Cited by 55Cardiovascular Health and Disease PreventionCardiovascular Disease and AdiposityAdipokines, Inflammation, and Metabolic Diseases

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An update on the role of adipokines in arterial stiffness and hypertension

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Sabbatini, Andréa R., Fontana, Vanessa, Laurent, Stephane, Moreno, Heitor·2015·Journal of Hypertension

DOI 10.1097/hjh.0000000000000444

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Abstract

Adipokines are hormones produced by adipocytes and have been involved in multiple pathologic pathways, including inflammatory and cardiovascular complications in essential hypertension. Arterial stiffness is a frequent vascular complication that represents increased cardiovascular risk in hypertensive patients. Adipokines, such as adiponectin, leptin and resistin, might be implicated in hypertension, as well as in vascular alterations associated with this condition. Arterial stiffness has proven to be a predictor of cardiovascular events. Obesity and target-organ damage such as arterial stiffness are features associated with hypertension. This review aims to update the association between adipokines and arterial stiffness in essential and resistant hypertension (RHTN).

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Authors: Sabbatini, A. R., Fontana, V., Laurent, S., & Moreno, H.
Affiliations: Universidade Estadual de Campinas (UNICAMP) (BR)
Corresponding author: Moreno, Heitor
ORCID: Fontana, Vanessa
Moreno, Heitor
Venue: Journal of Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-03
Volume: 33
Issue: 3
Pages: 435-444
ISSN: 0263-6352 (ISSN-L)
DOI: 10.1097/hjh.0000000000000444
OpenAlex: W2333731035
Cited by: 55
References: 109
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 1
FWCI: 0.43
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: Journal of Hypertension (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: adipokines, arterial stiffness, essential hypertension, resistant hypertension, adiponectin, leptin, resistin, obesity, target organ damage, cardiovascular risk, vascular inflammation
MeSH terms: Essential Hypertension, Humans, Hypertension, Obesity, Risk Factors, Adipocytes, Leptin, Adiponectin, Resistin, Adipokines, Vascular Stiffness

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An update on the role of adipokines in arterial stiffness and hypertension

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