Cited by 34Heart Rate Variability and Autonomic ControlBlood Pressure and Hypertension StudiesCardiovascular Health and Disease Prevention

A reduced heart rate variability is independently associated with a blunted nocturnal blood pressure fall in patients with resistant hypertension

Salles, Gil F., Ribeiro, Frederico M., Guimarães, Gleison M., Muxfeldt, Elizabeth S., Cardoso, Claudia R.L.·2014·Journal of Hypertension

Abstract

BACKGROUND: A blunted nocturnal blood pressure (BP) fall is a marker of worse cardiovascular outcomes, and autonomic imbalance may be involved. The objective was to evaluate the associations between the nocturnal BP fall and heart rate variability (HRV) parameters in resistant hypertension. DESIGN AND METHODS: In a cross-sectional analysis, 424 resistant hypertensive patients performed 24-h ambulatory BP and Holter monitoring, and 221 patients also performed polysomnography. Time-domain HRV parameters evaluated were the standard deviation of all normal RR intervals (SDNN), the standard deviation of the averaged normal RR intervals for all 5-min segments (SDANN), the root mean square of differences between adjacent R-R intervals (rMSSD) and the percentage of adjacent R-R intervals that varied by more than 50 ms (pNN50). Multivariate linear and logistic regressions assessed associations between the nocturnal BP fall and HRV parameters. RESULTS: Two hundred and sixty-six patients (63%) presented a nondipping pattern. These patients had lower SDNN and SDANN than normal dipping patients, but equal rMSSD and pNN50. On multivariate analysis, after adjustments for several confounders, a reduced SDNN (<70 ms) implied a 2.9 to 3.4-fold [95% confidence interval (CI) 1.2-8.5] and a reduced SDANN (<50 ms) a 3.7 to 4.2-fold (95% CI 1.5-11.4) higher odds of having a nondipping pattern. Further adjustment for the presence and severity of obstructive sleep apnoea did not change the results. CONCLUSION: Reduced SDNN and SDANN, two HRV parameters that mainly reflect sympathetic overactivity, were independently associated with a blunted nocturnal BP fall in resistant hypertension. These relationships offer insight into physiopathological mechanisms linking the circadian BP variability to cardiovascular outcomes.

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Crossref · 10.1097/hjh.0000000000000068

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Authors
Salles, G. F., Ribeiro, F. M., Guimarães, G. M., Muxfeldt, E. S., & Cardoso, C. R. L.
Affiliations
Universidade Federal do Rio de Janeiro (BR)
Corresponding author
Salles, Gil F.
Venue
Journal of Hypertension
Published
2014-03
Volume
32
Issue
3
Pages
644-651
ISSN
0263-6352 (ISSN-L)
OpenAlex
W2313251981
Cited by
34
References
38
Citations by year
2026: 1 · 2025: 4 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 2
FWCI
1.60
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
resistant hypertension, heart rate variability, nocturnal blood pressure dipping, autonomic imbalance, sympathetic hyperactivity, circadian blood pressure variation, obstructive sleep apnea, cardiovascular risk
MeSH terms
Aged, Antihypertensive Agents, Blood Pressure, Circadian Rhythm, Cross-Sectional Studies, Drug Resistance, Female, Heart Rate, Humans, Hypertension, Male, Middle Aged, Prospective Studies, Electrocardiography, Ambulatory, Multivariate Analysis, Polysomnography, Blood Pressure Monitoring, Ambulatory, Sleep Apnea, Obstructive

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