Does Nitrous Oxide Help Veterans With Posttraumatic Stress Disorder? A Case Series
Open accessAbstract
This case series investigates the potential for nitrous oxide to rapidly reduce symptoms of posttraumatic stress disorder. Did it help the 3 Veteran outpatients who received it? Read this report to find out.
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Inhaled 50% nitrous oxide had significant and rapid-acting antidepressant effects in a small cohort of three participants with PTSD.
“and in a small cohort (n = 3) of participants with PTSD [178]”
From Ketamine in neuropsychiatric disorders: an update (2024) · cites this paper as [178]
The Method section describes three participants with PTSD inhaling 50% nitrous oxide. The Results report rapid improvement in PTSD symptoms in two participants, but do not report antidepressant outcomes or a statistically significant effect; the authors also caution that this was an uncontrolled case series. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Cites
Weathers, F. W., Bovin, M. J., Lee, D. J., Sloan, D. M., Schnurr, P. P., Kaloupek, D. G., Keane, T. M., & Marx, B. P. (2018) · Psychological Assessment · doi:10.1037/pas0000486 · Cited by 1,799 · see citing works
What Is a “Mood Stabilizer”? An Evidence-Based Response
Bauer, M. S., & Mitchner, L. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.3 · Cited by 862 · see citing works
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(2007) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9780890423363.52257 · Cited by 422 · see citing works
Krystal, J. H., Davis, L. L., Neylan, T. C., A. Raskind, M., Schnurr, P. P., Stein, M. B., Vessicchio, J., Shiner, B., Gleason, T. D., & Huang, G. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.03.007 · Cited by 265 · see citing works
Self-citationNitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial
Nagele, P., Duma, A., Kopec, M., Gebara, M. A., Parsoei, A., Walker, M., Janski, A., Panagopoulos, V. N., Cristancho, P., Miller, J. P., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.016 · Cited by 230 · see citing works
Self-citationFirst-line Psychotherapies for Military-Related PTSD
Steenkamp, M. M., Litz, B. T., & Marmar, C. R. (2020) · JAMA · doi:10.1001/jama.2019.20825 · Cited by 194 · see citing works
Stefanovics, E. A., Rosenheck, R. A., Jones, K. M., Huang, G., & Krystal, J. H. (2018) · Psychiatric Quarterly · doi:10.1007/s11126-017-9522-y · Cited by 74 · see citing works
Use of Evidence-Based Treatment for Posttraumatic Stress Disorder in Army Behavioral Healthcare
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Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts
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Flagged first, then by citations
Research works printed but not linked: 1
- [10]Weiss DS, Marmar CR: Impact of Events Scale - Revised. in Assessing psychological trauma and PTSD. Edited by Wilson J, Keane TM. New York, Guilford; 1996. pp. 399– 411.
Cited by
Sorted by citations
A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression
Nagele, P., Palanca, B. J., Gott, B., Brown, F., Barnes, L., Nguyen, T., Xiong, W., Salloum, N. C., Espejo, G. D., Lessov-Schlaggar, C. N., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe1376 · Cited by 133 · see citing works
Ketamine in neuropsychiatric disorders: an update
Johnston, J. N., Kadriu, B., Kraus, C., Henter, I. D., & Zarate, C. A. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-023-01632-1 · Cited by 108 · see citing works
Jumaili, W. A., Trivedi, C., Chao, T., Kubosumi, A., & Jain, S. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113804 · Cited by 29 · see citing works
- Authors
- Varias, A., van Roessel, P., Parsiani, M., Filippou-Frye, M., Neylan, T. C., Nagele, P., Yesavage, J., Clark, J. D., & Rodriguez, C. I.
- Affiliations
- Stanford Medicine (US)
- VA Palo Alto Health Care System (US)
- San Francisco VA Medical Center (US)
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2020-06-30
- Volume
- 81
- Issue
- 4
- ISSN
- 0160-6689 (ISSN-L)
- 1555-2101
- PMC
- PMC8218879
- OpenAlex
- W3039143683
- Cited by
- 20
- References
- 11
- Citations by year
- 2025: 6 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 CX001789)
- National Institute on Aging (P30AG059307)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Social Sciences › Psychology › Social Psychology › Music Therapy and Health
- Keywords
- nitrous oxide, post-traumatic stress disorder, veterans, outpatient care
- MeSH terms
- Adult, Humans, Middle Aged, Nitrous Oxide, Stress Disorders, Post-Traumatic, Veterans, Anesthetics, Inhalation
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