Cited by 403Musculoskeletal pain and rehabilitationPain Mechanisms and TreatmentsPain Management and Opioid Use

The DOI matches its Crossref record; 274 of the 275 references it cites were found in a registry or an index.

Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

Open access

Edwards, Robert R., Dworkin, Robert H., Turk, Dennis C., Angst, Martin S., Dionne, Raymond, Freeman, Roy, Hansson, Per, Haroutounian, Simon, Arendt-Nielsen, Lars, Attal, Nadine, Baron, Ralf, Brell, Joanna, Bujanover, Shay, Burke, Laurie B., Carr, Daniel, Chappell, Amy S., Cowan, Penney, Etropolski, Mila, Fillingim, Roger B., Gewandter, Jennifer S., Katz, Nathaniel P., Kopecky, Ernest A., Markman, John D., Nomikos, George, Porter, Linda, Rappaport, Bob A., Rice, Andrew S.C., Scavone, Joseph M., Scholz, Joachim, Simon, Lee S., Smith, Shannon M., Tobias, Jeffrey, Tockarshewsky, Tina, Veasley, Christine, Versavel, Mark, Wasan, Ajay D., Wen, Warren, Yarnitsky, David·2016·Pain

DOI 10.1097/j.pain.0000000000000602PMC PMC5965275

Open this paper in CoChat — free account

Abstract

There is tremendous interpatient variability in the response to analgesic therapy (even for efficacious treatments), which can be the source of great frustration in clinical practice. This has led to calls for “precision medicine” or personalized pain therapeutics (ie, empirically based algorithms that determine the optimal treatments, or treatment combinations, for individual patients) that would presumably improve both the clinical care of patients with pain and the success rates for putative analgesic drugs in phase 2 and 3 clinical trials. However, before implementing this approach, the characteristics of individual patients or subgroups of patients that increase or decrease the response to a specific treatment need to be identified. The challenge is to identify the measurable phenotypic characteristics of patients that are most predictive of individual variation in analgesic treatment outcomes, and the measurement tools that are best suited to evaluate these characteristics. In this article, we present evidence on the most promising of these phenotypic characteristics for use in future research, including psychosocial factors, symptom characteristics, sleep patterns, responses to noxious stimulation, endogenous pain-modulatory processes, and response to pharmacologic challenge. We provide evidence-based recommendations for core phenotyping domains and recommend measures of each domain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1097/j.pain.0000000000000602

Cites

274 of 274 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
Self-citation
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
The Pain Catastrophizing Scale: Development and validation.
Sullivan, M. J. L., Bishop, S. R., & Pivik, J. (1995) · Psychological Assessment · doi:10.1037//1040-3590.7.4.524 · Cited by 8,227
Validation of the Insomnia Severity Index as an outcome measure for insomnia research
Bastien, C. (2001) · Sleep Medicine · doi:10.1016/s1389-9457(00)00065-4 · Cited by 8,067
Ecological momentary assessment
Shiffman, S., Stone, A. A., & Hufford, M. R. (2008) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.3.022806.091415 · Cited by 6,454
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60692-4 · Cited by 6,414
The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005–2008
Cella, D., Riley, W., Stone, A., Rothrock, N., Reeve, B., Yount, S., Amtmann, D., Bode, R., Buysse, D., Choi, S., et al. (2010) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.04.011 · Cited by 5,128
Persistent postsurgical pain: risk factors and prevention
Kehlet, H., Jensen, T. S., & Woolf, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68700-x · Cited by 4,086
Core outcome measures for chronic pain clinical trials: IMMPACT recommendations
Dworkin, R. H., Turk, D. C., Farrar, J. T., Haythornthwaite, J. A., Jensen, M. P., Katz, N. P., Kerns, R. D., Stucki, G., Allen, R. R., Bellamy, N., et al. (2005) · Pain · doi:10.1016/j.pain.2004.09.012 · Cited by 3,732
Self-citation
Core outcome domains for chronic pain clinical trials: IMMPACT recommendations
Turk, D. C., Dworkin, R. H., Allen, R. R., Bellamy, N., Brandenburg, N., Carr, D. B., Cleeland, C., Dionne, R., Farrar, J. T., Galer, B. S., et al. (2003) · Pain · doi:10.1016/j.pain.2003.08.001 · Cited by 3,510
Self-citation

