The DOI matches its Crossref record; 274 of the 275 references it cites were found in a registry or an index.
Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations
Open accessAbstract
There is tremendous interpatient variability in the response to analgesic therapy (even for efficacious treatments), which can be the source of great frustration in clinical practice. This has led to calls for “precision medicine” or personalized pain therapeutics (ie, empirically based algorithms that determine the optimal treatments, or treatment combinations, for individual patients) that would presumably improve both the clinical care of patients with pain and the success rates for putative analgesic drugs in phase 2 and 3 clinical trials. However, before implementing this approach, the characteristics of individual patients or subgroups of patients that increase or decrease the response to a specific treatment need to be identified. The challenge is to identify the measurable phenotypic characteristics of patients that are most predictive of individual variation in analgesic treatment outcomes, and the measurement tools that are best suited to evaluate these characteristics. In this article, we present evidence on the most promising of these phenotypic characteristics for use in future research, including psychosocial factors, symptom characteristics, sleep patterns, responses to noxious stimulation, endogenous pain-modulatory processes, and response to pharmacologic challenge. We provide evidence-based recommendations for core phenotyping domains and recommend measures of each domain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the presence of a supportive partner has been associated with reduced symptom burden (including less pain), improved quality of life, and fewer symptoms of distress in patients with chronic lymphocytic leukemia 92, metastatic breast cancer 93, 94, and other cancer types such as colorectal cancer95, 96.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [93]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
Self-citationThe Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
The Pain Catastrophizing Scale: Development and validation.
Sullivan, M. J. L., Bishop, S. R., & Pivik, J. (1995) · Psychological Assessment · doi:10.1037//1040-3590.7.4.524 · Cited by 8,227
Validation of the Insomnia Severity Index as an outcome measure for insomnia research
Bastien, C. (2001) · Sleep Medicine · doi:10.1016/s1389-9457(00)00065-4 · Cited by 8,067
Ecological momentary assessment
Shiffman, S., Stone, A. A., & Hufford, M. R. (2008) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.3.022806.091415 · Cited by 6,454
Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60692-4 · Cited by 6,414
Cella, D., Riley, W., Stone, A., Rothrock, N., Reeve, B., Yount, S., Amtmann, D., Bode, R., Buysse, D., Choi, S., et al. (2010) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.04.011 · Cited by 5,128
Persistent postsurgical pain: risk factors and prevention
Kehlet, H., Jensen, T. S., & Woolf, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68700-x · Cited by 4,086
Core outcome measures for chronic pain clinical trials: IMMPACT recommendations
Dworkin, R. H., Turk, D. C., Farrar, J. T., Haythornthwaite, J. A., Jensen, M. P., Katz, N. P., Kerns, R. D., Stucki, G., Allen, R. R., Bellamy, N., et al. (2005) · Pain · doi:10.1016/j.pain.2004.09.012 · Cited by 3,732
Self-citationCore outcome domains for chronic pain clinical trials: IMMPACT recommendations
Turk, D. C., Dworkin, R. H., Allen, R. R., Bellamy, N., Brandenburg, N., Carr, D. B., Cleeland, C., Dionne, R., Farrar, J. T., Galer, B. S., et al. (2003) · Pain · doi:10.1016/j.pain.2003.08.001 · Cited by 3,510
Self-citation
Cited by
Sorted by citations
Items 101–200 of 402
Reproducible and fully automated testing of nocifensive behavior in mice
Dedek, C., Azadgoleh, M. A., & Prescott, S. A. (2023) · Cell Reports Methods · doi:10.1016/j.crmeth.2023.100650 · Cited by 30
Lee, J.-E., & Won, J. C. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.0299 · Cited by 37
Murray, C. B., de la Vega, R., Loren, D. M., & Palermo, T. M. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.10.001 · Cited by 26
AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders
Freeman, R. L., Edwards, R. R., Baron, R., Bruehl, S. P., Cruccu, G., Dworkin, R. H., & Haroutounian, S. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.10.002 · Cited by 28
Self-citationCliment‐Sanz, C., Hamilton, K. R., Martínez-Navarro, O., Briones‐Vozmediano, E., Gracia-Lasheras, M., Fernández‐Lago, H., Valenzuela‐Pascual, F., & Finan, P. H. (2023) · Disability and Rehabilitation · doi:10.1080/09638288.2023.2280057 · Cited by 29
Integrating Person-Centered Concepts and Modern Manual Therapy
Keter, D. L., Hutting, N., Vogsland, R., & Cook, C. E. (2024) · JOSPT open. · doi:10.2519/josptopen.2023.0812 · Cited by 28
Validity of the cold pressor test and pain sensitivity questionnaire via online self-administration
McIntyre, M. H., Kless, A., Hein, P., Field, M. J., & Tung, J. Y. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231697 · Cited by 25
Variability in experimental pain studies: nuisance or opportunity?
