Effectiveness of nonpharmacological secondary prevention of coronary heart disease
Open accessAbstract
AIM: To summarize the current evidence with regard to the effectiveness of nonpharmacological secondary prevention strategies of coronary heart disease (CHD) and to investigate the comparative effectiveness of interventions of different categories, specific intervention components and the effectiveness in patient subgroups. METHODS: A structured search of databases and manual search were conducted. Clinical trials and meta-analyses published between January 2003 and September 2008 were included if they targeted adults with CHD, had a follow-up of at least 12 months, and reported mortality, cardiac events or quality of life. Two researchers assessed eligibility and methodological quality, in which appropriate, pooled effect estimates were calculated and tested in sensitivity analyses. RESULTS: Of 4798 publications 43 met the inclusion criteria. Overall study quality was satisfactory, but only about half of the studies reported mortality. Follow-up duration varied between 12 and 120 months. Despite substantial heterogeneity, there was strong evidence of intervention effectiveness overall. The evidence for exercise and multimodal interventions was more conclusive for reducing mortality, whereas psychosocial interventions seemed to be more effective in improving the quality of life. Rigorous studies investigating dietary and smoking cessation interventions, specific intervention components and important patient subgroups, were scarce. CONCLUSION: Nonpharmacological secondary prevention is safe and effective, with exercise and multimodal interventions reducing mortality most substantially. There is a lack of studies concerning dietary and smoking cessation interventions. In addition, intervention effectiveness in patient subgroups and of intervention components could not be evaluated conclusively. Future research should investigate these issues in rigorous studies with appropriate follow-up duration to improve the current poor risk factor control of CHD patients.
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Multimodal interventions elicit greater survival benefits than exercise-only interventions.
“Indeed, multimodal interventions have been shown to elicit greater survival benefits when compared with exercise-only interventions.9,10”
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Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026 · see citing works
Lopez, A. D., Mathers, C. D., Ezzati, M., Jamison, D. T., & Murray, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68770-9 · Cited by 5,630 · see citing works
de Lorgeril, M., Salen, P., Martin, J.-L., Monjaud, I., Delaye, J., & Mamelle, N. (1999) · Circulation · doi:10.1161/01.cir.99.6.779 · Cited by 2,910 · see citing works
Explaining the decrease in U.S. deaths from coronary disease, 1980–2000
Ford, E. S., Ajani, U. A., Croft, J. B., Critchley, J. A., Labarthe, D. R., Kottke, T. E., Giles, W. H., & Capewell, S. (2007) · New England Journal of Medicine · doi:10.1056/nejmsa053935 · Cited by 2,757 · see citing works
A Potential Decline in Life Expectancy in the United States in the 21st Century
Olshansky, S. J., Passaro, D. J., Hershow, R. C., Layden, J., Carnes, B. A., Brody, J., Hayflick, L., Butler, R. N., Allison, D. B., & Ludwig, D. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmsr043743 · Cited by 2,612 · see citing works
Taylor, R. S., Brown, A., Ebrahim, S., Jolliffe, J., Noorani, H., Rees, K., Skidmore, B., Stone, J. A., Thompson, D. R., & Oldridge, N. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.01.009 · Cited by 2,239 · see citing works
A Potential Decline in Life Expectancy in the United States in the 21st Century
Olshansky, S. J., Passaro, D. J., Hershow, R. C., Layden, J. E., Carnes, B. A., Brody, J. A., Hayflick, L., Butler, R. N., Allison, D. B., & Ludwig, D. S. (2005) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000167407.83915.e7 · Cited by 1,944 · see citing works
Graham (2007) · doi:10.1097/01.hjr.0000277983.23934.c9 · Cited by 1,647 · see citing works
A new system for grading recommendations in evidence based guidelines
Harbour, R., & Miller, J. (2001) · BMJ · doi:10.1136/bmj.323.7308.334 · Cited by 1,637 · see citing works
Mente, A., de Koning, L., Shannon, H. S., & Anand, S. S. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.38 · Cited by 1,267 · see citing works
Meta-analysis: secondary prevention programs for patients with coronary artery disease
Clark, A. M., Hartling, L., Vandermeer, B., & McAlister, F. A. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-143-9-200511010-00010 · Cited by 979 · see citing works
Kotseva, K., Wood, D., De Backer, G., De Bacquer, D., Pyörälä, K., & Keil, U. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60330-5 · Cited by 833 · see citing works
