The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Perturbed connectivity of the amygdala and its subregions with the central executive and default mode networks in chronic pain
Open accessAbstract
Maladaptive responses to pain-related distress, such as pain catastrophizing, amplify the impairments associated with chronic pain. Many of these aspects of chronic pain are similar to affective distress in clinical anxiety disorders. In light of the role of the amygdala in pain and affective distress, disruption of amygdalar functional connectivity in anxiety states, and its implication in the response to noxious stimuli, we investigated amygdala functional connectivity in 17 patients with chronic low back pain and 17 healthy comparison subjects, with respect to normal targets of amygdala subregions (basolateral vs centromedial nuclei), and connectivity to large-scale cognitive–emotional networks, including the default mode network, central executive network, and salience network. We found that patients with chronic pain had exaggerated and abnormal amygdala connectivity with central executive network, which was most exaggerated in patients with the greatest pain catastrophizing. We also found that the normally basolateral-predominant amygdala connectivity to the default mode network was blunted in patients with chronic pain. Our results therefore highlight the importance of the amygdala and its network-level interaction with large-scale cognitive/affective cortical networks in chronic pain, and help link the neurobiological mechanisms of cognitive theories for pain with other clinical states of affective distress.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, a second subset of studies have found no sex differences in DNIC response 179–181.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [179]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139
Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881
(1998) · PubMed · Cited by 10,216
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888
The Pain Catastrophizing Scale: Development and validation.
Sullivan, M. J. L., Bishop, S. R., & Pivik, J. (1995) · Psychological Assessment · doi:10.1037//1040-3590.7.4.524 · Cited by 8,227
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Eickhoff, S. B., Stephan, K. E., Mohlberg, H., Grefkes, C., Fink, G. R., Amunts, K., & Zilles, K. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.034 · Cited by 4,033
Spatial registration and normalization of images
Friston, K. J., Ashburner, J., Frith, C., Poline, J.-B., Heather, J. D., & Frackowiak, R. S. J. (1995) · Human Brain Mapping · doi:10.1002/hbm.460030303 · Cited by 3,744
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059
Self-citationA systematic review of the global prevalence of low back pain
Hoy, D. G., Bain, C. J., Williams, G. M., MARCH, L. M., Brooks, P., Blyth, F., Woolf, A. D., Vos, T., & Buchbinder, R. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34347 · Cited by 3,025
Toward discovery science of human brain function
Biswal, B. B., Mennes, M., Zuo, X.-N., Gohel, S., Kelly, C., Smith, S. M., Beckmann, C. F., Adelstein, J. S., Buckner, R. L., Colcombe, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911855107 · Cited by 2,970
Distinct brain networks for adaptive and stable task control in humans
Dosenbach, N. U. F., Fair, D. A., Miezin, F. M., Cohen, A. L., Wenger, K. K., Dosenbach, R. A. T., Fox, M. D., Snyder, A. Z., Vincent, J. L., Raichle, M. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704320104 · Cited by 2,632
The influence of head motion on intrinsic functional connectivity MRI
Van Dijk, K. R. A., Sabuncu, M. R., & Buckner, R. L. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.044 · Cited by 2,344
Psychological and neural mechanisms of the affective dimension of pain
Price, D. D. (2000) · Science · doi:10.1126/science.288.5472.1769 · Cited by 2,092
Cognitive and emotional control of pain and its disruption in chronic pain
Bushnell, M. C., Čeko, M., & Low, L. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3516 · Cited by 2,076
Spinal Fusion in the United States: Analysis of Trends From 1998 to 2008
Rajaee, S. S., Bae, H. W., Kanim, L. E. A., & Delamarter, R. B. (2012) · Spine · doi:10.1097/brs.0b013e31820cccfb · Cited by 1,041
Switching on and off fear by distinct neuronal circuits
Herry, C., Ciocchi, S., Senn, V., Demmou, L., Müller, C., & Lüthi, A. (2008) · Nature · doi:10.1038/nature07166 · Cited by 950
Quirk, G. J., Likhtik, E., Pelletier, J. G., & Paré, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08800.2003 · Cited by 927