Madden, V. J., Kamerman, P. R., Catley, M. J., Bellan, V., Russek, L. N., Camfferman, D., & Moseley, G. L. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.11.005 · Cited by 25
Longtin, C., Décary, S., Cook, C. E., Martel, M. O., Lafrenaye, S., Carlesso, L. C., Naye, F., & Tousignant‐Laflamme, Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245689 · Cited by 28
Sanchis‐Mora, S., Chang, Y., Abeyesinghe, S. M., Fisher, A. S., Volk, H. A., & Pelligand, L. (2017) · Veterinary Anaesthesia and Analgesia · doi:10.1016/j.vaa.2016.09.004 · Cited by 25
Time to evolve: the applicability of pain phenotyping in manual therapy
Keter, D. L., Cook, C., Kenneth, L., & Griswold, D. (2022) · Journal of Manual & Manipulative Therapy · doi:10.1080/10669817.2022.2052560 · Cited by 26
Hassan, S. I., Nesovic, K., Babineau, J., Furlan, A. D., Kumbhare, D. A., & Carlesso, L. C. (2023) · Pain · doi:10.1097/j.pain.0000000000002911 · Cited by 27
Hurtado‐Lorenzo, A., Honig, G., Weaver, S. A., Larkin, P. B., & Heller, C. A. (2021) · Crohn s & Colitis 360 · doi:10.1093/crocol/otab034 · Cited by 27
Shetty, A., Delanerolle, G., Zeng, Y., Shi, J. Q., Ebrahim, R., Pang, J. T., Hapangama, D. K., Sillem, M., Shetty, S., Shetty, B., et al. (2022) · Frontiers in Digital Health · doi:10.3389/fdgth.2022.850601 · Cited by 26
Overton, M., Swain, N., Falling, C., Gwynne‐Jones, D., Fillingim, R. B., & Mani, R. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2022.1082252 · Cited by 27
Self-citationNetwork targets for therapeutic brain stimulation: towards personalized therapy for pain
Motzkin, J. C., Kanungo, I., D’Esposito, M., & Shirvalkar, P. R. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1156108 · Cited by 25
Daytime and Nighttime Sleep Characteristics and Pain Among Adults With Stable Heart Failure
Conley, S., Feder, S. L., Jeon, S., & Redeker, N. S. (2019) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000593 · Cited by 23
Simon, C. B., Valencia, C., Coronado, R. A., Wu, S. S., Li, Z., Dai, Y. E., Farmer, K. W., Moser, M., Wright, T. W., Fillingim, R. B., et al. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.11.008 · Cited by 24
Self-citationBehavioral, Psychological, Neurophysiological, and Neuroanatomic Determinants of Pain
Meints, S. M., Edwards, R. R., Gilligan, C. J., & Schreiber, K. L. (2020) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.20.00082 · Cited by 24
Self-citationSingle-Blind Placebo-Controlled Response Test with Phenytoin 10% Cream in Neuropathic Pain Patients
Kopsky, D. J., & Hesselink, J. M. K. (2018) · Pharmaceuticals · doi:10.3390/ph11040122 · Cited by 22
COMT Genotype and Efficacy of Propranolol for TMD Pain: A Randomized Trial
Slade, G. D., Fillingim, R. B., Ohrbach, R. K., Hadgraft, H., Willis, J., Arbes, S. J., & Tchivileva, I. E. (2020) · Journal of Dental Research · doi:10.1177/0022034520962733 · Cited by 22
Self-citationTeixeira, P. E. P., Pacheco‐Barrios, K., Uygur-Kucukseymen, E., Machado, R. M., Balbuena-Pareja, A., Giannoni‐Luza, S., Luna‐Cuadros, M. A., Cardenas‐Rojas, A., Gonzalez‐Mego, P., Mejia-Pando, P. F., et al. (2021) · Pain Medicine · doi:10.1093/pm/pnab293 · Cited by 23
Osteoarthritis today: Lost in translation?
