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Validation of EQ-5D and 15D in the assessment of health-related quality of life in chronic pain
Abstract
Chronic pain has a significant impact on quality of life. Measurement of health-related quality of life (HRQoL) is essential in the assessment of pain management outcomes, but different instruments have produced varying results. We assessed the validity of 2 HRQoL instruments, EuroQol 5 dimensions questionnaire (EQ-5D) and 15-dimensional health-related quality of life measure (15D), in patients with challenging chronic pain. Three hundred ninety-one chronic noncancer pain patients referred to tertiary pain clinics completed EQ-5D, 15D, and a broad set of questionnaires mapping socioeconomic factors, self-rated health, pain intensity and interference, depression, pain acceptance, pain-related anxiety, and sleep. The 2 HRQoL instruments were compared with each other, and head-to-head comparisons were made with self-rated health and the symptom-specific questionnaires. 15D and EQ-5D showed moderate agreement (ρ = 0.66), but there were also considerable differences between the instruments. 15D correlated better with self-rated health than EQ-5D (ρ = −0.62 vs −0.45, P < 0.001). The EQ-5D appeared less sensitive than 15D especially in those patients with chronic pain who had a better health status. The principal component constructed from measures of pain intensity and interference, anxiety, pain acceptance, depression, and sleep had higher standardized beta coefficients with 15D than with EQ-5D ( P = 0.038). The principal component explained more variance in the 15D ( R 2 = 0.65) than in the EQ-5D ( R 2 = 0.43). The study identified differences in the pain-related variables between the EQ-5D and the 15D. In patients with chronic pain, both instruments are valid, but 15D appears somewhat more sensitive than EQ-5D.
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“15D has recently been validated as a health-related quality of life measure in chronic pain [29].”
From Symptom reduction and improved function in chronic CRPS type 1 after 12-week integrated, interdisciplinary therapy (2019) · cites this paper as [29]
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Metadata
- Authors
- Vartiainen, P., Mäntyselkä, P., Heiskanen, T., Hagelberg, N., Mustola, S., Forssell, H., Kautiainen, H., & Kalso, E.
- Affiliations
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- University of Turku (FI)
- South Karelia Central Hospital (FI)
- Corresponding author
- Vartiainen, Pekka
- Venue
- Pain
- Published
- 2017-05-23
- Volume
- 158
- Issue
- 8
- Pages
- 1577-1585
- ISSN
- 0304-3959 (ISSN-L)
- 1872-6623
- OpenAlex
- W2620532887
- Cited by
- 80
- References
- 55
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 22 · 2020: 7 · 2019: 10 · 2018: 2 · 2017: 2
- FWCI
- 10.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- UEF eRepo (University of Eastern Finland) (acceptedVersion)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- chronic non-cancer pain, health-related quality of life, EQ-5D, 15D, instrument validation, self-rated health, pain-related anxiety, pain acceptance, depression, sleep, measurement sensitivity
- MeSH terms
- Adult, Anxiety, Female, Health Status, Humans, Male, Middle Aged, Psychometrics, Quality of Life, Surveys and Questionnaires, Socioeconomic Factors, Chronic Pain
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