Show all 275 references

Sorted by citations

Items 301–400 of 402

Riding a Tiger: Maximizing Effects of Manual Therapies for Pelvic Pain
Bishop, M. D., Bialosky, J. E., & Alappattu, M. J. (2020) · Journal of Womenʼs Health Physical Therapy · doi:10.1097/jwh.0000000000000156 · Cited by 2
High individual pain variability in people living with HIV: A graphical analysis
Wadley, A. L., Venter, F., Moorhouse, M. A., Akpomiemie, G., Serenata, C. M., Hill, A., Sokhela, S. M., Mqamelo, N., & Kamerman, P. R. (2020) · European Journal of Pain · doi:10.1002/ejp.1658 · Cited by 3
Electrophysiological Recording Techniques from Human Dorsal Root Ganglion
Moy, J. K., Loeza‐Alcocer, E., & Gold, M. S. (2022) · Neuromethods · doi:10.1007/978-1-0716-2039-7_7 · Cited by 2
Precision Medicine for Diabetic Neuropathy
Davalos, L., Stino, A. M., Selvarajah, D., Sakowski, S. A., Tesfaye, S. H., & Feldman, E. L. (2022) · Springer eBooks · doi:10.1007/978-3-030-98927-9_8 · Cited by 2
Lessons learnt in evidence-based perioperative pain medicine: changing the focus from the medication and procedure to the patient
Lirk, P. B., & Schreiber, K. L. (2024) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2023-105235 · Cited by 2
Association between chronic pain classes and cognitive function in older adults: A cross-sectional study based on latent class analysis
Yuan, H., Wang, S., Sun, Y., Liu, M., Wu, F., Sun, H., & Zhou, F. J. (2024) · Geriatric Nursing · doi:10.1016/j.gerinurse.2024.02.028 · Cited by 2
Update: Noziplastischer Schmerz
Magerl, W. (2024) · MSK – Muskuloskelettale Physiotherapie · doi:10.1055/a-2235-4858 · Cited by 2
CPM-Related Mechanisms Could Play a Key Role in the Effects on Pain Sensitivity Induced by Manual Therapy: Three Crossover Trials Investigating the Effects of Manual Pressure
Arribas‐Romano, A., Fernández‐Carnero, J., Rodríguez‐Lagos, L., Álvarez, M. M., Zabala-Zambrano, J., Lezaun-Hernández, L., Contreras-Padilla, L., & Mercado, F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13133648 · Cited by 2
Quantitative sensory testing and chronic pain syndromes: a cross-sectional study from TwinsUK
Rhee, A., Smith, I. G., Compte, R., Vehof, J., Nessa, A., Wadge, S., Freidin, M. B., Bennett, D., & Williams, F. M. K. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-085814 · Cited by 4
Clinical predictors of treatment response to gabapentin in women with unexplained chronic pelvic pain
Coxon, L., Amer, M., DANIELS, J. P., Doust, A. M., Mackenzie, S. C., Horne, A. W., & Vincent, K. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1460206 · Cited by 2
Pain phenotype trajectories and links to family relationship quality among black older adults
Woods, S., Roberson, P. N. E., Thakur, B., Sola-Odeseye, Z., Udezi, V., Wood, B. L., & Booker, S. Q. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105484 · Cited by 2
Changing the Perceived Pain Intensity in Populations With Spinal Cord Injury and With Health Disparities (HAPPINESS): Protocol for a Feasibility Study
de Winckel, A. V., Zhang, L., Lim, K. O., Morse, L. R., Woodliff, B., Maestre, G. E., & Baker, K. (2025) · JMIR Research Protocols · doi:10.2196/82431 · Cited by 2
Prospective evaluation of chronic pain disorders and treatments
Vierck, C. J., & Chapman, C. R. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.11.020 · Cited by 2
Qualitative Sensory Testing in Outcome Prediction of Transforaminal Epidural Steroid Injection for Chronic Painful Unilateral Lumbosacral Radiculopathy: Prospective Observational Study
Vaitkus, A., & Šipylaitė, J. (2021) · Pain Practice · doi:10.1111/papr.12997 · Cited by 2
Sensory Perception in Lumbosacral Radiculopathy with Radicular Pain: Feasibility Study of Multimodal Bedside-Suitable Somatosensory Testing
Vaitkus, A., & Šipylaitė, J. (2021) · Acta medica Lituanica · doi:10.15388/amed.2021.28.1.18 · Cited by 2
Self-regulation training for people with knee osteoarthritis: a protocol for a feasibility randomised control trial (MiNT trial)
Mani, R., Adhia, D. B., Awatere, S., Gray, A. R., Mathew, J., Wilson, L. C., Still, A., Jackson, D., Hudson, B., Zeidan, F. Z., et al. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1271839 · Cited by 3
Self-citation