Kennedy, S. J., Tambiah, J. R. S., & Lane, N. E. (2022) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2022.101810 · Cited by 22
Reconnecting the Brain With the Rest of the Body in Musculoskeletal Pain Research
Langevin, H. M. (2021) · The Journal of Pain · doi:10.1016/j.jpain.2020.02.006 · Cited by 24
Bouhassira, D., Perrot, S., Riant, T., Martiné, G., Pickering, G. P., Maindet, C., Attal, N., Garnier, S. R., Nguyen, J., Kuhn, E., et al. (2020) · Pain · doi:10.1097/j.pain.0000000000002109 · Cited by 22
Self-citationAAAPT Diagnostic Criteria for Acute Neuropathic Pain
Doshi, T. L., Dworkin, R. H., Polomano, R. C., Carr, D. B., Edwards, R. R., Finnerup, N. B., Freeman, R. L., Paice, J. A., Weisman, S. J., & Raja, S. N. (2020) · Pain Medicine · doi:10.1093/pm/pnaa407 · Cited by 23
Self-citationBedside testing for precision pain medicine
Reimer, M., Sachau, J., Forstenpointner, J., & Baron, R. (2021) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000556 · Cited by 21
Self-citationLandmann, G., Dumat, W., Egloff, N., Gantenbein, A. R., Matter, S., Pirrotta, R., Sándor, P. S., Schleinzer, W., Seifert, B., Sprott, H., et al. (2016) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000456 · Cited by 20
Ding, M., & Luo, Y. (2021) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-021-01460-7 · Cited by 20
Sachau, J., Sendel, M., Péchard, M., Schnabel, K., Schmieg, I., Medkour, T., Ecochard, L., Woischnik, M., Liedgens, H., Pogatzki-Zahn, E. M., et al. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.09.003 · Cited by 22
Self-citationHigh-Intensity Training for Knee Osteoarthritis: A Narrative Review
Tarantino, D., Theysmans, T., Mottola, R., & Verbrugghe, J. (2023) · Sports · doi:10.3390/sports11040091 · Cited by 20
Bested, K., Jensen, L. M., Andresen, T., Tarp, G., Skovbjerg, L., Johansen, T. S. D., Schmedes, A., Storgaard, I. K., Madsen, J. S., Werner, M. U., et al. (2023) · PAIN Reports · doi:10.1097/pr9.0000000000001080 · Cited by 21
Phenotypes and treatment response: it's difficult to make predictions, especially about the future
Dworkin, R. H., & Edwards, R. R. (2016) · Pain · doi:10.1097/j.pain.0000000000000771 · Cited by 20
Self-citationSkolasky, R. L., Wegener, S. T., Aaron, R. V., Ephraim, P. L., Brennan, G. P., Greene, T., Lane, E., Minick, K. I., Hanley, A. W., Garland, E. L., et al. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-03324-z · Cited by 21
Identifying patient subgroups in the heterogeneous chronic pain population using cluster analysis
Rijsdijk, M., Smits, H. M., Azizoglu, H. R., Brugman, S., van de Burgt, Y., van Charldorp, T. C., van Gelder, D. J., de Grauw, J. C., van Lange, E. A., Meye, F. J., et al. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.104792 · Cited by 22
