The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Prolonged sitting: is it a distinct coronary heart disease risk factor?
Abstract
PURPOSE OF REVIEW: Prolonged sitting (sedentary behavior) has deleterious cardiovascular and metabolic correlates; however, little is known about the associations of too much sitting with all-cause and cardiovascular mortality risk. In addition to the adverse effects of total sitting time, the manner in which it is accumulated has also been postulated to be important for cardiovascular health. RECENT FINDINGS: We describe recent evidence from several research papers published in the last 12-18 months, showing deleterious relationships of sedentary behavior with mortality outcomes. We also explore emerging findings on breaking up sedentary time and its potential beneficial impact on cardiovascular health. SUMMARY: Consistent independent associations have been observed between sitting time/sedentary behaviors and elevated all-cause and cardiovascular disease mortality risk. Generally, these associations have persisted following adjustment for physical activity. Furthermore, total sedentary time (measured objectively via accelerometer) is detrimentally associated with several cardiovascular risk factors, whereas breaking up sedentary time (independent of total sedentary time and moderate-to-vigorous intensity activity) is beneficially associated. This evidence provides further support to the importance of avoiding prolonged, uninterrupted periods of sitting time for cardiovascular health. However, further evidence from intervention trials is required to establish the causal pathways.
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“The importance of long sleepers reporting significantly more television viewing time lies in the fact that sedentary behavior is an independent risk factor for cardiovascular disease [71, 72].”
From Smoking, screen-based sedentary behavior, and diet associated with habitual sleep duration and chronotype: data from the UK Biobank (2016) · cites this paper as [71]
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“Some authors claim that sedentary time has specific effects on health that are not mitigated by activity [5,28] whilst others consider it as inactivity together with LIPA which simply has an effect because it displaces active time [10,14,27].”
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Metadata
- Authors
- Dunstan, D. W., Thorp, A. A., & Healy, G. N.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Dunstan, David W.
- Venue
- Current Opinion in Cardiology
- Published
- 2011-09
- Volume
- 26
- Issue
- 5
- Pages
- 412-419
- ISSN
- 0268-4705 (ISSN-L)
- OpenAlex
- W2010126073
- Cited by
- 166
- References
- 46
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 10 · 2019: 12 · 2018: 19 · 2017: 13 · 2016: 18 · 2015: 19 · 2014: 17 · 2013: 15 · 2012: 8
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cardiology (publishedVersion)
- PubMed (publishedVersion)
- eSpace (Curtin University) (submittedVersion)
- Funders
- National Heart Foundation of Australia
- Australian Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Social Sciences › Human Factors and Ergonomics › Ergonomics and Musculoskeletal Disorders
- Keywords
- sedentary behavior, prolonged sitting, all-cause mortality, cardiovascular mortality, cardiovascular risk factors, physical activity, cardiovascular health
- MeSH terms
- Coronary Disease, Humans, Risk Factors, Time Factors, Sedentary Behavior
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