Validity and Diagnosis in Physical and Rehabilitation Medicine: Critical View and Future Perspectives.
Hassan, S. I., & Kumbhare, D. A. (2022) · PubMed · doi:10.1097/phm.0000000000001768 · Cited by 1
Diabetic neuropathy: Current issues in diagnosis and prevention
Spallone, V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-88426-6.00016-6 · Cited by 1
Chronic postoperative pain in cardiac surgery: analysis of quantitative sensory testing and pain history data
Tsedinova, Y. B., Churyukanov, M. V., Zagorulko, O. I., Medvedeva, L. A., Yarygin, I. V., Dombrovskaya, A. V., Kabanova, M. N., Neizvestnykh, D. P., Melkonyan, K. U., Aleksandrova, E. N., et al. (2025) · Russian Journal of Pain · doi:10.17116/pain20252301116 · Cited by 1
A Semi-structured Interview Predicts Spinal Cord Stimulator Implantation in Patients with Chronic Pain
Russell, J. A., Hamilton, N. A., & Hamilton, J. L. (2025) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-025-10077-1 · Cited by 1
Patient phenotyping for molecular profiling of neck and low back pain – Study protocol
Curatolo, M., Payne, C., Chiu, A. P., Tran, N. T., Yap, N., Hofstetter, C. P., Lesnak, J. B., Arendt-Tranholm, A., Price, T. J., Jarvik, J. G., et al. (2025) · Neurobiology of Pain · doi:10.1016/j.ynpai.2025.100186 · Cited by 1
From theory to practice: Simple rules for improving clinical trial confidence with covariate adjustment
Ooghe, A., Pereira, Á. R., Jr., Colloca, L., Stannard, E., Ambrose, C., Lissin, D., & Branders, S. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105489 · Cited by 1
Patient‐Reported Outcomes Among an Observational Cohort of Individuals With Chronic Low Back Pain
Greco, C. M., Dodds, N. E., Acevedo, A. M., Anderst, W. J., Bell, K. M., Darwin, J., Delitto, A., Jakicic, J. M., McKernan, G., Patterson, C. G., et al. (2025) · JOR Spine · doi:10.1002/jsp2.70097 · Cited by 1
Self-citation
Pain Science Knowledge Among Healthcare Professionals: A Cross-Sectional Survey Within the United States Department of Veterans Affairs
Keter, D. L., Eneberg-Boldon, K., Kurszewski, W., Marth, L. A., Rich, T. L., Schopmeyer, K., & Vogsland, R. (2025) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2025.103422 · Cited by 1
Widespread reductions in white matter-gray matter functional connectivity in long-term fibromyalgia syndrome patients
Gao, Z., Xu, T., Zhang, N., Liu, F., Zhang, X., Zhang, P., Kong, Y., Lv, D., & Wu, T. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120499 · Cited by 1
Psychological Phenotyping in Osteoarthritis Management: Recommendations for Implementation in Physical Therapy Practice
Kinsey, A., Roundy, P. E., Fleming, O., Christian, A., Austin, M., Jiranek, W. A., & Lentz, T. A. (2025) · JOSPT open. · doi:10.2519/josptopen.2025.0177 · Cited by 1
Clinical phenotype matters: structural and functional thalamic changes in neuropathic low-back pain
Yuan, R., Cole, M., Gewandter, J. S., Markman, J. D., Zhang, Z., & Geha, P. (2025) · Pain · doi:10.1097/j.pain.0000000000003843 · Cited by 1
Self-citation
Dealing with complexity in decision-making for chronic shoulder pain: a pragmatic approach for individual phenotyping
Guerra-Armas, J., Flores-Cortés, M., García-Altube, Á., Paris‐Alemany, A., Meulders, A., & Touche, R. L. (2026) · Disability and Rehabilitation · doi:10.1080/09638288.2025.2604533 · Cited by 1
Wearable sensor-based spinal motion assessments for identifying phenotypic clusters in chronic low back pain
Mageswaran, P., Dufour, J. S., Aurand, A. M., Gifford, R. C., Brock, G., Alish, Y., Knapik, G. G., Hani, H., Hanes, L., Krening, S., et al. (2026) · European Spine Journal · doi:10.1007/s00586-026-09781-9 · Cited by 1
Association of Nociplastic Pain Features with Function in Aging Veterans with Chronic Low Back Pain
Powell, V. D., Ha, J., Galecki, A., Clauw, D. J., Lagisetty, P., Silveira, M. J., Logue, C., & Krein, S. L. (2026) · Journal of Pain · doi:10.1016/j.jpain.2025.105914 · Cited by 1
Understanding Pain in Osteoarthritis
Pedersini, P., Buraschi, R., Pollet, J., Pullara, R., & Gobbo, M. (2026) · Topics in Geriatric Rehabilitation · doi:10.1097/tgr.0000000000000504 · Cited by 1
Amitriptyline for neuropathic pain in patients with leprosy: a bicenter randomized controlled trial
