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Cited by 80Health Systems, Economic Evaluations, Quality of LifeMusculoskeletal pain and rehabilitationPain Management and Opioid Use

The DOI matches its Crossref record; 52 of the 55 references it cites were found in a registry or an index.

Validation of EQ-5D and 15D in the assessment of health-related quality of life in chronic pain

Vartiainen, Pekka, Mäntyselkä, Pekka, Heiskanen, Tarja, Hagelberg, Nora, Mustola, Seppo, Forssell, Heli, Kautiainen, Hannu, Kalso, Eija·2017·Pain
DOI 10.1097/j.pain.0000000000000954
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Abstract

Chronic pain has a significant impact on quality of life. Measurement of health-related quality of life (HRQoL) is essential in the assessment of pain management outcomes, but different instruments have produced varying results. We assessed the validity of 2 HRQoL instruments, EuroQol 5 dimensions questionnaire (EQ-5D) and 15-dimensional health-related quality of life measure (15D), in patients with challenging chronic pain. Three hundred ninety-one chronic noncancer pain patients referred to tertiary pain clinics completed EQ-5D, 15D, and a broad set of questionnaires mapping socioeconomic factors, self-rated health, pain intensity and interference, depression, pain acceptance, pain-related anxiety, and sleep. The 2 HRQoL instruments were compared with each other, and head-to-head comparisons were made with self-rated health and the symptom-specific questionnaires. 15D and EQ-5D showed moderate agreement (ρ = 0.66), but there were also considerable differences between the instruments. 15D correlated better with self-rated health than EQ-5D (ρ = −0.62 vs −0.45, P < 0.001). The EQ-5D appeared less sensitive than 15D especially in those patients with chronic pain who had a better health status. The principal component constructed from measures of pain intensity and interference, anxiety, pain acceptance, depression, and sleep had higher standardized beta coefficients with 15D than with EQ-5D ( P = 0.038). The principal component explained more variance in the 15D ( R 2 = 0.65) than in the EQ-5D ( R 2 = 0.43). The study identified differences in the pain-related variables between the EQ-5D and the 15D. In patients with chronic pain, both instruments are valid, but 15D appears somewhat more sensitive than EQ-5D.

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Metadata

Authors
Vartiainen, P., Mäntyselkä, P., Heiskanen, T., Hagelberg, N., Mustola, S., Forssell, H., Kautiainen, H., & Kalso, E.
Affiliations
  • University of Helsinki (FI)
  • University of Eastern Finland (FI)
  • University of Turku (FI)
  • South Karelia Central Hospital (FI)
Corresponding author
Vartiainen, Pekka
ORCID
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-05-23
Volume
158
Issue
8
Pages
1577-1585
ISSN
  • 0304-3959 (ISSN-L)
  • 1872-6623
DOI
10.1097/j.pain.0000000000000954
OpenAlex
W2620532887
Cited by
80
References
55
Citations by year
2026: 2 · 2025: 9 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 22 · 2020: 7 · 2019: 10 · 2018: 2 · 2017: 2
FWCI
10.32
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
  • UEF eRepo (University of Eastern Finland) (acceptedVersion)
Topics
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
chronic non-cancer pain, health-related quality of life, EQ-5D, 15D, instrument validation, self-rated health, pain-related anxiety, pain acceptance, depression, sleep, measurement sensitivity
MeSH terms
Adult, Anxiety, Female, Health Status, Humans, Male, Middle Aged, Psychometrics, Quality of Life, Surveys and Questionnaires, Socioeconomic Factors, Chronic Pain

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