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Perturbed connectivity of the amygdala and its subregions with the central executive and default mode networks in chronic pain
Open accessAbstract
Maladaptive responses to pain-related distress, such as pain catastrophizing, amplify the impairments associated with chronic pain. Many of these aspects of chronic pain are similar to affective distress in clinical anxiety disorders. In light of the role of the amygdala in pain and affective distress, disruption of amygdalar functional connectivity in anxiety states, and its implication in the response to noxious stimuli, we investigated amygdala functional connectivity in 17 patients with chronic low back pain and 17 healthy comparison subjects, with respect to normal targets of amygdala subregions (basolateral vs centromedial nuclei), and connectivity to large-scale cognitive–emotional networks, including the default mode network, central executive network, and salience network. We found that patients with chronic pain had exaggerated and abnormal amygdala connectivity with central executive network, which was most exaggerated in patients with the greatest pain catastrophizing. We also found that the normally basolateral-predominant amygdala connectivity to the default mode network was blunted in patients with chronic pain. Our results therefore highlight the importance of the amygdala and its network-level interaction with large-scale cognitive/affective cortical networks in chronic pain, and help link the neurobiological mechanisms of cognitive theories for pain with other clinical states of affective distress.
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“However, a second subset of studies have found no sex differences in DNIC response 179–181.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [179]
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Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719
Darnall, B. D., Roy, A., Chen, A. L., Ziadni, M. S., Keane, R. T., You, D. S., Slater, K., Poupore-King, H., Mackey, I., Kao, M.-C., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.13401 · Cited by 191
Self-citationKim, K.-W., Park, K., Park, H.-J., Jahng, G.-H., Jo, D.-J., Cho, J.-H., Song, E.-M., Shin, W.-C., Yoon, Y.-J., Kim, S.-J., et al. (2019) · Trials · doi:10.1186/s13063-018-3164-8 · Cited by 13
Metadata
- Authors
- Jiang, Y., Oathes, D., Hush, J., Darnall, B., Charvat, M., Mackey, S., & Etkin, A.
- Affiliations
- VA Palo Alto Health Care System (US)
- Macquarie University (AU)
- Stanford Medicine (US)
- Corresponding author
- Etkin, Amit
- Venue
- Pain
- Published
- 2016-05-06
- Volume
- 157
- Issue
- 9
- Pages
- 1970-1978
- ISSN
- 0304-3959 (ISSN-L)
- 1872-6623
- PMC
- PMC6647855
- OpenAlex
- W2362907575
- Cited by
- 120
- References
- 60
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 8 · 2023: 8 · 2022: 19 · 2021: 23 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 4 · 2016: 1
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K24DA029262)
- National Center for Complementary and Integrative Health (P01AT006651, R01AT008561)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- chronic low back pain, amygdala, functional connectivity, frontoparietal network, default mode network, salience network, pain catastrophizing, basolateral amygdala, centromedial amygdala, emotional distress, anxiety disorders
- MeSH terms
- Adult, Amygdala, Analysis of Variance, Brain Mapping, Cognition Disorders, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Models, Neurological, Mood Disorders, Executive Function, Catastrophization, Chronic Pain
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- Jiang, Y., Oathes, D., Hush, J., Darnall, B., Charvat, M., Mackey, S., & Etkin, A. (2016). Perturbed connectivity of the amygdala and its subregions with the central executive and default mode networks in chronic pain. Pain. https://doi.org/10.1097/j.pain.0000000000000606