Pain catastrophizing and neural responses to pain among persons with fibromyalgia
Gracely, R. H. (2004) · Brain · doi:10.1093/brain/awh098 · Cited by 892
Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics
Baliki, M. N., Geha, P., Apkarian, A. V., & Chialvo, D. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4123-07.2008 · Cited by 881
New Vistas on Amygdala Networks in Conditioned Fear
Paré, D., Quirk, G. J., & Ledoux, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00153.2004 · Cited by 841
Baliki, M. N., Chialvo, D. R., Geha, P. Y., Levy, R. M., Harden, R. N., Parrish, T. B., & Apkarian, A. V. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3576-06.2006 · Cited by 756
Functional connectivity of the human amygdala using resting state fMRI
Roy, A. K., Shehzad, Z., Margulies, D. S., Kelly, A. M. C., Uddin, L. Q., Gotimer, K., Biswal, B. B., Castellanos, F. X., & Milham, M. P. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.030 · Cited by 749
Etkin, A., Prater, K. E., Schatzberg, A. F., Menon, V., & Greicius, M. D. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.104 · Cited by 664
Self-citationIntrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity
Napadow, V., LaCount, L., Park, K., As‐Sanie, S., Clauw, D. J., & Harris, R. E. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27497 · Cited by 645
Testing anatomically specified hypotheses in functional imaging using cytoarchitectonic maps
Eickhoff, S. B., Heim, S., Zilles, K., & Amunts, K. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.204 · Cited by 643
Severeijns, R., Vlaeyen, J. W. S., van den Hout, M. A., & Weber, W. E. J. (2001) · The Clinical Journal of Pain · doi:10.1097/00002508-200106000-00009 · Cited by 622
Demyttenaere, K., Bruffaerts, R., Lee, S., Posada-Villa, J., Kovess, V., Angermeyer, M. C., Levinson, D., de Girolamo, G., Nakane, H., Mneimneh, Z., et al. (2007) · Pain · doi:10.1016/j.pain.2007.01.022 · Cited by 608
Causal interactions between fronto-parietal central executive and default-mode networks in humans
Chen, A. C., Oathes, D. J., Chang, C., Bradley, T., Zhou, Z.-W., Williams, L. M., Glover, G. H., Deisseroth, K. A., & Etkin, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311772110 · Cited by 580
Self-citationSelf‐navigated spiral fMRI: Interleaved versus single‐shot
Glover, G. H., & Lai, S. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390305 · Cited by 476
Bernard, J., & Besson, J. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.3.473 · Cited by 447
Emotional Perseveration: An Update on Prefrontal-Amygdala Interactions in Fear ExtinctionPreprint
Sotres-Bayón, F., Bush, D. E. A., & LeDoux, J. E. (2004) · Learning & Memory · doi:10.1101/lm.79504 · Cited by 419
Cortical responses to pain in healthy individuals depends on pain catastrophizing
Seminowicz, D. A., & Davis, K. D. (2006) · Pain · doi:10.1016/j.pain.2005.11.008 · Cited by 407
Sensory-affective relationships among different types of clinical and experimental pain
Price, D. D., Harkins, S. W., & Baker, C. (1987) · Pain · doi:10.1016/0304-3959(87)90065-0 · Cited by 396
Kucyi, A., Moayedi, M., Weissman-Fogel, I., Goldberg, M. B., Freeman, B. V., Tenenbaum, H. C., & Davis, K. D. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5055-13.2014 · Cited by 396
Prefrontal Control of the Amygdala
Likhtik, E., Pelletier, J. G., Paz, R., & Paré, D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2314-05.2005 · Cited by 361
Amygdaloid projections to the frontal cortex and the striatum in the rat
Kita, H., & Kitai, S. T. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902980104 · Cited by 351
The amygdala modulates prefrontal cortex activity relative to conditioned fear
Garcia, R., Vouimba, R.-M., Baudry, M., & Thompson, R. F. (1999) · Nature · doi:10.1038/46286 · Cited by 347
Default mode network connectivity encodes clinical pain: An arterial spin labeling study
Loggia, M. L., Kim, J., Gollub, R. L., Vangel, M. G., Kirsch, I., Kong, J., Wasan, A. D., & Napadow, V. (2012) · Pain · doi:10.1016/j.pain.2012.07.029 · Cited by 323
The Cortical Rhythms of Chronic Back Pain
Baliki, M. N., Baria, A. T., & Apkarian, A. V. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1984-11.2011 · Cited by 291
Strigo, I. A., Simmons, A. N., Matthews, S. C., Craig, A. D. B., & Paulus, M. P. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1275 · Cited by 277
The human amygdala and pain: Evidence from neuroimaging
Simons, L. E., Moulton, E. A., Linnman, C., Carpino, E. A., Becerra, L. R., & Borsook, D. (2012) · Human Brain Mapping · doi:10.1002/hbm.22199 · Cited by 269
Perceived Controllability Modulates the Neural Response to Pain
