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Cited by 121Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityAdipokines, Inflammation, and Metabolic Diseases

Associations among plasma adiponectin, hypertension, left ventricular diastolic function and left ventricular mass index

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Hong, Soon Jun, Park, Chang Gyu, Seo, Hong Seog, Oh, Dong Joo, Ro, Young Moo·2004·Blood Pressure
DOI 10.1080/08037050410021397
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Abstract

OBJECTIVE: The purpose of this study was to characterize the relationships among plasma adiponectin, essential hypertension, left ventricular diastolic function and left ventricular hypertrophy. METHODS AND RESULTS: Plasma adiponectin concentration was assessed by radioimmunoassay, and body mass index (BMI) was measured in 275 patients (138 women and 137 men). Various echocardiographic parameters such as deceleration time (DT) and isovolumetric relaxation time (IVRT) were measured by using echocardiograms. The authors calculated left ventricular mass index (LVMI) and E/A ratio. Pulse wave velocity (PWV) was calculated by dividing the distance between the left subclavian artery ostium and the tip of the femoral sheath with the time interval between two pulse waves. The plasma adiponectin concentration of the hypertensive group was significantly lower than that of the non-hypertensive group (9.9 +/- 9.8 microg/ml vs. 12.9 +/- 9.5 microg/ml, p = 0.019). PWV in the hypertensive group was 12.0 +/- 3.9 m/s compared with 9.3 +/- 2.8 m/s in the normotensive group (p < 0.001). LVMI in the hypertensive group was 135.1 +/- 35.4 g/m2 compared with 100.5 +/- 18.7 g/m2 in the normotensive group (p < 0.001). E/A ratio (0.8 +/- 0.3 vs. 1.1 +/- 0.4, p = 0.041) was lower in the hypertensive group. DT (200.0 +/- 61.2 ms vs. 177.3 +/- 40.8 ms, p = 0.048) and IVRT (106.9 +/- 25.4 vs. 91.3 +/- 27.6 ms, p = 0.243) were higher in the hypertensive group. Plasma adiponectin showed an inverse correlation with LVMI (r = -0.525; p < 0.001) and PWV (r = -0.557; p < 0.001), IVRT (r = -0.485; p = 0.008), and showed a positive correlation with E/A ratio (r = 0.359; p < 0.001). Multiple regression analyses showed that PWV and plasma adiponectin were able to explain the 73.3% of LVMI variability (r = 0.856; p < 0.001). CONCLUSION: The results suggest that a decrease in plasma adiponectin concentration is associated with the progression of left ventricular hypertrophy with diastolic dysfunction.

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  • Clinical studies have established correlations between plasma adiponectin levels and various aspects and severity of heart failure.

    “First, an important pathophysiological contribution was suggested by the recent explosion in the number of clinical studies that have established correlations between plasma adiponectin levels and various aspects and severity of heart failure (107, 113, 143, 166, 172, 183, 198, 209, 251, 275, 282, 286, 303, 312, 366).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [143]

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  1. Garcia MJ, Thomas JD, Klein AL. New Doppler echocar- diographic applications for the study of diastolic function. J Am Coll Cardiol 1998; 32: 865-75.

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Authors
Hong, S. J., Park, C. G., Seo, H. S., Oh, D. J., & Ro, Y. M.
Affiliations
Korea University (KR)
Corresponding author
Park, Chang Gyu
ORCID
Venue
Blood Pressure
Publisher
Informa UK Limited
Published
2004-01
Volume
13
Issue
4
Pages
236-242
ISSN
  • 0803-7051 (ISSN-L)
  • 1651-1999
DOI
10.1080/08037050410021397
OpenAlex
W2016738173
Cited by
121
References
20
Citations by year
2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 9 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 13 · 2012: 8
FWCI
3.52
Type
journal article
Language
en
Open access
Locations
  • Blood Pressure (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
adiponectin, essential hypertension, left ventricular diastolic function, left ventricular hypertrophy, left ventricular mass index, pulse wave velocity, arterial stiffness, diastolic relaxation, isovolumic relaxation time, deceleration time, E/A ratio, body mass index, adipokines, cardiovascular risk factors, echocardiography, pulse wave analysis
MeSH terms
Adult, Aged, Blood Pressure, Echocardiography, Female, Heart Ventricles, Humans, Hypertension, Male, Middle Aged, Case-Control Studies, Ventricular Function, Left, Intercellular Signaling Peptides and Proteins, Adiponectin

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