Pentiado, J. A. M., Kubota, G. T., Moreira, L. I., Fernandes, A. M., da Silva, V. A., Stump, P., do Nascimento, D. C., Marciano, L. H. S. C., Cleto, N. G., Barreto, J. A., et al. (2026) · Pain · doi:10.1097/j.pain.0000000000004005 · Cited by 1
Postoperative Pain Treatments: Intensive Care, First Aid, Alternative Medicine, Acupuncture (Part 4)
Шаповалова, В. (2026) · SSP Modern Pharmacy and Medicine · doi:10.53933/tznr2436 · Cited by 1
Redesigning the path of care and treatment goals in patients with chronic pain: ideas from the Science of Relief 2.0 event
Natale, M. R., Degirolamo, C., Perversi, F., & Varrassi, G. (2021) · Drugs in Context · doi:10.7573/dic.2021-6-4 · Cited by 1
Comparison of the efficacy of Sufentanil and Morphine Titration for patient-controlled Subcutaneous Analgesia in severe advanced cancer pain
Liu, D., Li, W., & Chen, L. (2023) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.39.2.6664 · Cited by 1
Utilization of Blood Flow Restriction Therapy with a Former Triathlete After Total Knee Arthroplasty: A Case Report
Keating, C., Muth, S., Hui, C., & Hoglund, L. T. (2024) · International Journal of Sports Physical Therapy · doi:10.26603/001c.122488 · Cited by 1
Optimising clinical trial methods for complex regional pain syndrome: a methodological framework (OptiMeth-CRPS)
Smart, K. M., Abbott-Fleming, V., Birklein, F., Bruehl, S. P., Corcoran, E., Day, S. J., Ferraro, M. C., Grieve, S., Hilgers, R.-D., Ingram, C., et al. (2025) · PAIN Reports · doi:10.1097/pr9.0000000000001320 · Cited by 1
Current and Emerging Payment Models for Spine Pain Care: Evidence-Based, Outcomes-Based, or Both?
Williams, K., & Carr, D. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-27447-4_3 · Cited by 1
Self-citation
Neuropathic Pain: Mechanisms, Clinical Aspects and Treatment Options
Kersebaum, D., Sachau, J., Fabig, S., & Baron, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.24257-0 · Cited by 1
Self-citation
Técnicas de rehabilitación abdominal y espinal y del control sensitivomotor para el paciente con lumbalgia crónica
Demoulin, C., Grosdent, S., Vanderthommen, M., & Henrotin, Y. E. (2021) · EMC - Kinesiterapia - Medicina Física · doi:10.1016/s1293-2965(21)45679-3 · Cited by 1
Relief of phantom limb pain using mirror therapy: A bit more optimism from retrospective analysis of two studies
Butler, S. (2017) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2017.01.005 · Cited by 1
Information, back pain, and radiology
Butler, S. H. (2019) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2019-2011 · Cited by 1
Response to Mylius et al.
Lawn, T., Rukavina, K., Malcangio, M., Howard, M. A., & Chaudhuri, К. R. (2022) · Pain · doi:10.1097/j.pain.0000000000002445 · Cited by 1
Pain in psoriatic arthritis and hand osteoarthritis
Vela, J. (2021) · doi:10.54337/aau460188407 · Cited by 1
Divergent treatment responses in chronic pain: Identifying subgroups of patients through cluster analysisPreprint
Rijsdijk, M., Smits, H. M., Azizoglu, H. R., Brugman, S., van de Burgt, Y., van Charldorp, T. C., van Gelder, D. J., de Grauw, J. C., van Lange, E. A., Meye, F. J., et al. (2024) · medRxiv · doi:10.1101/2024.02.23.24302234 · Cited by 1
The Comprehensive PT Management Of A Patient With Chronic Low Back Pain And Lumbar Radiculopathy: A Case Report
McGuire, R. K. (2017) · DUNE - DigitalUNE (University of New England)
Caracterização da dor, da sensibilidade discriminativa e dos achados neuropatológicos na biópsia cutânea em hanseníase em doentes após término do tratamento poliquimioterápico
Raicher, I. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-09042018-111203
Epigenetics of Chronic Visceral Nociception
Zhou, Q., & Verne, G. N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814070-3.00010-7
Achieving a Balance: Cost-effectiveness of Treatment Guidelines vs Precision Medicine—“the Cart or the Horse”?
Williams, K. (2019) · Pain Medicine · doi:10.1093/pm/pnz204
Pain communication during medical examination: beyond words
Piraccini, E., & Maitan, S. (2019) · Minerva Anestesiologica · doi:10.23736/s0375-9393.19.13784-4
Persistent musculoskeletal pain in individuals with inflammatory bowel diseases
Falling, C. (2020) · Otago University Research Archive (University of Otago)
