A reduced heart rate variability is independently associated with a blunted nocturnal blood pressure fall in patients with resistant hypertension
Abstract
BACKGROUND: A blunted nocturnal blood pressure (BP) fall is a marker of worse cardiovascular outcomes, and autonomic imbalance may be involved. The objective was to evaluate the associations between the nocturnal BP fall and heart rate variability (HRV) parameters in resistant hypertension. DESIGN AND METHODS: In a cross-sectional analysis, 424 resistant hypertensive patients performed 24-h ambulatory BP and Holter monitoring, and 221 patients also performed polysomnography. Time-domain HRV parameters evaluated were the standard deviation of all normal RR intervals (SDNN), the standard deviation of the averaged normal RR intervals for all 5-min segments (SDANN), the root mean square of differences between adjacent R-R intervals (rMSSD) and the percentage of adjacent R-R intervals that varied by more than 50 ms (pNN50). Multivariate linear and logistic regressions assessed associations between the nocturnal BP fall and HRV parameters. RESULTS: Two hundred and sixty-six patients (63%) presented a nondipping pattern. These patients had lower SDNN and SDANN than normal dipping patients, but equal rMSSD and pNN50. On multivariate analysis, after adjustments for several confounders, a reduced SDNN (<70 ms) implied a 2.9 to 3.4-fold [95% confidence interval (CI) 1.2-8.5] and a reduced SDANN (<50 ms) a 3.7 to 4.2-fold (95% CI 1.5-11.4) higher odds of having a nondipping pattern. Further adjustment for the presence and severity of obstructive sleep apnoea did not change the results. CONCLUSION: Reduced SDNN and SDANN, two HRV parameters that mainly reflect sympathetic overactivity, were independently associated with a blunted nocturnal BP fall in resistant hypertension. These relationships offer insight into physiopathological mechanisms linking the circadian BP variability to cardiovascular outcomes.
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The normal nocturnal decline in blood pressure is attenuated in a high proportion (43%-65%) of individuals with resistant hypertension.
“The normal nocturnal decline in BP is also attenuated in a high proportion (43%−65%) of individuals with RH.32,53,54”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [53]
Nondipping ambulatory blood pressure in individuals with resistant hypertension has been linked to reduced heart rate variability, a marker of sympathetic nervous system overactivity.
“Nondipping ambulatory BP in individuals with RH has been linked to reduced heart rate variability, a marker of sympathetic nervous system overactivity.53”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [53]
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- Authors
- Salles, G. F., Ribeiro, F. M., Guimarães, G. M., Muxfeldt, E. S., & Cardoso, C. R. L.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Corresponding author
- Salles, Gil F.
- Venue
- Journal of Hypertension
- Published
- 2014-03
- Volume
- 32
- Issue
- 3
- Pages
- 644-651
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2313251981
- Cited by
- 34
- References
- 38
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- resistant hypertension, heart rate variability, nocturnal blood pressure dipping, autonomic imbalance, sympathetic hyperactivity, circadian blood pressure variation, obstructive sleep apnea, cardiovascular risk
- MeSH terms
- Aged, Antihypertensive Agents, Blood Pressure, Circadian Rhythm, Cross-Sectional Studies, Drug Resistance, Female, Heart Rate, Humans, Hypertension, Male, Middle Aged, Prospective Studies, Electrocardiography, Ambulatory, Multivariate Analysis, Polysomnography, Blood Pressure Monitoring, Ambulatory, Sleep Apnea, Obstructive
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