Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts
Open accessAbstract
Nitrous oxide (laughing gas) has shown early promise as a rapidly acting antidepressant in patients with treatment-resistant major depression and is currently investigated in several clinical trials. Because nitrous oxide is rarely administered outside operating rooms or dental practices, most psychiatrists are not familiar with how nitrous oxide is administered in a medical setting and what regulations guide its use. The goal of this brief review was to educate psychiatrists about the basic concepts of nitrous oxide administration and pharmacology. Furthermore, common misconceptions about nitrous oxide will be discussed.
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Nitrous oxide inhibits NMDA currents in a dose-dependent manner.
“Nitrous oxide inhibits NMDA currents in a dose-dependent manner, amongst other documented mechanisms [176]”
From Ketamine in neuropsychiatric disorders: an update (2024) · cites this paper as [176]
The 'Basic facts about nitrous oxide' section (page unavailable) describes nitrous oxide as a non-competitive NMDA-receptor antagonist, supporting the inhibition mechanism. It does not say that inhibition of NMDA currents is dose-dependent; searches for dose- or concentration-dependent NMDA-current inhibition found no such passage. (LLM, conf=0.87)
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- Authors
- Nagele, P., Zorumski, C. F., & Conway, C.
- Affiliations
- From the *Division of Clinical and Translational Research, Department of Anesthesiology, †Taylor Family Institute for Innovative Psychiatric Research, and ‡Department of Psychiatry, Washington University in St Louis, St Louis, MO.
- Washington University in St. Louis (US)
- Venue
- Journal of Clinical Psychopharmacology
- Published
- 2018-04
- Volume
- 38
- Issue
- 2
- Pages
- 144-148
- ISSN
- 0271-0749 (ISSN-L)
- 1533-712X
- PMC
- PMC5825282
- OpenAlex
- W2789418706
- Cited by
- 43
- References
- 45
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 2 · 2018: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Bristol-Myers Squibb
- Sage Therapeutics
- Otsuka Pharmaceutical
- Institute of Innovative Research, Tokyo Institute of Technology
- National Institute of Mental Health (R21MH108901)
- Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Keywords
- nitrous oxide, mood disorders, treatment-resistant depression, rapid-acting antidepressants, regulatory guidelines
- MeSH terms
- Humans, Nitrous Oxide, Excitatory Amino Acid Antagonists, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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