Medical Treatment of Pain in Chronic Pancreatitis
Drewes, A. M., Kuhlmann, L., Andresen, T., & Olesen, S. S. (2021) · doi:10.1002/9781119570097.ch36
Techniques de rééducation abdominale et spinale et du contrôle sensorimoteur pour le patient souffrant de lombalgie chronique
Demoulin, C., Grosdent, S., & Vanderthommen, M. (2021)
Biomarker signatures for neuropathic pain after SCI
Hergenroeder, G. W., Molina, S. T., Burish, M. J., Schmitt, K. M., & Choi, H. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818662-6.00014-5
Tecniche di rieducazione addominale e spinale e del controllo sensorimotorio per il paziente affetto da lombalgia cronica
Demoulin, C., Grosdent, S., Vanderthommen, M., & Henrotin, Y. E. (2021) · EMC - Medicina Riabilitativa · doi:10.1016/s1283-078x(21)45661-0
Aportaciones a la teoría asintótica de polinomios ortogonales de Sobolev
Castaño-Garcı́a, L. (2010) · Dialnet (Universidad de la Rioja)
INSTRUMENTOS DE AVALIAÇÃO NEUROPSICOLÓGICA EM CRIANÇAS COM DOR CRÔNICA: UMA REVISÃO SISTEMÁTICA DE LITERATURA
Sales, S. S., Gai, M. J. P., Cruz, R. M., & da Rocha, R. E. R. (2021) · Revista Interdisciplinar de Estudos em Saúde · doi:10.33362/ries.v10i1.2699
Faculty Opinions recommendation of Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations.
Malik, R. A., & Azmi, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727695647.793556090
Reply
Drewes, A. M., Olesen, S. S., & Juel, J. (2020) · Pancreas · doi:10.1097/mpa.0000000000001641
Characterizing 16-Week Responder Profiles Using Group-Based Trajectory Modeling in Over 4300 Clinical Trial Participants Receiving Pharmaceutical Treatment for Moderate to Severe Osteoarthritis
Schnitzer, T. J., Bonfanti, G., Atkinson, J., Donevan, S. D., Viktrup, L., Barroso, J., Whalen, E., & Edwards, R. A. (2022) · Advances in Therapy · doi:10.1007/s12325-022-02290-3
Self-citation
Die Psychologie von Schmerzen
Röning, T. (2023) · Elsevier eBooks · doi:10.1016/b978-3-437-45252-9.00007-9
Literaturverzeichnis
(2023) · Elsevier eBooks · doi:10.1016/b978-3-437-45252-9.09976-4
Central Nervous System Involvement in Painful Diabetic Neuropathy
Selvarajah, D., Lim, J. T. S., Teh, K., Chen, X., Wu, J., & Tesfaye, S. H. (2023) · Contemporary diabetes · doi:10.1007/978-3-031-15613-7_24
Pain Management in Chronic Pancreatitis
Kuhlmann, L., Olesen, S. S., & Drewes, A. M. (2023) · doi:10.1002/9781119876007.ch59
Dose-responses of virtual reality exposure on chronic pain phenotypes: A pilot studyPreprint
Canori, A., Wright, W. G., Coffman, D. L., Finley, M. A., & Hiremath, S. V. (2023) · Research Square · doi:10.21203/rs.3.rs-3637168/v1
Antidepressants for chronic pain management: considerations from predictive modeling and personalized medicine perspectives
Liu, X., Radojčić, M. R., Huang, Z., Shi, B., Li, G., & Chen, L. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1359024
The CircaHealth CircaPain study protocol: A longitudinal multi-site study of the chronobiological control of chronic painPreprint
Taccardi, D., Gowdy, H. G. M., Singer, L. N., Daly-Cyr, J., Zacharias, A. M., Lu, Z., Choinière, M., Pagé, M. G., & Ghasemlou, N. (2024) · medRxiv · doi:10.1101/2024.03.22.24304751
Predicting severe pain after cesarean section: prospective cohort study
Вячеславовна, Ш. Н., Marshalov, D. V., Shifman, E. M., & Kuligin, A. V. (2024) · Regional Anesthesia and Acute Pain Management · doi:10.17816/ra623928
Consideraciones del diseño en investigación para ensayos controlados aleatorios de estimulación de la médula espinal para el dolor: recomendaciones de la iniciativa sobre métodos, medición y evaluación del dolor en ensayos clínicos/Instituto de Neuromodulación/Sociedad Internacional de Neuromodulación
Katz, N. P., Dworkin, R. H., North, R. B., Thomson, S., Eldabe, S. S., Hayek, S. M., Kopell, B. H., Markman, J. D., Rezai, A. R., Taylor, R. S., et al. (2022) · NeuroTarget · doi:10.47924/neurotarget2022124
Self-citation
Pain after cesarean section: do we have reliable predictors? Scoping review
Вячеславовна, Ш. Н., Marshalov, D. V., Shifman, E. M., & Kuligin, A. V. (2024) · Regional Anesthesia and Acute Pain Management · doi:10.17816/ra624540