Carlesso, L. C., Tousignant‐Laflamme, Y., Shaw, W. S., Larivière, C., & Choinière, M. (2021) · Canadian Journal of Pain · doi:10.1080/24740527.2020.1870103 · Cited by 18
Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis
Forsmark, C. E., Andersen, D. K., Farrar, J. T., Golden, M., Habtezion, A., Husain, S. Z., Li, L., Mayerle, J. V., Pandol, S. J., Uç, A., et al. (2018) · Pancreas · doi:10.1097/mpa.0000000000001174 · Cited by 19
Indices of pain variability: a paradigm shift
Winger, J. G., Vilardaga, J. P., & Keefe, F. J. (2019) · Pain · doi:10.1097/j.pain.0000000000001627 · Cited by 19
Didangelos, T., Karlafti, E., Kotzakioulafi, E., Giannoulaki, P., Kontoninas, Z., Kontana, A., Evripidou, P., Savopoulos, C., Birkenfeld, A. L., & Kantartzis, K. (2024) · Nutrients · doi:10.3390/nu16183045 · Cited by 18
Grosen, K., Olesen, A. E., Gram, M., Jonsson, T., Kamp-Jensen, M., Andresen, T., Nielsen, C., Požlep, G., Pfeiffer‐Jensen, M., Morlion, B. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171723 · Cited by 18
Ocay, D. D., Larche, C. L., Betinjane, N., Jolicoeur, A., Beaulieu, M. J., Saran, N., Ouellet, J. A., Ingelmo, P. M., & Ferland, C. E. (2022) · Journal of Pain Research · doi:10.2147/jpr.s352607 · Cited by 18
Use of IMMPACT Recommendations to Explore Pain Phenotypes in People with Knee Osteoarthritis
Carlesso, L. C., Feldman, D. E., Vendittoli, P., Lavoie, F., Choinière, M., Bolduc, M.-È., Fernandes, J., Newman, N. M., & Sabouret, P. (2022) · Pain Medicine · doi:10.1093/pm/pnac044 · Cited by 17
Combining Human and Rodent Genetics to Identify New Analgesics
Latrémolière, A., & Costigan, M. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0152-z · Cited by 17
Navigating trials of personalized pain treatments: we're going to need a bigger boat
Gewandter, J. S., McDermott, M. P., Mbowe, O. B., Edwards, R. R., Katz, N. P., Turk, D. C., & Dworkin, R. H. (2019) · Pain · doi:10.1097/j.pain.0000000000001504 · Cited by 17
Self-citationMusculoskeletal Pain in Individuals With Inflammatory Bowel Disease Reflects Three Distinct Profiles
Falling, C., Stebbings, S. M., Baxter, D. G., Gearry, R. B., & Mani, R. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000698 · Cited by 17
Hamwi, A., Veitl, M., Maenner, G., Vogelsang, H., & Szekeres, T. (2000) · PubMed · Cited by 17
Central Sensitization in Cancer Survivors and Its Clinical Implications: State of the Art
Nishigami, T., Manfuku, M., & Lahousse, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12144606 · Cited by 19
Qiu, L., Alhaskawi, A., & Moqbel, S. A. A. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1697192 · Cited by 24
Cervical disc degeneration: important considerations for the manual therapist
Swanson, B. T., & Creighton, D. (2021) · Journal of Manual & Manipulative Therapy · doi:10.1080/10669817.2021.2000089 · Cited by 16
Real-world patient data: Can they support decision making and patient engagement?