Wood, D. A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04235-5 · Cited by 761 · see citing works
Hambrecht, R., Walther, C., Möbius-Winkler, S., Gielen, S., Linke, A., Conradi, K., Erbs, S., Kluge, R., Kendziorra, K., Sabri, O., et al. (2004) · Circulation · doi:10.1161/01.cir.0000121360.31954.1f · Cited by 752 · see citing works
Lack of benefit of dietary advice to men with angina: results of a controlled trial
Burr, M. L., Ashfield-Watt, P. A. L., Dunstan, F. D. J., Fehily, A. M., Breay, P., Ashton, T., Zotos, P. C., Haboubi, N. A. A., & Elwood, P. C. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601539 · Cited by 409 · see citing works
Marchionni, N., Fattirolli, F., Fumagalli, S., Oldridge, N., Lungo, F. D., Morosi, L., Bürgisser, C., & Masotti, G. (2003) · Circulation · doi:10.1161/01.cir.0000066322.21016.4a · Cited by 316 · see citing works
Graham, I. D., Atar, D., Borch‐Johnsen, K., Boysen, G., Burell, G. K., Cífková, R., Dallongeville, J., Backer, G. D., Ebrahim, S. B. J., Gjelsvik, B., et al. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000277984.31558.c4 · Cited by 286 · see citing works
Psychological treatment of cardiac patients: a meta-analysis
Linden, W., Phillips, M. J., & Leclerc, J. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm504 · Cited by 284 · see citing works
Mohiuddin, S. M., Mooss, A. N., Hunter, C. B., Grollmes, T. L., Cloutier, D. A., & Hilleman, D. E. (2007) · Chest · doi:10.1378/chest.06-1587 · Cited by 281 · see citing works
Murchie, P., Campbell, N. C., Ritchie, L. D., Simpson, J. A., & Thain, J. (2003) · BMJ · doi:10.1136/bmj.326.7380.84 · Cited by 272 · see citing works
Iestra, J. A., Kromhout, D., van der Schouw, Y. T., Grobbee, D. E., Boshuizen, H. C., & van Staveren, W. A. (2005) · Circulation · doi:10.1161/circulationaha.104.503995 · Cited by 262 · see citing works
Jolly, K. B., Taylor, R. S., Lip, G. Y. H., Greenfield, S., Raftery, J. P., Mant, J., Lane, D. A., Jones, M., Lee, K., & Stevens, A. J. (2007) · Health Technology Assessment · doi:10.3310/hta11350 · Cited by 216 · see citing works
Jolly, K. B., Taylor, R. S., Lip, G. Y. H., & Stevens, A. J. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.11.002 · Cited by 177 · see citing works
Behavioural interventions for smoking cessation: a meta-analysis of randomized controlled trials
Mottillo, S., Filion, K. B., Bélisle, P., Joseph, L., Gervais, A., O'Loughlin, J., Paradis, G., Pihl, R., Pilote, L., Rinfret, S., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehn552 · Cited by 171 · see citing works
van Dixhoorn, J., & White, A. R. (2005) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000166451.38593.de · Cited by 166 · see citing works
Tuttle, K. R., Shuler, L. A., Packard, D. P., Milton, J. E., Daratha, K. B., Bibus, D. M., & Short, R. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.01.038 · Cited by 126 · see citing works
Cost‐effectiveness of rehabilitation after an acute coronary event: a randomised controlled trial
Briffa, T. G., Eckermann, S. D., Griffiths, A. D., KEECH, A. C., Harris, P. J., Heath, M. R., Freedman, S. B., Donaldson, L. T., & Briffa, K. (2005) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2005.tb07121.x · Cited by 117 · see citing works
Quist‐Paulsen, P., & Gallefoss, F. (2003) · BMJ · doi:10.1136/bmj.327.7426.1254 · Cited by 115 · see citing works
Smith, K. M., Arthur, H. M., McKelvie, R. S., & Kodis, J. A. (2004) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000136414.40017.10 · Cited by 103 · see citing works
Michalsen, A., Grossman, P., Lehmann, N., Knoblauch, N. T. M., Paul, A. E., Moebus, S., Budde, T., & Dobos, G. J. (2005) · Psychotherapy and Psychosomatics · doi:10.1159/000087781 · Cited by 99 · see citing works
O’Flaherty, M., Bishop, J., Redpath, A., McLaughlin, T., Murphy, D., Chalmers, J., & Capewell, S. (2009) · BMJ · doi:10.1136/bmj.b2613 · Cited by 97 · see citing works
Arrigo, I., Rocca, H. B., Lefkovits, M., Pfisterer, M. E., & Hoffmann, A. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282f40e01 · Cited by 96 · see citing works
Yu, C.-M., Li, L. S.-W., Ho, H. H., & Lau, C.-P. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03159-4 · Cited by 96 · see citing works
Karlssön, M., Edström-Plüss, C., Held, C., Henriksson, P., Billing, E., & Wallén, N. H. (2007) · Journal of Behavioral Medicine · doi:10.1007/s10865-007-9096-5 · Cited by 76 · see citing works
Arthur, H. M., Gunn, E., Thorpe, K. E., Ginis, K. A. M., Mataseje, L., McCartney, N., & McKelvie, R. S. (2007) · Acta Dermato Venereologica · doi:10.2340/16501977-0122 · Cited by 74 · see citing works
Appels, A., Bär, F. W. H. M., van der Pol, G. A., Erdman, R. A. M., Assman, M., Trijsburg, W., van Diest, R., van Dixhoorn, J., & de Leon, C. F. M. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000151485.38411.36 · Cited by 74 · see citing works