Subgrouping Leprosy Patients with Neuropathic Pain in Central Brazil Based on Pain-Related Sensory Abnormalities
Martins, A. M. C. B., Cavalcante, L. R. D. S., Hongyu, K., & Fontes, C. J. F. (2024) · Journal of Advances in Medicine and Medical Research · doi:10.9734/jammr/2024/v36i85539
Association Between Diagnostic Imaging, Medication Intake, and Health Outcomes in Chronic Whiplash-Associated Disorders: An Observational Study
Smith, A. D., Westaway, M. D., Schneider, G. M., & Andruski, B. (2025) · Physiotherapy Canada · doi:10.3138/ptc-2024-0032
Noziplastischer Schmerz (1): Konzept und Abgrenzung
Magerl, W. (2025) · VPT Magazin · doi:10.1055/s-0045-1809855
Real-Time and Long-Term Effects of Medical Marijuana on Older Adults: Protocol for the Study on Medical Marijuana and its Long-Term Effects (the SMILE study) Prospective Cohort (Preprint)Preprint
Robinson, K. R., Seeger, S. D., Nave, L., Mejia, M., Meulen, M. V., Rashid, A., Mickle, A. M., Sibille, K. T., Li, Z., Przkora, R., et al. (2025) · doi:10.2196/preprints.78900
Utilidad diagnóstica de la anamnesis estructurada para la identificación de fenotipos en el síndrome de dolor pélvico crónico: estudio retrospectivo orientado a la práctica clínica
Palacio, E. V., Knape, P. B., Gabarró, S. T., Álvarez, C. C., Román, L. D. V., Sánchez-Puy, A., Castell, B. J., Solorzano, S. C., Burillo, E. S., pérez, L. M. M., et al. (2025) · Actas Urológicas Españolas · doi:10.1016/j.acuro.2025.501858
Functional connectivity-targeted high-definition transcranial infraslow grey noise stimulation for chronic low back pain: protocol for a double-blinded, randomised, controlled clinical trial
Adhia, D. B., Mani, R., Reynolds, J. N. J., Glue, P., Potiki, J., Vanneste, S., & Ridder, D. D. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-103019 · Cited by 1
Development and validation of a measure of sensory sensitivity – the Sensory Sensitivity Profile: a Rasch analysis
Amris, K., Rasmussen, M. U., Alkjær, T., Magnúsdóttir, S., & Wæhrens, E. E. (2025) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.2025.2548704
Diagnostic value of structured anamnesis for phenotype identification in chronic pelvic pain syndrome: A practice-oriented retrospective study
Palacio, E. V., Knape, P. B., Gabarró, S. T., Álvarez, C. C., Román, L. D. V., Sánchez-Puy, A., Castell, B. J., Solorzano, S. C., Burillo, E. S., pérez, L. M. M., et al. (2025) · Actas Urológicas Españolas (English Edition) · doi:10.1016/j.acuroe.2025.501858
Artificial Intelligence, Informatics, and Pain in Aging
Snigurska, U. A., & Bjarnadóttir, R. I. (2025) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2025.08.010
Prolonged aftersensations to thermal noxious stimulation as a screening tool for central contributions to chronic ocular pain
Gunawardene, A. N., Dobzinski, N., Valdés-Arias, D., Kantor, N. B., Zalvidar, A., Moulton, E. A., Donthineni, P. R., O’Brien, R. C., Galor, A., & Felix, E. R. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105561
Quantifying intra-individual variations in anatomical sites of pain in longitudinal studiesPreprint
Madden, V. J., Arendse, G., Kamerman, P. R., Bedwell, G. J., Mqadi, L., Wadley, A. L., Edwards, R. R., Joska, J. A., & Parker, R. (2025) · medRxiv · doi:10.1101/2025.10.23.25337565
Self-citation
Real-Time and Long-Term Effects of Medical Marijuana on Older Adults: Protocol for a Prospective Cohort Study
Robinson, K. R., Seeger, S. D., Nave, L., Mejia, M., Meulen, M. V., Rashid, A., Mickle, A. M., Sibille, K. T., Li, Z., Przkora, R., et al. (2025) · JMIR Research Protocols · doi:10.2196/78900 · Cited by 1
Additional file 1 of The PerPAIN trial: a pilot randomized controlled trial of personalized treatment allocation for chronic musculoskeletal pain—a protocol
Beiner, E., Baumeister, D., Buhai, D.-V., Löffler, M., Löffler, A., Schick, A., Ader, L., Eich, W., Sirazitdinov, A., Malone, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26552533
Electrical stimulation after mechanical conditioning in dogs for assessment of conditioned pain modulation
Brause, S., Rupp, V., Kästner, S., & Schütter, A. F. (2026) · Veterinary Anaesthesia and Analgesia · doi:10.1016/j.vaa.2026.101189
Reflections on suzetrigine and the evolving landscape of non-opioid analgesia
