Effect and neurophysiological mechanism of acupuncture in patients with chronic sciatica: protocol for a randomized, patient-assessor blind, sham-controlled clinical trial
Open accessAbstract
BACKGROUND: Sciatica is a relatively frequent illness that easily becomes a chronic and relapsing condition. Although numerous systematic reviews have analyzed various therapies for sciatica, the validity of their included studies is limited. Considering the limitations of conventional treatment options for sciatica, acupuncture is a possible option; however, evidence supporting its efficacy and mechanism in patients with sciatica is lacking. The aim of this proposed protocol is to investigate the effect and neurophysiological mechanism of acupuncture in patients with chronic sciatica. METHODS/DESIGN: This study is a randomized, patient-assessor blind, two-arm, parallel, non-penetrating, sham-controlled clinical trial. Eligible participants will include adults (aged 19-70 years old) with a clinical diagnosis of chronic sciatica (40 mm or more of a 100-mm visual analog scale (VAS) for bothersomeness) blinded to the treatment received. Patients will be randomly allocated into the acupuncture treatment group (manual acupuncture plus electroacupuncture (EA), n = 34) or the sham acupuncture control group (sham acupuncture plus placebo EA without electrical stimulation, n = 34). Groups will receive treatment twice a week for a total of eight sessions over 4 weeks. Functional magnetic resonance imaging will be implemented at baseline and endpoint to investigate the mechanism of acupuncture. The primary outcome measure is the VAS for bothersomeness and secondary outcomes include the VAS for pain intensity, Oswestry Disability Index, EuroQol 5-Dimension, Coping Strategy Questionnaire, Beck's Depression Inventory, and State-Trait Anxiety Inventory. Adverse events will be assessed at every visit. DISCUSSION: The results of this trial (which will be available in 2020) should provide important clinical evidence for the effect of acupuncture and demonstrate how acupuncture can be helpful for the treatment of chronic sciatica. TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT03350789 . Registered on 15 November 2017.
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Acupuncture's potential efficacy in sciatica has been preliminarily demonstrated in several clinical studies.
“Its potential efficacy in sciatica has been preliminarily demonstrated in several clinical studies.9–11”
From Acupuncture Therapy for Sciatica: An Overview of Systematic Reviews and Meta-Analysis (2025) · cites this paper as [9]
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EFEITOS DA DOR NEUROPÁTICA NA ANSIEDADE EM ROEDORES: UMA REVISÃO SISTEMÁTICA
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- Authors
- Kim, K.-W., Park, K., Park, H.-J., Jahng, G.-H., Jo, D.-J., Cho, J.-H., Song, E.-M., Shin, W.-C., Yoon, Y.-J., Kim, S.-J., Eun, S., & Song, M.-Y.
- Affiliations
- Kyung Hee University (KR)
- Corresponding author
- Song, Mi-Yeon
- ORCID
- Venue
- Trials
- Published
- 2019-01-16
- Volume
- 20
- Issue
- 1
- Pages
- 56-56
- ISSN
- 1745-6215 (ISSN-L)
- PMC
- PMC6335765
- OpenAlex
- W2947676720
- Cited by
- 13
- References
- 63
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Trials (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (NRF-2017R1A2B4011707)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Myofascial pain diagnosis and treatment
- Keywords
- chronic sciatica, acupuncture, electroacupuncture, sham acupuncture, neurophysiological mechanisms, functional MRI, pain intensity, disability, quality of life, depression, anxiety, coping strategies
- MeSH terms
- Adaptation, Psychological, Adult, Aged, Disability Evaluation, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pain Measurement, Sciatica, Time Factors, Acupuncture Therapy, Randomized Controlled Trials as Topic, Treatment Outcome, Young Adult, Chronic Pain
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