Joeris, A., ZHU, T. Y., Lambert, S. M., Wood, A., & Jayakumar, P. (2021) · Injury · doi:10.1016/j.injury.2021.12.012 · Cited by 17
Mathew, J., Adhia, D. B., Smith, M. L., Ridder, D. D., & Mani, R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.899772 · Cited by 19
Antonio, S. D., Arendt‐Nielsen, L., Ponzano, M., Bovis, F., Torelli, P., Finocchi, C., & Castaldo, M. (2023) · Pain Medicine · doi:10.1093/pm/pnad048 · Cited by 16
Self-citationMiller, R. E., Brown, D. S., Keith, S. W., Hegarty, S., Setty, Y. B. N., Campbell, C. M., McCahan, S. M., Betal, S. G., Byck, H., & Stuart, M. J. (2019) · British Journal of Haematology · doi:10.1111/bjh.15876 · Cited by 16
Wilson, A. T., Riley, J. L., Bishop, M. D., Beneciuk, J. M., Godza, M., Cruz‐Almeida, Y., & Bialosky, J. E. (2021) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2021.02.014 · Cited by 18
Albrecht, P. J., Houk, G., Ruggiero, E., Dockum, M., Czerwinski, M., Betts, J., Wymer, J. P., Argoff, C. E., & Rice, F. L. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.790524 · Cited by 17
Bartley, E. J., Makhoul, M., Palit, S., Robinson, M. E., & Fillingim, R. B. (2022) · Pain Medicine · doi:10.1093/pm/pnac156 · Cited by 16
Self-citationOxycodone or Higher Dose of Levodopa for the Treatment of Parkinsonian Central Pain: OXYDOPA Trial
Brefel‐Courbon, C., Harroch, E., Marquès, A., Devos, D., Thalamas, C., Rousseau, V., Ory‐Magne, F., Fabbri, M., Maltête, D., Rouaud, T., et al. (2024) · Movement Disorders · doi:10.1002/mds.29878 · Cited by 15
Kaboré, J., Saïdi, H., Dassieu, L., Choinière, M., & Pagé, M. G. (2020) · Pain Practice · doi:10.1111/papr.12883 · Cited by 15
Dagliati, A., Plant, D., Nair, N., Jani, M., Amico, B., Peek, N. B., Morgan, A. W., Isaacs, J. D., Wilson, A. G., Hyrich, K. L., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41379 · Cited by 15
Du, E., Fan, R., Rong, L.-L., Xie, Z., & Xu, C. (2020) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900425 · Cited by 14
Lopes, F., Rodrigues, M. J. F., & Silva, A. G. (2021) · JMIR mhealth and uhealth · doi:10.2196/25316 · Cited by 14
Moens, M., Billet, B., Molenberghs, G., Smedt, A. D., Pilitsis, J. G., Vos, R. D., Hanssens, K., Billot, M., Manuel Roulaud, B., Rigoard, P., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002868 · Cited by 14
Collins, J., Walsh, D. A., Gladman, J. R. F., Pătraşcu, M., Husebo, B. S., Adam, E., Cowley, A., Gordon, A. L., Ogliari, G., Smaling, H. J. A., et al. (2024) · Drugs & Aging · doi:10.1007/s40266-024-01101-4 · Cited by 14
Keter, D. L., Esteves, J. E., Loghmani, M. T., Rossettini, G., & Cook, C. E. (2025) · International journal of osteopathic medicine · doi:10.1016/j.ijosm.2025.100750 · Cited by 17
Rethinking the criteria for fibromyalgia in 2019: the ABC indicators
Stewart, J. A., Mailler-Burch, S., Müller, D., Studer, M., von Känel, R., Holtforth, M. G., Schwegler, K., & Egloff, N. (2019) · Journal of Pain Research · doi:10.2147/jpr.s205299 · Cited by 14
El-Damanawi, R., Lee, M., Harris, T., Cowley, L. B., Scholtes, I., Bond, S. J., Sandford, R. N., Wilkinson, I. B., Casteleijn, N. F., Hogan, M. C., et al. (2020) · Clinical Kidney Journal · doi:10.1093/ckj/sfaa259 · Cited by 14
Biobehavioral Assessments in BACPAC: Recommendations, Rationale, and Methods
Greco, C. M., Wasan, A. D., Schneider, M. J., Mehling, W., Williams, D. A., Darwin, J., & Harte, S. E. (2023) · Pain Medicine · doi:10.1093/pm/pnac175 · Cited by 13
Self-citationLakha, S. F., Deshpande, A., Assimakopoulos, D., & Mailis, A. (2021) · Pain and Therapy · doi:10.1007/s40122-021-00301-9 · Cited by 13
Shepherd, M. H., Shumway, J., Salvatori, R. T., Rhon, D. I., & Young, J. L. (2022) · Journal of Manual & Manipulative Therapy · doi:10.1080/10669817.2022.2037193 · Cited by 13
Yang, M., Baser, R. E., Khanin, R., Autuori, I., Li, Q. S., Panageas, K. S., Orlow, I., & Mao, J. J. J. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.05.005 · Cited by 14
Keter, D. L., Bent, J. A., Bialosky, J. E., Courtney, C. A., Esteves, J. E., Funabashi, M., Howarth, S. J., Injeyan, H. S., Mazzieri, A. M., Nim, C. G., et al. (2023) · Journal of Manual & Manipulative Therapy · doi:10.1080/10669817.2023.2262336 · Cited by 13
Subgroups of Pediatric Patients With Functional Abdominal Pain
Stone, A. L., Han, G. T., Bruehl, S. P., Garber, J., Smith, C. A., Anderson, J., Palermo, T. M., & Walker, L. S. (2020) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000882 · Cited by 14
Polycystic Kidney Disease Drug Development: A Conference Report
Liebau, M. C., Mekahli, D., Perrone, R. D., Soyfer, B., & Fedeles, S. V. (2022) · Kidney Medicine · doi:10.1016/j.xkme.2022.100596 · Cited by 12
Harris‐Hayes, M., Zorn, P., Steger-May, K., Burgess, M. M., DeMargel, R. D., Kuebler, S., Clohisy, J. C. F., & Haroutounian, S. (2023) · Physical Therapy · doi:10.1093/ptj/pzad111 · Cited by 12
Self-citationThe ACTTION Guide to Clinical Trials of Pain Treatments, part II: mitigating bias, maximizing value
Dworkin, R. H., Kerns, R. D., McDermott, M. P., Turk, D. C., & Veasley, C. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000886 · Cited by 12
Self-citationSchneider, A. T., & Hirth, M. (2021) · Drugs · doi:10.1007/s40265-021-01472-7 · Cited by 12
Exploring the Domains of Gender as Measured by a New Gender, Pain and Expectations Scale
Ghodrati, M., Walton, D. M., & MacDermid, J. C. (2021) · Women s Health Reports · doi:10.1089/whr.2020.0109 · Cited by 12
Chen, J., Zhang, Y., Barandouzi, Z. A., Xu, W., Feng, B., Chon, K. H., Santos, M., Starkweather, A. R., & Cong, X. S. (2022) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000001046 · Cited by 12
Wilson, A. T., Riley, J. L., Bishop, M. D., Beneciuk, J. M., Cruz‐Almeida, Y., Markut, K. A., Redd, C., LeBlond, N. D., Pham, P. H., Shirey, D., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281517 · Cited by 14
The Natural History of Knee Osteoarthritis Pain Experience and Risk Profiles
Chang, A. H., Almagor, O., Lee, J. J., Song, J., Muhammad, L. N., Chmiel, J. S., Moisio, K. C., & Sharma, L. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.07.002 · Cited by 12
Do Changes in Sensory Processing Precede Low Back Pain Development in Healthy Individuals?