Montero, A. A. (2026) · British Journal of Pain · doi:10.1177/20494637261430909
Approche pharmaco-épidémiologique de la douleur chronique neuropathique en France et évaluation d'une nouvelle stratégie thérapeutique : intérêt de l'agomélatine
Chenaf, C. (2019) · theses.fr (ABES) · doi:10.70675/71957743zd607z4a60zb21cz2c5e39d86d3d
Invisible pain: Sex/gender differences in pain-related stigma
Meints, S. M., Thomas, H. N., Wilson, J. M., Taubenberger, S. P., Edwards, R. R., & Wasan, A. D. (2026) · Acta Psychologica · doi:10.1016/j.actpsy.2026.106838
Self-citation
First steps toward pain classification among adults with cerebral palsy: A modified Delphi study
Gannotti, M. E., Kohns, D. J., Noritz, G. H., Wyeth, D. O., Lucas, E. J., Bates, E. B., Azizi, H. F., Sarmiento, C. A., Thorpe, D. E., Nichols, S. A., et al. (2026) · Disability and health journal · doi:10.1016/j.dhjo.2026.102080
Let’s talk about pain: A mixed methods exploration of patients’ pain knowledge and preferred ways to introduce the biopsychosocial model of pain
Thomson, C. J., Holden, K. N., Giles, L. V., & Cianfrini, L. R. (2026) · Canadian Journal of Pain · doi:10.1080/24740527.2026.2650304
Prevalence and associated factors of opioid-related disorders among patients with chronic pain: a single-center retrospective study in a Chinese tertiary hospital
Xu, Z., Si, C., Dong, Y., Zhang, H., Zhang, J., Ge, W., & Wu, X. (2026) · BMC Anesthesiology · doi:10.1186/s12871-026-03941-6
Manual therapy treatment mechanisms are complex: Challenges and a call to action
Cook, C. E., Keter, D. L., Napadow, V., Barbe, M. F., Perle, S. M., Bent, J. A., Learman, K., & Reed, W. R. (2026) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2026.103393
Presurgical immune biomarkers associated with pain intensity and pain interference recovery after total knee arthroplasty: findings from the PRIME-KNEE studyPreprint
Simon, C. B., Kraus, V. B., Huebner, J. L., Ashner, M. C., Bareja, A., Peskoe, S., Hall, K. S., Whitson, H. E., & Colon-Emeric, C. S. (2026) · medRxiv · doi:10.64898/2026.06.15.26355689
Modern pharmacological approaches to pain management in oncology patients. Part II (narrative review)
Pogosyan, M. L., Petrova, M. V., Grebenchikov, O. A., Antonova, V. V., & Cherpakov, R. A. (2026) · Messenger of Anesthesiology and Resuscitation · doi:10.24884/2078-5658-2026-23-3-121-133
From Empirical Scales to Multimodal Data-Driven Approaches: The Role of Artificial Intelligence
Cai, W., Ang, Y., Zhou, X., Li, Y., Long, Y., Yu, Z., Bao, H., & Li, Q. (2026) · AI in Neurology · doi:10.64187/ain.2026.v1.i3.003
Transcranial electric stimulation in chronic pain: Effects on quality of life, physical function, activity and clinical status
Gil‐Ugidos, A., López-Corchón, M., Tsiarleston, G., Segura‐Jiménez, V., & Carrillo‐de‐la‐Peña, M. T. (2026) · Journal of Neuropsychology · doi:10.1111/jnp.70063
Clinical, psychosocial, and somatosensory differences between bruxers with and without painful temporomandibular disorders
Torino, G. G., Svensson, P. J., & Boscato, N. (2026) · Journal of Dentistry · doi:10.1016/j.jdent.2026.106952
Pain state-dependent multimodal assessment in non-specific low back pain: a pseudorandomized study design with implementation insightsPreprint
Barrientos, B. C., Hau, M., Sirucek, L., Langenfeld, A., Wirth, B., Wirth, B., Zoelch, N., Deván, J., Dudli, S., & Schweinhardt, P. (2026) · medRxiv · doi:10.64898/2026.08.26.26359760
Chasing the Wrong Door for 30 Years: Is Suzetrigine the Key to Selective Pain Relief?
Ancuceanu, R., Ribigan, A. C., Anghel, A.-I., & Dinu, M. (2026) · Medicina · doi:10.3390/medicina62091698
Baseline symptom severity profiles and response to physiotherapy treatment in chronic musculoskeletal pain: A cluster analysis in primary care
González-Flores, J. M., Espejo-Antúnez, L., Cardero‐Durán, M. D. L. Á., Costillo-Rodríguez, J., & Fernández‐Morales, C. (2026) · British Journal of Pain · doi:10.1177/20494637261487995
Determination of candidate predictors for chiropractic treatment outcome of spinal pain using a machine learning framework for small datasets
Meier, M. L., Wirth, B., Wehrli, M., Hollenstein, V., Bergander, T., & Schweinhardt, P. (2026) · Pain Management · doi:10.1080/17581869.2026.2718881

