Systolic blood pressure, diabetes and the risk of cardiovascular diseases in the Asia–Pacific region
Open accessAbstract
OBJECTIVE: To assess the association between systolic blood pressure (SBP) and cardiovascular diseases (CVD) among participants with and without diabetes from cohorts in the Asia-Pacific region. RESEARCH DESIGN AND METHODS: Hazards ratios and 95% confidence intervals (CI) for CVD were calculated from Cox models, stratified by sex and region and adjusted for age using individual participant data from 36 cohort studies. Repeat measurements of SBP were used to adjust for regression dilution bias. RESULTS: During follow-up, 7387 fatal or non-fatal cardiovascular endpoints were recorded among 368 307 participants (6.4% with diabetes). SBP was associated with coronary heart disease (CHD), ischaemic stroke and haemorrhagic stroke in a continuous log-linear fashion among individuals with diabetes, as well as those without diabetes. Overall, each 10 mmHg higher usual SBP was associated with 18% (95% CI: 9-27%) and 23% (19-26%) greater risk for CHD among those with and without diabetes, respectively. The corresponding values for ischaemic stroke were 29% (14-45%) and 43% (37-50%), and for haemorrhagic stroke, 56% (32-83%) and 74% (66-82%). The test for heterogeneity by diabetes status in each of these associations was not significant (P >or= 0.10). CONCLUSIONS: Systolic blood pressure is an important marker of risk of CVD in people with and without diabetes. A given reduction in systolic blood pressure is likely to have a similar relative effect on reducing the risk of a cardiovascular event, regardless of diabetes status.
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The additional administration of EPA significantly decreased coronary events in Japanese patients who were taking statins for treating hypercholesterolemia complicated with impaired glucose metabolism.
“The additional administration of EPA was also reported to significantly decrease coronary events in Japanese patients who were taking statins for treating hypercholesterolemia complicated with impaired glucose metabolism807).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [807]
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The Impact of Blood Pressure on the Risk for Cardiovascular Diseases: What Should Be Done Now?
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Translation of Safety Pharmacology Studies
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Translation of Safety Pharmacology Studies
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Effect of Blood Pressure Management on Coronary Heart Disease Risk in Patients With Type 2 Diabetes
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- Authors
- Asia Pacific Cohort Studies Collaboration
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Asia Pacific Cohort Studies Collaboration
- Venue
- Journal of Hypertension
- Published
- 2007-06
- Volume
- 25
- Issue
- 6
- Pages
- 1205-1213
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W1565722632
- Cited by
- 94
- References
- 28
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 7 · 2012: 7
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- green
- ovidsp.ovid.com
- Licence
- cc-by-nc-nd
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Pfizer
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- systolic blood pressure, diabetes mellitus, cardiovascular risk, coronary artery disease, ischemic stroke, hemorrhagic stroke, hypertension, Asia-Pacific region, cohort studies, regression dilution bias
- MeSH terms
- Adult, Australia, Blood Pressure, Cardiovascular Diseases, Diabetes Mellitus, Humans, Risk Factors, Systole, Cohort Studies, Survival Analysis, Stroke, White People, Asian People
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