Hwang, C., Dillen, L. R. V., & Haroutounian, S. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000563 · Cited by 12
Self-citationDelineating conditions and subtypes in chronic pain using neuroimaging
Holmes, S. A., Upadhyay, J., & Borsook, D. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000768 · Cited by 11
Kennedy, D. L., Ridout, D. A., Lysakova, L., Vollert, J., Alexander, C. M., & Rice, A. S. C. (2021) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-021-04832-2 · Cited by 12
Self-citationProgress in pain medicine: where are we now?
Colvin, L., & Rice, A. S. C. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.04.051 · Cited by 12
Self-citationCognitive flexibility training for chronic pain: a randomized clinical study
Holzer, K. J., Todorovic, M. S., Wilson, E. A. H., Steinberg, A., Avidan, M. S., & Haroutounian, S. (2024) · PAIN Reports · doi:10.1097/pr9.0000000000001120 · Cited by 11
Self-citationBuosi, J. A. O., Nogueira, S., Sousa, M., Maia, C. S. C., Regis, R. R., Pontes, K. M. D. F., Bonjardim, L. R., & Fiamengui, L. M. S. P. (2021) · Journal of Oral & Facial Pain and Headache · doi:10.11607/ofph.2823 · Cited by 11
Psychological Aspect and Quality of Life in Porphyrias: A Review
Granata, F., Nicolli, A., Colaiocco, A., Pierro, E. D., & Graziadei, G. (2022) · Diagnostics · doi:10.3390/diagnostics12051193 · Cited by 13
Nielsen, S. S., Skou, S. T., Larsen, A. E., Bricca, A., Søndergaard, J., & Christensen, J. R. (2022) · Occupational Therapy International · doi:10.1155/2022/7082159 · Cited by 12
Costa, Y. M., Ferreira, D. M. A. O., Conti, P. C. R., Baad‐Hansen, L., Svensson, P. J., & Bonjardim, L. R. (2019) · Journal of Oral Rehabilitation · doi:10.1111/joor.12874 · Cited by 11
Pharmacotherapeutic considerations and options for the management of osteoarthritis in women
Trivedi, S. M., FANG, W. H., Ayyalasomayajula, I., & Vangsness, C. T. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1718649 · Cited by 11
McCormick, Z. L., Hurley, R. W., Anițescu, M., Bhaskar, A., Bhatia, A., Cassidy, R. C., Chen, A. S., Dawson, T. C., Ares, J. D. A., de Campos, J. L., et al. (2025) · Pain Medicine · doi:10.1093/pm/pnaf129 · Cited by 10
Wilson, A. T., Riley, J. L., Bishop, M. D., Beneciuk, J. M., Cruz‐Almeida, Y., & Bialosky, J. E. (2023) · Pain Research and Management · doi:10.1155/2023/5326261 · Cited by 12
Duff, I. T., Krolick, K. N., Mahmoud, H., & Chidambaran, V. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12165176 · Cited by 11
Antonio, S. D., Arendt‐Nielsen, L., Ponzano, M., Bovis, F., Torelli, P., Pelosin, E., Finocchi, C., & Castaldo, M. (2023) · Neurological Sciences · doi:10.1007/s10072-023-07118-8 · Cited by 10
Self-citationBeyond pain intensity: Validating single-item pain bothersomeness measures
Edwards, K. A., You, D. S., Lannon, E. W., Dildine, T. C., Darnall, B. D., & Mackey, S. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105395 · Cited by 11
Koechlin, H., Kharko, A., Probst, T., Pradela, J., Buechi, S., & Locher, C. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.750523 · Cited by 8
Murphy, M., Mkumbuzi, N. S., Keightley, J. G. A., Gibson, W., Vallance, P., Riel, H., Plinsinga, M. L., & Rio, E. (2023) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2023.11940 · Cited by 10
Zhou, Q., Wesselmann, U., Walker, L. S., Lee, L. S., Zeltzer, L. K., & Verne, G. N. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.10.002 · Cited by 11
Carlesso, L. C., & Neogi, T. (2020) · Current Treatment Options in Rheumatology · doi:10.1007/s40674-020-00144-z · Cited by 10
Smith, S. S., Kitterick, P. T., Scutt, P., Baguley, D., & Pierzycki, R. H. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.10.002 · Cited by 10
Self-citation
Metadata
- Authors
- Edwards, R. R., Dworkin, R. H., Turk, D. C., Angst, M. S., Dionne, R., Freeman, R., Hansson, P., Haroutounian, S., Arendt-Nielsen, L., Attal, N., Baron, R., Brell, J., Bujanover, S., Burke, L. B., Carr, D., Chappell, A. S., Cowan, P., Etropolski, M., Fillingim, R. B., Gewandter, J. S., Katz, N. P., Kopecky, E. A., Markman, J. D., Nomikos, G., Porter, L., Rappaport, B. A., Rice, A. S. C., Scavone, J. M., Scholz, J., Simon, L. S., Smith, S. M., Tobias, J., Tockarshewsky, T., Veasley, C., Versavel, M., Wasan, A. D., Wen, W., & Yarnitsky, D.
