, G. A., Willett, W. C., & Manson, J. E. (2003) · JAMA · doi:10.1001/jama.289.14.1785 · Cited by 1,892
Hamilton, M. T., Hamilton, D. G., & Zderic, T. W. (2007) · Diabetes · doi:10.2337/db07-0882 · Cited by 1,655
Sitting time and mortality from all causes, cardiovascular disease, and cancer
KATZMARZYK, P. T., CHURCH, T. S., CRAIG, C. L., & BOUCHARD, C. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181930355 · Cited by 1,611
Healy, G. N., Dunstan, D. W., Salmon, J., Cerin, E., Shaw, J. E., Zimmet, P. Z., & Owen, N. (2008) · Diabetes Care · doi:10.2337/dc07-2046 · Cited by 1,465
Self-citationSedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06
Healy, G. N., Matthews, C. E., Dunstan, D. W., Winkler, E. A. H., & Owen, N. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq451 · Cited by 1,368
Self-citationThe evolving definition of “sedentary.”
Pate, R. R., O'Neill, J. R., & Lobelo, F. (2008) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3181877d1a · Cited by 1,280
Objectively Measured Sedentary Time, Physical Activity, and Metabolic Risk
Healy, G. N., Wijndaele, K., Dunstan, D. W., Shaw, J. E., Salmon, J., Zimmet, P. Z., & Owen, N. (2008) · Diabetes Care · doi:10.2337/dc07-1795 · Cited by 1,100
Self-citation
Research works printed but not linked: 3
- Owen, 2009, Too much sitting: a novel and important predictor of chronic disease risk Br J Sports M, ed, 43, 81
- Jeffery, 1998, Epidemic obesity in the United States: are fast foods and television viewing contributing Am J Public H, ealth, 88, 277
- Healy, 2008, Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab)., Diabetes Care, 31, 369, 10.2337/dc07-1795 · DOI · Paper page
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Chastin, S. F. M., Palarea-Albaladejo, J., Dontje, M. L., & Skelton, D. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0139984 · Cited by 1,034
“Some authors claim that sedentary time has specific effects on health that are not mitigated by activity [5,28] whilst others consider it as inactivity together with LIPA which simply has an effect because it displaces active time [10,14,27].”
Workplace interventions for reducing sitting at work
Shrestha, N., Kukkonen-Harjula, K. T., Verbeek, J. H. A. M., Ijaz, S., Hermans, V., & Bhaumik, S. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010912.pub3 · Cited by 403
Bailey, D. P., & Locke, C. D. (2014) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2014.03.008 · Cited by 358
Utilization and Harmonization of Adult Accelerometry Data
Wijndaele, K., Westgate, K. L., Stephens, S., Blair, S. N., Bull, F., CHASTIN, S. F. M., Dunstan, D. W., Ekelund, U., Esliger, D., Freedson, P. S., et al. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000661 · Cited by 304
Self-citationPhysical activity and the pelvic floor
Nygaard, I., & Shaw, J. M. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.08.067 · Cited by 244
Metadata
- Authors
- Dunstan, D. W., Thorp, A. A., & Healy, G. N.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Dunstan, David W.
- Venue
- Current Opinion in Cardiology
- Published
- 2011-09
- Volume
- 26
- Issue
- 5
- Pages
- 412-419
- ISSN
- 0268-4705 (ISSN-L)
- OpenAlex
- W2010126073
- Cited by
- 166
- References
- 46
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 10 · 2019: 12 · 2018: 19 · 2017: 13 · 2016: 18 · 2015: 19 · 2014: 17 · 2013: 15 · 2012: 8
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cardiology (publishedVersion)
- PubMed (publishedVersion)
- eSpace (Curtin University) (submittedVersion)
- Funders
- National Heart Foundation of Australia
- Australian Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Social Sciences › Human Factors and Ergonomics › Ergonomics and Musculoskeletal Disorders
- Keywords
- sedentary behavior, prolonged sitting, all-cause mortality, cardiovascular mortality, cardiovascular risk factors, physical activity, cardiovascular health
- MeSH terms
- Coronary Disease, Humans, Risk Factors, Time Factors, Sedentary Behavior
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