Authors: Edwards, R. R., Dworkin, R. H., Turk, D. C., Angst, M. S., Dionne, R., Freeman, R., Hansson, P., Haroutounian, S., Arendt-Nielsen, L., Attal, N., Baron, R., Brell, J., Bujanover, S., Burke, L. B., Carr, D., Chappell, A. S., Cowan, P., Etropolski, M., Fillingim, R. B., Gewandter, J. S., Katz, N. P., Kopecky, E. A., Markman, J. D., Nomikos, G., Porter, L., Rappaport, B. A., Rice, A. S. C., Scavone, J. M., Scholz, J., Simon, L. S., Smith, S. M., Tobias, J., Tockarshewsky, T., Veasley, C., Versavel, M., Wasan, A. D., Wen, W., & Yarnitsky, D.
Affiliations: Harvard University (US)
University of Rochester (US)
University of Washington (US)
Stanford University (US)
East Carolina University (US)
Oslo University Hospital (NO)
Washington University in St. Louis (US)
Aalborg University, Aalborg, Denmark
Inserm (FR)
Christian-Albrechts-Universität zu Kiel (DE)
MetroHealth Medical Center (US)
Depomed (United States) (US)
University of Maryland, Baltimore (US)
Tufts University (US)
Eli Lilly (United States) (US)
American Chronic Pain Association (US)
Johnson & Johnson (United States) (US)
University of Florida (US)
Collegium Pharmaceutical (United States) (US)
Astellas Pharma (United States) (US)
National Institutes of Health (US)
Arlington, VA, USA
Imperial College London (GB)
Pfizer (United States) (US)
Columbia University (US)
SDG LLC, Cambridge, MA, USA
Jazz Pharmaceuticals (United States) (US)
Ceres (US)
Chronic Pain Research Alliance, North Kingstown, RI, USA
Zalicus, Cambridge, MA, USA
University of Pittsburgh (US)
Purdue Pharma (United States) (US)
Technion – Israel Institute of Technology (IL)
Corresponding author: Edwards, Robert R.
ORCID: Edwards, Robert R.
Dworkin, Robert H.
Angst, Martin S.
Freeman, Roy
Hansson, Per
Haroutounian, Simon
Attal, Nadine
Baron, Ralf
Burke, Laurie B.
Fillingim, Roger B.
Gewandter, Jennifer S.
Katz, Nathaniel P.
Kopecky, Ernest A.
Markman, John D.
Nomikos, George
Rice, Andrew S.C.
Scholz, Joachim
Simon, Lee S.
Smith, Shannon M.
Tobias, Jeffrey
Tockarshewsky, Tina
Wasan, Ajay D.
Wen, Warren
Yarnitsky, David
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2016-05-05
Volume: 157
Issue: 9
Pages: 1851-1871
ISSN: 0304-3959 (ISSN-L)
1872-6623
DOI: 10.1097/j.pain.0000000000000602
PMC: PMC5965275
OpenAlex: W2359535866
Cited by: 403
References: 275
Citations by year: 2026: 29 · 2025: 51 · 2024: 45 · 2023: 47 · 2022: 35 · 2021: 64 · 2020: 44 · 2019: 32 · 2018: 26 · 2017: 24 · 2016: 3
FWCI: 3.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Funders: U.S. Food and Drug Administration (U01-FD005936)
National Institute on Aging (R01AG034982)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR064367)
Topics: Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords: patient phenotyping, chronic pain, precision medicine, psychosocial factors, symptom characteristics, sleep patterns, endogenous pain modulation, clinical trial design
MeSH terms: Analgesics, Clinical Trials as Topic, Humans, Pain Measurement, Phenotype, Treatment Outcome, Chronic Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks