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Cited by 208Pneumonia and Respiratory InfectionsRespiratory viral infections researchMicrobial infections and disease research

Association between nasopharyngeal load of Streptococcus pneumoniae, viral coinfection, and radiologically confirmed pneumonia in Vietnamese children

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Vu, Huong Thi Thu, Yoshida, Lay Myint, Suzuki, Motoi, Nguyen, Hien Anh Thi, Nguyen, Cat Dinh Lien, Nguyen, Ai Thi Thuy, Oishi, Kengo, Yamamoto, Takeshi +10 more·2011·Pediatric Infectious Disease Journal
DOI 10.1097/inf.0b013e3181f111a2
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Abstract

BACKGROUND: The interplay between nasopharyngeal bacterial carriage, viral coinfection, and lower respiratory tract infections (LRTIs) is poorly understood. We explored this association in Vietnamese children aged less than 5 years. METHODS: A hospital-based case-control study of pediatric LRTIs was conducted in Nha Trang, Vietnam. A total of 550 hospitalized children (274 radiologically confirmed pneumonia [RCP] and 276 other LRTIs) were enrolled and 350 healthy controls were randomly selected from the community. Polymerase chain reaction-based methods were used to measure bacterial loads of Streptococcus pneumoniae (SP), Haemophilus influenzae, and Moraxella catarrhalis and to detect 13 respiratory viruses and bacterial serotypes in nasopharyngeal samples of study participants. RESULTS: The median nasopharyngeal bacterial load of SP was substantially higher in children with RCP compared with healthy controls or children with other LRTIs (P < 0.001). SP load was 15-fold higher in pneumonia children with viral coinfection compared with those children without viral coinfection (1.4 x 10⁷/mL vs. 9.1 x 10⁵/mL; P 0.0001). SP load was over 200-fold higher in serotypeable SP compared with nontypeable SP (2.5 x 10⁶/mL vs. 1 x 10⁴/mL; P < 0.0001). These associations were independent of potential confounders in multiple regression models. No clear association was found between nasopharyngeal load of Haemophilus influenzae or Moraxella catarrhalis and viral coinfection in either RCP or other LRTIs groups. CONCLUSIONS: An increased load of SP in the nasopharynx was associated with RCP, viral coinfection, and presence of pneumococcal capsule.

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Authors
Vu, H. T. T., Yoshida, L. M., Suzuki, M., Nguyen, H. A. T., Nguyen, C. D. L., Nguyen, A. T. T., Oishi, K., Yamamoto, T., Watanabe, K., Vu, T. D., Schmidt, W.-P., Phan, H. T. L., Morimoto, K., Le, T. H., Yanai, H., Kilgore, P. E., Dang, A. D., & Ariyoshi, K.
Affiliations
  • National Institute Of Hygiene And Epidemiology (VN)
  • Nagasaki University (JP)
  • Khanh Hoa General Hospital (VN)
  • International Vaccine Institute (KR)
Corresponding author
  • Vu, Huong Thi Thu
  • Yoshida, Lay Myint
  • Suzuki, Motoi
  • Oishi, Kengo
  • Yamamoto, Takeshi
  • Watanabe, Kiwao
  • Schmidt, Wolf-Peter
  • Morimoto, Konosuke
  • Yanai, Hideki
  • Ariyoshi, Koya
ORCID
Venue
Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-01
Volume
30
Issue
1
Pages
11-18
ISSN
0891-3668 (ISSN-L)
DOI
10.1097/inf.0b013e3181f111a2
OpenAlex
W2121586076
Cited by
208
References
38
Citations by year
2026: 4 · 2025: 5 · 2024: 7 · 2023: 15 · 2022: 8 · 2021: 5 · 2020: 13 · 2019: 12 · 2018: 15 · 2017: 26 · 2016: 13 · 2015: 17 · 2014: 23 · 2013: 19 · 2012: 16
FWCI
10.24
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • The Pediatric Infectious Disease Journal (publishedVersion)
  • PubMed (publishedVersion)
  • Nagasaki University's Academic Output SITE (Nagasaki University) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords
Streptococcus pneumoniae, viral coinfection, lower respiratory tract infection, pneumococcal serotypes, pneumococcal capsule, Haemophilus influenzae, Moraxella catarrhalis, pediatric pneumonia, Vietnamese children
MeSH terms
Child, Preschool, Female, Humans, Infant, Male, Nasopharynx, Pneumonia, Pneumococcal, Pneumonia, Viral, Regression Analysis, RNA Viruses, Streptococcus pneumoniae, Radiography, Thoracic, Vietnam, Case-Control Studies, Viral Load, Bacterial Load

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