Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study
Abstract
Background The prognostic implications of alterations in heart rate variability have not been studied in a large community-based population. Methods and results The first 2 hours of ambulatory ECG recordings obtained on original subjects of the Framingham Heart Study attending the 18th biennial examination were reprocessed to assess heart rate variability. Subjects with transient or persistent nonsinus rhythm, premature beats > 10% of total beats, 50 milliseconds, and the square root of the mean of the squared differences between adjacent normal RR intervals. During follow-up, 74 subjects died. In separate proportional hazards regression analyses that adjusted for relevant risk factors, very-low-frequency power (P Conclusions The estimation of heart rate variability by ambulatory monitoring offers prognostic information beyond that provided by the evaluation of traditional risk factors.
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Low frequency heart rate variability is an independent predictor of death.
“In particular, low frequency heart rate variability is an independent predictor of death (Tsuji et al., 1994).”
From Maladaptive autonomic regulation in PTSD accelerates physiological aging (2015) · cites this paper as Tsuji et al., 1994
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- Authors
- Tsuji, H., Venditti, F. J., Manders, E. S., Evans, J. C., Larson, M. G., Feldman, C. L., & Levy, D.
- Affiliations
- Lahey Hospital and Medical Center (US)
- Venue
- Circulation
- Published
- 1994-08
- Volume
- 90
- Issue
- 2
- Pages
- 878-883
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1480640136
- Cited by
- 1,114
- References
- 0
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 30 · 2023: 34 · 2022: 42 · 2021: 54 · 2020: 59 · 2019: 41 · 2018: 45 · 2017: 42 · 2016: 46 · 2015: 35 · 2014: 58 · 2013: 45 · 2012: 46
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Japanese Circulation Journal-english Edition
- Funders
- Dana Foundation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- heart rate variability, all-cause mortality, prognostic factors, older adults, low-frequency power, very low frequency power, high-frequency power, RR interval variability, autonomic nervous system, Holter monitoring, Framingham Heart Study
- MeSH terms
- Aged, Cardiovascular Diseases, Coronary Disease, Female, Follow-Up Studies, Heart Rate, Humans, Male, Massachusetts, Neoplasms, Prognosis, Prospective Studies, Risk Factors, Signal Processing, Computer-Assisted, Time Factors, Cohort Studies, Electrocardiography, Ambulatory, Proportional Hazards Models
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