Salomons, T. V., Johnstone, T., Backonja, M.-M., & Davidson, R. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1315-04.2004 · Cited by 253
Qin, S., Young, C. B., Duan, X., Chen, T., Supekar, K., & Menon, V. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.006 · Cited by 249
Neural correlates of individual differences in pain-related fear and anxiety
Ochsner, K. N., Ludlow, D. H., Knierim, K. E., Hanelin, J., Ramachandran, T., Glover, G. H., & Mackey, S. (2005) · Pain · doi:10.1016/j.pain.2005.10.014 · Cited by 230
Self-citationInfluence of Catastrophizing on Treatment Outcome in Patients With Nonspecific Low Back Pain
Wertli, M. M., Burgstaller, J. M., Weiser, S. R., Steurer, J., Kofmehl, R., & Held, U. (2013) · Spine · doi:10.1097/brs.0000000000000110 · Cited by 229
Multivariate Classification of Structural MRI Data Detects Chronic Low Back Pain
Ung, H., Brown, J. E., Johnson, K. A., Younger, J., Hush, J. M., & Mackey, S. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs378 · Cited by 219
Self-citationGray matter alterations in chronic pain: A network-oriented meta-analytic approach
Cauda, F., Palermo, S., Costa, T., Torta, R., Duca, S., Vercelli, U., Geminiani, G., & Torta, D. M. E. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.04.007 · Cited by 212
Brain resting state is disrupted in chronic back pain patients
Tagliazucchi, E., Balenzuela, P., Fraiman, D., & Chialvo, D. R. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.08.053 · Cited by 203
Amygdala input to medial prefrontal cortex (mPFC) in the rat: A light and electron microscope study
Bacon, S. J., Headlam, A. J. N., Gabbott, P. L. A., & Smith, A. D. (1996) · Brain Research · doi:10.1016/0006-8993(96)00155-2 · Cited by 191
Assessing the stages of pain processing: a multivariate analytical approach
Wade, J. B., Dougherty, L. M., Archer, R. C., & Price, D. D. (1996) · Pain · doi:10.1016/s0304-3959(96)03162-4 · Cited by 140
Bravo, L., Micó, J. A., Rey-Brea, R., Perez‐Nievas, B. G., Leza, J. C., & Berrocoso, E. (2012) · Anesthesiology · doi:10.1097/aln.0b013e3182657b3e · Cited by 109
Plasticity in the Mediodorsal Thalamo-Prefrontal Cortical Transmission in Behaving Mice
Herry, C., Vouimba, R., & Garcia, R. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.5.2827 · Cited by 104
Luo, Y., Qin, S., Fernández, G., Zhang, Y., Klumpers, F., & Li, H. (2014) · Human Brain Mapping · doi:10.1002/hbm.22573 · Cited by 84
Cognitive Theories of Generalized Anxiety Disorder
Aikins, D. E., & Craske, M. G. (2001) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70206-9 · Cited by 62
Functional imaging and the neural systems of chronic pain
Mackey, S., & Maeda, F. (2004) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2004.03.001 · Cited by 41
Self-citationMitchell, R. L. C. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.016 · Cited by 39
Cited by
Sorted by citations
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719
Darnall, B. D., Roy, A., Chen, A. L., Ziadni, M. S., Keane, R. T., You, D. S., Slater, K., Poupore-King, H., Mackey, I., Kao, M.-C., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.13401 · Cited by 191
Self-citationKim, K.-W., Park, K., Park, H.-J., Jahng, G.-H., Jo, D.-J., Cho, J.-H., Song, E.-M., Shin, W.-C., Yoon, Y.-J., Kim, S.-J., et al. (2019) · Trials · doi:10.1186/s13063-018-3164-8 · Cited by 13
Metadata
- Authors
- Jiang, Y., Oathes, D., Hush, J., Darnall, B., Charvat, M., Mackey, S., & Etkin, A.
- Affiliations
- VA Palo Alto Health Care System (US)
- Macquarie University (AU)
- Stanford Medicine (US)
- Corresponding author
- Etkin, Amit
- Venue
- Pain
- Published
- 2016-05-06
- Volume
- 157
- Issue
- 9
- Pages
- 1970-1978
- ISSN
- 0304-3959 (ISSN-L)
- 1872-6623
- PMC
- PMC6647855
- OpenAlex
- W2362907575
- Cited by
- 120
- References
- 60
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 8 · 2023: 8 · 2022: 19 · 2021: 23 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 4 · 2016: 1
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K24DA029262)
- National Center for Complementary and Integrative Health (P01AT006651, R01AT008561)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- chronic low back pain, amygdala, functional connectivity, frontoparietal network, default mode network, salience network, pain catastrophizing, basolateral amygdala, centromedial amygdala, emotional distress, anxiety disorders
- MeSH terms
- Adult, Amygdala, Analysis of Variance, Brain Mapping, Cognition Disorders, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Models, Neurological, Mood Disorders, Executive Function, Catastrophization, Chronic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