Coull, A. J. (2004) · Age and Ageing · doi:10.1093/ageing/afh098 · Cited by 64 · see citing works
Revista portuguesa de cardiologia
de Cardiologia, S. B., & ScienceDirect (1999) · Cited by 62 · see citing works
Young, W., Rewa, G., Goodman, S. G., Jaglal, S. B., Cash, L., Lefkowitz, C. A., & Coyte, P. C. (2003) · Europe PMC (PubMed Central) · Cited by 61 · see citing works
Hage, C., Mattsson, E., & Ståhle, A. (2003) · Physiotherapy Research International · doi:10.1002/pri.268 · Cited by 55 · see citing works
Hughes, A. R., Mutrie, N., & MACINTYRE, P. D. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3280116485 · Cited by 54 · see citing works
Appels, A., van Elderen, T., Bär, F. W. H. M., van der Pol, G. A., Erdman, R. A. M., Assman, M., Trijsburg, W., van Diest, R., van Dixhoorn, J., & Pedersen, S. S. (2006) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2005.12.008 · Cited by 48 · see citing works
Reid, R. D., Dafoe, W. A., Morrin, L. I., Mayhew, A., Papadakis, S., Beaton, L. J., Oldridge, N., Coyle, D., & Wells, G. A. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.09.029 · Cited by 46 · see citing works
Auer, R., Gaume, J., Rodondi, N., Cornuz, J., & Ghali, W. A. (2008) · Circulation · doi:10.1161/circulationaha.107.748095 · Cited by 46 · see citing works
Joseph, A. M., Hecht, S. S., Murphy, S. E., Lando, H. A., Carmella, S. G., Gross, M., Bliss, R., Le, C. T., & Hatsukami, D. K. (2008) · Nicotine & Tobacco Research · doi:10.1080/14622200801901948 · Cited by 43 · see citing works
Muñoz, M. Á., Vila, J., Cabañero, M., Rebato, C., Subirana, I., Sala, J., & Marrugat, J. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.07.015 · Cited by 30 · see citing works
Impact of cardiac rehabilitation on quality of life and depression after acute coronary syndrome.
Bettencourt, N., Dias, C., Mateus, P., Sampaio, F., Santos, L., Adão, L., Mateus, C., Salomé, N., Miranda, F., Teixeira, M., et al. (2005) · PubMed · Cited by 30 · see citing works
Rehabilitation of elderly with coronary heart disease – Improvement in quality of life at a low cost
Sandström, L., & Ståhle, A. (2005) · Advances in Physiotherapy · doi:10.1080/14038190510010287 · Cited by 26 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- N Engl J Med 2007; 356:2388-2398.
- Lisspers J, Sundin O, Ohman A, Hofman-Bang C, Ryden L, Nygren A. Long- term effects of lifestyle behavior change in coronary artery disease: effects on recurrent coronary events after percutaneous coronary intervention. Health psychology: official journal of the Division of Health Psychology. Am Psychol Assoc 2005; 24:41.
- Tuttle KR, Shuler LA, Packard DP, Milton JE, Daratha KB, Bibus DM, et al. Comparison of low-fat versus Mediterranean-style dietary intervention after first myocardial infarction (from The Heart Institute of Spokane Diet Intervention and Evaluation Trial). Am J Cardiol 2008; 101:1523.
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Scherrenberg, M., Wilhelm, M., Hansen, D., Völler, H., Cornelissen, V., Frederix, I., Kemps, H., & Dendale, P. (2021) · European Journal of Preventive Cardiology · doi:10.1177/2047487320939671 · Cited by 251 · see citing works
Eijsvogels, T. M. H., Maessen, M. F. H., Bakker, E. A., Meindersma, E. P., van Gorp, N., Pijnenburg, N., Thompson, P. D., & Hopman, M. T. E. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.11686 · Cited by 122 · see citing works
- Authors
- Müller-Riemenschneider, F., Meinhard, C., Damm, K., Vauth, C., Bockelbrink, A., Greiner, W., & Willich, S. N.
- Affiliations
- Institute for Social Medicine, Epidemiology, and Health Economics, Charité University Medical Center, Berlin
- Charité – Universitätsmedizin Berlin (DE)
- Leibniz University Hannover (DE)
- Bielefeld University (DE)
- Venue
- European Journal of Cardiovascular Prevention & Rehabilitation
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-12
- Volume
- 17
- Issue
- 6
- Pages
- 688-700
- ISSN
- 1741-8267 (ISSN-L)
- OpenAlex
- W2148386216
- Cited by
- 57
- References
- 50
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 9 · 2014: 5 · 2013: 9 · 2012: 3
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Cardiovascular Prevention & Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover) (submittedVersion, cc-by-nc-nd)
- Leibniz Universität Hannover
- Funders
- Bundesministerium für Gesundheit
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Keywords
- coronary artery disease, secondary prevention, non-pharmacological treatment, exercise therapy, multimodal intervention, psychosocial interventions, dietary intervention, smoking cessation, mortality, quality of life, cardiovascular risk management, patient subgroups
- MeSH terms
- Coronary Disease, Diet, Humans, Psychotherapy, Quality of Life, Risk Factors, Exercise, Smoking Cessation, Treatment Outcome, Risk Assessment, Risk Reduction Behavior, Secondary Prevention
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