- Affiliations
- Harvard University (US)
- University of Rochester (US)
- University of Washington (US)
- Stanford University (US)
- East Carolina University (US)
- Oslo University Hospital (NO)
- Washington University in St. Louis (US)
- Aalborg University, Aalborg, Denmark
- Inserm (FR)
- Christian-Albrechts-Universität zu Kiel (DE)
- MetroHealth Medical Center (US)
- Depomed (United States) (US)
- University of Maryland, Baltimore (US)
- Tufts University (US)
- Eli Lilly (United States) (US)
- American Chronic Pain Association (US)
- Johnson & Johnson (United States) (US)
- University of Florida (US)
- Collegium Pharmaceutical (United States) (US)
- Astellas Pharma (United States) (US)
- National Institutes of Health (US)
- Arlington, VA, USA
- Imperial College London (GB)
- Pfizer (United States) (US)
- Columbia University (US)
- SDG LLC, Cambridge, MA, USA
- Jazz Pharmaceuticals (United States) (US)
- Ceres (US)
- Chronic Pain Research Alliance, North Kingstown, RI, USA
- Zalicus, Cambridge, MA, USA
- University of Pittsburgh (US)
- Purdue Pharma (United States) (US)
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Edwards, Robert R.
- ORCID
- Edwards, Robert R.
- Dworkin, Robert H.
- Angst, Martin S.
- Freeman, Roy
- Hansson, Per
- Haroutounian, Simon
- Attal, Nadine
- Baron, Ralf
- Burke, Laurie B.
- Fillingim, Roger B.
- Gewandter, Jennifer S.
- Katz, Nathaniel P.
- Kopecky, Ernest A.
- Markman, John D.
- Nomikos, George
- Rice, Andrew S.C.
- Scholz, Joachim
- Simon, Lee S.
- Smith, Shannon M.
- Tobias, Jeffrey
- Tockarshewsky, Tina
- Wasan, Ajay D.
- Wen, Warren
- Yarnitsky, David
- Venue
- Pain
- Published
- 2016-05-05
- Volume
- 157
- Issue
- 9
- Pages
- 1851-1871
- ISSN
- 0304-3959 (ISSN-L)
- 1872-6623
- PMC
- PMC5965275
- OpenAlex
- W2359535866
- Cited by
- 403
- References
- 275
- Citations by year
- 2026: 29 · 2025: 51 · 2024: 45 · 2023: 47 · 2022: 35 · 2021: 64 · 2020: 44 · 2019: 32 · 2018: 26 · 2017: 24 · 2016: 3
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Funders
- U.S. Food and Drug Administration (U01-FD005936)
- National Institute on Aging (R01AG034982)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR064367)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- patient phenotyping, chronic pain, precision medicine, psychosocial factors, symptom characteristics, sleep patterns, endogenous pain modulation, clinical trial design
- MeSH terms
- Analgesics, Clinical Trials as Topic, Humans, Pain Measurement, Phenotype, Treatment Outcome, Chronic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
