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Cited by 72Influenza Virus Research StudiesPneumonia and Respiratory InfectionsAntimicrobial Resistance in Staphylococcus

Infection With Community-Onset Staphylococcus aureus and Influenza Virus in Hospitalized Children

Reed, Carrie, Kallen, Alexander J., Patton, Monica, Arnold, Kathryn E., Farley, Monica M., Hageman, Jeff, Finelli, Lyn·2009·Pediatric Infectious Disease Journal
DOI 10.1097/inf.0b013e31819d8b71
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Abstract

Background Coinfection with influenza virus and Staphylococcus aureus can cause severe illness or death, and may be increasing. During the 2006-2007 influenza season, 30% of influenza-associated pediatric deaths reported to Centers for Disease Control and Prevention had S. aureus coinfection, compared with 2% to 7% in 2004-2006. The overall occurrence, however, remains unclear. Methods To assess the burden of coinfection with influenza and community-onset S. aureus in hospitalized children, we conducted a retrospective medical record review of all children admitted to Atlanta pediatric hospitals from October 2006 to April 2007 with laboratory-confirmed influenza or S. aureus cultured from a respiratory or sterile site within 72 hours of admission. Results Of 65 children with influenza, 7 (11%) had influenza-S. aureus coinfection; an additional 155 had community-onset S. aureus alone. Of S. aureus isolates, 43% were methicillin-resistant. Coinfected children were more frequently admitted to the intensive care unit (71%, P = 0.05) than other children with influenza (28%) or S. aureus (36%) alone and also had a significantly higher case fatality (29%, P = 0.01; 0% influenza, 5% S. aureus). Recent skin or soft tissue infection was documented in 29% of coinfected children, compared with 2% with influenza alone (P = 0.03). Conclusions Children with influenza-S. aureus coinfection had a higher frequency of severe outcomes than children hospitalized with influenza or S. aureus alone.…

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Crossref · 10.1097/inf.0b013e31819d8b71

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  • The frequency of overall bacterial coinfection in influenza patients is still poorly characterized.

    “While prior studies have examined the frequency of select bacterial species in influenza cases,13, 14 particularly the presence of methicillin‐resistant S. aureus (MRSA),15, 16, 17, 18 the frequency of overall coinfection in influenza patients is still poorly characterized.”

    From The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis. (2016) · cites this paper as [18]

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Authors
Reed, C., Kallen, A. J., Patton, M., Arnold, K. E., Farley, M. M., Hageman, J., & Finelli, L.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • Georgia Department of Public Health (US)
  • Emory University (US)
Corresponding author
  • Reed, Carrie
  • Patton, Monica
  • Finelli, Lyn
ORCID
Venue
Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-07
Volume
28
Issue
7
Pages
572-576
ISSN
0891-3668 (ISSN-L)
DOI
10.1097/inf.0b013e31819d8b71
OpenAlex
W2045314491
Cited by
72
References
31
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 7 · 2020: 4 · 2019: 4 · 2018: 9 · 2017: 1 · 2016: 5 · 2015: 4 · 2013: 5 · 2012: 6
FWCI
6.49
Type
journal article
Language
en
Open access
closed
Locations
  • The Pediatric Infectious Disease Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords
Staphylococcus aureus, influenza virus, co-infection, community-onset infection, hospitalized children, methicillin-resistant Staphylococcus aureus, case fatality, intensive care unit admission, skin and soft tissue infections, pediatric respiratory disease, 2006-2007 influenza season
MeSH terms
Adolescent, Child, Child, Hospitalized, Child, Preschool, Female, Georgia, Hospitals, Pediatric, Humans, Infant, Infant, Newborn, Influenza, Human, Male, Orthomyxoviridae, Retrospective Studies, Staphylococcal Infections, Staphylococcus aureus, Comorbidity, Community-Acquired Infections

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